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Journal Article
Journal Article
by Su, WC and Lin, YH and Pagac, M and Wang, CW
JOURNAL OF CELL BIOLOGY, ISSN 0021-9525, 11/2019, Volume 218, Issue 11, pp. 3663 - 3680
Seipin is known for its critical role in controlling lipid droplet (LD) assembly at the LD-forming subdomain of the endoplasmic reticulum (ER). Here, we... 
YEAST | FATTY-ACID ELONGATION | METABOLISM | SERINE PALMITOYLTRANSFERASE | ENDOPLASMIC-RETICULUM | PHOSPHATIDIC-ACID | MEMBRANE-PROTEINS | CERAMIDE | SACCHAROMYCES-CEREVISIAE | LIPID DROPLETS | CELL BIOLOGY | Yeasts | Yeast | Serine palmitoyltransferase | Serine | Lipids | Sphingolipids | Palmitoyltransferase | Fatty acids | Mutants | Intermediates | Inhibitors | Synthesis | Morphology | Endoplasmic reticulum
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 06/2019, Volume 29, Issue 11, pp. 1357 - 1362
Two α-GalCer analogues were newly designed with the help of docking calculation and efficiently synthesized taking advantages of inverse glycosylation... 
Th2 cytokines | NKT cells | CD1d | KRN7000 | OCH | BIOACTIVITY | CHEMISTRY, MEDICINAL | RECOGNITION | ANALOGS | CHEMISTRY, ORGANIC | CERAMIDE
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2010, Volume 107, Issue 43, pp. 18439 - 18444
Very long-chain fatty acids (VLCFAs) exert a variety of cellular functions and are associated with numerous diseases. However, the precise pathway behind their... 
Enzymes | Messenger RNA | Substrate specificity | HeLa cells | Small interfering RNA | Ceramides | Lipids | Sphingolipids | Mammals | Fatty acids | Monounsaturated fatty acid | Polyunsaturated fatty acid | Acyl-CoA | Lipid metabolism | Saturated fatty acid | acyl-CoA | CERAMIDE SYNTHASE 2 | MULTIDISCIPLINARY SCIENCES | lipid metabolism | IDENTIFICATION | SACCHAROMYCES-CEREVISIAE | MASS-SPECTROMETRY | saturated fatty acid | CHAIN FATTY-ACIDS | ELONGATION | BIOSYNTHESIS | GENE FAMILY | SKIN FUNCTION | monounsaturated fatty acid | polyunsaturated fatty acid | ADIPOSE-TISSUE | Acyl Coenzyme A - biosynthesis | Sphingolipids - biosynthesis | Sphingolipids - chemistry | RNA, Small Interfering - genetics | Acetyltransferases - metabolism | Membrane Microdomains - metabolism | Saccharomyces cerevisiae - genetics | Humans | Substrate Specificity | Male | DNA Primers - genetics | RNA, Messenger - metabolism | Acetyltransferases - genetics | Gene Knockdown Techniques | Saccharomyces cerevisiae - metabolism | Tissue Distribution | Base Sequence | Acetyltransferases - antagonists & inhibitors | Female | Membrane Proteins - metabolism | Sphingosine N-Acyltransferase - metabolism | Recombinant Proteins - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | Fatty Acids - chemistry | RNA, Messenger - genetics | Recombinant Proteins - genetics | Acyl Coenzyme A - chemistry | HeLa Cells | In Vitro Techniques | Fatty Acids - biosynthesis | Research | Molecular biology | Health aspects | Biological Sciences
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2016, Volume 11, Issue 1, p. e0146944
Here, we studied the underlying mechanism of aldosterone (Aldo)-induced vascular endothelial cell damages by focusing on ceramide. We confirmed that Aldo (at... 
DAUNORUBICIN-INDUCED APOPTOSIS | METABOLISM | MULTIDISCIPLINARY SCIENCES | IN-VIVO | DISEASE | TUBULAR EPITHELIAL-CELLS | RECEPTOR | DEATH | SPHINGOLIPIDS | NEUROBLASTOMA-CELLS | ANGIOTENSIN | Human Umbilical Vein Endothelial Cells - metabolism | Membrane Proteins - genetics | Humans | Aldosterone - pharmacology | Signal Transduction - genetics | Ceramides - biosynthesis | Gene Knockdown Techniques | Ceramides - genetics | Lysophospholipids - genetics | Sphingosine - analogs & derivatives | Spironolactone - pharmacology | Eplerenone | Signal Transduction - drug effects | Sphingosine - biosynthesis | Sphingosine N-Acyltransferase - genetics | Lysophospholipids - biosynthesis | Sphingosine - genetics | Human Umbilical Vein Endothelial Cells - pathology | Membrane Proteins - metabolism | Spironolactone - analogs & derivatives | Sphingosine N-Acyltransferase - metabolism | Physiological aspects | Dosage and administration | Research | Steroids | Endothelium | Phosphates | Nephrology | Cell survival | Neuroblastoma | Aldosterone | Kinases | Endothelial cells | Sphingosine 1-phosphate | Ceramide glucosyltransferase | Medicine | Signaling | Hospitals | Rodents | Cell cycle | Ceramide | Inhibition | Umbilical vein | Growth factors | Deoxyribonucleic acid--DNA | Cancer | Apoptosis | Veins & arteries | Deoxyribonucleic acid | DNA
Journal Article
by Yang, J and Dang, GH and Lu, SL and Liu, HY and Ma, XL and Han, LL and Deng, JC and Miao, YT and Li, XP and Shao, FY and Jiang, CT and Xu, QB and Wang, X and Feng, J
FASEB JOURNAL, ISSN 0892-6638, 11/2019, Volume 33, Issue 11, pp. 12780 - 12799
Intercellular communication between lymphocytes plays a fundamental role in numerous immune responses. Previously, we demonstrated that hyperhomocysteinemia... 
HOMOCYSTEINE | antibody | INITIATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | lymphocyte | CELL BIOLOGY | ceramide | BIOGENESIS | BIOLOGY | EXOSOMES | SECRETION | PROTEINS
Journal Article