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chlorproguanil-dapsone (97) 97
malaria (85) 85
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drug resistance (65) 65
drug combinations (62) 62
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tetrahydrofolate dehydrogenase - genetics (40) 40
infectious diseases (38) 38
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public, environmental & occupational health (33) 33
mutation (31) 31
pyrimethamine - pharmacology (31) 31
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research (28) 28
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dihydropteroate synthase - genetics (27) 27
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drug therapy, combination (26) 26
sulfadoxine - pharmacology (26) 26
chlorproguanil-dapsone treatment (25) 25
drug-resistance (25) 25
malaria, falciparum - epidemiology (25) 25
pyrimethamine (25) 25
drug resistance - genetics (24) 24
point mutations (23) 23
proguanil - analogs & derivatives (22) 22
abridged index medicus (21) 21
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artemisinins - therapeutic use (20) 20
malaria - drug therapy (20) 20
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africa (19) 19
chloroquine resistance (19) 19
molecular markers (19) 19
pharmacology & pharmacy (19) 19
adolescent (18) 18
adult (18) 18
alleles (18) 18
dapsone (18) 18
dihydrofolate reductase (18) 18
plasmodium falciparum - enzymology (18) 18
arctic medicine. tropical medicine (17) 17
artemether-lumefantrine (17) 17
dapsone - therapeutic use (17) 17
drug therapy (17) 17
in-vitro (17) 17
infectious and parasitic diseases (17) 17
mutations (17) 17
uncomplicated malaria (17) 17
african children (16) 16
antimalarials - administration & dosage (16) 16
double-blind (16) 16
microbiology (16) 16
polymerase chain reaction (16) 16
proguanil - therapeutic use (16) 16
pyrimethamine-sulfadoxine resistance (16) 16
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amodiaquine (15) 15
artesunate (15) 15
genetic aspects (15) 15
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resistance (15) 15
thymidylate synthase gene (15) 15
efficacy (14) 14
plasmodium falciparum - isolation & purification (14) 14
point mutation (14) 14
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haplotypes (13) 13
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03/2013
Cardiac toxicity has been reported with a number of antimalarial drugs. In this study we compared the cardiac effects of chlorproguanil/dapsone (CD) a new... 
children | falciparum malaria | Cardiac effects | Chlorproguanil-dapsone
Web Resource
Transactions of The Royal Society of Tropical Medicine and Hygiene, ISSN 0035-9203, 08/2019, Volume 113, Issue 8, pp. 483 - 488
Abstract Background Namibia has made significant gains in the fight against malaria, with a target of elimination by 2023. We examined the genotype and allele... 
G6PDd alleles | G6PD DEFICIENCY | VARIANTS | UNCOMPLICATED FALCIPARUM-MALARIA | SULFADOXINE-PYRIMETHAMINE | genotypes | TROPICAL MEDICINE | CHILDREN | HEMOLYTIC-ANEMIA | HETEROGENEITY | PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH | Kavango | primaquine | CHLORPROGUANIL-DAPSONE | Namibia | MUTATIONS | Zambezi
Journal Article
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 03/2014, Volume 14, Issue 14, pp. 1706 - 1733
In recent times, the novel concept of generating hybrid molecules by pharmacophoric hybridisation approach is fast becoming an alternative to other existing... 
Hybrid | Antimalarial | 4-Aminoquinoline | pfDHFR | Artemisinin | ANTIPLASMODIAL ACTIVITY | CHEMISTRY, MEDICINAL | COMBINATION THERAPY | SULFADOXINE-PYRIMETHAMINE | DRUG DISCOVERY | IMPROVED IN-VITRO | antimalarial | PLASMODIUM-FALCIPARUM MALARIA | artemisinin | HEME POLYMERIZATION | hybrid | CHLORPROGUANIL-DAPSONE | ARTEMISININ RESISTANCE | CONJUGATES SYNTHESIS
Journal Article
MALARIA JOURNAL, ISSN 1475-2875, 03/2018, Volume 17
Journal Article
PLoS medicine, ISSN 1549-1277, 2009, Volume 6, Issue 4, pp. e1000055 - e1000055
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 05/2010, Volume 54, Issue 5, pp. 1762 - 1768
Journal Article
PLoS Pathogens, ISSN 1553-7366, 03/2010, Volume 6, Issue 3, pp. e1000830 - e1000830
Journal Article
Malaria Journal, ISSN 1475-2875, 2009, Volume 8, Issue 1, pp. 106 - 106
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2015, Volume 10, Issue 9, pp. e0136828 - e0136828
Background Sulphadoxine-Pyrimethamine (SP) is still the only recommended antimalarial for use in intermittent preventive treatment of malaria during pregnancy... 
