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chek2-asterisk-1100delc (121) 121
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chek2-asterisk-1100delc variant (17) 17
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1. Full Text Multigene Panel Testing: Planning the Next Generation of Research Studies in Clinical Cancer Genetics
by Robson, M
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 07/2014, Volume 32, Issue 19, pp. 1987 - 1989
BREAST-CANCER | ONCOLOGY | RISK | BRCA1 | CHEK2-ASTERISK-1100DELC
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2. Full Text Increased risk for other cancers in addition to breast cancer for CHEK2∗1100delC heterozygotes estimated from the copenhagen general population study
by Naslund-Koch, Charlotte and Nordestgaard, Børge G and Bojesen, Stig E
Journal of Clinical Oncology, ISSN 0732-183X, 04/2016, Volume 34, Issue 11, pp. 1208 - 1216
Purpose CHEK2 is a cell cycle checkpoint regulator, and the CHEK2*1100delC germline mutation leads to loss of function and increased breast cancer risk. It... 
C-REACTIVE PROTEIN | WOMEN | ACTIVATION | METAANALYSIS | ONCOLOGY | SUSCEPTIBILITY | CHEK2 1100DELC MUTATION | BRCA1 | VARIANT | CHEK2-ASTERISK-1100DELC | HISTORY
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3. Full Text Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer
by Michailidou, Kyriaki and Beesley, Jonathan and Lindstrom, Stephen and Canisius, Sander and Dennis, Joe and Lush, Michael and Maranian, Melanie and Bolla, Manjeet and Wang, Qing and Shah, Mitul and Perkins, Barbara and Czene, Kamila and Eriksson, Mikael and Darabi, Hatef and Brand, Judith S and Bojesen, Stig and Nordestgaard, Børge and Flyger, Henrik and Nielsen, Sune and Rahman, Nazneen and Turnbull, Clare and Fletcher, Olivia and Peto, Julian and Gibson, Lorna and Santos Silva, Isabel and Chang-Claude, Jenny and Flesch-Janys, Dieter and Rudolph, Anja and Eilber, Ursula and Behrens, Timothy and Nevanlinna, Heli and Muranen, Taru and Aittomäki, Kristiina and Blomqvist, Carl and Khan, Sofia and Aaltonen, Kirsimari and Ahsan, Habibul and Kibriya, Muhammad and Whittemore, Alice S and John, Esther M and Malone, Kathleen E and Gammon, Marilie and Santella, Regina M and Ursin, Giske and Makalic, Enes and Schmidt, Daniel and Casey, Graham and Hunter, David J and Gapstur, Susan M and Gaudet, Mia and Diver, Ryan and Haiman, Christopher A and Schumacher, Freick and Henderson, Brian and Le Marchand, Loic and Berg, Christine and Chanock, Stephen and Figueroa, Jonine and Hoover, Robert N and Lambrechts, Diether and Neven, Patrick and Wildiers, Hans and Limbergen, Erik and Schmidt, Marjanka and Broeks, Annegien and Verhoef, S and Cornelissen, Sten and Couch, Fergus and Olson, Janet and Hallberg, Boubou and Vachon, Celine and Waisfisz, Quinten and Meijers-Heijboer, Hanne and Adank, Muriel and Luijt, Rob and Li, Jingmei and Liu, Jianjun and Humphreys, Manjeet and Kang, Daehee and Choi, Ji-Yeob and Park, Sue K and Yoo, K.Y and Matsuo, Keitaro and Ito, Hidemi and Iwata, Hiroji and Tajima, Kazuo and Guénel, Pascal and Truong, Thérèse and Mulot, Claire and Sanchez, Marie and Burwinkel, Barbara and Marme, Federick and Surowy, Harald and Sohn, Christof and Wu, Anna H and Tseng, Chiu-chen and Van Den Berg, David and Stram, Daniel O and González-Neira, Anna and Benítez, Javier and ... and KConFab Investigators and AOCS Grp and BOCS and NBCS and GENICA Network and kConFab Investigators and AOCS Group and Medicinska fakulteten and Kirurgi and Institutionen för kirurgisk och perioperativ vetenskap and Umeå universitet
Nature Genetics, ISSN 1061-4036, 04/2015, Volume 47, Issue 4, pp. 373 - 380
textabstractGenome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast... 
