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Journal of Clinical Oncology, ISSN 0732-183X, 04/2017, Volume 35, Issue 11, pp. 1261 - 1262
Journal Article
by Lee, ASG and Ang, P
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2008, Volume 26, Issue 14, pp. 2419 - 2419
Journal Article
Journal of Research in Medical and Dental Science, ISSN 2347-2545, 02/2019, Volume 7, Issue 1, pp. 206 - 210
Aims: The checkpoint kinase 2 (CHEK2) was identified as a gene in cell cycle control upon DNA damage. The mutation in this gene is associated with some kinds... 
ASP | Cancer | CHEK2 gene
Journal Article
Oncotarget, ISSN 1949-2553, 09/2018, Volume 9, Issue 75, pp. 34079 - 34089
Wilms tumour (WT), the most frequent malignant childhood renal tumour, shows a high degree of genetic and epigenetic heterogeneity. Loss of imprinting on... 
CHEK2 | Wilms tumor | SNP array
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 04/2016, Volume 34, Issue 11, pp. 1208 - 1216
Purpose CHEK2 is a cell cycle checkpoint regulator, and the CHEK2*1100delC germline mutation leads to loss of function and increased breast cancer risk. It... 
C-REACTIVE PROTEIN | WOMEN | ACTIVATION | METAANALYSIS | ONCOLOGY | SUSCEPTIBILITY | CHEK2 1100DELC MUTATION | BRCA1 | VARIANT | CHEK2-ASTERISK-1100DELC | HISTORY
Journal Article
Journal of Medical Genetics, ISSN 0022-2593, 2019
Chromosomal instability, as reflected by structural or copy-number changes, is a known cancer characteristic but are rarely observed in healthy tissue.... 
chromosomal translocations | Dna breakage | acute myeloid leukemia | chek2 | multi-organ tumorigenesis
Journal Article
Genetics in Medicine, ISSN 1098-3600, 05/2017, Volume 19, Issue 5, pp. 599 - 603
textabstractPurpose:CHEK2∗1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC).... 
breast cancer | Breast Cancer Association Consortium | polygenic risk score | CHEK2 | 1100delC | common variants
Journal Article
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 02/2008, Volume 26, Issue 4, pp. 542 - 548
Purpose CHEK2* 1100delC heterozygosity may be associated with an increased risk of breast cancer; however, it is unclear whether the evidence is sufficient to... 
POPULATION | PENETRANCE | GERMLINE MUTATION | CHEK2 1100DELC | ONCOLOGY | COLORECTAL-CANCER | SUSCEPTIBILITY | HEREDITARY BREAST | EARLY-ONSET | SPANISH FAMILIES | TUMOR CHARACTERISTICS
Journal Article
Journal Article
Breast Cancer Research and Treatment, ISSN 0167-6806, 2/2017, Volume 161, Issue 3, pp. 575 - 586
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2013, Volume 49, Issue 8, pp. 1993 - 1999
Aim: The CHEK2* 1100delC mutation confers a relative risk of two for breast cancer (BC) in the general population. This study aims to explore the excess cancer... 
SUSCEPTIBILITY | Breast cancer | BRCA2 | CARRIERS | VARIANT | CHEK21100delC | CHEK2 1100DELC | ONCOLOGY | Familial | CHEK2 | MUTATION | Cancer incidence | Relatives | HISTORY | Oncology, Experimental | Genetic aspects | Research | Health aspects | Epidemiology | Risk factors | Cancer
Journal Article
ONCOLOGY, ISSN 0030-2414, 2016, Volume 90, Issue 4, pp. 193 - 198
Objective: The suppressor gene CHEK2 encodes a cell cycle checkpoint kinase, involved in cell cycle regulation, apoptosis and response to DNA damage. The aim... 
CHEK2 mutation | ONCOLOGY | Clinicopathological factors | SUSCEPTIBILITY | RISK | Breast cancer
Journal Article
Genetics in Medicine, ISSN 1098-3600, 2019, Volume 21, Issue 8, pp. 1708 - 1718
Purpose: Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian... 
PRS | rare variants | breast cancer | BOADICEA | risk prediction | SUSCEPTIBILITY | TRUNCATING VARIANTS | BRCA2 | PALB2 | WOMEN | MODIFIERS | CHEK2 | MUTATION | GENETICS & HEREDITY | OVARIAN | MENOPAUSE
Journal Article
Journal of Clinical Oncology, ISSN 0732-183X, 12/2017, Volume 35, Issue 34, pp. 3796 - 3799
Journal Article
Breast Cancer Research, ISSN 1465-5411, 10/2016, Volume 18, Issue 1, p. 98
Background: P.I157T is a CHEK2 missense mutation associated with a modest increase in breast cancer risk. Previously, another CHEK2 mutation, the protein... 
I157T | Pathology | CHK2 | CHEK2 | Breast cancer | Gene expression | Survival | 1100delC | CHEK2 MUTATIONS | DNA-DAMAGE | SUSCEPTIBILITY | INTRINSIC SUBTYPES | RISK | CHEK2-ASTERISK-1100DELC | WOMEN | ONCOLOGY | MAMMARY-GLAND DEVELOPMENT | GENE-EXPRESSION | PROGNOSTIC-SIGNIFICANCE | Care and treatment | Gene mutations | Patient outcomes | Research | Tumor proteins
Journal Article
EUROPEAN JOURNAL OF HUMAN GENETICS, ISSN 1018-4813, 01/2014, Volume 22, Issue 1, pp. 46 - 51
The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an... 
bilateral breast cancer | REDUCED RISK | BIOCHEMISTRY & MOLECULAR BIOLOGY | SUSCEPTIBILITY | PHENOTYPE | SEQUENCE VARIANTS | genotype risk | lung cancer | 1100delC homozygotes | CHEK2 | COLORECTAL-CANCER | GENES | GENETICS & HEREDITY | CHEK2 1100DELC MUTATION | FUNCTIONAL-ANALYSIS | CHEK2-ASTERISK-1100DELC VARIANT | DNA-REPAIR
Journal Article
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