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Journal Article
Development, ISSN 0950-1991, 06/2008, Volume 135, Issue 11, pp. 1947 - 1956
Chondrocyte hypertrophy is an essential process required for endochondral bone formation. Proper regulation of chondrocyte hypertrophy is also required in... 
Ihh | Patched 1 | Cartilage | Chondrocyte hypertrophy | PTHrP | PATHWAYS | OSTEOBLAST | cartilage | chondrocyte hypertrophy | PROLIFERATION | DEVELOPMENTAL BIOLOGY | CARTILAGE DEVELOPMENT | ENDOCHONDRAL BONE | SKELETON | patched 1 | HORMONE-RELATED-PROTEIN | GROWTH-PLATE | DIFFERENTIATION | Immunohistochemistry | Hedgehog Proteins - pharmacology | Bone Morphogenetic Proteins - physiology | Hedgehog Proteins - metabolism | Hedgehog Proteins - physiology | Wnt Proteins - metabolism | Cell Differentiation - genetics | Bone Morphogenetic Proteins - metabolism | In Situ Hybridization | Wnt Proteins - genetics | Hedgehog Proteins - genetics | Receptors, Cell Surface - physiology | beta Catenin - physiology | Patched Receptors | Bone Morphogenetic Proteins - genetics | Cell Differentiation - physiology | Chondrocytes - metabolism | Organ Culture Techniques | Recombinant Proteins - metabolism | Chondrocytes - pathology | Parathyroid Hormone-Related Protein - genetics | Cells, Cultured | Receptors, Cell Surface - metabolism | Signal Transduction - genetics | Cell Enlargement | Recombinant Proteins - pharmacology | Forelimb - metabolism | Reverse Transcriptase Polymerase Chain Reaction | beta Catenin - metabolism | beta Catenin - genetics | Animals | Signal Transduction - drug effects | Parathyroid Hormone-Related Protein - physiology | Signal Transduction - physiology | Forelimb - cytology | Mice | Wnt Proteins - physiology | Mutation | Patched-1 Receptor | Receptors, Cell Surface - genetics | Index Medicus
Journal Article
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 08/2018, Volume 76, pp. 29 - 38
Articular cartilage has a very limited ability to self-heal after injury or degeneration due to its low cellularity, poor proliferative activity, and avascular... 
Bone marrow-derived mesenchymal stem cells | Matrilin-3 | Chondrogenesis | Endochondral ossification | Articular cartilage tissue engineering | Hypertrophy | KNEE | MATERIALS SCIENCE, BIOMATERIALS | ENGINEERING, BIOMEDICAL | TISSUE | OSTEOGENIC DIFFERENTIATION | IMPLANTATION | HOLLOW MICROSPHERES | BONE | OSTEOARTHRITIS | POLYMER SCAFFOLDS | AUTOLOGOUS CHONDROCYTE TRANSPLANTATION | Nanofibers - chemistry | Rabbits | Cells, Immobilized - metabolism | Cells, Immobilized - pathology | Mesenchymal Stem Cells - pathology | Tissue Scaffolds - chemistry | Mesenchymal Stem Cell Transplantation - methods | Polyesters - chemistry | Regeneration | Animals | Cartilage - physiology | Cells, Immobilized - transplantation | Matrilin Proteins - chemistry | Mesenchymal Stem Cells - metabolism | Biomimetic Materials - chemistry | Osteogenesis | Cartilage - injuries | Lactic acid | Cell differentiation | Tissue engineering | Analysis | Stem cells | Cell culture | Surgical implants | Mesenchyme | Stem cell transplantation | Mimicry | Ossification | Proteins | Cartilage | Cell growth | Pain | Biomimetics | Bone marrow | Extracellular matrix | Degeneration | Pretreatment | Repair | Bone (endochondral) | Phenotypes | Stability | Polylactic acid | Implantation | Cartilage (articular) | Trauma | Injury prevention | Grafts | Acids | Collagen | Calcification | In vivo methods and tests | Scaffolds | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2012, Volume 287, Issue 41, pp. 34500 - 34513
BMP2 (bone morphogenetic protein 2) is known to activate unfolded protein response signaling molecules, including XBP1S and ATF6. However, the influence on... 
