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Neuron (Cambridge, Mass.), ISSN 0896-6273, 06/2007, Volume 54, Issue 5, pp. 755 - 770
Ca2+ signaling plays a central role in activity-dependent regulation of dendritic arborization, but key molecular mechanisms downstream of calcium elevation... 
CELLBIO | DEVBIO | MOLNEURO
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2007, Volume 129, Issue 1, pp. 45 - 56
Caspases are intracellular proteases that cleave substrates involved in apoptosis or inflammation. In C. elegans, a paradigm for caspase regulation exists in... 
CELLBIO | CELLIMMUNO
Journal Article
Developmental cell, ISSN 1534-5807, 10/2007, Volume 13, Issue 4, pp. 496 - 510
Here, we report a direct interaction between the β1 integrin cytoplasmic tail and Rab25, a GTPase that has been linked to tumor aggressiveness and metastasis.... 
CELLBIO
Journal Article
Developmental cell, ISSN 1534-5807, 2007, Volume 13, Issue 5, pp. 635 - 645
The COPII vesicular coat forms on the endoplasmic reticulum from Sar1-GTP, Sec23/24 and Sec13/31 protein subunits. Here, we define the interaction between... 
CELLBIO
Journal Article
Immunity (Cambridge, Mass.), ISSN 1074-7613, 2006, Volume 25, Issue 4, pp. 583 - 594
We used negative stain electron microscopy (EM) to examine the conformational changes in the ectodomains required for activation of the leukocyte integrins α β... 
CELLBIO | PROTEINS | MOLIMMUNO
Journal Article
Developmental cell, ISSN 1534-5807, 2010, Volume 19, Issue 1, pp. 148 - 159
Cell migration requires endocytosis and recycling of integrins, but it is not known whether degradation of these membrane proteins is involved. Here we... 
CELLBIO | Cellbio
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2007, Volume 131, Issue 3, pp. 596 - 610
Communication between the endoplasmic reticulum (ER) and mitochondrion is important for bioenergetics and cellular survival. The ER supplies Ca directly to... 
CELLBIO | SIGNALING | TARGET | MEMBRANE-FRACTION | MICRODOMAINS | SIGMA BINDING-SITES | CALCIUM OSCILLATIONS | INOSITOL TRISPHOSPHATE RECEPTORS | ROLES | BIOCHEMISTRY & MOLECULAR BIOLOGY | DYNAMICS | ENDOPLASMIC-RETICULUM | AGONISTS | CELL BIOLOGY
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2010, Volume 141, Issue 5, pp. 897 - 907
Journal Article
Cell (Cambridge), ISSN 0092-8674, 2007, Volume 131, Issue 3, pp. 584 - 595
SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases (SENPs). The physiologic consequences of... 
CELLBIO | PROTEINS | DEVBIO | INDUCIBLE FACTOR 1-ALPHA | DEPENDENT TRANSCRIPTION | PROLYL HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | DEGRADATION | VHL | HIF-1-ALPHA | DIFFERENTIAL REGULATION | O-2 TENSION | HIF-ALPHA | CELL BIOLOGY
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2007, Volume 55, Issue 1, pp. 25 - 36
Many biological functions depend critically upon fine details of tissue molecular architecture that have resisted exploration by existing imaging techniques.... 
CELLBIO | MOLNEURO | FLUORESCENCE MICROSCOPY | IMMUNOFLUORESCENCE | PROTEIN | ADULT-RAT | SYNAPSES | SEMITHIN SECTIONS | NEURONS | ELECTRON-MICROSCOPY | ANTIGENS | LR-WHITE | NEUROSCIENCES | Tomography | Physiological aspects | Proteins | Neurosciences | Medical imaging | Architecture | Microscopy | Rodents | Arrays | Microscopes | Methods
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2008, Volume 60, Issue 6, pp. 988 - 1009
β-site APP cleaving enzyme-1 (BACE1), the rate-limiting enzyme for β-amyloid (Aβ) production, is elevated in Alzheimer's disease (AD). Here, we show that... 
CELLBIO | HUMDISEASE | MOLNEURO | CLEAVING ENZYME-1 | BETA-SECRETASE ACTIVITY | TRAUMATIC BRAIN-INJURY | IN-VIVO | ALZHEIMERS-DISEASE PATHOGENESIS | ENDOPLASMIC-RETICULUM | AMYLOID PRECURSOR PROTEIN | ENERGY-METABOLISM | SYNAPTIC PLASTICITY | NEUROSCIENCES | TRANSGENIC MICE
Journal Article