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1. Full Text Fremanezumab inhibits vasodilatory effects of CGRP and capsaicin in rat cerebral artery - Potential role in conditions of severe vasoconstriction
by Grell, Anne-Sofie and Haanes, Kristian Agmund and Johansson, Sara Ellinor and Edvinsson, Lars and Sams, Anette
European Journal of Pharmacology, ISSN 0014-2999, 12/2019, Volume 864, p. 172726
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2. Full Text Characterisation of CGRP receptors in human and porcine isolated coronary arteries: Evidence for CGRP receptor heterogeneity
by Gupta, Saurabh and Mehrotra, Suneet and Villalón, Carlos M and Garrelds, Ingrid M and de Vries, René and van Kats, Jorge P and Sharma, Hari S and Saxena, Pramod R and MaassenVanDenBrink, Antoinette
European Journal of Pharmacology, ISSN 0014-2999, 2006, Volume 530, Issue 1, pp. 107 - 116
This study sets out to characterise calcitonin gene-related peptide (CGRP) receptors in human and porcine isolated proximal and distal coronary arteries using... 
[Cys(Et) 2,7]-h-αCGRP | Human coronary artery | CGRP receptor | BIBN4096BS | [Cys(Acm) 2,7]-h-αCGRP | h-αCalcitonin gene-related peptide (h-αCGRP) | h-αCGRP 8-37 | h-αCGRP | Cys(Acm) | Cys(Et) | h-alpha CGRP(8-37) | GENE-RELATED PEPTIDE | ANTAGONIST | VAS-DEFERENS | [Cys(Et)(2.7)]-h-alpha CGRP | PHARMACOLOGICAL CHARACTERIZATION | human coronary artery | [Cys(Acm)(2.7)]-h-alpha CGRP | ADRENOMEDULLIN | PROFILE | PHARMACOLOGY & PHARMACY | INDUCED RELAXATION | h-alpha calcitonin gene-related peptide (h-alpha CGRP) | EXPRESSION | BRAIN | Receptors, Calcitonin - metabolism | Calcitonin Gene-Related Peptide - analogs & derivatives | Humans | Middle Aged | Child, Preschool | Male | Receptors, Calcitonin - genetics | Substance P - pharmacology | Intracellular Signaling Peptides and Proteins - metabolism | Calcitonin Receptor-Like Protein | Coronary Vessels - metabolism | Endothelium, Vascular - physiology | Dose-Response Relationship, Drug | Time Factors | Swine | Potassium Chloride - pharmacology | Adult | Female | Membrane Proteins - metabolism | Child | Cyclic AMP - metabolism | Intracellular Signaling Peptides and Proteins - genetics | Vasoconstrictor Agents - pharmacology | Coronary Vessels - drug effects | Calcitonin Gene-Related Peptide - pharmacology | Colforsin - pharmacology | Coronary Vessels - physiology | Membrane Proteins - genetics | Transcription Factor Brn-3A - metabolism | Reverse Transcriptase Polymerase Chain Reaction | Piperazines - pharmacology | Protein Isoforms - physiology | Receptors, Calcitonin Gene-Related Peptide - physiology | Carrier Proteins - genetics | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Transcription Factor Brn-3A - genetics | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology | Adolescent | Receptor Activity-Modifying Proteins | Receptors, Calcitonin Gene-Related Peptide - genetics | Aged | Vasodilation - drug effects | In Vitro Techniques | Quinazolines - pharmacology | Protein Isoforms - genetics | Peptide hormones | Analysis | Calcitonin | Arteries
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3. Full Text Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens
by Wisskirchen, F. M and Burt, R. P and Marshall, I
British Journal of Pharmacology, ISSN 0007-1188, 04/1998, Volume 123, Issue 8, pp. 1673 - 1683
CGRP receptors mediating vasorelaxation of the rat isolated pulmonary artery and inhibition of contractions of the rat isolated prostatic vas deferens were... 
