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cgmp-specific phosphodiesterase (126) 126
animals (89) 89
humans (78) 78
biochemistry & molecular biology (44) 44
index medicus (39) 39
dependent protein-kinase (38) 38
cyclic gmp - metabolism (37) 37
phosphodiesterase inhibitors - pharmacology (37) 37
phosphodiesterase (36) 36
cyclic-nucleotide phosphodiesterases (34) 34
phosphoric diester hydrolases - metabolism (33) 33
cgmp (29) 29
male (29) 29
cyclic nucleotide phosphodiesterases, type 5 (27) 27
molecular sequence data (27) 27
amino acid sequence (26) 26
expression (26) 26
pharmacology & pharmacy (26) 26
camp (25) 25
rats (23) 23
3',5'-cyclic-amp phosphodiesterases - metabolism (22) 22
camp-specific phosphodiesterase (22) 22
binding (21) 21
catalytic domain (21) 21
neurosciences (21) 21
nitric-oxide (21) 21
mice (19) 19
cyclic gmp (18) 18
cyclic-nucleotide phosphodiesterase (18) 18
kinetics (18) 18
sildenafil (18) 18
cell biology (17) 17
cyclic amp - metabolism (17) 17
identification (17) 17
phosphoric diester hydrolases - genetics (17) 17
3',5'-cyclic-gmp phosphodiesterases - metabolism (16) 16
pde5 (16) 16
sildenafil citrate (16) 16
3',5'-cyclic-amp phosphodiesterases - genetics (15) 15
messenger-rna (15) 15
piperazines - pharmacology (15) 15
3',5'-cyclic-amp phosphodiesterases - chemistry (13) 13
base sequence (13) 13
binding sites (13) 13
phosphodiesterases (13) 13
rat-brain (13) 13
signal transduction (13) 13
phosphorylation (12) 12
purines (12) 12
tissue distribution (12) 12
3',5'-cyclic-gmp phosphodiesterases - antagonists & inhibitors (11) 11
cloning (11) 11
cyclic amp (11) 11
models, molecular (11) 11
purinones - pharmacology (11) 11
rats, sprague-dawley (11) 11
rna, messenger - metabolism (11) 11
sequence homology, amino acid (11) 11
biophysics (10) 10
cloning, molecular (10) 10
dimerization (10) 10
phosphodiesterase inhibitors - therapeutic use (10) 10
proteins (10) 10
signal transduction - physiology (10) 10
sulfones (10) 10
3',5'-cyclic-amp phosphodiesterases - antagonists & inhibitors (9) 9
3',5'-cyclic-gmp phosphodiesterases (9) 9
3',5'-cyclic-gmp phosphodiesterases - genetics (9) 9
activation (9) 9
analysis (9) 9
chemistry, medicinal (9) 9
cyclic-gmp (9) 9
isoenzymes - metabolism (9) 9
molecular-cloning (9) 9
phosphoric diester hydrolases - chemistry (9) 9
protein structure, tertiary (9) 9
cardiac & cardiovascular systems (8) 8
cos cells (8) 8
cyclic gmp - physiology (8) 8
gmp-stimulated phosphodiesterase (8) 8
nitric-oxide synthase (8) 8
phosphoric diester hydrolases - physiology (8) 8
protein binding (8) 8
research (8) 8
vascular smooth-muscle (8) 8
zaprinast (8) 8
amp-specific phosphodiesterase (7) 7
article (7) 7
brain (7) 7
crystal structure (7) 7
cyclic gmp - pharmacology (7) 7
erectile dysfunction (7) 7
female (7) 7
gene (7) 7
phosphodiesterase inhibitors (7) 7
recombinant proteins - metabolism (7) 7
regulatory domain (7) 7
structure-activity relationship (7) 7
transfection (7) 7
urology & nephrology (7) 7
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