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21. Full Text Resveratrol‐induced apoptosis in MCF‐7 human breast cancer cells involves a caspase‐independent mechanism with downregulation of Bcl‐2 and NF‐κB
by Pozo‐Guisado, Eulalia and Merino, Jaime M and Mulero‐Navarro, Sonia and Lorenzo‐Benayas, M. Jesús and Centeno, Francisco and Alvarez‐Barrientos, Alberto and Salguero, Pedro M. Fernandez
International Journal of Cancer, ISSN 0020-7136, 05/2005, Volume 115, Issue 1, pp. 74 - 84
Resveratrol (RES), a chemopreventive molecule, inhibits the proliferation of tumor cells of different etiologies. We previously showed that RES alters the cell... 
Bcl‐2 | apoptosis | NF‐κB | resveratrol | caspase | Bcl-2 | Caspase | NF-κB | Resveratrol | Apoptosis | PHOSPHOINOSITIDE 3-KINASE PATHWAY | DENDRITIC CELLS | MUSCULAR-DYSTROPHY | DIOXIN RECEPTOR | TUMOR-CELLS | resveratrol caspase | ESTROGEN-RECEPTOR | NUCLEAR TRANSLOCATION | NF-kappa B | ONCOLOGY | CHEMOPREVENTIVE AGENT RESVERATROL | CYTOCHROME-C RELEASE | MATRIX METALLOPROTEASE-9
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22. Full Text Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?
by Saiko, Philipp and Szakmary, Akos and Jaeger, Walter and Szekeres, Thomas
Mutation Research-Reviews in Mutation Research, ISSN 1383-5742, 2008, Volume 658, Issue 1, pp. 68 - 94
Resveratrol (3,5,4′-trihydroxy- -stilbene; RV), a dietary constituent found in grapes and wine, exerts a wide variety of pharmacological activities. Because... 
Neurologic disease | Mitochondrial dysfunction | Parkinson's disease | Chemoprevention | Natural stilbenes | Hydroxylated and methoxylated resveratrol analogs | Cardiovascular disease | Huntington's disease | Alzheimer's disease | cardiovascular disease | PROTEIN-KINASE-D | LOW-DENSITY-LIPOPROTEIN | mitochondrial dysfunction | FACTOR-KAPPA-B | natural stilbenes | hydroxylated and methoxylated resveratrol analogs | GENE-EXPRESSION PATTERN | chemoprevention | neurologic disease | APOPTOSIS-INDUCING AGENTS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | PROMYELOCYTIC LEUKEMIA-CELLS | ESTROGEN-RECEPTOR-ALPHA | GENETICS & HEREDITY | CHEMOPREVENTIVE AGENT RESVERATROL | SMOOTH-MUSCLE-CELLS | TOXICOLOGY | MAMMARY EPITHELIAL-CELLS | Medical colleges | Nervous system diseases | Low density lipoproteins | Amyloid beta-protein | Sulfates | Coronary heart disease | Prevention | Antioxidants | Metabolites | Resveratrol | DNA polymerases | Production processes | Cancer
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23. Full Text Chemopreventive agent resveratrol, a natural product derived from grapes, reversibly inhibits progression through S and G2 phases of the cell cycle in U937 cells
by Park, Jong-Wook and Choi, Yun-Jung and Jang, Min-Ah and Lee, Young-Sun and Jun, Do Youn and Suh, Min-Ho and Suh, Seong-Il and Baek, Won-Ki and Jin, Ing-Nyol and Kwon, Taeg Kyu
Cancer Letters, ISSN 0304-3835, 2001, Volume 163, Issue 1, pp. 43 - 49
Resveratrol, a natural product derived from grapes, has been shown to prevent carcinogenesis in murine models. We report here that resveratrol induces... 
Cyclin | Cancer chemopreventive agent | Resveratrol | Cell cycle | cyclin | ONCOLOGY | cell cycle | KINASE | cancer chemopreventive agent | ACCUMULATION | resveratrol | P53 | Cell Cycle Proteins - drug effects | Cell Count | Humans | Cell Cycle Proteins - metabolism | Stilbenes - pharmacology | Blotting, Western | Cell Division - drug effects | G2 Phase - drug effects | Dose-Response Relationship, Drug | Rosales - chemistry | Flow Cytometry | Time Factors | U937 Cells | S Phase - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Cell Cycle - drug effects
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24. Full Text Resveratrol as MDR reversion molecule in breast cancer: An overview
by Alamolhodaei, Nafiseh Sadat and Tsatsakis, Aristidis M and Ramezani, Mohammad and Hayes, A. Wallace and Karimi, Gholamreza
Food and Chemical Toxicology, ISSN 0278-6915, 05/2017, Volume 103, pp. 223 - 232
Breast cancer is the most common cause of cancer mortality among women worldwide; therefore, a strategy to defeat breast cancer is an extremely important... 