CGRP1 receptor | rat β‐CGRP | [Cys(ACM2,7)] hα‐CGRP | human adrenomedullin | hα‐CGRP | hβ‐CGRP8‐37 | CGRP2 receptor | rat amylin | hα‐CGRP8‐37 | peptidase inhibitors | Peptidase inhibitors | Cys(ACM | hα-CGRP | receptor | Adrenomedullin | CGRP | Rat amylin | Rat β-CGRP | hβ-CGRP | GENE-RELATED PEPTIDE | ANTAGONIST | ALPHA-CGRP | CALCITONIN | ADRENOMEDULLIN | VASORELAXATION | AMYLIN | h alpha-CGRP | rat beta-CGRP | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | VASODILATATION | CGRP receptor | [Cys(ACM(2,7))] h alpha-CGRP | h alpha-CGRP(8-37) | h beta-CGRP(8-37) | BRAIN | Receptors, Calcitonin Gene-Related Peptide - drug effects | Calcitonin Gene-Related Peptide - pharmacology | Calcitonin Gene-Related Peptide - analogs & derivatives | Rats | Male | Nitric Oxide - physiology | Pulmonary Artery - drug effects | Rats, Sprague-Dawley | Protease Inhibitors - pharmacology | Animals | Muscle Contraction - drug effects | Muscle Relaxation - drug effects | In Vitro Techniques | Vas Deferens - drug effects | Muscle, Smooth, Vascular - drug effects | hβ-CGRP8-37 | Papers | rat β-CGRP | [Cys(ACM2,7)] hα-CGRP | hα-CGRP8-37
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4. Full Text Getting to the Heart of the Matter: Migraine, Triptans, DHE, Ditans, CGRP Antibodies, First/Second‐Generation Gepants, and Cardiovascular Risk
by Mathew, Paul G and Klein, Brad C
Headache: The Journal of Head and Face Pain, ISSN 0017-8748, 09/2019, Volume 59, Issue 8, pp. 1421 - 1426
The science of migraine pathophysiology has advanced significantly since the 1930's. Imaging techniques, neurochemical analysis, clinical trials, and the... 
first‐generation CGRP antagonists | second‐generation CGRP antagonists | triptan | CGRP antibody | dihydroergotamine | Gepant | CONTROLLED-TRIAL | second-generation CGRP antagonists | TELCAGEPANT | EXERCISE TIME | ERENUMAB | CLINICAL NEUROLOGY | PREVENTIVE TREATMENT | first-generation CGRP antagonists | DOUBLE-BLIND | FAMILIAL HEMIPLEGIC MIGRAINE | EPISODIC MIGRAINE | AMG 334 | Viral antibodies | Gene mutations | Migraine | Liver | Antibodies | Dihydroergotamine | Cardiovascular diseases | Risk factors | Heart | Headache | Cerebral infarction | Immunoglobulins | Toxicity | Brain stem | Vasoconstriction | Health risks | Clinical trials | Imaging techniques | Patients | Calcitonin gene-related peptide | Ischemia | Calcitonin | Infarction | Safety | Mutation
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5. Full Text Triptans and CGRP blockade – impact on the cranial vasculature
by Benemei, Silvia and Cortese, Francesca and Labastida-Ramírez, Alejandro and Marchese, Francesca and Pellesi, Lanfranco and Romoli, Michele and Vollesen, Anne Luise and Lampl, Christian and Ashina, Messoud and Sch Adv Studies European Head and School of Advanced Studies of the European Headache Federation (EHF-SAS) and On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)
The Journal of Headache and Pain, ISSN 1129-2369, 12/2017, Volume 18, Issue 1, pp. 1 - 7
The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various... 
Neurology | Triptans | Calcitonin gene related peptide – CGRP | Pain Medicine | Middle cerebral arteries | Magnetic resonance angiography (MRA) | Medicine & Public Health | Anti-CGRP (receptor) monoclonal antibodies – mAbs | Migraine models | Middle meningeal artery | Internal Medicine | FLOW-VELOCITY | GENE-RELATED PEPTIDE | MIGRAINE-LIKE ATTACKS | NEUROSCIENCES | CLINICAL NEUROLOGY | ISOLATED BLOOD-VESSELS | PREVENTIVE TREATMENT | Anti-CGRP (receptor) monoclonal antibodies - mAbs | CRANIOVASCULAR SELECTIVITY | Calcitonin gene related peptide - CGRP | RECEPTOR ANTAGONIST BIBN4096BS | DOUBLE-BLIND | HEALTHY-VOLUNTEERS | Receptors, Calcitonin Gene-Related Peptide - drug effects | Migraine Disorders - therapy | Tryptamines - pharmacology | Humans | Usage | Cerebral arteries | Analysis | Magnetic resonance angiography | Brain | Headache | Migraine | Blood vessels | Neuropeptides | Serotonin S1 receptors | Calcitonin gene-related peptide | Pathology | Neurotransmitters | Pain | Antagonist drugs | Calcitonin | Skull
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6. Full Text Safety and tolerability of LBR-101, a humanized monoclonal antibody that blocks the binding of CGRP to its receptor: Results of the Phase 1 program
by Bigal, Marcelo E and Escandon, Rafael and Bronson, Michele and Walter, Sarah and Sudworth, Maria and Huggins, John P and Garzone, Pamela
Cephalalgia, ISSN 0333-1024, 6/2014, Volume 34, Issue 7, pp. 483 - 492
Background LBR-101 is a fully humanized monoclonal antibody that binds to calcitonin gene-related peptide. Objective The objective of this article is to... 
