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1. The chemistry of chalcones and related compounds
by Dhar, Durga Nath
xiii, 285
Chalcones
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2. Full Text Natural and synthetic 2′-hydroxy-chalcones and aurones: Synthesis, characterization and evaluation of the antioxidant and soybean lipoxygenase inhibitory activity
by Detsi, Anastasia and Majdalani, Maya and Kontogiorgis, Christos A and Hadjipavlou-Litina, Dimitra and Kefalas, Panagiotis
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2009, Volume 17, Issue 23, pp. 8073 - 8085
Naturally occurring and synthetic flavonoids belonging to the 2’hydroxy-chalcone and aurone families, have been synthesized and tested for their antioxidant... 
Lipid peroxidation | Aureusidin | Soybean lipoxygenase | Antioxidant | Aurones | 2′-Hydroxy-chalcones | SUBSTITUTED CHALCONES | OXIDATION | ANTIINFLAMMATORY ACTIVITY | DESIGN | CHEMISTRY, MEDICINAL | RAW-264.7 CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | FLAVONOIDS | 2 '-Hydroxy-chalcones | BIOLOGICAL EVALUATION | AGENTS | 5-LIPOXYGENASE | DERIVATIVES | Chalcones - chemistry | Antioxidants - chemistry | Magnetic Resonance Spectroscopy | Linoleic Acid - metabolism | Picrates - metabolism | Benzofurans - chemical synthesis | Benzofurans - pharmacology | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Biphenyl Compounds - metabolism | Benzofurans - chemistry | Linoleic Acid - antagonists & inhibitors | Lipoxygenase - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Picrates - antagonists & inhibitors | Biphenyl Compounds - antagonists & inhibitors | Chalcones - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Mass Spectrometry | Chalcones - pharmacology | Lipoxygenase Inhibitors - pharmacology
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3. Full Text Methoxylated 2'-hydroxychalcones as antiparasitic hit compounds
by Borsari, Chiara and Santarem, Nuno and Torrado, Juan and Olías, Ana Isabel and Corral, María Jesús and Baptista, Catarina and Gul, Sheraz and Wolf, Markus and Kuzikov, Maria and Ellinger, Bernhard and Witt, Gesa and Gribbon, Philip and Reinshagen, Jeanette and Linciano, Pasquale and Tait, Annalisa and Costantino, Luca and Freitas-Junior, Lucio H and Moraes, Carolina B and Bruno dos Santos, Pascoalino and Alcântara, Laura Maria and Franco, Caio Haddad and Bertolacini, Claudia Danielli and Fontana, Vanessa and Tejera Nevado, Paloma and Clos, Joachim and Alunda, José María and Cordeiro-da-Silva, Anabela and Ferrari, Stefania and Costi, Maria Paola
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2017, Volume 126, pp. 1129 - 1135
Chalcones display a broad spectrum of pharmacological activities. Herein, a series of 2’-hydroxy methoxylated chalcones was synthesized and evaluated towards ,... 
Cyclodextrins formulation | Chalcones | Leishmania infantum | Trypanosoma brucei | Early toxicity studies | Trypanosoma cruzi | Trypanosome cruzi | CHEMISTRY, MEDICINAL | HUMAN AFRICAN TRYPANOSOMIASIS | MOLECULAR TARGET PERSPECTIVES | LICOCHALCONE | SCREENING ASSAY | AMASTIGOTES | PTERIDINE REDUCTASE INHIBITORS | ANTILEISHMANIAL ACTIVITY | LEISHMANIA-DONOVANI | DERIVATIVES | Chalcones - chemistry | Antiparasitic Agents - pharmacokinetics | Antiparasitic Agents - toxicity | Solubility | Drug Carriers - chemistry | Trypanosomatina - drug effects | Animals | Chalcones - pharmacokinetics | Chalcones - toxicity | Antiparasitic Agents - pharmacology | Chalcones - pharmacology | Cyclodextrins - chemistry | Cell Line, Tumor | Mice | Antiparasitic Agents - chemistry | Cyclodextrins | Dextrins | Molecular biology | Cells | Index Medicus
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4. Full Text Synthesis, cytotoxicity, anti-oxidative and anti-inflammatory activity of chalcones and influence of A-ring modifications on the pharmacological effect
by Vogel, Susanne and Barbic, Matej and Jürgenliemk, Guido and Heilmann, Jörg
European Journal of Medicinal Chemistry, ISSN 0223-5234, 2010, Volume 45, Issue 6, pp. 2206 - 2213
Besides 2′,4′-dihydroxy-4,6′-dimethoxy-3′-prenylchalcone ( ) and 4-acetoxy-2′,4′-dihydroxy-6′-methoxy-3′-prenylchalkon ( ), both phase II metabolites of... 
