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TOXICOLOGIC PATHOLOGY, ISSN 0192-6233, 2007, Volume 35, Issue 6, pp. 838 - 845
The cyclin-dependent kinase (CDK) inhibitor p16(INK4a) and the MDM2 ubiquitin ligase inhibitor p19(ARF) are critical to the regulation of cell cycle... 
meningioma | CELLS | CDKN2B | meningiomatosis | tumor suppressor gene deficiency | PATHOLOGY | LOCUS | central nervous system | mouse | P14(ARF) | GROWTH | TOXICOLOGY | animal model | ethylnitrosourea | TUMORIGENESIS | EXPRESSION
Journal Article
Genetics and Molecular Biology, ISSN 1415-4757, 2008, Volume 31, Issue 3, pp. 632 - 638
The aim of this work was to evaluate the methylation profile of the p15 (CDKN2B) gene in Brazilian patients with leukemia and to correlate the CDKN2B gene... 
DNA methylation | CpG island | CDKN2B | BIOCHEMISTRY & MOLECULAR BIOLOGY | FUNDAMENTAL ROLE | ACUTE MYELOID-LEUKEMIA | CANCER | ADULT | EPIGENETICS | P15 | GENETICS & HEREDITY | HEMATOLOGIC MALIGNANCIES | CPG ISLANDS | HEMATOPOIETIC MALIGNANCIES
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/1995, Volume 92, Issue 14, pp. 6489 - 6493
Journal Article
Cancer Letters, ISSN 0304-3835, 2008, Volume 264, Issue 1, pp. 145 - 161
Actinic keratosis (AK) is a well-established pre-cancerous skin lesion that has the potential to progress to squamous cell carcinoma (SCC). We investigated the... 
Actinic keratosis | Mutations | CDKN2B | MSI/LOH | CDKN2A | mRNA expression
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 01/2013, Volume 33, Issue 1, pp. e1 - e10
OBJECTIVE—Genomewide association studies have implicated allelic variation at 9p21.3 in multiple forms of vascular disease, including atherosclerotic coronary... 
CDKN2B | remodeling | smooth muscle | apoptosis | genomewide association studies | abdominal aortic aneurysm | p53 | ABDOMINAL AORTIC-ANEURYSMS | MYOCARDIAL-INFARCTION | CHROMOSOME 9P21 | MOUSE MODELS | HEART-DISEASE | TUMOR-SUPPRESSOR | MYELOID-LEUKEMIA | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | UP-REGULATION | CORONARY-ARTERY-DISEASE | GENOME-WIDE ASSOCIATION | Carotid Arteries - metabolism | Aortic Aneurysm, Abdominal - chemically induced | Aortic Aneurysm, Abdominal - prevention & control | Cell Proliferation | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Middle Aged | Child, Preschool | Male | Aortic Aneurysm, Abdominal - metabolism | Young Adult | Neointima | RNA Interference | Time Factors | Carotid Artery Diseases - pathology | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Bone Marrow Transplantation | Toluene - pharmacology | Child | Infant, Newborn | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Signal Transduction | Benzothiazoles - pharmacology | Cyclin-Dependent Kinase Inhibitor p15 - deficiency | Genotype | Mice, Knockout | Phenotype | Adolescent | Carotid Artery Diseases - genetics | Pancreatic Elastase | Mice | Cell Movement | Carotid Artery Diseases - prevention & control | Muscle, Smooth, Vascular - metabolism | Infant | Case-Control Studies | Toluene - analogs & derivatives | Transfection | Adult | Aorta, Abdominal - pathology | Aorta, Abdominal - metabolism | Carotid Artery Diseases - metabolism | Proto-Oncogene Proteins c-mdm2 - metabolism | Aortic Aneurysm, Abdominal - pathology | Mice, Inbred C57BL | Cells, Cultured | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Aortic Aneurysm, Abdominal - genetics | Muscle, Smooth, Vascular - pathology | Animals | Aged | Carotid Arteries - pathology | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Index Medicus | genome wide association studies
Journal Article
Circulation Research, ISSN 0009-7330, 01/2016, Volume 118, Issue 2, pp. 230 - 240
RATIONALE:Genetic variation at the chromosome 9p21 cardiovascular risk locus has been associated with peripheral artery disease, but its mechanism remains... 
