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Mut.Res.-Genetic Toxicology and Environmental Mutagenesis, ISSN 1383-5718, 2012, Volume 742, Issue 1, pp. 11 - 25
Current mammalian cell genotoxicity assays show a high rate of positive results, many of which are misleading when compared with genotoxicity or rodent... 
Misleading positive results | Genotoxicity | Mammalian cells | DNA-DAMAGE | FOLLOW-UP | MUTATION ASSAY | ACCURATE ASSESSMENT | CHROMOSOME-ABERRATIONS | BETA-CAROTENE | CHEMICALS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ANTIOXIDANT | CHINESE-HAMSTER | GENETICS & HEREDITY | TOXICOLOGY | ECVAM WORKSHOP | Urea | Ethionamide | Tumor proteins | Sulfisoxazole | Phthalic anhydride | Cells | Index Medicus
Journal Article
Journal Article
Journal Article
mAbs, ISSN 1942-0862, 01/2015, Volume 7, Issue 3, pp. 584 - 604
To harness the potent tumor-killing capacity of T cells for the treatment of CD19(+) malignancies, we constructed AFM11, a humanized tetravalent bispecific... 
Non-Hodgkin lymphoma | ALL | CD3 | T cells | Bispecific antibodies | NHL, non-Hodgkin lymphoma | CHO, Chinese hamster ovary | ACTIVATION | MWCO, molecular weight cut-off | FC-RECEPTORS | MONOCLONAL-ANTIBODY | PROLIFERATION | BBB, blood-brain barrier | WBA, whole body autoradiography | KD, dissociation constant | ECL, electrochemiluminescence | FACS, fluorescence-activated cell sorting | LYMPHOMA | CCS, cell culture supernatant | SDS-PAGE, sodium dodecyl sulfate polyacrylamide gel electrophoresis | ANALYSIS TOOL | i.v., intravenous | ORR, overall response rate | PI, propidium iodide | TNF, tumor necrosis factor | VH, variable heavy | Vss, volume of distribution at steady state | PBS, phosphate buffered saline | FcRn, neonatal Fc receptor | Fab, fragment antigen-binding | ctrl., control | t(1/2), terminal elimination half-life | BITE ANTIBODY BLINATUMOMAB | IgG, immunoglobulin G | B-ALL, B-precursor acute lymphoblastic leukemia | NK, natural killer | E:T, effector:target | CLL, chronic lymphocytic leukemia | IL, interleukin | MALIGNANCIES | s.c., subcutaneous | His, histidine | FR, framework region | EC50, half maximal effective concentration | FCS, fetal calf serum | MEDICINE, RESEARCH & EXPERIMENTAL | CONSTRUCT | kd, dissociation rate constant | w/o, without | Fc, fragment crystallizable | LMF, low molecular weight forms | VL, variable light | HMF, high molecular weight forms | FcgR, Fc gamma receptor | F, fluorescence | SABC, standardized antibody binding capacity | SE-HPLC, size exclusion high-pressure liquid chromatography | CD, cluster of differentiation | CL, clearance | ACUTE LYMPHOBLASTIC-LEUKEMIA | SD, standard deviation | SEC, size exclusion chromatography | PBMC, peripheral blood mononuclear cell | scFv, single-chain variable fragment | IFN, interferon | MSD, MesoScale Discovery | BiTE, bispecific T cell engager | PHA, phytohemagglutinin | Fv, variable fragment | CAR, chimeric antigen receptor | HSA, human serum albumin | AUCtot, total area under the curve | PES, polyethersulfone | CNS, central nervous system | TandAb, tandem diabody | CDR, complementarity determining region | ka, association rate constant | DMSO, dimethyl sulfoxide | SPR, surface plasmon resonance | NOD/scid, nonobese diabetic/severe combined immunodeficiency | Cmax, maximal concentration | Cricetulus | Humans | Male | Neoplasms, Experimental - pathology | Antibodies, Neoplasm - pharmacology | Neoplasms, Experimental - immunology | HEK293 Cells | Antigens, CD19 - immunology | CHO Cells | Antibodies, Neoplasm - immunology | Cricetinae | Single-Chain Antibodies - pharmacology | Antibodies, Bispecific - pharmacology | Jurkat Cells | Mice, SCID | Antibodies, Bispecific - immunology | Xenograft Model Antitumor Assays | Animals | CD3 Complex - immunology | Antibodies, Bispecific - chemistry | Mice, Inbred NOD | Antibodies, Neoplasm - chemistry | Mice | Neoplasms, Experimental - drug therapy | Single-Chain Antibodies - chemistry | Single-Chain Antibodies - immunology
Journal Article
Journal Article
Applied Biochemistry and Biotechnology, ISSN 0273-2289, 1/2018, Volume 184, Issue 1, pp. 303 - 322
Recent developments in medical biotechnology have facilitated to enhance the production of monoclonal antibodies (mAbs) and recombinant proteins in mammalian... 
Biochemistry, general | Anti-apoptotic cell engineering | Polyethylenimine (PEI) | Biotechnology | Chemistry | Bcl-xL | Transient gene expression (TGE) | Chinese hamster ovary cells | PROTEIN-PRODUCTION | HIGH-THROUGHPUT | TRANSFECTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | LARGE-SCALE | MAMMALIAN-CELLS | CULTURE | BCL-2 | HAMSTER OVARY CELLS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | TRANSIENT GENE-EXPRESSION | MONOCLONAL-ANTIBODIES | Animals | Cricetulus | Recombination, Genetic | Antibodies, Monoclonal, Humanized - biosynthesis | Antibodies, Monoclonal, Humanized - immunology | Biosimilar Pharmaceuticals | Tumor Necrosis Factor-alpha - biosynthesis | Staurosporine - pharmacology | Apoptosis | CHO Cells | Case studies | Stem cell research | Biomimetics | Tumor necrosis factor | Stem cells | Physiological aspects | Monoclonal antibodies | T cells | Gene expression | Recombinant proteins | Lymphocytes T | Mammalian cells | Proteins | Engineering | Transfection | Immunology | Bcl-x protein | Lymphocytes | Tumor necrosis factor-TNF | Deoxyribonucleic acid--DNA | Recombinant | Polyethyleneimine | Medical research | Immunological memory | Memory cells | Cell survival | Immunoregulation | Therapeutic applications | Tumor cells | Inflammation | Tumor necrosis factor-α | Mammals | Metabolism | Cells | Infectious diseases | Lymphocytes B | Cell death | Bioreactors | Yield | Viability | Cancer | Pharmaceuticals
Journal Article
Journal Article