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Journal Article
CANCER SCIENCE, ISSN 1349-7006, 01/2018, Volume 109, pp. 771 - 771
Conference Proceeding
BMC Cancer, ISSN 1471-2407, 12/2012, Volume 12, Issue 1, pp. 571 - 571
Background: Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro... 
AMPK | cisplatin therapy | ATM/Chk2/p53 signaling | Serum starvation | short-term food starvation (STS) | PROTEIN-KINASE | DNA-DAMAGE | TUMOR-CELLS | H2AX PHOSPHORYLATION | ONCOGENE | ONCOLOGY | GROWTH | MESOTHELIOMA | ATM ACTIVATION | STRESS | CARCINOMA | Cell Cycle - genetics | Protein Kinases - genetics | Humans | Tumor Suppressor Protein p53 - genetics | Starvation - metabolism | DNA-Binding Proteins - metabolism | Tumor Suppressor Proteins - genetics | Cell Cycle Proteins - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Female | Antineoplastic Agents - pharmacology | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Tumor Suppressor Proteins - metabolism | HCT116 Cells | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | Signal Transduction - genetics | Ataxia Telangiectasia Mutated Proteins | Cisplatin - pharmacology | DNA-Binding Proteins - genetics | Enzyme Activation - drug effects | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Cell Line, Tumor | Checkpoint Kinase 2 | Cell Proliferation - drug effects | Mice | DNA Damage | Cell Cycle - drug effects | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Cisplatin | Cancer cells | Antimitotic agents | Starvation | Chemotherapy | Lung cancer | Comparative analysis | Antineoplastic agents | Tumor proteins | Cancer | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 02/2000, Volume 14, Issue 3, pp. 278 - 288
Chk2/hcds1 , the human homolog of the Saccharomyces cerevisiae RAD53/SPK1 and Schizosaccharomyces pombe cds1 DNA damage checkpoint genes, encodes a protein... 
ATM | Chk2 | DNA damage | hCds1 | Checkpoints | p53 | checkpoints | Research Paper
Journal Article
Oncogene, ISSN 0950-9232, 01/2014, Volume 33, Issue 1, pp. 108 - 115
Journal Article
Oncogene, ISSN 0950-9232, 10/2008, Volume 27, Issue 47, pp. 6093 - 6101
Journal Article
Gut, ISSN 0017-5749, 02/2018, Volume 67, Issue 2, pp. 204 - 205
Journal Article
Cancer Biology & Therapy, ISSN 1538-4047, 07/2018, Volume 19, Issue 7, pp. 609 - 621
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, and novel effective drugs against NSCLC are urgently needed. Isodon... 
Chk1/Chk2 | NSCLC | reactive oxygen species | apoptosis | Acetyl-macrocalin B | G2/M phase arrest | p38 MAPK | SIGNALING PATHWAYS | ACTIVATION | NATURAL-PRODUCTS | DNA-DAMAGE | DRUG DISCOVERY | KINASE | Chk1 | Chk2 | M phase arrest | ONCOLOGY | GROWTH | ROS | CHECKPOINT | INHIBITOR | Index Medicus
Journal Article
Genetics, ISSN 0016-6731, 2017, Volume 206, Issue 4, pp. 1823 - 1828
Journal Article
by Yu, Q and Pu, SY and Wu, H and Chen, XQ and Jiang, JJ and Gu, KS and He, YH and Kong, QP
FRONTIERS IN ONCOLOGY, ISSN 2234-943X, 06/2019, Volume 9, pp. 516 - 516
DNA replication is precisely regulated in cells and its dysregulation can trigger tumorigenesis. Here we identified that the TOPBP1 interacting checkpoint and... 
DNA replication | KEY STEP | ACTIVATION | proliferation | INITIATION | p53 pathway | DOUBLE-STRAND BREAKS | PATTERNS | ESTABLISHMENT | TICRR | ATM/CHK2 | GENE | ONCOLOGY | S-PHASE | CHECKPOINT | tumorigenesis | PROTEINS | Usage | Genetic aspects | Research | Gene expression | Carcinogenesis | Cancer
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 10/2004, Volume 101, Issue 40, pp. 14443 - 14448
Response to DNA damage and cell-cycle regulation differ markedly between embryonic stem (ES) cells and somatic cells. ES cells require exquisitely sensitive... 
ACTIVATION | CHK2 | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | DNA-DAMAGE | MUTATION | KINASE | MICE | ATM | P53 | CYCLE
Journal Article