UNFOLDED PROTEIN RESPONSE | HORMONE-RELATED PEPTIDE | MESSENGER-RNA | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION FACTOR XBP-1 | INDIAN-HEDGEHOG | P204 PROTEIN | IRE1-ALPHA-XBP1 PATHWAY | ENDOPLASMIC-RETICULUM STRESS | PLASMA-CELL DIFFERENTIATION | Growth Plate - pathology | Hedgehog Proteins - metabolism | Activating Transcription Factor 6 - genetics | Core Binding Factor Alpha 1 Subunit - metabolism | X-Box Binding Protein 1 | Gene Knockdown Techniques | Collagen Type II - metabolism | DNA-Binding Proteins - metabolism | Hedgehog Proteins - genetics | Bone Morphogenetic Protein 2 - metabolism | Female | Cell Differentiation | Chondrocytes - metabolism | Bone Morphogenetic Protein 2 - genetics | Cell Line | Chondrocytes - pathology | Gene Expression Regulation - genetics | Parathyroid Hormone-Related Protein - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Growth Plate - metabolism | Parathyroid Hormone-Related Protein - metabolism | Regulatory Factor X Transcription Factors | Collagen Type II - genetics | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Animals | Mice | Mice, Inbred BALB C | Core Binding Factor Alpha 1 Subunit - genetics | Hypertrophy | Index Medicus | Adenovirus | RNA Interference (RNAi) | Runt-related Transcription Factor 2 (RUNX2) | Chondrogenesis | Differentiation | Unfolded Protein Response | X-box-binding Protein 1 Spliced (XBP1S) | Chondrocyte Hypertrophy | Cell Biology
Journal Article
Cells Tissues Organs, ISSN 1422-6405, 08/2010, Volume 192, Issue 3, pp. 158 - 166
Induction of chondrogenesis in mesenchymal stem cells (MSCs) with TGF-β leads to a hypertrophic phenotype. The hypertrophic maturation of the chondrocytes is... 
Original Paper | Bone marrow stromal cell | Cartilage repair | Chondrogenic differentiation | Tissue engineering | Mesenchymal progenitor cell differentiation | Cell biology | Cartilage biology | Hypertrophy | Mesenchymal stem cells | PROGENITOR CELLS | ENDOCHONDRAL OSSIFICATION | ANATOMY & MORPHOLOGY | BONE-MARROW | CHONDROCYTE MATURATION | DEVELOPMENTAL BIOLOGY | CULTURE | MOLECULAR EVENTS | GROWTH | GENE-EXPRESSION | DIFFERENTIATION | VITRO CARTILAGE FORMATION | Chondrocytes - cytology | Chondrogenesis - drug effects | Humans | Alkaline Phosphatase - metabolism | Extracellular Matrix - metabolism | Male | Collagen Type II - metabolism | Young Adult | Mesenchymal Stromal Cells - cytology | Cell Enlargement - drug effects | Collagen Type X - metabolism | Adult | Female | Glycerophosphates - pharmacology | Cell Differentiation - physiology | Chondrocytes - metabolism | Transforming Growth Factor beta1 - pharmacology | Transforming Growth Factor beta3 - pharmacology | Mesenchymal Stromal Cells - drug effects | Collagen Type I - metabolism | Calcification, Physiologic - drug effects | Glycosaminoglycans - metabolism | Mesenchymal Stromal Cells - metabolism | DNA - metabolism | Protein Isoforms - pharmacology | Chondrogenesis - physiology | Transforming Growth Factor beta - pharmacology | Cell Differentiation - drug effects | Culture Media, Conditioned - metabolism | Index Medicus
Journal Article
Journal Article