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Biochemical Journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases.... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
1997, Cancer surveys, ISBN 0879695188, Volume 29., vi, 363
Book
eLife, ISSN 2050-084X, 04/2015, Volume 2015, Issue 4, pp. 1 - 44
The AAA+ family ATPase TRIP13 is a key regulator of meiotic recombination and the spindle assembly checkpoint, acting on signaling proteins of the conserved... 
N-Ethylmaleimide-Sensitive Proteins - metabolism | Mad2 Proteins - metabolism | Molecular Chaperones - metabolism | Caenorhabditis elegans Proteins - chemistry | Humans | Crystallography, X-Ray | Phylogeny | N-Ethylmaleimide-Sensitive Proteins - genetics | Amino Acid Sequence | Gene Expression | Caenorhabditis elegans - genetics | Cell Cycle Proteins - metabolism | Molecular Chaperones - genetics | Adenosine Triphosphatases - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - chemistry | Caenorhabditis elegans - classification | Escherichia coli - genetics | Adenosine Triphosphatases - genetics | Escherichia coli Proteins - chemistry | Caenorhabditis elegans Proteins - genetics | Caenorhabditis elegans - enzymology | Adaptor Proteins, Signal Transducing - chemistry | Endopeptidase Clp - chemistry | M Phase Cell Cycle Checkpoints | Caenorhabditis elegans Proteins - metabolism | Molecular Sequence Data | Molecular Chaperones - chemistry | Cell Cycle Proteins - chemistry | Spindle Apparatus - genetics | Escherichia coli - metabolism | Cell Cycle Proteins - genetics | Carrier Proteins - chemistry | Nuclear Proteins - genetics | N-Ethylmaleimide-Sensitive Proteins - chemistry | Protein Structure, Tertiary | Recombinant Proteins - metabolism | ATPases Associated with Diverse Cellular Activities | Endopeptidase Clp - genetics | Escherichia coli Proteins - metabolism | Nuclear Proteins - metabolism | Endopeptidase Clp - metabolism | Mad2 Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | Carrier Proteins - genetics | Sequence Alignment | Animals | Carrier Proteins - metabolism | Adaptor Proteins, Signal Transducing - genetics | Mad2 Proteins - genetics | Escherichia coli Proteins - genetics | Protein Binding | Adenosine Triphosphatases - chemistry | Adaptor Proteins, Signal Transducing - metabolism | Spindle Apparatus - enzymology | Proteins | Medical research | Recombination | Software | Meiosis | Mammals | Chromosomes | DNA repair | Deoxyribonucleic acid--DNA | Adenosine triphosphatase | BASIC BIOLOGICAL SCIENCES
Journal Article
Cell Death and Disease, ISSN 2041-4889, 04/2016, Volume 7, Issue 4, pp. e2195 - e2195
Inactivation of p53 found in more than half of human cancers is often associated with increased tumor resistance to anti-cancer therapy. We have previously... 
CISPLATIN | DNA-DAMAGE RESPONSE | P53 ACTIVATION | KINASE | GAMMA-H2AX | HISTONE H2AX | ATM | TP53 MUTATIONS | WIP1 | H2AX PHOSPHORYLATION | CELL BIOLOGY | Apoptosis - drug effects | Protein Phosphatase 2C - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Caspase 3 - metabolism | Antineoplastic Agents - therapeutic use | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | G2 Phase Cell Cycle Checkpoints - drug effects | RNA Interference | Colorectal Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Colorectal Neoplasms - mortality | DNA Damage - drug effects | Carrier Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Nuclear Proteins - metabolism | Survival Rate | Mitochondria - metabolism | Cisplatin - pharmacology | Tumor Suppressor Protein p53 - deficiency | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Cisplatin - therapeutic use | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Mice | Histones - metabolism | Protein Phosphatase 2C - genetics | Colorectal Neoplasms - pathology | Protein-Tyrosine Kinases - antagonists & inhibitors | Proteins | Phosphorylation | Cancer therapies | Apoptosis | Tumors | Protein-Serine-Threonine Kinases | Cellular Biology | Life Sciences | Mitochondria | Histones | Caspase 3 | Colorectal Neoplasms | Carrier Proteins | Protein Phosphatase 2C | Antineoplastic Agents | G2 Phase Cell Cycle Checkpoints | Cisplatin | Nuclear Proteins | Tumor Suppressor Protein p53 | DNA Damage | Protein-Tyrosine Kinases | Cell Cycle Proteins | Original
Journal Article
Oncogene, ISSN 0950-9232, 10/2011, Volume 30, Issue 41, pp. 4261 - 4274
In the presence of sustained DNA damage occurring in S-phase or G2, normal cells arrest before mitosis and eventually become senescent. The checkpoint kinases... 