3′-Coumaroyl-2′,4,4′-trihydroxy-6′-methoxychalcone | Chalcones | Xanthohumol | Cytotoxic | Anti-oxidative | Anti-inflammatory | CANCER-CELLS | CHEMISTRY, MEDICINAL | PROLIFERATION | HUMAN LIVER-MICROSOMES | HOPS | 3 '-Coumaroyl-2 ',4,4 '-trihydroxy-6 '-methoxychalcone | BIOLOGICAL EVALUATION | PRENYLATED CHALCONES | HUMULUS-LUPULUS | NF-KAPPA-B | EXPRESSION | Chalcones - chemistry | Antioxidants - chemistry | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemical synthesis | Antioxidants - metabolism | Humans | Rats | Structure-Activity Relationship | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Chalcones - metabolism | Animals | Anti-Inflammatory Agents - chemistry | Chalcones - chemical synthesis | Chalcones - pharmacology | Inhibitory Concentration 50 | Anti-Inflammatory Agents - chemical synthesis | Antineoplastic Agents - pharmacology | HeLa Cells
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5. Full Text Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs
by Padhye, Subhash and Ahmad, Aamir and Oswal, Nikhil and Sarkar, Fazlul H
Journal of Hematology and Oncology, ISSN 1756-8722, 2009, Volume 2, Issue 1, pp. 38 - 38
Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are... 
PERFORMANCE LIQUID-CHROMATOGRAPHY | INDUCED GASTRIC-ULCERATION | ONCOLOGY | CANCER CHEMOPREVENTIVE AGENTS | GLOBAL GENE-EXPRESSION | ESI-MS METHOD | ANTIMALARIAL ACTIVITY | CELL-GROWTH | TANDEM MASS-SPECTROMETRY | HEMATOLOGY | ACTIVE POLYISOPRENYLATED BENZOPHENONES | RADICAL REACTION-PRODUCTS | Chalcone - chemistry | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Antineoplastic Agents - therapeutic use | Chalcones - isolation & purification | Terpenes - pharmacology | Terpenes - chemistry | Chalcone - pharmacology | Chalcone - analogs & derivatives | Chalcones - chemical synthesis | Garcinia - chemistry | Inflammation - drug therapy | Chalcones - pharmacology | Chalcone - therapeutic use | Antineoplastic Agents - pharmacology | Terpenes - isolation & purification | Antioxidants - pharmacology | Neoplasms - drug therapy | Antioxidants - therapeutic use | Animals | Models, Biological | Terpenes - therapeutic use | Chalcones - therapeutic use | HIV Infections - drug therapy | Cellular signal transduction | Research | Health aspects | Benzophenone
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6. Full Text Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents
by Peng, Fei and Peng, Aihua and Wang, Guangcheng and Li, Xiuxia and Cao, Dong and Yang, Zhuang and Ma, Liang and Ye, Haoyu and Liang, Xiaolin and Ran, Yan and Chen, Jinying and Chen, Lijuan and Qiu, Jingxiang and Xie, Caifeng and Deng, Chongyang and Xiang, Mingli and Wei, Yuquan
European Journal of Medicinal Chemistry, ISSN 0223-5234, 08/2012, Volume 54, pp. 272 - 280
24 derivatives ( – ) derived from natural pyranochalcones ( and ) were designed and evaluated for their inhibitory potency on the production of nitric oxide... 