COMMON VARIANTS | ALLELES | METAANALYSIS | GENOTYPE IMPUTATION | GENETICS & HEREDITY | ESTROGEN | CONFER SUSCEPTIBILITY | RISK | OVARIAN-CANCER | BRCA1 | CHEK2-ASTERISK-1100DELC | Genetic Predisposition to Disease | Genome-Wide Association Study | Meta-Analysis as Topic | Breast Neoplasms - genetics | Microarray Analysis | Humans | Female | Polymorphism, Single Nucleotide | Genetic Loci | Case-Control Studies | Cohort Studies | Quantitative trait loci | Genetic susceptibility | Genetic research | Breast cancer | Genetic aspects | Research | Identification and classification | Risk factors | Studies | Datasets | Genealogy | Disease | Womens health | Genes | Genomes | Index Medicus | Clinical Medicine | Medical and Health Sciences | Cancer and Oncology | Klinisk medicin | Medicin och hälsovetenskap | Cancer och onkologi
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4. Full Text Breast Cancer Family History and Contralateral Breast Cancer Risk in Young Women: An Update From the Women's Environmental Cancer and Radiation Epidemiology Study
by Reiner, AS and Sisti, J and John, EM and Lynch, CF and Brooks, JD and Mellemkjaer, L and Boice, JD and Knight, JA and Concannon, P and Capanu, M and Tischkowitz, M and Robson, M and Liang, XL and Woods, M and Conti, DV and Duggan, D and Shore, R and Stram, DO and Thomas, DC and Malone, KE and Bernstein, L and Bernstein, JL and WECARE Study Collaborative Grp and WECARE Study Collaborative Group
JOURNAL OF CLINICAL ONCOLOGY, ISSN 0732-183X, 05/2018, Volume 36, Issue 15, pp. 1513 - 1513
PurposeThe Women's Environmental Cancer and Radiation Epidemiology (WECARE) study demonstrated the importance of breast cancer family history on contralateral... 
FUNCTIONAL VARIANTS | COMMON VARIANTS | POPULATION | IDENTIFIES 2 | ONCOLOGY | MUTATION CARRIERS | SUSCEPTIBILITY LOCI | CONFER SUSCEPTIBILITY | ATM GENE | CHEK2-ASTERISK-1100DELC | GENOME-WIDE ASSOCIATION
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5. Full Text Genome-wide association study identifies novel breast cancer susceptibility loci
by Easton, Douglas F and Pooley, Karen A and Dunning, Alison M and Pharoah, Paul D. P and Thompson, Deborah and Ballinger, Dennis G and Struewing, Jeffery P and Morrison, Jonathan and Field, Helen and Luben, Robert and Wareham, Nicholas and Ahmed, Shahana and Healey, Catherine S and Bowman, Richard and Meyer, Kerstin B and Haiman, Christopher A and Kolonel, Laurence K and Henderson, Brian E and Le Marchand, Loic and Brennan, Paul and Sangrajrang, Suleeporn and Gaborieau, Valerie and Odefrey, Fabrice and Shen, Chen-Yang and Wu, Pei-Ei and Wang, Hui-Chun and Eccles, Diana and Evans, D. Gareth and Peto, Julian and Fletcher, Olivia and Johnson, Nichola and Seal, Sheila and Stratton, Michael R and Rahman, Nazneen and Chenevix-Trench, Georgia and Bojesen, Stig E and Nordestgaard, Børge G and Axelsson, Christen K and Garcia-Closas, Montserrat and Brinton, Louise and Chanock, Stephen and Lissowska, Jolanta and Peplonska, Beata and Nevanlinna, Heli and Fagerholm, Rainer and Eerola, Hannaleena and Kang, Daehee and Yoo, Keun-Young and Noh, Dong-Young and Ahn, Sei-Hyun and Hunter, David J and Hankinson, Susan E and Cox, David G and Hall, Per and Ween, Sara and Liu, Jianjun and Low, Yen-Ling and Bogdanova, Natalia and Schürmann, Peter and Dörk, Thilo and Tollenaar, Rob A. E. M and Jacobi, Catharina E and Devilee, Peter and Klijn, Jan G. M and Sigurdson, Alice J and Doody, Michele M and Alexander, Bruce H and Zhang, Jinghui and Cox, Angela and Brock, Ian W and MacPherson, Gordon and Reed, Malcolm W. R and Couch, Fergus J and Goode, Ellen L and Olson, Janet E and Meijers-Heijboer, Hanne and van den Ouweland, Ans and Uitterlinden, Ané and Rivadeneira, Fernando and Milne, Roger L and Ribas, Gloria and Gonzalez-Neira, Anna and Benitez, Javier and Hopper, John L and McCredie, Margaret and Southey, Melissa and Giles, Graham G and Schroen, Chris and Justenhoven, Christina and Brauch, Hiltrud and Hamann, Ute and Ko, Yon-Dschun and Spurdle, Amanda B and Beesley, Jonathan and Chen, Xiaoqing and Mannermaa, Arto and Kosma, Veli-Matti and Kataja, Vesa and Hartikainen, Jaana and Day, Nicholas E and ... and kConFab and AOCS Management Grp and SEARCH Collaborators and AOCS Management Group and SEARCH collaborators and The SEARCH collaborators
Nature, ISSN 0028-0836, 2007, Volume 447, Issue 7148, pp. 1087 - 1093
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility to the disease. Known susceptibility genes account for less... 