cyclin B1 | ATM | Chk2 | G2-M checkpoint | cell cycle | GENOTOXIC STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOTIC CATASTROPHE | TRANSCRIPTIONAL REPRESSION | G CHECKPOINT | CELL BIOLOGY | GENOMIC INSTABILITY | RETINOBLASTOMA PROTEIN | ONCOLOGY | GENETICS & HEREDITY | P53-DEFICIENT CELLS | CELL-CYCLE EXIT | IONIZING-RADIATION | ATAXIA-TELANGIECTASIA | Protein Kinases - metabolism | G2 Phase Cell Cycle Checkpoints - physiology | Phosphorylation | Protein Kinases - genetics | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Immunoblotting | Male | Cyclin B1 - metabolism | Pyrones - pharmacology | Tumor Suppressor Protein p53 - genetics | Cell Cycle Proteins - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | G2 Phase Cell Cycle Checkpoints - drug effects | RNA Interference | Tumor Suppressor Proteins - genetics | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Antineoplastic Agents - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Tumor Suppressor Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | HCT116 Cells | Cell Cycle Proteins - metabolism | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Cyclin B1 - genetics | Morpholines - pharmacology | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Piperazines - pharmacology | G2 Phase Cell Cycle Checkpoints - genetics | Signal Transduction - drug effects | Cell Line, Tumor | Checkpoint Kinase 2 | Bleomycin - pharmacology | Checkpoint Kinase 1 | Signal Transduction - physiology | DNA Damage | HeLa Cells | Cell division | Oxidative stress | Signal transduction | DNA damage | Cyclin-dependent kinases | Cell cycle | CHK2 protein | Epithelial cells | Mitosis | CHK1 protein | G2 phase | Genotoxicity | Osteosarcoma cells | p53 protein | Cyclin-dependent kinase | Chemotherapy | Fibroblasts | Cancer
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 04/2011, Volume 22, Issue 8, pp. 1191 - 1206
Mitosis requires precise coordination of multiple global reorganizations of the nucleus and cytoplasm. Cyclin-dependent kinase 1 (Cdk1) is the primary upstream... 
ANAPHASE-PROMOTING COMPLEX | XENOPUS EGG EXTRACTS | PROTEIN PHOSPHATASES | CYCLE-DEPENDENT PHOSPHORYLATION | UBIQUITIN LIGASE | M-PHASE | CHROMOSOME ALIGNMENT | CELL-CYCLE | TUMOR-CELLS | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Cyclin-Dependent Kinases - metabolism | Gene Expression - drug effects | Xenopus Proteins - genetics | Mitosis | Protein-Tyrosine Kinases - metabolism | Humans | Phosphoprotein Phosphatases - metabolism | G2 Phase - drug effects | CDC2 Protein Kinase - metabolism | Cell Cycle Proteins - antagonists & inhibitors | Protein-Tyrosine Kinases - genetics | Cyclin B - genetics | cdc25 Phosphatases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Prometaphase - drug effects | Female | Cyclin-Dependent Kinases - antagonists & inhibitors | Phosphorylation - drug effects | cdc25 Phosphatases - metabolism | Cyclin-Dependent Kinases - genetics | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CDC2 Protein Kinase - genetics | Protein Phosphatase 2 - antagonists & inhibitors | CDC2 Protein Kinase - antagonists & inhibitors | Xenopus laevis | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Phosphoprotein Phosphatases - antagonists & inhibitors | cdc25 Phosphatases - genetics | Xenopus Proteins - antagonists & inhibitors | Membrane Proteins | Animals | Phosphoprotein Phosphatases - genetics | Nuclear Proteins - antagonists & inhibitors | Protein Phosphatase 2 - metabolism | Cyclin B - metabolism | Feedback, Physiological - drug effects | Xenopus Proteins - metabolism | Protein Kinase Inhibitors - pharmacology | S Phase - drug effects | HeLa Cells | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
The FEBS Journal, ISSN 1742-464X, 08/2017, Volume 284, Issue 15, pp. 2378 - 2395
The molecular chaperone heat shock protein 90 (Hsp90α) regulates cell proteostasis and mitigates the harmful effects of endogenous and exogenous stressors on... 