Adjuvant-induced arthritis | NO production | iNOS | Paw edema | Pyranochalcones | Anti-inflammation | OXIDE SYNTHASE EXPRESSION | ORALLY-ACTIVE GLITAZONE | CHEMISTRY, MEDICINAL | ACUTE LIVER-INJURY | LEAVES | FLAVONOIDS | (Z)-5-(4-METHOXYBENZYLIDENE)THIAZOLIDINE-2,4-DIONE | INHIBITION | CHALCONES | TWIGS | Arthritis, Experimental - drug therapy | Benzopyrans - therapeutic use | Nitric Oxide Synthase Type II - chemistry | Benzopyrans - metabolism | Male | Anti-Inflammatory Agents - metabolism | Chalcones - metabolism | Benzopyrans - chemical synthesis | Chalcone - pharmacology | Chalcones - chemical synthesis | Nitric Oxide Synthase Type II - antagonists & inhibitors | Carrageenan - pharmacology | Chalcones - pharmacology | Drug Design | Anti-Inflammatory Agents - therapeutic use | Chalcone - therapeutic use | Benzopyrans - pharmacology | Cell Line | Catalytic Domain | Chemistry Techniques, Synthetic | Anti-Inflammatory Agents - pharmacology | Edema - drug therapy | Animals | Chalcone - metabolism | Chalcones - therapeutic use | Anti-Inflammatory Agents - chemical synthesis | Mice | Molecular Docking Simulation | Edema - chemically induced | Chalcone - chemical synthesis | Nitric Oxide Synthase Type II - metabolism | Nitrogen oxide | Indomethacin | Anti-inflammatory drugs | Nitric oxide | Analysis
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7. Exploring pharmacological significance of chalcone scaffold: A review
by Sahu, N.K and Balbhadra, S.S and Choudhary, J and Kohli, D.V
Current Medicinal Chemistry, ISSN 0929-8673, 01/2012, Volume 19, Issue 2, pp. 209 - 225
Chalcones (1,3-diaryl-2-propen-1-ones) and their heterocyclic analogues, belong to the flavonoid family, which possess a number of interesting biological... 
α,β-unsaturated ketone | Antimalarial | Xanthohumol | Anticancer activity | Licochalcone | Chalcone | Butein | ANTIINFLAMMATORY ACTIVITY | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITORY-ACTIVITY | butein | alpha,beta-unsaturated ketone | METHOXYLATED CHALCONES | TYROSINASE INHIBITORS | antimalarial | chalcone | IN-VITRO | PLASMODIUM-FALCIPARUM | BIOLOGICAL EVALUATION | ANTIMALARIAL ACTIVITY | PHARMACOLOGY & PHARMACY | anticancer activity | xanthohumol | NF-KAPPA-B | QUINOLINYL CHALCONES | Antioxidants - chemistry | Anti-Inflammatory Agents - pharmacology | Anti-Infective Agents - pharmacology | Enzyme Inhibitors - pharmacology | Hypoglycemic Agents - chemistry | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Hypoglycemic Agents - pharmacology | Anti-Inflammatory Agents - chemistry | Chalcone - pharmacology | Chalcone - analogs & derivatives | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Antineoplastic Agents - pharmacology
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8. Full Text Synthesis of new chalcone derivatives containing acridinyl moiety with potential antimalarial activity
by Tomar, V and Bhattacharjee, G and Kamaluddin and Rajakumar, S and Srivastava, Kumkum and Puri, S.K
European Journal of Medicinal Chemistry, ISSN 0223-5234, 02/2010, Volume 45, Issue 2, pp. 745 - 751
A series of novel chalcones bearing acridine moiety attached to the amino group in their ring A have been synthesized through noncatalyzed nucleophilic... 
