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1. Full Text Cerebral organoids model human brain development and microcephaly
by Lancaster, Madeline A and Renner, Magdalena and Martin, Carol-Anne and Wenzel, Daniel and Bicknell, Louise S and Hurles, Matthew E and Homfray, Tessa and Penninger, Josef M and Jackson, Andrew P and Knoblich, Juergen A
Nature, ISSN 0028-0836, 2013, Volume 501, Issue 7467, pp. 373 - 379
The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human... 
HUMAN NEOCORTEX | IN-VITRO | OUTER SUBVENTRICULAR ZONE | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | SPINDLE ORIENTATION | MOUSE NEOCORTEX | 3-DIMENSIONAL CULTURE | SELF-FORMATION | MAMMALIAN NEUROGENESIS | EXTRINSIC SIGNALS | Neurons - pathology | Brain - anatomy & histology | Humans | Cerebral Cortex - pathology | Neurons - cytology | Brain - growth & development | Neural Stem Cells - cytology | Cerebral Cortex - cytology | Neurogenesis | Microcephaly - pathology | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - pathology | Brain - cytology | Organoids - pathology | Organoids - cytology | Neural Stem Cells - pathology | Animals | Cerebral Cortex - embryology | Organoids - growth & development | Models, Biological | Brain - pathology | Cerebral Cortex - growth & development | Mice | Organoids - embryology | Tissue Culture Techniques - methods | Research | Brain diseases | Brain | Population | Kinases | Pathogenesis | Methods
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2. Full Text Zika virus impairs growth in human neurospheres and brain organoids
by Garcez, PP and Loiola, EC and Da Costa, RM and Higa, LM and Trindade, P and Delvecchio, R and Nascimento, JM and Brindeiro, R and Tanuri, A and Rehen, SK
SCIENCE, ISSN 0036-8075, 05/2016, Volume 352, Issue 6287, pp. 816 - 818
Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and... 
TRANSMISSION | INFECTION | GENERATION | CEREBRAL ORGANOIDS | MULTIDISCIPLINARY SCIENCES | Zika Virus Infection - pathology | Humans | Neural Stem Cells - virology | Cells, Cultured | Brain - virology | Brain - abnormalities | Microcephaly - virology | Neural Stem Cells - pathology | Neurogenesis | Microcephaly - pathology | Cell Death | Brazil | Zika Virus Infection - complications | Organoids - abnormalities | Zika Virus - pathogenicity | Organoids - virology | Brain | Host-virus relationships | Observations | Health aspects | Mosquitoes | Zika virus
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3. Full Text Cell diversity and network dynamics in photosensitive human brain organoids
by Quadrato, Giorgia and Nguyen, Tuan and Macosko, Evan Z and Sherwood, John L and Yang, Sung Min and Berger, Daniel R and Maria, Natalie and Scholvin, Jorg and Goldman, Melissa and Kinney, Justin P and Boyden, Edward S and Lichtman, Jeff W and Williams, Ziv M and McCarroll, Steven A and Arlotta, Paola
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7652, pp. 48 - 53
In vitro models of the developing brain such as three-dimensional brain organoids offer an unprecedented opportunity to study aspects of human brain... 