Monoclonal antibodies | LBR-101 | chronic migraine | CGRP | TRIGEMINAL GANGLION | ANTAGONIST | ALPHA-CGRP | NEUROSCIENCES | CLINICAL NEUROLOGY | MOLECULES | GENE | CLINICAL-TRIALS | CGRP(8-37) | BIBN4096BS | PEPTIDE CGRP | Double-Blind Method | Adverse Drug Reaction Reporting Systems | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Aortic Aneurysm, Thoracic - chemically induced | Cross-Over Studies | Dose-Response Relationship, Drug | Young Adult | Ehlers-Danlos Syndrome - complications | Adolescent | Calcitonin Gene-Related Peptide - antagonists & inhibitors | Adult | Female | Aged | Infusions, Intravenous
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7. Full Text Blocking CGRP in migraine patients – a review of pros and cons
by Deen, Marie and Correnti, Edvige and Kamm, Katharina and Kelderman, Tim and Papetti, Laura and Rubio-Beltrán, Eloisa and Vigneri, Simone and Edvinsson, Lars and Maassen Van Den Brink, Antoinette and European Headache Federation Sch and European Headache Federation School of Advanced Studies (EHF-SAS) and On behalf of the European Headache Federation School of Advanced Studies (EHF-SAS) and Experimentell kärlforskning and Medicine, Lund and Lund University and Medicin, Lund and Lunds universitet and Experimental Vascular Research
The Journal of Headache and Pain, ISSN 1129-2369, 12/2017, Volume 18, Issue 1, pp. 1 - 9
Migraine is the most prevalent neurological disorder worldwide and it has immense socioeconomic impact. Currently, preventative treatment options for migraine... 
Cgrp receptor | Neurology | Acute treatment | Pain Medicine | Cgrp | Medicine & Public Health | Gepants | Migraine | Internal Medicine | Prophylactic treatment | NERVE-FIBERS | GENE-RELATED PEPTIDE | MONOCLONAL-ANTIBODY | RANDOMIZED CONTROLLED-TRIAL | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | CLINICAL NEUROLOGY | PREVENTIVE TREATMENT | DOUBLE-BLIND | RECEPTOR ANTAGONIST TELCAGEPANT | PLACEBO-CONTROLLED TRIAL | EPISODIC MIGRAINE | Animals | Receptors, Calcitonin Gene-Related Peptide - antagonists & inhibitors | Migraine Disorders - drug therapy | Humans | Calcitonin Gene-Related Peptide - antagonists & inhibitors | Drugs | Nervous system diseases | Care and treatment | Usage | Headache | Wound healing | Epilepsy | Socio-economic aspects | Central nervous system | Clinical trials | Mental depression | Calcitonin gene-related peptide | Pituitary | Calcitonin | Monoclonal antibodies | Cardiovascular diseases | Constipation | Long-term effects | Neurologi | Clinical Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Klinisk medicin
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8. Full Text Calcitonin Gene‐Related Peptide Modulators – The History and Renaissance of a New Migraine Drug Class
by Hargreaves, Richard and Olesen, Jes
Headache: The Journal of Head and Face Pain, ISSN 0017-8748, 06/2019, Volume 59, Issue 6, pp. 951 - 970
Several lines of evidence pointed to an important role for CGRP in migraine. These included the anatomic colocalization of CGRP and its receptor in sensory... 
CGRP receptor antagonist | calcitonin gene‐related peptide | migraine treatment | migraine prevention | CGRP receptor antibody | CGRP neutralizing antibody | calcitonin gene-related peptide | DERMAL BLOOD-FLOW | MONOCLONAL-ANTIBODY | RANDOMIZED CONTROLLED-TRIAL | ERENUMAB AMG 334 | CLINICAL NEUROLOGY | PREVENTIVE TREATMENT | SUPERIOR SAGITTAL SINUS | ACTIVITY-MODIFYING PROTEINS | IN-VIVO | DOUBLE-BLIND | CGRP-RECEPTOR ANTAGONIST | Viral antibodies | Peptides | Migraine | Calcitonin | Genes | Antibodies | Drug therapy | Neuroimaging | Headache | Brain | Intravenous administration | Target recognition | Sumatriptan | Clinical trials | Drug development | Blood | Modulators | Fibers | Prevention | Receptors | Pain | Developmental stages | Occupancy | Sensory neurons | Tomography | Medical research | Effectiveness | Oral administration | Positron emission | Blood vessels | Pharmacology | Calcitonin gene-related peptide | Monoclonal antibodies | Positron emission tomography
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9. Full Text Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX
by Sheykhzade, Majid and Abdolalizadeh, Bahareh and Koole, Cassandra and Pickering, Darryl Scott and Dreisig, Karin and Johansson, Sara Ellinor and Abboud, Balsam Kadri and Dreier, Rasmus and Berg, Jais Oliver and Jeppesen, Jørgen Lykke and Sexton, Patrick M and Edvinsson, Lars and Wootten, Denise and Sams, Anette
European Journal of Pharmacology, ISSN 0014-2999, 06/2018, Volume 829, pp. 85 - 92
The main purpose of this study was to compare in vitro pharmacological properties of human αCGRP (CGRP) and a recently discovered metabolically stable CGRP... 