Plasmodium yoelii N-67 | Acdridne containing chalcones | Plasmodium falciparum NF-54 | ANTIPLASMODIAL ACTIVITY | CHEMISTRY, MEDICINAL | OXYGENATED CHALCONES | FLAVONOIDS | CHLOROQUINE | FERROCENYL CHALCONES | IN-VITRO EVALUATION | PARASITE PLASMODIUM-FALCIPARUM | RESISTANCE | AGENTS | INHIBITORS | Acridines - chemistry | Chalcone - chemistry | Male | Plasmodium - drug effects | Antimalarials - pharmacology | Erythrocytes - drug effects | Animals | Chalcone - pharmacology | Chalcone - analogs & derivatives | Antimalarials - chemistry | Plasmodium - growth & development | Female | Mice | Erythrocytes - parasitology | Chalcone - chemical synthesis | Antimalarials - chemical synthesis | Malaria | Substitution reactions | Plasmodium falciparum
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9. Full Text Monoamine oxidase inhibitory activity of methoxy-substituted chalcones
by Mathew, Bijo and Mathew, Githa Elizabeth and Ucar, Gulberk and Joy, Monu and Nafna, E.K and Lohidakshan, Krishnakumar K and Suresh, Jerad
International Journal of Biological Macromolecules, ISSN 0141-8130, 11/2017, Volume 104, Issue Pt A, pp. 1321 - 1329
The MAO-B inhibitory activity of chalcone (1, 3- diphenyl-2-propen-1-one) based compounds arise from its structural similarity with 1, 4-diphenyl-2-butene, a... 
Reversibility | Monoamine oxidase | Substrate cavity | Entrance cavity | Chalcone | Molecular docking | POLYMER SCIENCE | THIENYL CHALCONES | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | NEUROLOGICAL DISORDERS | DISCOVERY | POTENT | BIOCHEMISTRY | CHEMISTRY, APPLIED | MAO-B INHIBITORS | DERIVATIVES | PARKINSONS-DISEASE | Chalcones - chemistry | Monoamine Oxidase Inhibitors - pharmacology | Catalytic Domain | Humans | Blood-Brain Barrier - metabolism | Hep G2 Cells | Chalcones - metabolism | Monoamine Oxidase - chemistry | Monoamine Oxidase Inhibitors - toxicity | Chalcones - toxicity | Chalcones - pharmacology | Drug Design | Monoamine Oxidase Inhibitors - metabolism | Molecular Docking Simulation | Monoamine Oxidase Inhibitors - chemistry | Monoamine Oxidase - metabolism | Drugstores | Butylene | Pharmacy
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10. Heterocyclic Chalcone Analogues as Potential Anticancer Agents
by Sharma, V and Kumar, V and Kumar, P
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, ISSN 1871-5206, 03/2013, Volume 13, Issue 3, pp. 422 - 432
Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as Quercetin, are known for their anticancer effects. Although, parent... 
ANTI-HIV CHALCONE | CHEMISTRY, MEDICINAL | CHEMOPROTECTIVE PROPERTIES | Anticancer agents | HUMAN CANCER-CELLS | P-GLYCOPROTEIN | Heterocyclic chalcone analogues | ANGELICA-KEISKEI | IN-VITRO | ONCOLOGY | BIOLOGICAL EVALUATION | ANTIMALARIAL ACTIVITY | Chalcone analogues | MULTIDRUG-RESISTANCE | ANTIBACTERIAL CHALCONES | Cell Survival - drug effects | Chalcones - chemistry | Chalcones - chemical synthesis | Antineoplastic Agents - chemical synthesis | Humans | Chalcones - pharmacology | Antineoplastic Agents - pharmacology | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Neoplasms - drug therapy
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11. Full Text Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combination with antibiotics
by Tran, Thanh-Dao and Nguyen, Thi-Thao-Nhu and Do, Tuong-Ha and Huynh, Thi-Ngoc-Phuong and Tran, Cat-Dong and Thai, Khac-Minh
Molecules (Basel, Switzerland), ISSN 1420-3049, 2012, Volume 17, Issue 6, pp. 6684 - 6696
A series of simple heterocyclic chalcone analogues have been synthesized by Claisen Schmidt condensation reactions between substituted benzaldehydes and... 
synthesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | antibacterial | FLAVONOIDS | RESISTANT STAPHYLOCOCCUS-AUREUS | CHEMISTRY, MULTIDISCIPLINARY | heterocyclic chalcone analogues | chalcone | METHICILLIN-RESISTANT | MRSA | PRENYLATED CHALCONES | synergitic activity | CYTOTOXICITY | DERIVATIVES | antibiotics combination | Anti-Bacterial Agents - chemical synthesis | Drug Synergism | Microbial Sensitivity Tests | Chalcone - chemistry | Chalcone - pharmacology | Chalcone - analogs & derivatives | Anti-Bacterial Agents - chemistry | Anti-Bacterial Agents - pharmacology | Structure-Activity Relationship | Staphylococcus aureus - drug effects | Chalcone - chemical synthesis
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12. Full Text Synthesis, anticancer and antioxidant activities of 2,4,5-trimethoxy chalcones and analogues from asaronaldehyde: Structure–activity relationship
by Shenvi, Suvarna and Kumar, Krishna and Hatti, Kaushik S and Rijesh, K and Diwakar, Latha and Reddy, G. Chandrasekara
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2013, Volume 62, pp. 435 - 442
2,4,5-Trimethoxy chalcones and analogues were synthesized from asaronaldehyde derived from β-asarone. These novel compounds when tested against three human... 
Flavonols | Chalcones | In-silico | Flavones | Antioxidant | Anticancer | GROWTH-INHIBITION | DESIGN | CHEMISTRY, MEDICINAL | FLAVONOIDS | METHOXYLATED CHALCONES | BIOLOGICAL EVALUATION | CELL-CYCLE | DERIVATIVES | Cell Survival - drug effects | Chalcones - chemistry | Antioxidants - chemistry | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Chalcones - chemical synthesis | MCF-7 Cells | Chalcones - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Cell Death - drug effects | HeLa Cells | Aldehydes - chemistry | Drug Screening Assays, Antitumor | Antioxidants | Care and treatment | Hydrazine | Analysis | Cancer | Flavonoids | Bioflavonoids
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13. Full Text Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds
by Guantai, Eric M and Ncokazi, Kanyile and Egan, Timothy J and Gut, Jiri and Rosenthal, Philip J and Smith, Peter J and Chibale, Kelly
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 2010, Volume 18, Issue 23, pp. 8243 - 8256
A targeted series of chalcone and dienone hybrid compounds containing aminoquinoline and nucleoside templates was synthesized and evaluated for in vitro... 
Plasmodium falciparum | Chalcones | Dienones | Triazole | Malaria | Nucleosides | Hybrid compounds | Aminoquinolines | HUMAN MALARIA PARASITES | CYSTEINE PROTEASE | CHEMISTRY, MEDICINAL | AZIDES | CLICK CHEMISTRY | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | CHLOROQUINE | BETA-HEMATIN FORMATION | PLASMODIUM-FALCIPARUM | RESISTANCE | Chalcones - chemistry | Nucleosides - chemistry | Chalcone - chemistry | Triazoles - chemistry | Quinolines - chemistry | Alkynes - chemistry | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Azides - chemistry | Quinolines - pharmacology | Antimalarials - pharmacology | Hemin - metabolism | Quinolines - chemical synthesis | Animals | Copper - chemistry | Chalcones - chemical synthesis | Aminoquinolines - chemistry | Antimalarials - chemistry | Chalcones - pharmacology | Drug Design | Catalysis | Antimalarials - chemical synthesis | Triazoles | Analysis
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14. Full Text Synthesis and anti-cancer activity evaluation of novel prenylated and geranylated chalcone natural products and their analogs
by Wang, Hao-Meng and Zhang, Li and Zhang, Yong-Min and Liu, Jiang and Yang, Zhao-Liang and Yang, Yao and Zhao, Hong-Ye and Shen, Di and Lu, Kui and Fan, Zhen-Chuan and Yao, Qing-Wei and Teng, Yu-Ou and Peng, Yu
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 92, pp. 439 - 448
Four natural chalcones bearing prenyl or geranyl groups, i.e., bavachalcone ( ), xanthoangelol ( ), isobavachalcone ( ), and isoxanthoangelol ( ) were... 