PHASE-III TRIAL | WOMEN | G6PD DEFICIENCY | CHLORPROGUANIL-DAPSONE-ARTESUNATE | AFRICAN CHILDREN | NEONATAL-MORTALITY | MULTIDISCIPLINARY SCIENCES | DOUBLE-BLIND | BIRTH-WEIGHT | ANEMIA | PLASMODIUM-FALCIPARUM MALARIA | Pyrimethamine - therapeutic use | Antimalarials - adverse effects | Hematologic Diseases - chemically induced | Pyrimethamine - adverse effects | Hematologic Diseases - metabolism | Humans | Hemoglobins - metabolism | Antimalarials - therapeutic use | Ghana | Sulfadoxine - adverse effects | Pregnancy | Sulfadoxine - therapeutic use | Glucosephosphate Dehydrogenase - metabolism | Glucosephosphate Dehydrogenase Deficiency - metabolism | Adult | Female | Malaria - drug therapy | Glucosephosphate Dehydrogenase Deficiency - chemically induced | Drug Combinations | Cohort Studies | Usage | Malaria | Pyrimethamine | Research | Preventive health services | Prevention | Complications and side effects | Pregnant women | Physiological aspects | Dosage and administration | Drug therapy | Medicine, Preventive | Health aspects | Phosphates | Vector-borne diseases | Oxidative stress | Medical research | Transfusion | Dehydrogenases | Enzyme activity | Anemia | Health services | Glucose | Metabolism | Studies | Glucose 6 phosphate dehydrogenase | Glucose dehydrogenase | Enzymatic activity | Surveillance | Metabolites | Womens health | Antimalarial agents | Hemoglobin | Glucosephosphate dehydrogenase | Index Medicus
Journal Article
Malaria Journal, ISSN 1475-2875, 2011, Volume 10, Issue 1, pp. 241 - 241
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is common in populations living in malaria endemic areas. G6PD genotype and phenotype were... 
PHASE-III TRIAL | HETEROGENEITY | G6PD DEFICIENCY | CHLORPROGUANIL-DAPSONE-ARTESUNATE | SUSCEPTIBILITY | DOUBLE-BLIND | PLASMODIUM-FALCIPARUM MALARIA | DEHYDROGENASE | PARASITOLOGY | TROPICAL MEDICINE | NIGERIAN POPULATION | CHILDREN | Proguanil - administration & dosage | Africa - epidemiology | Glucosephosphate Dehydrogenase Deficiency - epidemiology | Humans | Artemisinins - administration & dosage | Child, Preschool | Genotype | Infant | Male | Treatment Outcome | Malaria, Falciparum - complications | Proguanil - analogs & derivatives | Glucosephosphate Dehydrogenase Deficiency - complications | Glucosephosphate Dehydrogenase Deficiency - diagnosis | Phenotype | Antimalarials - administration & dosage | Adolescent | Dapsone - administration & dosage | Malaria, Falciparum - epidemiology | Female | Glucosephosphate Dehydrogenase - genetics | Child | Drug Combinations | Glucose-6-phosphate dehydrogenase deficiency | Complications and side effects | Malaria | Antimalarials | Dosage and administration | Genetic aspects | Research | Drug therapy | Risk factors | Chlorproguanil | Phosphates | Therapy | Temperature | Dehydrogenases | Endemic species | Countries | Clinical trials | Dapsone | Fluorescence | Glucose | Males | Dehydrogenase | Tropical diseases | Regressions | Genotype & phenotype | Glucose dehydrogenase | Specificity | Temperature effects | Artesunate | Hemoglobin | Population | NADP | Glucosephosphate dehydrogenase | Public health | Genotypes | Vector-borne diseases | Enzymes | Phenotypes | Human diseases | Frequency | Artemether | Mutation | Females | Index Medicus
Journal Article