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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2019, Volume 116, Issue 7, pp. 2603 - 2611
The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of... 
cdkn2a | Aging | Senescence | Index Medicus
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 02/2014, Volume 12, Issue 2, pp. 167 - 183
Located on chromosome 9p21.3, p16 INK4a seems lost amongst a cluster of neighboring tumor suppressor genes. While best known for inhibiting cyclin dependent... 
senescence | INK4 | ARF | CDKN2A | polycomb
Journal Article
Oncogene, ISSN 0950-9232, 01/2004, Volume 23, Issue 2, pp. 379 - 385
Mounting genetic evidence suggests that each product of the Ink4a/Arf locus, p16[sup.INK4a] and p19[sup.ARF], possesses tumor-suppressor activity (Kamijo et... 
cdkn2a | Rb | p14 | p53
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2019, Volume 116, Issue 7, pp. 2603 - 2611
The accumulation of senescent cells over a lifetime causes age-related pathologies; however, the inability to reliably identify senescent cells in vivo has... 
senescence | cdkn2a | Biological Sciences | aging | PNAS Plus
Journal Article
Cancer, ISSN 0008-543X, 09/2018, Volume 124, Issue 18, pp. 3715 - 3723
Regardless of cyclin‐dependent kinase inhibitor 2A ( CDKN2A ) status, melanoma‐prone families are reported to have 6‐fold to 28‐fold higher percentages of... 
genetics | CDKN2A | family research | pediatrics | melanoma | cyclin‐dependent kinase inhibitor 2A | sun protection | cyclin-dependent kinase inhibitor 2A (CDKN2A) | GERMLINE CDKN2A MUTATIONS | RISK | DYSPLASTIC NEVI | MALIGNANT-MELANOMA | PREVALENCE | CHILDREN | ADOLESCENT CUTANEOUS MELANOMA | ONCOLOGY | GENOMEL | Pediatrics | Melanoma | Population studies | Skin | Children | Mutation | Patients | Age | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
Oncotarget, 11/2017, Volume 8, Issue 55, pp. 94330 - 94344
Journal Article
Human Pathology, ISSN 0046-8177, 2016, Volume 60, pp. 86 - 94
BRCA-associated protein 1 (BAP1) immunohistochemistry (IHC) and CDKN2A (p16) fluorescence in situ hybridization (FISH) have shown clinical utility in... 
Pathology | Prognosis | Malignant pleural mesothelioma | BAP1 immunohistochemistry | Diagnosis | CDKN2A (p16) FISH | P16/CDKN2A DELETION | HOMOZYGOUS DELETION | EFFUSION CYTOLOGY | GERMLINE | PROLIFERATIONS | PATHOLOGY | SOMATIC MUTATIONS | GENE | FISH | CDKN2A (p6) FISH | EXPRESSION | Immunohistochemistry | Multivariate Analysis | Predictive Value of Tests | Pleural Neoplasms - genetics | Ubiquitin Thiolesterase - analysis | Mesothelioma - pathology | Tissue Array Analysis | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Aged, 80 and over | Adult | Female | Pleural Neoplasms - pathology | Lung Neoplasms - genetics | Genetic Predisposition to Disease | Mesothelioma - therapy | Reproducibility of Results | Mesothelioma - chemistry | Lung Neoplasms - chemistry | Biomarkers, Tumor - analysis | Risk Factors | Proportional Hazards Models | In Situ Hybridization, Fluorescence | Lung Neoplasms - therapy | Mesothelioma - genetics | Pleural Neoplasms - therapy | Pleural Neoplasms - chemistry | Phenotype | Cyclin-Dependent Kinase Inhibitor p18 - genetics | Biopsy | Aged | Biomarkers, Tumor - genetics | Tumor Suppressor Proteins - analysis | Fluorescence | Mesothelioma | Analysis | Statistical analysis | Cloning | Colleges & universities | Melanoma | Medical records | Histology | Hybridization | Multivariate analysis | Confidence intervals | Medical prognosis | Morphology | Software | Mutation | Index Medicus
Journal Article
Modern Pathology, ISSN 0893-3952, 03/2012, Volume 25, Issue 3, pp. 465 - 470
Journal Article
Journal Article
Oncology Reports, ISSN 1021-335X, 09/2010, Volume 24, Issue 3, pp. 701 - 707
Journal Article
Aging Cell, ISSN 1474-9718, 08/2009, Volume 8, Issue 4, pp. 439 - 448
Summary Expression of the p16INK4a tumor suppressor sharply increases with age in most mammalian tissues, and contributes to an age-induced functional decline... 