CGRP receptor antagonist | Rat mesenteric artery | CGRP receptor | CGRP | Human artery | GENE-RELATED PEPTIDE | PERIVASCULAR PEPTIDES | ADRENOMEDULLIN RECEPTORS | PATHOPHYSIOLOGY | CALCITONIN-RECEPTOR | GLUCAGON-LIKE PEPTIDE-1 | NEUROPEPTIDE | PHARMACOLOGY & PHARMACY | CEREBRAL-ARTERIES | BIBN4096BS | EXPRESSION | Vasodilators | Pharmacology | Drug discovery
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10. Full Text Effects of adrenomedullin and calcitonin gene‐related peptide on contractions of the rat aorta and porcine coronary artery
by Yoshimoto, Ryo and Mitsui‐Saito, Minori and Ozaki, Hiroshi and Karaki, Hideaki
British Journal of Pharmacology, ISSN 0007-1188, 04/1998, Volume 123, Issue 8, pp. 1645 - 1654
Effects of adrenomedullin and α‐calcitonin gene‐related peptide (CGRP) on the contractions and cytosolic Ca2+ concentrations ([Ca2+]i) of the rat aorta and... 
endothelium | calcium | CGRP (8–37) | Adrenomedullin | smooth muscle | cyclic AMP | α‐calcitonin gene‐related peptide (α‐CGRP): β‐CGRP | Cgrp (8-37) | α-calcitonin gene-related peptide (α-CGRP) | Calcium | Cyclic AMP | Smooth muscle | β-CGRP | Endothelium | CYCLIC-AMP FORMATION | adrenomedullin | HYPOTENSIVE PEPTIDE | beta-CGRP | VASORELAXANT RESPONSES | THORACIC AORTA | VASCULAR SMOOTH-MUSCLE | alpha-calcitonin gene-related peptide (alpha-CGRP) | CGRP (8-37) | ENDOTHELIAL-CELLS | MULTIPLE RECEPTORS | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | BINDING-SITES | Muscle, Smooth, Vascular - metabolism | Peptides - antagonists & inhibitors | Rats, Wistar | Calcium - metabolism | Nitric Oxide Synthase - antagonists & inhibitors | Male | omega-N-Methylarginine - pharmacology | Coronary Vessels - metabolism | Swine | Calcitonin Gene-Related Peptide - antagonists & inhibitors | Aorta, Thoracic - drug effects | Cyclic AMP - metabolism | Muscle, Smooth, Vascular - drug effects | Coronary Vessels - drug effects | Vasodilator Agents - pharmacology | Calcitonin Gene-Related Peptide - pharmacology | Vasodilator Agents - antagonists & inhibitors | Enzyme Inhibitors - pharmacology | Aorta, Thoracic - metabolism | Rats | Peptides - pharmacology | Animals | Muscle Contraction - drug effects | In Vitro Techniques | α-calcitonin gene-related peptide (α-CGRP): β-CGRP | Papers
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11. Full Text An efficient synthesis of the piperidinyl dihydroquinazolinone (PDQ) fragment of olcegepant
by Habay, Stephen A and Miller, Julia M and Bowler, Matthew M and Manchak, Randi and Thomas, John Z
Tetrahedron Letters, ISSN 0040-4039, 09/2018, Volume 59, Issue 36, pp. 3389 - 3391
Olcegepant is one of the most potent and selective small molecule CGRP antagonists for the treatment of migraine headaches. Herein, we describe a new and... 
Reductive amination | Isocyanate | CGRP | Migraine | Protecting groups | POTENT | CHEMISTRY, ORGANIC | CGRP RECEPTOR ANTAGONISTS | DERIVATIVES | DISCOVERY
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12. Full Text Calcitonin gene-related peptide levels in tear fluid are elevated in migraine patients compared to healthy controls
by Kamm, Katharina and Straube, Andreas and Ruscheweyh, Ruth
Cephalalgia, ISSN 0333-1024, 10/2019, Volume 39, Issue 12, pp. 1535 - 1543
Background Calcitonin gene-related peptide (CGRP) released from trigeminal nerve fibres indicates trigeminal activation and has a key role in migraine... 
triptan | Episodic migraine | chronic migraine | CGRP | NSAID
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