Phytoestrogens | Breast cancer | Multidrug resistance | Resveratrol | ANTIOXIDANT ACTIVITY | POLYPHENOLIC CONTENT | GROWTH-INHIBITION | CARCINOMA A431 CELLS | INDUCED APOPTOSIS | FOOD SCIENCE & TECHNOLOGY | PLANT POLYPHENOLS | INDUCED CARDIOTOXICITY | IN-VITRO | CHEMOPREVENTIVE AGENT RESVERATROL | TOXICOLOGY | MULTIDRUG-RESISTANCE | Inactivation, Metabolic | DNA Repair - drug effects | Apoptosis - drug effects | Drug Resistance, Multiple - drug effects | Humans | Stilbenes - chemistry | Stilbenes - pharmacology | Breast Neoplasms - drug therapy | Estrogen Receptor Modulators - pharmacology | Breast Neoplasms - metabolism | Animals | Breast Neoplasms - pathology | Female | Antineoplastic Agents, Phytogenic - pharmacology | Phytoestrogens - pharmacology | Drug Resistance, Neoplasm - drug effects | Drug resistance in microorganisms | Pharmacy | Mortality | Estrogen | Forensic sciences | Drugstores | Pharmaceutical biotechnology | Anthracyclines | Cyclic adenylic acid | Estradiol | Cyclic guanylic acid | Cytochrome c | Mitogens | Protein kinases | Index Medicus
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25. Full Text Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: Role of nuclear factor-κB, cyclooxygenase 2, and matrix metalloprotease 9
by Banerjee, Sanjeev and Bueso-Ramos, Carlos and Aggarwal, Bharat B
Cancer Research, ISSN 0008-5472, 09/2002, Volume 62, Issue 17, pp. 4945 - 4954
We have reported recently that resveratrol (trans-3,4',5-trihydroxystilbene), a polyphenolic phytoalexin found in grapes, fruits, and root extracts of the weed... 
TNF-INDUCED ACTIVATION | BREAST-CANCER | CYP1A1 EXPRESSION | TUMOR-NECROSIS-FACTOR | EPITHELIAL-CELLS | ONCOLOGY | NITRIC-OXIDE SYNTHASE | N-TERMINAL KINASE | GENE-EXPRESSION | CHEMOPREVENTIVE AGENT RESVERATROL | TRANSCRIPTION FACTOR
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26. Full Text Drug interaction potential of resveratrol
by Detampel, Pascal and Beck, Mareike and Krähenbühl, Stephan and Huwyler, Jörg
Drug Metabolism Reviews, ISSN 0360-2532, 8/2012, Volume 44, Issue 3, pp. 253 - 265
Resveratrol is a naturally occurring polyphenol that is often used as a food supplement. Many positive health effects, including cardio protection, tumor... 
drug-drug interactions | cytochrome P450 | Resveratrol | drug metabolism | DIFFERENTIAL INHIBITION | MECHANISM-BASED INACTIVATION | ARYL-HYDROCARBON RECEPTOR | GRAPEFRUIT JUICE | TRANS-RESVERATROL | PHARMACOLOGY & PHARMACY | CHEMOPREVENTIVE AGENT RESVERATROL | METABOLIZING ENZYMES | HUMAN CYTOCHROME-P450 ENZYMES | RED WINE | HEALTHY-VOLUNTEERS | Enzyme Inhibitors - adverse effects | Stilbenes - adverse effects | Cytochrome P-450 Enzyme Inhibitors | Food-Drug Interactions | Humans | Cytochrome P-450 Enzyme System - metabolism | Wine - analysis | Animals | Cardiotonic Agents - adverse effects | Wine - adverse effects | Anticarcinogenic Agents - adverse effects | Immunologic Factors - adverse effects | Dietary Supplements - adverse effects | Vasodilator Agents - adverse effects
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27. Full Text Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics
by Huang, Xiang-tao and Huang, Zhen and Huang, Yong-xiu and Li, Xi and Xie, Ming-ling and Wu, Gui-xian and Peng, Zhi-rong and Sun, Yan-ni and Ming, Qian-liang and Liu, Yan-xia and Chen, Jie-ping and Xu, Shuang-nian
Chemico-Biological Interactions, ISSN 0009-2797, 06/2019, Volume 306, pp. 29 - 38
Resveratrol, found in variety of plants, is a natural stilbene structure polyphenol. It has various pharmacological effects, such as antioxidation, anti-aging,... 
