X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (22) 22
dna damage (17) 17
cell biology (16) 16
animals (13) 13
cell cycle (12) 12
oncology (12) 12
phosphorylation (12) 12
apoptosis (11) 11
biochemistry & molecular biology (11) 11
cancer (10) 10
checkpoint kinase 1 (10) 10
protein-serine-threonine kinases - metabolism (9) 9
cell cycle proteins - metabolism (8) 8
checkpoint kinase 2 (8) 8
chk (8) 8
proteins (8) 8
activation (7) 7
atm (7) 7
protein kinases - metabolism (7) 7
signal transduction (7) 7
ataxia telangiectasia mutated proteins (6) 6
checkpoint (6) 6
dna-binding proteins - metabolism (6) 6
hela cells (6) 6
p53 (6) 6
tumor suppressor protein p53 - metabolism (6) 6
tumor suppressor proteins - metabolism (6) 6
cell line, tumor (5) 5
chemotherapy (5) 5
chk tyrosine kinase (5) 5
chk, checkpoint kinase (5) 5
dna repair (5) 5
expression (5) 5
kinases (5) 5
mammalian-cells (5) 5
mice (5) 5
mitosis (5) 5
biology (4) 4
calcium (4) 4
cell-cycle (4) 4
chk 1 (4) 4
chk2 (4) 4
cycle (4) 4
cyclin b1 (4) 4
deoxyribonucleic acid--dna (4) 4
gene expression (4) 4
protein kinase inhibitors - pharmacology (4) 4
antineoplastic agents - pharmacology (3) 3
atr (3) 3
binding (3) 3
biophysics (3) 3
bioscience (3) 3
cell (3) 3
cell division (3) 3
cell line (3) 3
cell proliferation (3) 3
chk inhibitors (3) 3
chk1 protein (3) 3
chk2 protein (3) 3
dna damage response (3) 3
dna-damage (3) 3
dna-damage response (3) 3
double-strand breaks (3) 3
er, endoplasmic reticulum (3) 3
female (3) 3
in-vitro (3) 3
in-vivo (3) 3
ionizing-radiation (3) 3
jnk, c-jun n-terminal kinase (3) 3
kinase (3) 3
landes (3) 3
life sciences (3) 3
mapk, mitogen-activated protein kinase (3) 3
mice, inbred c57bl (3) 3
mitosis - drug effects (3) 3
organogenesis (3) 3
pkb, protein kinase b (3) 3
pkc, protein kinase c (3) 3
protein kinases - physiology (3) 3
protein-serine-threonine kinases - antagonists & inhibitors (3) 3
protein-serine-threonine kinases - genetics (3) 3
repair (3) 3
replication (3) 3
s-phase (3) 3
s-phase checkpoint (3) 3
senescence (3) 3
signal transduction - physiology (3) 3
tumor cells, cultured (3) 3
tumors (3) 3
tyrosine (3) 3
acnu (2) 2
adult (2) 2
advanced cancer (2) 2
aged (2) 2
amino acid sequence (2) 2
ampk, amp-activated protein kinase (2) 2
anaphase - drug effects (2) 2
antineoplastic agents - therapeutic use (2) 2
antineoplastic combined chemotherapy protocols - pharmacology (2) 2
apoptosis - genetics (2) 2
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
FEBS letters, ISSN 0014-5793, 2001, Volume 496, Issue 1, pp. 44 - 48
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2... 
Casein kinase | Inhibitor | Casein kinase-2 | Protein phosphorylation | Protein kinase | nCK, native casein kinase | OA, okadaic acid | PRAK, p38-regulated/activated kinase | CSK, C-terminal Src kinase | AMPK, AMP-activated protein kinase | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | MAPKAP, MAPK-activated protein kinase | p70S6K, p70 ribosomal protein S6 kinase | CK, casein kinase | SAPK, stress-activated protein kinase | PDK, 3-phosphoinositide-dependent kinase | ROCK, Rho-dependent protein kinase | CDK, cyclin-dependent kinase | G-CK, Golgi casein kinase | PKC, protein kinase C | MKK, MAPK kinase (also called MEK) | PKA, cAMP-dependent protein kinase | DRB, 1-(β-D-ribofuranosyl)-5,6-dichlorobenzimidazole | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | rCK, recombinant casein kinase | ERK, extracellular signal-regulated kinase | HS1, hematopoietic lineage cell-specific protein 1 | MSK, mitogen- and stress-activated protein kinase | TBB, 4,5,6,7-tetrabromo-2-azabenzimidazole or 4,5,6,7-tetrabromobenzotriazole | MAPK, mitogen-activated protein kinase | SGK, serum- and glucocorticoid-induced kinase | CATALYTIC SUBUNIT | ZEA-MAYS | TYROSINE KINASE | CRYSTAL-STRUCTURE | COMPETITIVE INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein phosphorylation | IMMUNOPHILIN FPR3 | SACCHAROMYCES-CEREVISIAE | protein kinase | CELL BIOLOGY | casein kinase | BIOPHYSICS | inhibitor | CELL-CYCLE | BETA-SUBUNIT | casein kinase-2 | MAMMARY-GLAND | Protein Kinases - metabolism | Jurkat Cells - cytology | Protein Kinases - drug effects | Casein Kinase II | Emodin - pharmacology | Jurkat Cells - metabolism | Humans | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Substrate Specificity | Adenosine Triphosphate | Binding Sites - genetics | Binding, Competitive - drug effects | Triazoles - pharmacology | Triazoles - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Binding Sites - drug effects | Protein-Serine-Threonine Kinases - metabolism | Staurosporine - pharmacology | Amino Acid Substitution | Jurkat Cells - drug effects
Journal Article
Biochemical journal, ISSN 1470-8728, 2004, Volume 381, Issue 2, pp. 329 - 342
14-3-3 proteins exert an extraordinarily widespread influence on cellular processes in all eukaryotes. They operate by binding to specific phosphorylated sites... 