PLURIPOTENT STEM-CELLS | TRANSCRIPTOME | MODELS | CORTEX | CEREBRAL ORGANOIDS | RECONSTRUCTION | MULTIDISCIPLINARY SCIENCES | NEURONS | DIFFERENTIATION | SUBTYPE-SPECIFIC GENES | EXPRESSION | Retina - metabolism | Humans | Transcriptome | Gene Expression Profiling | Cerebral Cortex - cytology | Neural Pathways - physiology | Neurogenesis | Cerebral Cortex - metabolism | Nerve Net - cytology | Retina - cytology | Time Factors | Light | Neural Pathways - radiation effects | Dendrites | Nerve Net - radiation effects | Single-Cell Analysis | Organoids - radiation effects | Cell Line | Brain - cytology | Pluripotent Stem Cells - cytology | Cell Separation | Organoids - cytology | Photoreceptor Cells, Vertebrate - cytology | Organ Specificity | Sequence Analysis, RNA | Organoids - growth & development | Neural Pathways - cytology | In Vitro Techniques | Brain cells | Physiological aspects | Brain research | Research | Biological diversity | Brain | Photosensitivity | Cerebral cortex | Neurons | Developmental biology | Circuits | Cortex | Retina | Stimulation | Cortex (somatosensory) | Gene expression | Dendritic spines | Organoids | Neural networks | Stem cells | Three dimensional models | Active control | In vitro methods and tests | Sensory stimuli
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4. Full Text Generation of human vascularized brain organoids
by Pham, Missy T and Pollock, Kari M and Rose, Melanie D and Cary, Whitney A and Stewart, Heather R and Zhou, Ping and Nolta, Jan A and Waldau, Ben
NeuroReport, ISSN 0959-4965, 03/2018, Volume 29, Issue 7, pp. 588 - 593
The aim of this study was to vascularize brain organoids with a patient’s own endothelial cells (ECs). Induced pluripotent stem cells (iPSCs) of one UC Davis... 
CD31 | Transplantation | STEM121 | Brain organoid | Blood vessel | Vascularization | PLURIPOTENT STEM-CELLS | blood vessel | brain organoid | CEREBRAL ORGANOIDS | transplantation | vascularization | NEUROSCIENCES | Organoids - physiology | Brain - cytology | Induced Pluripotent Stem Cells - physiology | Tissue Culture Techniques | Humans | Organoids - cytology | Male | Brain - physiology | Blood Vessels - cytology | Organoids - blood supply | Animals | Endothelial Cells - cytology | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Mice | Blood Vessels - physiology | Induced Pluripotent Stem Cells - cytology | Endothelial Cells - physiology | Neovascularization, Physiologic | Brain | Research | Endothelium
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5. Full Text Fusion of Regionally Specified hPSC-Derived Organoids Models Human Brain Development and Interneuron Migration
by Xiang, Yangfei and Tanaka, Yoshiaki and Patterson, Benjamin and Kang, Young-Jin and Govindaiah, Gubbi and Roselaar, Naomi and Cakir, Bilal and Kim, Kun-Yong and Lombroso, Adam P and Hwang, Sung-Min and Zhong, Mei and Stanley, Edouard G and Elefanty, Andrew G and Naegele, Janice R and Lee, Sang-Hun and Weissman, Sherman M and Park, In-Hyun
Cell Stem Cell, ISSN 1934-5909, 09/2017, Volume 21, Issue 3, pp. 383 - 398.e7
Organoid techniques provide unique platforms to model brain development and neurological disorders. Whereas several methods for recapitulating corticogenesis... 
cortex | fusion | single cell RNA-seq | brain organoid | transcriptional regulation | neuronal migration | interneuron | MGE | hESC | ATAC-seq | PLURIPOTENT STEM-CELLS | CORTICAL INTERNEURONS | DIRECTED DIFFERENTIATION | HUMAN ES | FOREBRAIN | FUNCTIONAL MATURATION | RNA-SEQ | CEREBRAL ORGANOIDS | DYNAMICS | TRANSCRIPTION FACTOR | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Chromatin - metabolism | Brain - cytology | Brain - embryology | Pluripotent Stem Cells - cytology | Humans | Organoids - cytology | Transcriptome - genetics | Cerebral Cortex - cytology | Pluripotent Stem Cells - metabolism | Cell Lineage | Interneurons - metabolism | Sequence Analysis, RNA | Models, Biological | Cell Differentiation | Interneurons - cytology | Median Eminence - cytology | Cell Movement
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6. Full Text Fused cerebral organoids model interactions between brain regions
by Bagley, Joshua A and Reumann, Daniel and Bian, Shan and Lévi-Strauss, Julie and Knoblich, Juergen A
Nature Methods, ISSN 1548-7091, 06/2017, Volume 14, Issue 7, pp. 743 - 751
Human brain development involves complex interactions between different regions, including long-distance neuronal migration or formation of major axonal... 