BRCA2 MUTATIONS | GENE | DATABASE | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | DISEASE | GROWTH-FACTOR RECEPTOR-2 | POPULATIONS | PATTERNS | OVARIAN-CANCER | CHEK2-ASTERISK-1100DELC | Genetic Predisposition to Disease - genetics | Humans | Genotype | Receptors, Progesterone - genetics | North America | Case-Control Studies | Europe - ethnology | Genome, Human - genetics | Asia, Southeastern | Breast Neoplasms - genetics | Alleles | Polymorphism, Single Nucleotide - genetics | Female | MAP Kinase Kinase Kinase 1 - genetics | Australia | Odds Ratio | Microfilament Proteins - genetics | Receptor, Fibroblast Growth Factor, Type 2 - genetics | Breast cancer | Genetic aspects | Research | Genetic susceptibility | Risk factors | Medical research | Genomics | Polymorphism | Genes | Control equipment | Breast | Risk | Genetics | Nucleotides | Loci | Cancer | Index Medicus
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6. Full Text Polygenes, Risk Prediction, and Targeted Prevention of Breast Cancer
by Pharoah, Paul D.P and Antoniou, Antonis C and Easton, Douglas F and Ponder, Bruce A.J
The New England Journal of Medicine, ISSN 0028-4793, 06/2008, Volume 358, Issue 26, pp. 2796 - 2803
This article reviews the genetic susceptibility to breast cancer, with emphasis on genomewide association studies that have uncovered six single-nucleotide... 
WOMEN | MEDICINE, GENERAL & INTERNAL | ALLELES | VARIANTS | GENETICS | SUSCEPTIBILITY | MUTATIONS | BRCA1 | MEDICINE | CHEK2-ASTERISK-1100DELC | GENOME-WIDE ASSOCIATION | Risk Assessment - methods | Genetic Predisposition to Disease | Breast Neoplasms - genetics | Humans | Alleles | Female | Genotype | Penetrance | Risk | Polymorphism, Single Nucleotide | Genetic Markers | Multifactorial Inheritance | Prevention | Breast cancer | Genetic aspects | Research | Population genetics | Womens health | Normal distribution | Genetics | Population | Mammography | Family medical history | Health risk assessment | Kinases | Index Medicus | Abridged Index Medicus
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7. Full Text Multidisciplinary Meeting on Male Breast Cancer: Summary and Research Recommendations
by Larissa A. Korde and Jo Anne Zujewski and Leah Kamin and Sharon Giordano and Susan Domchek and William F. Anderson and John M.S. Bartlett and Karen Gelmon and Zeina Nahleh and Jonas Bergh and Bruno Cutuli and Giancarlo Pruneri and Worta McCaskill-Stevens and Julie Gralow and Gabriel Hortobagyi and Fatima Cardoso
Journal of Clinical Oncology, ISSN 0732-183X, 04/2010, Volume 28, Issue 12, pp. 2114 - 2122
Male breast cancer is a rare disease, accounting for less than 1% of all breast cancer diagnoses worldwide. Most data on male breast cancer comes from small... 