Cell signalling | Neurodegenerative disorder | Protein kinase B (PKB) | 14-3-3 protein | Plant | Cancer | RICH AKT SUBSTRATE | PHOTONEUROENDOCRINE TRANSDUCTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEPENDENT PROTEIN-KINASE | neurodegenerative disorder | SPECIFICALLY PHOSPHORYLATES | NUCLEAR-LOCALIZATION | GLUCOCORTICOID-RECEPTOR | EXOENZYME-S | cell signalling | plant | IN-VIVO | protein kinase B (PKB) | SEROTONIN N-ACETYLTRANSFERASE | cancer | 14-3-3 SIGMA GENE | 14-3-3 Proteins - metabolism | Animals | Humans | Cell Physiological Phenomena | 14-3-3 Proteins - chemistry | Protein Structure, Quaternary - physiology | Phosphoproteins - metabolism | Phosphoproteins - chemistry | Protein Interaction Mapping | PI3K, phosphoinositide 3-kinase | HCV, hepatitis C virus | serotonin N-acetyltransferase | CJD, Creutzfeldt–Jakob disease | BAD, Bcl-2 | Review | AANAT, arylalkamine | FOXO, Forkhead box, class O | ERK, extracellular-signal-regulated kinase | PKB, protein kinase B | CDK, cyclin-dependent kinase | SnRK, SNF1-related kinase | WPK4, wheat protein kinase 4 | LR axis, left–right axis | COPI, coatamer I | IRS-1, insulin receptor substrate-1 | PDE3B, phosphodiesterase 3B | SCA, spinocerebellar ataxia | PKC, protein kinase C | NLS, nuclear localization signal | NR, nitrate reductase | MDS, Miller–Dieker syndrome | TSE, transmissible spongiform encephalopathy | SH2, Src homology 2 | Bcl-XL-antagonist, causing cell death | Cdc, cell-division cycle | chk, checkpoint kinase | BSE, bovine spongiform encephalopathy | ER, endoplasmic reticulum | CSF, cerebrospinal fluid | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | FKHR, Forkhead in rhabdomyosarcoma
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 04/2012, Volume 13, Issue 6, pp. 379 - 388
... activated protein kinase; CHK, checkpoint kinase; ca, constitutively active; dn, dominant negative; GX, obatoclax; EGFR, epidermal growth factor receptor; CMV, empty... 
apoptosis | glioma | MEK1/2 inhibitors | CHK 1 inhibitor | Binding | Proteins | Landes | Calcium | Bioscience | Biology | Cell | Cycle | Cancer | Organogenesis | Glioma | Apoptosis | GLIOMA-CELLS | KINASE | INDUCE APOPTOSIS | MULTIPLE-MYELOMA CELLS | UCN-01 | FAMILY INHIBITORS | IN-VITRO | ONCOLOGY | GROWTH ARREST | PATHWAY | CHECKPOINT | Protein Kinases - metabolism | Phosphorylation | Humans | Staurosporine - analogs & derivatives | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Antineoplastic Combined Chemotherapy Protocols - pharmacology | MAP Kinase Kinase 4 - metabolism | Medulloblastoma - pathology | src-Family Kinases - metabolism | Antineoplastic Agents - pharmacology | Benzamides - pharmacology | Tumor Cells, Cultured | MAP Kinase Kinase 1 - antagonists & inhibitors | Radiation-Sensitizing Agents - pharmacology | src-Family Kinases - antagonists & inhibitors | bcl-2-Associated X Protein - metabolism | Poly(ADP-ribose) Polymerases - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Glioblastoma - pathology | Benzimidazoles - pharmacology | Checkpoint Kinase 1 | Protein Kinase Inhibitors - pharmacology | Poly (ADP-Ribose) Polymerase-1 | Glioblastoma - drug therapy | Medulloblastoma - drug therapy | bcl-X Protein - metabolism | Staurosporine - pharmacology | Research Paper | MEK1 | 2 inhibitors
Journal Article
Expert opinion on investigational drugs, ISSN 1354-3784, 06/2020, pp. 1 - 14
Journal Article
Journal Article
Journal Article