Prenyled chalcones | Geranylated chalcones | Antitumor agents | K562 cell | Apoptosis | ANGELICA-KEISKEI | CHEMISTRY, MEDICINAL | ANTIBACTERIAL ACTIVITY | XANTHOANGELOL | CHEMICAL-COMPONENTS | ISOBAVACHALCONE | IODINATION | Chalcone - chemistry | Apoptosis - drug effects | Antineoplastic Agents - chemical synthesis | Humans | Endothelium, Vascular - drug effects | Biological Products - pharmacology | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Biological Products - chemical synthesis | Biological Products - chemistry | Chalcone - pharmacology | Chalcone - analogs & derivatives | K562 Cells | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Chalcone - chemical synthesis | Care and treatment | Synthesis | Safety and security measures | Organic compounds | Food | Cancer | Chemical Sciences
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15. Full Text Sulfonamide chalcones: Synthesis and in vitro exploration for therapeutic potential against Brugia malayi
by Bahekar, Sandeep P and Hande, Sneha V and Agrawal, Nikita R and Chandak, Hemant S and Bhoj, Priyanka S and Goswami, Kalyan and Reddy, M.V.R
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 124, pp. 262 - 269
Keeping in mind the immense biological potential of chalcones and sulfonamide scaffolds, a library of sulfonamide chalcones has been synthesized and evaluated... 
Sulfonamide chalcone | Antifilarial | Claisen-Schimdt condensation | Brugia malayi | CHEMISTRY, MEDICINAL | MICROFILARIAE | LICOCHALCONE-A | ANTICANCER | GLUTATHIONE | PLASMODIUM-FALCIPARUM | BIOLOGICAL EVALUATION | ANTIMALARIAL ACTIVITY | AGENTS | INHIBITORS | DERIVATIVES | Chalcones - chemistry | Brugia malayi - drug effects | Chemistry Techniques, Synthetic | Filaricides - chemistry | Humans | Molecular Conformation | Models, Molecular | Brugia malayi - growth & development | Life Cycle Stages | Filaricides - chemical synthesis | Animals | Chalcones - chemical synthesis | Chalcones - toxicity | Chalcones - pharmacology | Drug Design | Hydrophobic and Hydrophilic Interactions | Inhibitory Concentration 50 | Filaricides - pharmacology | Filaricides - toxicity | DNA synthesis | Sulfonamides | Health aspects | Folic acid
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16. Full Text Synthesis and biological evaluation of indolyl chalcones as antitumor agents
by Kumar, N. Maruthi and Kumar, Dalip and Akamatsu, Kanako and Kusaka, Eriko and Harada, Hiroshi and Ito, Takeo
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2010, Volume 20, Issue 13, pp. 3916 - 3919
A series of indolyl chalcones were synthesized and evaluated for their in vitro anti-proliferative activities against various cancer cell lines. A series of... 
1,3-Diaryl-2-propen-1-ones | Indolyl chalcones | Anticancer agents | CHEMISTRY, MEDICINAL | ANALOGS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | CONDENSATION | INHIBITORS | DERIVATIVES | CYTOTOXICITY | HIGHLY EFFICIENT | Chalcones - chemistry | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Chalcones - chemical synthesis | Chalcones - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Drug Screening Assays, Antitumor
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17. Full Text Chalcones with electron-withdrawing and electron-donating substituents: Anticancer activity against TRAIL resistant cancer cells, structure–activity relationship analysis and regulation of apoptotic proteins
by Mai, Chun Wai and Yaeghoobi, Marzieh and Abd-Rahman, Noorsaadah and Kang, Yew Beng and Pichika, Mallikarjuna Rao
European Journal of Medicinal Chemistry, ISSN 0223-5234, 04/2014, Volume 77, pp. 378 - 387
In the present study, a series of 46 chalcones were synthesised and evaluated f