KLINEFELTERS-SYNDROME | SURVIVAL | RISK-FACTORS | ONCOLOGY | MEN | SUSCEPTIBILITY | GERMLINE MUTATIONS | BRCA1 MUTATION CARRIERS | LYMPH-NODE BIOPSY | CARCINOMA | CHEK2-ASTERISK-1100DELC | Breast Neoplasms, Male - diagnosis | Breast Neoplasms, Male - genetics | Guidelines as Topic | Breast Neoplasms, Male - therapy | Humans | Risk Factors | Cooperative Behavior | Biomedical Research | Male | Treatment Outcome | Breast Neoplasms, Male - epidemiology | International Cooperation | Index Medicus | Bc2 | Special | Bc1 | Rare | Bc7
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8. Full Text ATM mutations that cause ataxia-telangiectasia are breast cancer susceptibility alleles
by Seal, Sheila and Jayatilake, Hiran and Barfoot, Rita and Rahman, Nazneen and Chagtai, Tasnim and Eccles, Diana and Thompson, Deborah and Renwick, Anthony and Kelly, Patrick and Spanova, Katarina and Evans, D Gareth and McGuffog, Lesley and Ahmed, Munaza and Stratton, Michael R and Easton, Douglas F and North, Bernard and Breast Cancer Susceptibility and Breast Cancer Susceptibility Collaboration (UK) and The Breast Cancer Susceptibility Collaboration (UK)
Nature Genetics, ISSN 1061-4036, 08/2006, Volume 38, Issue 8, pp. 873 - 875
We screened individuals from 443 familial breast cancer pedigrees and 521 controls for ATM sequence variants and identified 12 mutations in affected... 
EARLY-ONSET | MISSENSE | FAMILIES | CHEK2-ASTERISK-1100DELC | GENETICS & HEREDITY | Genetic Predisposition to Disease | Humans | Protein-Serine-Threonine Kinases - genetics | Male | Ataxia Telangiectasia Mutated Proteins | DNA-Binding Proteins - genetics | Case-Control Studies | Breast Neoplasms - genetics | Pedigree | Tumor Suppressor Proteins - genetics | Alleles | Cell Cycle Proteins - genetics | Ataxia Telangiectasia - genetics | Female | Mutation | Complications and side effects | Gene mutations | Ataxia telangiectasia | Genetic aspects | Breast cancer | Diagnosis | Risk factors | Medical screening | Index Medicus
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9. Full Text Risk of Breast Cancer in Women With a CHEK2 Mutation With and Without a Family History of Breast Cancer
by Cezary Cybulski and Dominika Wokołorczyk and Anna Jakubowska and Tomasz Huzarski and Tomasz Byrski and Jacek Gronwald and Bartłomiej Masojć and Tadeusz Dębniak and Bohdan Górski and Paweł Blecharz and Steven A. Narod and Jan Lubiński
Journal of Clinical Oncology, ISSN 0732-183X, 10/2011, Volume 29, Issue 28, pp. 3747 - 3752
Purpose To estimate the risk of breast cancer in a woman who has a CHEK2 mutation depending on her family history of breast cancer. Patients and Methods Seven... 
POPULATION | GERMLINE MUTATION | 1100DELC MUTATION | GENE | ONCOLOGY | SUSCEPTIBILITY | FREQUENCY | EARLY-ONSET | CHEK2-ASTERISK-1100DELC VARIANT | BRCA1 | TUMOR CHARACTERISTICS | Genetic Predisposition to Disease | Follow-Up Studies | Humans | Middle Aged | Risk Factors | Protein-Serine-Threonine Kinases - genetics | Family Health | Genotype | Young Adult | Breast Neoplasms - genetics | Aged, 80 and over | Checkpoint Kinase 2 | Adult | Female | Aged | Mutation | Breast cancer | BRCA1 protein | Magnetic resonance imaging | Tamoxifen | Index Medicus
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10. Full Text Are the so-called low penetrance breast cancer genes, ATM, BRIP1, PALB2 and CHEK2, high risk for women with strong family histories?
by Byrnes, GB and Southey, MC and Hopper, JL
BREAST CANCER RESEARCH, ISSN 1465-5411, 2008, Volume 10, Issue 3
A woman typically presents for genetic counselling because she has a strong family history and is interested in knowing the probability she will develop... 
BRCA2 MUTATIONS | ALLELES | ONCOLOGY | SUSCEPTIBILITY | DISEASE | CHEK2-ASTERISK-1100DELC | AGGREGATION | GENOME-WIDE ASSOCIATION
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11. Full Text CHEK2 Is a Multiorgan Cancer Susceptibility Gene
by Cybulski, C and Górski, B and Huzarski, T and Masojć, B and Mierzejewski, M and Dębniak, T and Teodorczyk, U and Byrski, T and Gronwald, J and Matyjasik, J and Złowocka, E and Lenner, M and Grabowska, E and Nej, K and Castaneda, J and Mędrek, K and Szymańska, A and Szymańska, J and Kurzawski, G and Suchy, J and Oszurek, O and Witek, A and Narod, S.A and Lubiński, J
The American Journal of Human Genetics, ISSN 0002-9297, 2004, Volume 75, Issue 6, pp. 1131 - 1135
A single founder allele of the gene has been associated with predisposition to breast and prostate cancer in North America and Europe. The CHEK2 protein... 