PLURIPOTENT STEM-CELLS | CORTICAL INTERNEURONS | DIRECTED DIFFERENTIATION | GLUTAMATERGIC NEURONS | IN-VITRO | FUNCTIONAL MATURATION | BIOCHEMICAL RESEARCH METHODS | GABAERGIC INTERNEURONS | TANGENTIAL MIGRATION | SELF-ORGANIZATION | EXPRESSION | Organoids - physiology | Interneurons - physiology | Brain - embryology | Animals | Humans | Cell Communication | Cerebral Cortex - physiology | Cell Culture Techniques | Cerebral Cortex - cytology | Cell Movement | Brain | Neural circuitry | Brain research | Localization of functions | Cerebrum | Models | Observations | Neuroimaging | Leukocyte migration | Regional analysis | Forebrain | Fluorescence | Cultures | Pharmacology | Chemical compounds | Patients | CXCR4 protein | Defects | γ-Aminobutyric acid | Organoids | Fusion | In vitro methods and tests | Cell migration
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7. Full Text Organoids as an in vitro model of human development and disease
by Fatehullah, Aliya and Tan, Si Hui and Barker, Nick
Nature Cell Biology, ISSN 1465-7392, 02/2016, Volume 18, Issue 3, pp. 246 - 254
The in vitro organoid model is a major technological breakthrough that has already been established as an essential tool in many basic biology and clinical... 
PLURIPOTENT STEM-CELLS | PROGENITOR CELLS | DIRECTED DIFFERENTIATION | EPITHELIAL-CELLS | CEREBRAL ORGANOIDS | FUNCTIONAL HUMAN LIVER | 3-DIMENSIONAL CULTURE | BUD TRANSPLANT | INTESTINAL ORGANOIDS | EX-VIVO | CELL BIOLOGY | Animals | Models, Biological | Humans | Organoids - cytology | Stem Cell Niche - physiology | Stem Cells - cytology | Cell Culture Techniques | Cell Differentiation - physiology | Medical laboratory technology | Biomedical materials | Usage | Medical technology | Innovations | Extracellular matrix | Models
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8. Full Text Organoids — Preclinical Models of Human Disease
by Li, Mo and Izpisua Belmonte, Juan C
The New England Journal of Medicine, ISSN 0028-4793, 02/2019, Volume 380, Issue 6, pp. 569 - 579
An organoid is a three-dimensional construct composed of multiple cell types that originates from stem cells through self-organization and can simulate the... 
PLURIPOTENT STEM-CELLS | NEPHRON PROGENITORS | DIRECTED DIFFERENTIATION | HAIR-CELLS | MEDICINE, GENERAL & INTERNAL | CEREBRAL ORGANOIDS | IN-VITRO EXPANSION | 3D CULTURE | SELF-FORMATION | HUMAN LIVER | LONG-TERM EXPANSION | Adult Stem Cells | Animals | Pluripotent Stem Cells | Organoids | Models, Biological | Humans | Biomedical Research | Cell Culture Techniques | Drug Discovery | Disease Models, Animal | Medical research | Pathology | Laboratories | Liver | Technological change | Stem cells | Nervous system | Pancreas | Urogenital system | Cell adhesion & migration | Tumors
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9. Full Text Induction of Expansion and Folding in Human Cerebral Organoids
by Li, Yun and Muffat, Julien and Omer, Attya and Bosch, Irene and Lancaster, Madeline A and Sur, Mriganka and Gehrke, Lee and Knoblich, Juergen A and Jaenisch, Rudolf
Cell Stem Cell, ISSN 1934-5909, 03/2017, Volume 20, Issue 3, pp. 385 - 396.e3
An expansion of the cerebral neocortex is thought to be the foundation for the unique intellectual abilities of humans. It has been suggested that an increase... 
