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Molecular Cell, ISSN 1097-2765, 12/2011, Volume 44, Issue 5, pp. 785 - 796
The functional significance of the signaling pathway induced by O super(6-methylguanine (O) super(6)-MeG) lesions is poorly understood. Here, we identify the... 
CHK1 protein
Journal Article
by Xu, J and Li, Y and Wang, F and Wang, X and Cheng, B and Ye, F and Xie, X and Zhou, C and Lu, W
Oncogene, ISSN 0950-9232, 02/2013, Volume 32, Issue 8, pp. 976 - 987
MicroRNAs (miRNAs) act as important gene regulators in human genomes and their aberrant expression links to many malignancies. We previously identified a... 
p-Chk1 | progression | miR-424 | Chk1 | cervical cancer | PROFILES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | CELL BIOLOGY | MICRORNA MIR-21 | BREAST-CANCER | TONGUE | LYMPH-NODE METASTASIS | ONCOLOGY | POOR-PROGNOSIS | GENETICS & HEREDITY | CHECKPOINT | DIFFERENTIATION | SQUAMOUS-CELL CARCINOMAS | Protein Kinases - metabolism | Up-Regulation | Phosphorylation | Protein Kinases - genetics | Humans | Apoptosis - genetics | Uterine Cervical Neoplasms - pathology | Cell Movement - genetics | Matrix Metalloproteinase 9 - metabolism | Transfection | Uterine Cervical Neoplasms - metabolism | Female | G1 Phase - genetics | 3' Untranslated Regions | Cell Growth Processes - genetics | Protein Kinases - biosynthesis | Genes, Tumor Suppressor | Down-Regulation | MicroRNAs - biosynthesis | Uterine Cervical Neoplasms - genetics | S Phase - genetics | Disease Progression | Cell Line, Tumor | Checkpoint Kinase 1 | MicroRNAs - genetics | Development and progression | Genetic aspects | MicroRNA | Research | Analysis | Cervical cancer | Proteins | Gene expression | Medical prognosis | Cell culture | CHK1 protein | Genomes | Malignancy | Matrix metalloproteinase | Tumor cell lines | Cervix | Lymph nodes | Metastases | Polymerase chain reaction | 3' Untranslated regions | Tumor suppressor genes | miRNA | Differentiation | Cell migration | Apoptosis | Tumors
Journal Article
Journal Article
Cancers, ISSN 2072-6694, 09/2019, Volume 11, Issue 9, p. 1320
The poor selectivity of standard cytotoxic chemotherapy regimens causes severe side-effects in patients and reduces the quality of life during treatment.... 
replication stress | CHK1 inhibitor | immunotherapy
Journal Article
Genome Biology, ISSN 1474-7596, 09/2016, Volume 17, Issue 1, p. 185
Background: The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream... 
Somatic mutation | Replication stress | APOBEC | Genomic instability | MUTATIONAL PROCESSES | ACTIVATION | BARRIER | PATTERNS | CYTIDINE DEAMINASE | CHK1 INHIBITOR | EVOLUTION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | MYC | GENETICS & HEREDITY | EXPRESSION | Multigene Family | Ataxia Telangiectasia Mutated Proteins - metabolism | Signal Transduction | DNA Replication - drug effects | Humans | Biomarkers, Tumor | Cell Transformation, Neoplastic - metabolism | Breast Neoplasms - metabolism | Gene Knockdown Techniques | Breast Neoplasms - genetics | Gene Amplification | Cytosine Deaminase - metabolism | Mutagenesis | Cell Transformation, Neoplastic - genetics | Female | Antineoplastic Agents - pharmacology | Stress, Physiological - drug effects | DNA Damage | Enzyme Activation | Gene Expression Regulation, Neoplastic - drug effects | Mutation | Cytosine Deaminase - genetics | Oncogenes | Antibody diversity | Nucleosides | Breast cancer | Genetic aspects | Research | Nucleotide sequencing | DNA sequencing | Cancer | Camptothecin | Gemcitabine | Transcription | DNA damage | Cytotoxicity | Hydroxyurea | Genomes | DNA repair | Breast carcinoma | Signal transduction | Next-generation sequencing | Cell cycle | Protein-tyrosine kinase receptors | Tumorigenesis | Supplementation | Protein-tyrosine kinase | Deoxyribonucleic acid--DNA | Tyrosine | CHK1 protein | ErbB-2 protein | Aphidicolin | DNA biosynthesis | Replication | Lymphomas | PTEN protein | Cytidine deaminase | Tumors
Journal Article
Clinical cancer research : an official journal of the American Association for Cancer Research, ISSN 1078-0432, 6/2017, Volume 23, Issue 12, pp. 3097 - 3108
Journal Article
EMBO Journal, ISSN 0261-4189, 08/2010, Volume 29, Issue 16, pp. 2802 - 2812
Journal Article
Experimental Cell Research, ISSN 0014-4827, 11/2014, Volume 329, Issue 1, pp. 26 - 34
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 09/2016, Volume 35, Issue 1, p. 153
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 07/2019, Volume 173, pp. 44 - 62
Through virtual screening, we identified the lead compound MCL1020, which exhibited modest CHK1 inhibitory activity. Then a series of... 
CHK1 kinase inhibitor | Hematologic malignancies | Selectivity | Monotherapy | KINASE 1 CHK1 | POTENT | CHEMISTRY, MEDICINAL | BIOLOGICAL EVALUATION | CHECKPOINT | OPTIMIZATION | STRUCTURE-BASED DESIGN
Journal Article