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SEMINARS IN ONCOLOGY, ISSN 0093-7754, 12/2017, Volume 44, Issue 6, pp. 395 - 403
With 40,920 American women expected to die from breast cancer in 2018 and global health estimates that more than 508,000 women died in 2011 from this disease,... 
CDK 6 inhibitors | retinoblastoma protein | SOLID TUMORS | EFFICACY | Palbociclib | Ribociclib | ENDOCRINE THERAPY | DEPENDENT KINASE INHIBITOR | COMBINATION | CDK 4 | CDK 4 inhibitors | CDK 6 | Abemaciclib | me-too cancer therapies | ONCOLOGY | retinoblastoma | FULVESTRANT | CDK4/6 inhibitors | LETROZOLE | FDA approvals | SCHEDULE | PHASE-I | FLAVOPIRIDOL
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 32, pp. 12542 - 12562
The avian reovirus p17 protein is a nucleocytoplasmic shuttling protein. Although we have demonstrated that p17 causes cell growth retardation via activation... 
APOPTOSIS | ACTIVATION | cyclin | cyclin-dependent kinase 7 (CDK7) | cell cycle | avian reovirus | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | cyclin-dependent kinase (CDK) | IDENTIFICATION | mutagenesis | P21 | CDK inhibitor | CDK-cyclin complexes | WEB | p17 | SEQUENCE | NONSTRUCTURAL PROTEIN | cancer | INHIBITORS | DEPENDENT KINASES | Index Medicus | Microbiology | CDK–cyclin complexes
Journal Article
Genes and Development, ISSN 0890-9369, 06/2010, Volume 24, Issue 12, pp. 1208 - 1219
Journal Article
Oncogene, ISSN 0950-9232, 12/2001, Volume 20, Issue 58, pp. 8317 - 8325
Journal Article
Annals of Oncology, ISSN 0923-7534, 03/2018, Volume 29, Issue 3, pp. 640 - 645
Abstract Background While deregulation of the cyclin D1-CDK4/6-retinoblastoma pathway is common in hormone receptor positive (HR+) breast cancer, Rb is usually... 
RB1 | Metastatic breast cancer | Acquired resistance | CDK 4/6 inhibitor | Genomics | ENDOCRINE THERAPY | PATTERNS | 6 inhibitor | COMBINATION | CDK 4 | acquired resistance | EGFR | PALBOCICLIB | RETINOBLASTOMA | CIRCULATING TUMOR DNA | ONCOLOGY | FULVESTRANT | metastatic breast cancer | LETROZOLE | genomics | Index Medicus
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 01/2014, Volume 443, Issue 3, pp. 1105 - 1109
Mammalian cardiomyocytes actively proliferate during embryonic stages, following which cardiomyocytes exit their cell cycle after birth. The irreversible cell... 
Cell cycle exit | CDK inhibitor | Mouse | Cardiomyocyte
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 102, p. 37610
Journal Article
癌症:英文版, ISSN 1000-467X, 2017, Volume 36, Issue 4, pp. 163 - 164
Normally, cyclin interacts with cyclin-dependent kinase (CDK) to form a cyclin-CDK complex, which promotes cell cycle progression, whereas cyclin-dependent... 
roles;erythropoiesis;CDK
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 01/2018, Volume 17, Issue 1, pp. 9 - 10
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 04/2019, Volume 14, Issue 4, pp. 701 - 711
Introduction: This phase II study evaluated the efficacy and safety of the pan-cyclin–dependent kinase inhibitor roniciclib with platinum-based chemotherapy in... 
Carboplatin | Etoposide | CDK inhibitor | Extensive-disease small cell lung cancer | Cisplatin | Roniciclib | TRIAL | CDK INHIBITORS | ONCOLOGY | RESPIRATORY SYSTEM | DEPENDENT KINASE INHIBITOR | CHEMOTHERAPY
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2019, Volume 74, Issue 4, pp. 758 - 770.e4
The cyclin-dependent kinases Cdk4 and Cdk6 form complexes with D-type cyclins to drive cell proliferation. A well-known target of cyclin D-Cdk4,6 is the... 
docking | cell-cycle regulation | kinase | cyclin | E2F | Cdk | phosphorylation | G1/S
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 100, pp. 37352 - 37366
Aberrant activation of CDK4/6 kinase is the most common somatic event in non-small cell lung cancer (NSCLC). Palbociclib is a highly specific CDK4/6 inhibitor... 
Clinical trial | CDK 4/6 | MTOR | Non-small cell lung cancer | Palbociclib
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 08/2019, Volume 29, Issue 16, pp. 2136 - 2140
HDAC and CDK inhibitors have been demonstrated to be synergistically in suppressing cancer cell proliferation and inducing apoptosis. In this work, we... 
HDACs | Purin | CDKs | Dual inhibitors | Antitumor | CHEMISTRY, MEDICINAL | HISTONE DEACETYLASES | CHEMISTRY, ORGANIC | Drugstores | Medical colleges | Pharmacy | Index Medicus
Journal Article