cerebral organoids | outer radial glia | microcephaly | Dengue | PTEN | AKT | outer SVZ | cortical development | human embryonic stem cells | Zika | STEM-CELLS | ACTIVATION | EVOLUTION | CORTEX | AKT3 | GROWTH | MUTATIONS | RADIAL GLIA | BRAIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Zika Virus Infection - pathology | Humans | Zika Virus - physiology | Cells, Cultured | Organoids - cytology | PTEN Phosphohydrolase - metabolism | Neurons - cytology | Zika Virus - drug effects | Enzyme Activation - drug effects | Neural Stem Cells - cytology | Cerebrum - cytology | Zika Virus Infection - virology | Animals | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Gene Deletion | Organoids - drug effects | Cell Proliferation - drug effects | Mice | Neurons - metabolism | Neurons - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Neural Stem Cells - metabolism
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10. Full Text Specification of positional identity in forebrain organoids
by Cederquist, GY and Asciolla, JJ and Tchieu, J and Walsh, RM and Cornacchia, D and Resh, MD and Studer, L
NATURE BIOTECHNOLOGY, ISSN 1087-0156, 04/2019, Volume 37, Issue 4, pp. 436 - 436
Human brain organoids generated with current technologies recapitulate histological features of the human brain, but they lack a reproducible topographic... 
SHH | HUMAN BRAIN-DEVELOPMENT | SONIC HEDGEHOG | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CEREBRAL ORGANOIDS | CELLULAR CHOLESTEROL | LIPID RAFTS | GENERATION | DIFFERENTIATION | SELF-ORGANIZATION | INTERNEURONS | Brain | Social aspects | Tetracyclines | Tetracycline | Brain cells | Structure | Growth | Tissue engineering | Methods | Prosencephalon | Proteins | Signaling | Subdivisions | Brain architecture | Organoids | Hedgehog protein | Topography | Forebrain | Lipid metabolism | Metabolism | Cholesterol
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11. Full Text Human cerebral organoids recapitulate gene expression programs of fetal neocortex development
by J. Gray Camp and Farhath Badsha and Marta Florio and Sabina Kanton and Tobias Gerber and Michaela Wilsch-Bräuninger and Eric Lewitus and Alex Sykes and Wulf Hevers and Madeline Lancaster and Juergen A. Knoblich and Robert Lachmann and Svante Pääbo and Wieland B. Huttner and Barbara Treutlein
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 51, pp. 15672 - 15677
Cerebral organoids—3D cultures of human cerebral tissue derived from pluripotent stem cells—have emerged as models of human cortical development. However, the... 
Cerebral organoid | Corticogenesis | Neocortex | Single-cell RNA-seq | Stem cells | NEURAL PROGENITORS | REGULATORY DNA | stem cells | corticogenesis | MULTIDISCIPLINARY SCIENCES | single-cell RNA-seq | neocortex | CELL RNA-SEQ | PLURIPOTENT STEM-CELLS | HETEROGENEITY | EVOLUTION | CORTEX | cerebral organoid | OUTER SUBVENTRICULAR ZONE | EXPANSION | DIFFERENTIATION | Organoids - physiology | Cell Lineage | Neocortex - embryology | Sequence Analysis, RNA | Gene Expression Regulation, Developmental | Tissue Culture Techniques | Humans | Cell Differentiation | Single-Cell Analysis | RNA sequencing | Brain research | Growth | Brain mapping | Genetic research | Fetus | Genetic aspects | Research | Gene expression | Health aspects | Methods | Biological Sciences
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12. Full Text Using brain organoids to understand Zika virus-induced microcephaly
by Qian, Xuyu and Nguyen, Ha Nam and Jacob, Fadi and Song, Hongjun and Ming, Guo-Li
Development (Cambridge), ISSN 0950-1991, 03/2017, Volume 144, Issue 6, pp. 952 - 957
Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble in vivo organs are pushing the frontiers... 
Organoids | Microcephaly | Cortex | iPSC | Zika | NEURAL PROGENITORS | AMERICA | DEVELOPMENTAL BIOLOGY | RADIAL GLIA | BRAZIL | PLURIPOTENT STEM-CELLS | MODELS | CEREBRAL ORGANOIDS | NEURONS | INFECTION | DIFFERENTIATION | Zika Virus Infection - virology | Animals |