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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2011, Volume 108, Issue 20, pp. 8485 - 8490
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 10/2012, Volume 19, Issue 28, pp. 4742 - 4758
Journal Article
Naunyn-Schmiedeberg's Archives of Pharmacology, ISSN 0028-1298, 8/2015, Volume 388, Issue 8, pp. 883 - 903
G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today. The UniProt database has records for about 800 proteins... 
Neurosciences | CXCR 1 , CXCR 2 , CCR 4 and CCR 5 , chemokine receptors | TM, trans-membrane helix | β 2 AR, β 2 -adrenergic receptor | ProS, pairwise protein similarity method | CRF1, corticotropin releasing factor receptor 1 | T4L, T4-lysozyme | ECL, extracellular loop | GLP-1, Glucagon-like peptide-1 receptor | hM 3 R, human muscarinic M3 receptor | α1B Adrenergic receptor | Pharmacology/Toxicology | 7TM, seven-transmembrane domain | HGMP, hierarchical GPCR modelling protocol | PDB, Protein Data Bank | XFELs, x-ray free electron lasers | 5-HT 2B and 5-HT 2C , human 5-hydroxytryptamine receptors 2B and 2C, respectively | GLAS, GPCR-likeness assessment score | H 1 , histamine receptor 1 | 3D, three-dimensional | Biomedicine | CCK 2 R, cholecystokinin receptor-2 | MD, molecular dynamic simulations | GPCRs, G-protein coupled receptors | Dopamine D 2 receptor | BRIL, apocytochrome b 562 RIL | δ-OR, delta-opioid receptor | SDM, site-directed mutagenesis | CCK2R, cholecystokinin receptor-2 | PEPTIDE-1 RECEPTOR | DESIGN | CXCR1, CXCR2, CCR4, and CCR5, chemokine receptors | beta 2AR, beta 2-adrenergic receptor | hMR, human muscarinic M3 receptor | HUMAN OREXIN-1 | PHARMACOLOGY & PHARMACY | ANTAGONISTS | Dopamine D-2 receptor | PROTEIN-COUPLED RECEPTORS | SITE-DIRECTED MUTAGENESIS | alpha 1B Adrenergic receptor | LIPIDIC CUBIC PHASE | delta-OR, delta-opioid receptor | 5-HT2B and 5-HT2C, human 5-hydroxytryptamine receptors 2B and 2C, respectively | H-1, histamine receptor 1 | SERIAL FEMTOSECOND CRYSTALLOGRAPHY | BINDING | SELECTIVITY | BRIL, apocytochrome bRIL | Animals | Receptors, G-Protein-Coupled - metabolism | Computer Simulation | Drug Industry | Humans | Cooperative Behavior | Models, Molecular | Crystallography | Drug Discovery | Universities | Drug discovery | BRIL, apocytochrome b562RIL | Meeting Report | H1, histamine receptor 1 | β2AR, β2-adrenergic receptor | CXCR1, CXCR2, CCR4 and CCR5, chemokine receptors | hM3R, human muscarinic M3 receptor | Dopamine D2 receptor
Journal Article
The EMBO Journal, ISSN 0261-4189, 03/2002, Volume 21, Issue 5, pp. 909 - 919
In pancreatic acinar cells, low, threshold concentrations of acetylcholine (ACh) or cholecystokinin (CCK) induce repetitive local cytosolic Ca2+ spikes in the... 
cyclic ADP‐ribose | pancreatic acinar cells | inositol trisphosphate | NAADP | local and global calcium | Inositol trisphosphate | Pancreatic acinar cells | Cyclic ADP-ribose | Local and global calcium | cyclic ADP-ribose | PANCREATIC ACINAR-CELLS | ADENINE-DINUCLEOTIDE PHOSPHATE | INTRACELLULAR CALCIUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | SEA-URCHIN EGGS | EXOCRINE PANCREAS | CELL BIOLOGY | RYANODINE RECEPTORS | ENDOPLASMIC-RETICULUM | XENOPUS OOCYTES | Cell Polarity | Adenosine Diphosphate Ribose - analogs & derivatives | Calcium Signaling - physiology | Pancreas - cytology | Sincalide - pharmacology | Inositol 1,4,5-Trisphosphate - pharmacology | Exocytosis - drug effects | NADP - pharmacology | Receptors, Cholecystokinin - physiology | Calcium Channels - physiology | Receptors, Cell Surface - drug effects | Caffeine - pharmacology | Inositol 1,4,5-Trisphosphate Receptors | NADP - analogs & derivatives | NADP - physiology | Receptors, Cell Surface - physiology | Calcium Channels - drug effects | Acetylcholine - pharmacology | Receptors, Cytoplasmic and Nuclear - drug effects | Receptors, Cholinergic - drug effects | Cholecystokinin - pharmacology | Adenosine Diphosphate Ribose - physiology | Receptors, Cytoplasmic and Nuclear - physiology | Inositol 1,4,5-Trisphosphate - physiology | Receptors, Cholinergic - physiology | Receptors, Cholecystokinin - drug effects | Patch-Clamp Techniques | Animals | Calcium Signaling - drug effects | Cyclic ADP-Ribose | Second Messenger Systems - physiology | Mice | Adenosine Diphosphate Ribose | Calcium Channels | Sincalide | Neurons and Cognition | Receptors, Cell Surface | Exocytosis | Receptors, Cytoplasmic and Nuclear | Life Sciences | Receptors, Cholecystokinin | Acetylcholine | NADP | Cholecystokinin | Pancreas | Inositol 1,4,5-Trisphosphate | Receptors, Cholinergic | Second Messenger Systems | Calcium Signaling | Caffeine
Journal Article
Peptides, ISSN 0196-9781, 2011, Volume 32, Issue 3, pp. 607 - 619
Journal Article
Journal Article
Endocrinology, ISSN 0013-7227, 06/2009, Volume 150, Issue 6, pp. 2646 - 2653
Journal Article
Journal Article