atherosclerosis | smooth muscle cells | genetic variation | peripheral artery disease | cyclin-dependent kinase inhibitor p15 | pathologic angiogenesis | CARDIAC & CARDIOVASCULAR SYSTEMS | PROTEIN | MYOCARDIAL-INFARCTION | AORTIC-ANEURYSM | ANGIOGENESIS | RISK | CHROMOSOME 9P21 VARIANTS | PERIPHERAL ARTERY-DISEASE | TUMOR-SUPPRESSOR | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | ANEURYSM FORMATION | Hindlimb | Atherosclerosis - genetics | Humans | Transforming Growth Factor beta1 - metabolism | Neovascularization, Pathologic | Male | Muscle, Smooth, Vascular - physiopathology | Cell Hypoxia | Atherosclerosis - enzymology | Transfection | RNA Interference | Time Factors | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Carotid Arteries - enzymology | Female | Disease Models, Animal | Muscle, Skeletal - blood supply | Smad7 Protein - metabolism | Atherosclerosis - pathology | Coronary Vessels - pathology | Genetic Predisposition to Disease | Coronary Vessels - enzymology | Signal Transduction | Cyclin-Dependent Kinase Inhibitor p15 - deficiency | Myocytes, Smooth Muscle - enzymology | Mice, Inbred C57BL | Cells, Cultured | Atherosclerosis - mortality | Transforming Growth Factor beta1 - genetics | Chromosomes, Human, Pair 9 | Mice, Knockout | Phenotype | Animals | Carotid Arteries - pathology | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Muscle, Smooth, Vascular - enzymology | Neovascularization, Physiologic | Index Medicus | cardiovascular disease CDKN2B | Pathophysiology | Risk Factors | angiogenesis | Atherosclerosis | TGFβ | Peripheral Vascular Disease | 9p21 | Gene Expression and Regulation
Journal Article
Modern Pathology, ISSN 0893-3952, 04/2010, Volume 23, Issue 4, pp. 547 - 558
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2014, Volume 446, Issue 4, pp. 1126 - 1131
Risk alleles within a gene desert at the 9p21 locus constitute the most prevalent genetic determinant of cardiovascular disease. Previous research has... 
Chromosome 9p21 | CDKN2B | Adipose tissue | MYOCARDIAL-INFARCTION | GENOMEWIDE ASSOCIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RISK | CELL-PROLIFERATION | DIABETES-MELLITUS | HEART-DISEASE | OBESITY | BIOPHYSICS | CARDIOVASCULAR-DISEASE | CORONARY-ARTERY-DISEASE | Body Mass Index | Atherosclerosis - genetics | Humans | Middle Aged | Gene Expression Regulation | Lipid Metabolism | Male | Genetic Loci | Atherosclerosis - metabolism | Chromosomes, Human, Pair 9 - genetics | Subcutaneous Fat - metabolism | Energy Metabolism | Cyclin-Dependent Kinase Inhibitor p15 - genetics | Postprandial Period | Adult | Female | Cyclin-Dependent Kinase Inhibitor p15 - metabolism | Adipose tissues | Atherosclerosis | Index Medicus | CHEMICAL VAPOR DEPOSITION | HUMAN POPULATIONS | NEOPLASMS | RNA | BUILDUP | CELL PROLIFERATION | CHROMOSOMES | 60 APPLIED LIFE SCIENCES | ARTERIOSCLEROSIS | INDICATORS | GENES | LIVER | CARBOXYLIC ACIDS | FATS | METABOLIC DISEASES | ADIPOSE TISSUE | B | CVD, cardiovascular disease | MTAP, methylthioadenosine phosphorylase | CDKN2A | ANRIL, antisense noncoding RNA in the INK4 locus | B, cyclin-dependent kinase inhibitor 2A | SAT, subcutaneous adipose tissue | BMI, body mass index | TAG, triacylglycerol | VAT, visceral adipose tissue | Biofysik | Biophysics | Biokemi och molekylärbiologi | Biochemistry and Molecular Biology
Journal Article
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, ISSN 0027-8874, 06/2008, Volume 100, Issue 11, pp. 784 - 795
Background The tumor suppressors p14(ARF) (ARF) and p16(INK4A) (p16) are encoded by overlapping reading frames at the CDKN2A/INK4A locus on chromosome 9p21. In... 
BREAST-CANCER | PROMOTER HYPERMETHYLATION | ONCOLOGY | TUMOR SUPPRESSION | FAMILIAL MELANOMA | CUTANEOUS MELANOMA | CDKN2B GENES | GERMLINE MUTATIONS | SPORADIC MELANOMA | HUMAN-MALIGNANT MELANOMA | P53
Journal Article
BJU International, ISSN 1464-4096, 07/2019, Volume 124, Issue 1, pp. 155 - 162
Objective To investigate the genomic features of tertiary pattern 5 (TP5) on radical prostatectomy specimens in an effort to explain the poor clinical outcomes... 
CDC | tertiary Gleason 5 | progression‐free survival | PCSM | ProstateCancer | CDKN | PLK | CDKN2B | progression-free survival | PLK1 | VALIDATION | GENOMIC CLASSIFIER | PATTERNS | RADICAL PROSTATECTOMY | CDC20 | IMPACT | UROLOGY & NEPHROLOGY | Medical research | Prognosis | RNA | Analysis | Genes | Genomics | Medicine, Experimental | Prostate cancer | DNA microarrays | Polo-like kinase 1 | Transcription | Medical prognosis | Cell division | Genomes | Ribonucleic acid--RNA
Journal Article
Journal Article
Oncogene, ISSN 0950-9232, 12/2003, Volume 22, Issue 58, pp. 9265 - 9274
The Ink4b gene (Cdkn2b) encodes p15 super(Ink4b), a cyclin-dependent kinase inhibitor. It has been implicated in playing a role in the development of acute... 
Ink4b gene | Cdkn2b gene | 5-aza-2'-deoxycytidine
Journal Article