Anti-Leukemia | Drug candidate | Resveratrol | INDUCED APOPTOSIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER-CELL-LINES | ACUTE MYELOID-LEUKEMIA | IN-VITRO | LYMPHOCYTIC-LEUKEMIA | ACUTE LYMPHOBLASTIC-LEUKEMIA | PEANUT ARACHIS-HYPOGAEA | TRANS-RESVERATROL | PHARMACOLOGY & PHARMACY | CHEMOPREVENTIVE AGENT RESVERATROL | TOXICOLOGY | SOLID-PHASE EXTRACTION
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28. Full Text The grape antioxidant resveratrol for skin disorders: Promise, prospects, and challenges
by Ndiaye, Mary and Philippe, Carol and Mukhtar, Hasan and Ahmad, Nihal
Archives of Biochemistry and Biophysics, ISSN 0003-9861, 2011, Volume 508, Issue 2, pp. 164 - 170
► Background on skin, skin cancer, and oxidative stress. ► Resveratrol’s effects on skin disease and . ► Promise and prospects of resveratrol in skin... 
Skin | Ultraviolet | Antioxidant | Resveratrol | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VITRO | BIOPHYSICS | TRANS-RESVERATROL | HUMAN-MELANOMA | CHEMOPREVENTIVE AGENT RESVERATROL | CELL-CYCLE | NATURAL-PRODUCT PRESENT | RED WINE | DNA-REPAIR | MOUSE SKIN | Antioxidants - therapeutic use | Animals | Vitis - chemistry | Skin Diseases - metabolism | Stilbenes - therapeutic use | Skin - metabolism | Humans | Skin Diseases - drug therapy | Antioxidants - pharmacology | Oxidative Stress - drug effects | Stilbenes - pharmacology | Skin - drug effects | Antioxidants | Skin diseases
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29. Full Text Resveratrol protects primary rat hepatocytes against oxidative stress damage:. Activation of the Nrf2 transcription factor and augmented activities of antioxidant enzymes
by Rubiolo, Juan Andrés and Mithieux, Gilles and Vega, Félix Victor
European Journal of Pharmacology, ISSN 0014-2999, 09/2008, Volume 591, Issue 1-3, pp. 66 - 72
Oxidative stress is recognized as an important factor in the development of liver pathologies. The reactive oxygen species endogenously generated or as a... 
Oxidative stress | Primary rat hepatocyte | Antioxidant enzyme | Resveratrol | Cytoprotection | CELLS | WINE | NAD(P)H-QUINONE OXIDOREDUCTASE-1 | cytoprotection | GLUTATHIONE S-TRANSFERASES | CANCER | primary rat hepatocyte | antioxidant enzyme | RESPONSE ELEMENT | GENES | PHARMACOLOGY & PHARMACY | CHEMOPREVENTIVE AGENT RESVERATROL | resveratrol | SUPEROXIDE-DISMUTASE | EXPRESSION | oxidative stress | Antioxidants - metabolism | NF-E2-Related Factor 2 - drug effects | Cells, Cultured | Rats | Enzymes - drug effects | Male | Antioxidants - pharmacology | Hepatocytes - metabolism | Stilbenes - pharmacology | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Blotting, Western | Gene Expression Regulation - drug effects | Animals | NF-E2-Related Factor 2 - metabolism | Necrosis - etiology | Polymerase Chain Reaction | Oxidative Stress - drug effects | Enzymes - metabolism | Hepatocytes - drug effects | RNA, Messenger - drug effects
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30. Resveratrol, a phytochemical inducer of multiple cell death pathways: Apoptosis, autophagy and mitotic catastrophe
by Delmas, D and Solary, E and Latruffe, N
Current Medicinal Chemistry, ISSN 0929-8673, 03/2011, Volume 18, Issue 8, pp. 1100 - 1121
Cancers are the largest cause of mortality and morbidity in industrialized countries. In the field of the medicinal chemistry of natural products, numerous... 
