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British Journal of Pharmacology, ISSN 0007-1188, 08/2012, Volume 166, Issue 8, pp. 2289 - 2306
Journal Article
Science, ISSN 0036-8075, 9/2013, Volume 341, Issue 6152, pp. 1387 - 1390
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2015, Volume 388, Issue 8, pp. 883 - 903
G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today. The UniProt database has records for about 800 proteins... 
Neurosciences | CXCR 1 , CXCR 2 , CCR 4 and CCR 5 , chemokine receptors | TM, trans-membrane helix | β 2 AR, β 2 -adrenergic receptor | ProS, pairwise protein similarity method | CRF1, corticotropin releasing factor receptor 1 | T4L, T4-lysozyme | ECL, extracellular loop | GLP-1, Glucagon-like peptide-1 receptor | hM 3 R, human muscarinic M3 receptor | α1B Adrenergic receptor | Pharmacology/Toxicology | 7TM, seven-transmembrane domain | HGMP, hierarchical GPCR modelling protocol | PDB, Protein Data Bank | XFELs, x-ray free electron lasers | 5-HT 2B and 5-HT 2C , human 5-hydroxytryptamine receptors 2B and 2C, respectively | GLAS, GPCR-likeness assessment score | H 1 , histamine receptor 1 | 3D, three-dimensional | Biomedicine | CCK 2 R, cholecystokinin receptor-2 | MD, molecular dynamic simulations | GPCRs, G-protein coupled receptors | Dopamine D 2 receptor | BRIL, apocytochrome b 562 RIL | δ-OR, delta-opioid receptor | SDM, site-directed mutagenesis | CCK2R, cholecystokinin receptor-2 | PEPTIDE-1 RECEPTOR | DESIGN | CXCR1, CXCR2, CCR4, and CCR5, chemokine receptors | beta 2AR, beta 2-adrenergic receptor | hMR, human muscarinic M3 receptor | HUMAN OREXIN-1 | PHARMACOLOGY & PHARMACY | ANTAGONISTS | Dopamine D-2 receptor | PROTEIN-COUPLED RECEPTORS | SITE-DIRECTED MUTAGENESIS | alpha 1B Adrenergic receptor | LIPIDIC CUBIC PHASE | delta-OR, delta-opioid receptor | 5-HT2B and 5-HT2C, human 5-hydroxytryptamine receptors 2B and 2C, respectively | H-1, histamine receptor 1 | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | BINDING | SELECTIVITY | BRIL, apocytochrome bRIL | Animals | Receptors, G-Protein-Coupled - metabolism | Computer Simulation | Drug Industry | Humans | Cooperative Behavior | Models, Molecular | Crystallography | Drug Discovery | Universities | Drug discovery | Index Medicus | BRIL, apocytochrome b562RIL | Meeting Report | H1, histamine receptor 1 | β2AR, β2-adrenergic receptor | CXCR1, CXCR2, CCR4 and CCR5, chemokine receptors | hM3R, human muscarinic M3 receptor | Dopamine D2 receptor
Journal Article
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2010, Volume 126, Issue 5, pp. 985 - 993.e3
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 20, pp. 8485 - 8490
The trace amine-associated receptor 1 (TAAR1), activated by endogenous metabolites of amino acids like the trace amines p-tyramine and β-phenylethylamine, has... 
Receptors | Neurons | Serotonin receptors | Trace amines | Agonists | Inurement | Autoreceptors | Antipsychotic agents | Cocaine | Dosage | Schizophrenia | Depression | Anxiety | Drug discovery | Serotonin | AMINE-ASSOCIATED RECEPTOR-1 | MULTIDISCIPLINARY SCIENCES | TRACE AMINES | PROTEIN-COUPLED RECEPTORS | schizophrenia | DOPAMINE TRANSPORTER | FAMILY | anxiety | serotonin | BETA-PHENYLETHYLAMINE | drug discovery | ANIMAL-MODEL | depression | AMPHETAMINE | STRESS-INDUCED HYPERTHERMIA | Synaptic Transmission - physiology | Receptors, G-Protein-Coupled - metabolism | Humans | Glutamine - metabolism | Receptors, G-Protein-Coupled - agonists | Phenylpropionates - pharmacology | Animals | Receptors, G-Protein-Coupled - deficiency | Mental Disorders | HEK293 Cells | Mice | Biogenic Monoamines - metabolism | Benzodioxoles - pharmacology | Dopamine - metabolism | Physiological aspects | Neural transmission | Cell receptors | Research | Dopaminergic mechanisms | Health aspects | Proteins | Brain | Rodents | Amino acids | Mutation | Gene expression | Cells | Neuroleptics | Mental disorders | Glutamic acid receptors (ionotropic) | Hyperactivity | Brain slice preparation | Firing rate | amines | N-Methyl-D-aspartic acid receptors | Neuromodulation | Serotonin S1 receptors | dorsal raphe nucleus | Metabolites | Dopamine transporter | Norepinephrine | Neurotransmission | Index Medicus | Biological Sciences
Journal Article
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