frailty | exercise | CDKN2a | IL-6 | INK4/ARF | smoking | ARF | INK4
Journal Article
BMC CANCER, ISSN 1471-2407, 08/2019, Volume 19, Issue 1, pp. 772 - 772
Introduction Multiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several... 
SURVIVAL | Mutations | CDKN2A MUTATIONS | SINGLE | CDKN2A | Melanoma | SUSCEPTIBILITY | RISK | BRAF | POPULATION-BASED PREVALENCE | MALIGNANT-MELANOMA | FEATURES | ONCOLOGY | FAMILIES | Skin | NGS | MC1R VARIANTS | Cancer | Usage | Gene mutations | Physiological aspects | Genetic aspects | Research | Diagnosis | Nucleotide sequencing | Risk factors | DNA sequencing | Index Medicus
Journal Article
Journal of the American Academy of Dermatology, ISSN 0190-9622, 03/2016, Volume 74, Issue 3, pp. 411 - 420
Malignant melanoma is considered the most lethal skin cancer if it is not detected and treated during its early stages. About 10% of melanoma patients report a... 
melanoma genetics | familial melanoma syndromes | FAMMM | mixed cancer syndromes | CDK4 | CDKN2A
Journal Article
Annals of Medicine, ISSN 0785-3890, 01/2019, Volume 51, Issue 1, pp. 28 - 40
Background: Cyclin-dependent kinase inhibitor 2A/B (CDKN2A/B) genes are frequently altered in acute lymphoblastic leukaemia (ALL) patients. The aim of this... 
Acute lymphoblastic leukaemia; CDKN2A/B; deletions; prognosis; meta-analysis | ADULT PATIENTS | METHYLATION | CDKN2A | deletions | meta-analysis | CLASSIFICATION | RELAPSE-FREE SURVIVAL | prognosis | CHILDHOOD | INACTIVATION | MEDICINE, GENERAL & INTERNAL | GENE | Acute lymphoblastic leukaemia | MINIMAL RESIDUAL DISEASE | CPG ISLANDS | STRATIFICATION
Journal Article
Cell Cycle, ISSN 1538-4101, 08/2011, Volume 10, Issue 15, pp. 2497 - 2503
The CDKN2A gene is a tumor suppressor that encodes the CDK4/6 inhibitor p16ink4a. Loss of this tumor suppressor contributes to the bypass of critical senescent... 
Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | Therapy | p16 | CDKN2a | Radiation | Cyclin | E2F | CDK | cyclin | radiation | therapy | Review
Journal Article
Leukemia & Lymphoma, ISSN 1042-8194, 01/2019, Volume 60, Issue 2, pp. 433 - 441
Considering conflicting data on CDKN2A/B deletion in ALL, this study to assess its prognostic significance as an independent marker in a total of 96 pediatric... 
CDKN2A/B | minimal residual disease | copy number abnormality | Acute lymphoblastic leukemia | MLPA | BCP-ALL | INK4A/ARF | FREQUENT | CDKN2A | ABNORMALITIES | TUMOR-SUPPRESSOR GENE | RISK | COPY | PROGNOSTIC VALUE | 9P21 | ADULT | PROFILE | ONCOLOGY | HEMATOLOGY
Journal Article
Oncotarget, ISSN 1949-2553, 07/2018, Volume 9, Issue 51, pp. 29548 - 29564
The major part of the genome that was previously called junk DNA has been shown to be dynamically transcribed to produce non-coding RNAs. Among them, the long... 
ANRIL | LncRNA | CeRNA | CDKN2A-AS1 | Glioblastoma
Journal Article
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