BREAST-CANCER | LI-FRAUMENI-SYNDROME | CHK2 | COLORECTAL-CANCER | PROSTATE-CANCER | GENETICS & HEREDITY | HEREDITARY BREAST | RISK | MUTATIONS | CHEK2-ASTERISK-1100DELC | 1100DELC | Genetic Variation | Genetic Predisposition to Disease - genetics | Neoplasms - genetics | Polymorphism, Restriction Fragment Length | Gene Frequency | Humans | Protein-Serine-Threonine Kinases - genetics | Checkpoint Kinase 2 | Poland | DNA Primers | Odds Ratio | Case-Control Studies | Prostate cancer | Breast cancer | Research | Index Medicus | Report
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12. Full Text A comprehensive evaluation of CHEK2 germline mutations in men with prostate cancer
by Wu, Yishuo and Yu, Hongjie and Zheng, S. Lilly and Na, Rong and Mamawala, Mufaddal and Landis, Tricia and Wiley, Kathleen and Petkewicz, Jacqueline and Shah, Sameep and Shi, Zhuqing and Novakovic, Kristian and McGuire, Michael and Brendler, Charles B and Ding, Qiang and Helfand, Brian T and Carter, H. Ballentine and Cooney, Kathleen A and Isaacs, William B and Xu, Jianfeng
The Prostate, ISSN 0270-4137, 06/2018, Volume 78, Issue 8, pp. 607 - 615
BackgroundGermline mutations in CHEK2 have been associated with prostate cancer (PCa) risk. Our objective is to examine whether germline pathogenic CHEK2... 
mutation | germline | CHEK2 | lethal prostate cancer | ACTIVATION | CHECKPOINT KINASE | REPAIR GENE-MUTATIONS | DEATH | CHEK2-ASTERISK-1100DELC | BREAST-CANCER | GENOMICS | INCREASED RISK | ENDOCRINOLOGY & METABOLISM | UROLOGY & NEPHROLOGY | FOUNDER | ASSOCIATION | Case studies | Medical research | Gene mutations | Analysis | Medicine, Experimental | Genetic aspects | Prostate cancer | Survival analysis | Nucleotide sequence | Population studies | Mutation | Survival | Prostate | Deoxyribonucleic acid--DNA | Index Medicus
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13. Full Text Male breast cancer in a multi-gene panel testing cohort: insights and unexpected results
by Pritzlaff, Mary and Summerour, Pia and McFarland, Rachel and Li, Shuwei and Reineke, Patrick and Dolinsky, Jill S and Goldgar, David E and Shimelis, Hermela and Couch, Fergus J and Chao, Elizabeth C and LaDuca, Holly
Breast Cancer Research and Treatment, ISSN 0167-6806, 2/2017, Volume 161, Issue 3, pp. 575 - 586
Genetic predisposition to male breast cancer (MBC) is not well understood. The aim of this study was to better define the predisposition genes contributing to... 
Medicine & Public Health | Multi-gene panel testing | CHEK2 | Oncology | Male breast cancer | BRCA2 | PALB2 | POPULATION | BRCA2 MUTATIONS | SUSCEPTIBILITY | RISK | CHEK2-ASTERISK-1100DELC | CHEK2 1100DELC | GENE | ONCOLOGY | FAMILIES | GERMLINE MUTATIONS | Breast Neoplasms, Male - diagnosis | Breast Neoplasms, Male - genetics | Genetic Predisposition to Disease | Genetic Association Studies | Fanconi Anemia Complementation Group N Protein - genetics | Gene Frequency | Humans | Middle Aged | Genotype | Male | Risk | Genetic Testing - methods | Young Adult | Checkpoint Kinase 2 - genetics | Aged, 80 and over | Genes, BRCA2 | Germ-Line Mutation | Adult | Aged | Breast Neoplasms, Male - epidemiology | Genes, BRCA1 | Mutation | Cohort Studies | Gene mutations | Genes | Oncology, Experimental | Genetic aspects | Breast cancer | Disease susceptibility | Research | Cancer | Index Medicus | Epidemiology
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