H2AX | Hsp90α | 17‐AAG | DNA damage response | DNA double‐strand break | ATM | NBN | ionizing radiation | 17-AAG | DNA double-strand break | CANCER-CELLS | DEPENDENT PHOSPHORYLATION | GENOTOXIC STRESS | MRE11 COMPLEX | BIOCHEMISTRY & MOLECULAR BIOLOGY | Hsp90 alpha | HISTONE H2AX | HEAT-SHOCK-PROTEIN | HSP90 INHIBITORS | DAMAGE RESPONSE | CELL-CYCLE | IONIZING-RADIATION | Nijmegen Breakage Syndrome - pathology | Ataxia Telangiectasia Mutated Proteins - metabolism | Checkpoint Kinase 2 - chemistry | Humans | Checkpoint Kinase 1 - chemistry | DNA Breaks, Double-Stranded | Cell Cycle Proteins - chemistry | Checkpoint Kinase 2 - metabolism | Proteasome Endopeptidase Complex - drug effects | Ubiquitination - drug effects | Protein Processing, Post-Translational - drug effects | RNA Interference | Gene Deletion | Ataxia Telangiectasia Mutated Proteins - antagonists & inhibitors | Cell Cycle Proteins - genetics | HSP90 Heat-Shock Proteins - chemistry | Phosphorylation - drug effects | Nuclear Proteins - genetics | DNA Repair - drug effects | Ataxia Telangiectasia Mutated Proteins - chemistry | Nijmegen Breakage Syndrome - metabolism | Cell Cycle Proteins - metabolism | Cells, Cultured | Nuclear Proteins - metabolism | Lactams, Macrocyclic - pharmacology | Nuclear Proteins - chemistry | Nijmegen Breakage Syndrome - genetics | Benzoquinones - pharmacology | Checkpoint Kinase 1 - metabolism | Point Mutation | HSP90 Heat-Shock Proteins - antagonists & inhibitors | Models, Biological | Protein Stability - drug effects | HSP90 Heat-Shock Proteins - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Cell Line, Transformed | Protein Multimerization - drug effects | Amino Acid Substitution | Biotechnology | Hsp90 protein | Phosphorylation | DNA damage | Irradiated | Kinases | DNA repair | Degradation | Proteins | Ionizing radiation | MRE11 protein | Fibroblasts | Ataxia | Inhibition | Localization | Repair | Deoxyribonucleic acid--DNA | CHK2 protein | BRCA1 protein | Alpha rays | Lymphoblastoid cell lines | Heat shock proteins | I.R. radiation | Breast cancer | Clients | Damage localization | DNA-dependent protein kinase | Ataxia telangiectasia | Ataxia telangiectasia mutated protein | Control stability | Iridium | Proteomes | Position (location) | Radiation damage | Adenosine triphosphatase | Heat shock
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 08/2014, Volume 21, Issue 10, pp. 864 - 870
Orderly termination of sister-chromatid cohesion during mitosis is critical for accurate chromosome segregation. During prophase, mitotic kinases phosphorylate... 
SISTER-CHROMATID COHESION | SPINDLE CHECKPOINT | XENOPUS EGG EXTRACTS | SORORIN | COMPLEX | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN PHOSPHATASE 2A | MEIOSIS-I | DNA-REPLICATION | CELL BIOLOGY | BIOPHYSICS | CHROMOSOME SEGREGATION | Phosphorylation | Chromatids - genetics | Humans | Nuclear Proteins - ultrastructure | Cell Cycle Proteins - ultrastructure | Crystallography, X-Ray | Chromosomal Proteins, Non-Histone - ultrastructure | Centromere - metabolism | Mitosis - genetics | Cell Cycle Proteins - antagonists & inhibitors | RNA Interference | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Binding Sites | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carrier Proteins - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Protein Phosphatase 2 - genetics | Nuclear Proteins - metabolism | Proto-Oncogene Proteins - genetics | Phosphoproteins - ultrastructure | Chromosomal Proteins, Non-Histone - genetics | Carrier Proteins - genetics | Carrier Proteins - metabolism | Nuclear Proteins - antagonists & inhibitors | Protein Binding | RNA, Small Interfering | HeLa Cells | Adaptor Proteins, Signal Transducing - metabolism | Chromosome Segregation - genetics | Chromosome replication | Proteins | Mitosis | Genetic aspects | Observations | Structure | Identification and classification | Cell division | Molecular biology | Kinases | Chromosomes
Journal Article
Nature, ISSN 0028-0836, 04/2012, Volume 484, Issue 7393, pp. 208 - 213
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 7/2010, Volume 190, Issue 1, pp. 25 - 34
Mps1 is an essential component of the spindle assembly checkpoint. In this study, we describe a novel Mps1 inhibitor, AZ3146, and use it to probe the role of... 
HEK293 cells | Mitosis | Auroras | Kinetochores | Cell lines | Centromeres | HeLa cells | Antibodies | Reports | Chromosomes | Cells | MITOTIC CHECKPOINT PROTEINS | MAD2 | ACTIVATION | KINASE | DYNAMICS | CENP-E | CHROMOSOME ALIGNMENT | BUB1 | KINETOCHORE LOCALIZATION | SPINDLE-ASSEMBLY CHECKPOINT | CELL BIOLOGY | Phosphorylation - physiology | Humans | Multiprotein Complexes - genetics | Cell Cycle Proteins - antagonists & inhibitors | Aurora Kinase B | Multiprotein Complexes - metabolism | Protein Multimerization - physiology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Cell Cycle Proteins - genetics | Mad2 Proteins | Phosphorylation - drug effects | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Repressor Proteins - metabolism | Calcium-Binding Proteins - metabolism | Chromosomal Proteins, Non-Histone - metabolism | Kinetochores - metabolism | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aurora Kinases | Chromosomal Proteins, Non-Histone - genetics | Mitosis - drug effects | Mitosis - physiology | Signal Transduction - drug effects | Signal Transduction - physiology | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Protein-Tyrosine Kinases | Protein Multimerization - drug effects | Calcium-Binding Proteins - genetics | Genetic aspects | Chemical properties
Journal Article