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Cancer Cell, ISSN 1535-6108, 09/2009, Volume 16, Issue 3, pp. 183 - 194
TGF-β blockade significantly slows tumor growth through many mechanisms, including activation of CD8 T cells and macrophages. Here, we show that TGF-β blockade... 
CELLCYCLE | MOLIMMUNO
Journal Article
Cancer Cell, ISSN 1535-6108, 2010, Volume 18, Issue 1, pp. 74 - 87
Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to eradicate Bcr-Abl leukemia... 
CELLCYCLE
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 131, Issue 4, pp. 744 - 755
The status of spindle checkpoint signaling depends on the balance of two opposing dynamic processes that regulate the highly unusual two-state behavior of... 
CELLCYCLE
Journal Article
Cancer Cell, ISSN 1535-6108, 2007, Volume 12, Issue 3, pp. 266 - 279
Growth factors have been implicated in pancreatic carcinogenesis. In this study we analyzed the effect of Tgfa overexpression in addition to mutant Kras by... 
CELLCYCLE
Journal Article
Cancer Cell, ISSN 1535-6108, 2007, Volume 11, Issue 3, pp. 229 - 243
Oncogenic initiates pancreatic tumorigenesis, while subsequent genetic events shape the resultant disease. We show here that concomitant expression of and... 
CELLCYCLE
Journal Article
Molecular Cell, ISSN 1097-2765, 2006, Volume 22, Issue 4, pp. 463 - 475
The tumor suppressor functions of p19 have been attributed to its ability to induce cell cycle arrest or apoptosis by activating p53 and regulating ribosome... 
CELLCYCLE
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 2, pp. 113 - 120
Overexpression of Bcl-x , loss of p19 , and loss of p53 all accelerate Myc oncogenesis. All three lesions are implicated in suppressing Myc-induced apoptosis,... 
CELLCYCLE
Journal Article
Cancer Cell, ISSN 1535-6108, 2006, Volume 10, Issue 4, pp. 295 - 307
We discovered that monoclonal antibodies (mAbs) specific to human β -microglobulin (β M) induce apoptosis in vitro and were therapeutic in mouse models of... 
CELLCYCLE
Journal Article
Cell, ISSN 0092-8674, 04/2008, Volume 133, Issue 1, pp. 78 - 89
Characteristics of transformed and tumor cells include increased levels of protein synthesis and elevated expression of RNA polymerase (pol) III products, such... 
CELLBIO | PROTEINS | CELLCYCLE
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2009, Volume 36, Issue 4, pp. 696 - 703
A pivotal step toward apoptosis is oligomerization of the Bcl-2 relative Bak. We recently reported that its oligomerization initiates by insertion of an... 
PROTEINS | CELLCYCLE
Journal Article
Cancer Cell, ISSN 1535-6108, 03/2007, Volume 11, Issue 3, pp. 229 - 243
Oncogenic Kras initiates pancreatic tumorigenesis, while subsequent genetic events shape the resultant disease. We show here that concomitant expression of... 
CELLCYCLE
Journal Article
Cancer Cell, ISSN 1535-6108, 08/2008, Volume 14, Issue 2, pp. 146 - 155
Transgenic expression of activated AKT1 in the murine prostate induces prostatic intraepithelial neoplasia (PIN) that does not progress to invasive prostate... 
CELLCYCLE
Journal Article
Cancer Cell, ISSN 1535-6108, 07/2008, Volume 14, Issue 1, pp. 23 - 35
A reduction in the cellular levels of the cyclin kinase inhibitor p27 is frequently found in many human cancers and correlates directly with patient prognosis.... 
CHEMBIO | CELLCYCLE
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2007, Volume 27, Issue 3, pp. 462 - 473
During the G1/S transition, p21 proteolysis is mediated by Skp2; however, p21 reaccumulates in G2 and is degraded again in prometaphase. How p21 degradation is... 
PROTEINS | CELLCYCLE
Journal Article
Cancer Cell, ISSN 1535-6108, 09/2007, Volume 12, Issue 3, pp. 266 - 279
Growth factors have been implicated in pancreatic carcinogenesis. In this study we analyzed the effect of Tgfa overexpression in addition to mutant Kras by... 
CELLCYCLE
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2009, Volume 34, Issue 3, pp. 271 - 284
The p16 tumor suppressor gene is a frequent target of epigenetic inactivation in human cancers, which is an early event in breast carcinogenesis. We describe... 
CELLCYCLE | DNA | HUMDISEASE
Journal Article
Molecular Cell, ISSN 1097-2765, 06/2009, Volume 34, Issue 6, pp. 663 - 673
In response to oxidative stress, Nrf2 and p21 are both upregulated to protect cells from oxidative damage. Nrf2 is constantly ubiquitinated by a Keap1 dimer... 
PROTEINS | CELLCYCLE | SIGNALING
Journal Article
Cancer Cell, ISSN 1535-6108, 2009, Volume 15, Issue 5, pp. 389 - 401
Mammary epithelia are composed of luminal and myoepithelial/basal cells whose neoplastic transformations lead to distinct types of breast cancers with diverse... 
CELLCYCLE | STEMCELL
Journal Article
Cancer Cell, ISSN 1535-6108, 10/2007, Volume 12, Issue 4, pp. 313 - 327
Although TGFβ is a potent inhibitor of proliferation, epithelia lacking the essential receptor ( ) for TGFβ signaling display normal tissue homeostasis. By... 
CELLCYCLE | DEVBIO
Journal Article
ISSN 0969-2126, 2009
ABCG2 is a multidrug efflux pump associated with resistance of cancer cells to a plethora of unrelated drugs. ABCG2 is a "half-transporter," and previous... 
Cellcycle | Cellbio
Journal Article
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