Lipid rafts | Chemosensitization | Phagocytosis | Resveratrol | Apoptosis | Cancer | lipid rafts | phagocytosis | PROTEIN-KINASE-C | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | INHIBITS CYCLOOXYGENASE-2 TRANSCRIPTION | chemosensitization | FAS-INDEPENDENT APOPTOSIS | COLON-CARCINOMA CELLS | RADIATION-INDUCED APOPTOSIS | BREAST-CANCER CELLS | MITOCHONDRIAL PERMEABILITY TRANSITION | PROMYELOCYTIC LEUKEMIA-CELLS | PHARMACOLOGY & PHARMACY | cancer | CHEMOPREVENTIVE AGENT RESVERATROL | resveratrol | NF-KAPPA-B | Animals | Mitosis - drug effects | Apoptosis - drug effects | Humans | Stilbenes - chemistry | Structure-Activity Relationship | Phytotherapy | Stilbenes - pharmacology | Autophagy - drug effects | Cell proliferation | Senescence | Tumor cells | Mortality | Gene expression | p53 protein | Infection | Signal transduction | natural products | Mitochondria | Cell cycle | Ceramide | sphingomyelin | Electron transport | Tumors
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31. The resveratrol analogue, 3,4,5,4 '-trans-tetramethoxystilbene, inhibits the growth of A375 melanoma cells through multiple anticancer modes of action
by Androutsopoulos, VP and Fragiadaki, I and Spandidos, DA and Tosca, A
INTERNATIONAL JOURNAL OF ONCOLOGY, ISSN 1019-6439, 10/2016, Volume 49, Issue 4, pp. 1305 - 1314
Resveratrol is anatural dietary product that has demonstrated multifaceted anticancer activity. Several analogues of resveratrol have been synthesized in an... 
APOPTOSIS | MECHANISM | TRANS-3,4,5,4'-TETRAMETHOXYSTILBENE | melanoma | PROLIFERATION | tetramethoxystilbene | BREAST-CANCER CELLS | ERK1/2 | p38 | ONCOLOGY | TRANS 3,4,5,4'-TETRAMETHOXYSTILBENE DMU-212 | CHEMOPREVENTIVE AGENT RESVERATROL | THERAPIES | resveratrol | CARCINOMA | Aurora A
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32. Full Text Resveratrol: From Basic Science to the Clinic
by Cucciolla, Valeria and Borriello, Adriana and Oliva, Adriana and Galletti, Patrizia and Zappia, Vincenzo and Ragione, Fulvio Della
Cell Cycle, ISSN 1538-4101, 10/2007, Volume 6, Issue 20, pp. 2495 - 2510
Plants produce an extraordinary array of low-molecular-mass natural products endowed with biological activity. Among these molecules, resveratrol... 
Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Aging | Cancer therapy | Chemoprevention | Cell signaling | Resveratrol | NITRIC-OXIDE SYNTHASE | PACLITAXEL-INDUCED APOPTOSIS | S-PHASE ARREST | FAS-INDEPENDENT APOPTOSIS | HUMAN ENDOTHELIAL-CELLS | CELL BIOLOGY | cancer therapy | BREAST-CANCER CELLS | chemoprevention | ARYL-HYDROCARBON RECEPTOR | cell signaling | CHEMOPREVENTIVE AGENT RESVERATROL | aging | NATURAL-PRODUCT PRESENT | resveratrol | NF-KAPPA-B | Terpenes - pharmacology | Terpenes - chemistry | Animals | Humans | Sesquiterpenes | Cellular Senescence - drug effects | Biomedical Research | NF-kappa B - metabolism | Stilbenes - chemistry | Plants - chemistry | Stilbenes - pharmacology
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33. Full Text Resveratrol as an anticancer nutrient: molecular basis, open questions and promises
by Signorelli, Paola and Ghidoni, Riccardo
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 2005, Volume 16, Issue 8, pp. 449 - 466
The polyphenol resveratrol is an anticancer nutrient that was shown to inhibit cancer initiation and promotion [Jang M, Cai L, Udeani GO, Slowing KV, Thomas... 
Nutrient | Resveratrol | Cancer | PROTEIN-KINASE-C | nutrient | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | LOW-DENSITY-LIPOPROTEIN | PEROXIDE-INDUCED APOPTOSIS | S-PHASE ARREST | HUMAN ENDOTHELIAL-CELLS | BREAST-CANCER CELLS | NUTRITION & DIETETICS | cancer | CHEMOPREVENTIVE AGENT RESVERATROL | NATURAL-PRODUCT PRESENT | resveratrol | NF-KAPPA-B | Stilbenes - therapeutic use | Humans | Cell Cycle Proteins - metabolism | Nitric Oxide Synthase - drug effects | Stilbenes - metabolism | Prostaglandin-Endoperoxide Synthases - drug effects | Antioxidants - pharmacology | Sphingolipids - physiology | Stilbenes - pharmacology | Phytoestrogens - therapeutic use | Animals | Diet | Signal Transduction - drug effects | Phenols - therapeutic use | Cell Death - drug effects | Antineoplastic Agents, Phytogenic - therapeutic use | Anticarcinogenic Agents - therapeutic use | Tyrosine | Prevention | Care and treatment | Nitric oxide | Physiological aspects | Tumor proteins | Protein kinases
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