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International Journal of Molecular Sciences, ISSN 1661-6596, 09/2017, Volume 18, Issue 9, p. 1842
As in humans, osteoarthritis (OA) causes considerable economic loss to the equine industry. New hopes for cartilage repair have emerged with the... 
Col1a1 | Chondrocyte | Tissue engineering | Dedifferentiation | Hypoxia | Matrix-associated autologous chondrocyte implantation (MACI) | HtrA1 | BMP-2 | Equine model | Type II collagen | SiRNA | CARTILAGE REPAIR | OSTEOARTHRITIC CHONDROCYTES | matrix-associated autologous chondrocyte implantation (MACI) | hypoxia | tissue engineering | BONE MORPHOGENETIC PROTEIN-2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | SERINE-PROTEASE HTRA1 | dedifferentiation | siRNA | COLLAGEN SPONGE SCAFFOLDS | HUMAN ARTICULAR CHONDROCYTES | CHEMISTRY, MULTIDISCIPLINARY | MESENCHYMAL STEM-CELLS | CHONDROGENIC EXPRESSION | type II collagen | equine model | chondrocyte | II COLLAGEN | TERM-FOLLOW-UP | Bone Morphogenetic Protein 2 - pharmacology | RNA, Small Interfering - genetics | Chondrocytes - cytology | Collagen Type I - metabolism | Cartilage, Articular - cytology | Collagen Type III - metabolism | Extracellular Matrix - metabolism | Cell Differentiation - genetics | Chondrocytes - drug effects | Phenotype | Animals | RNA Interference | Cartilage, Articular - metabolism | Cell Differentiation - drug effects | Bone Morphogenetic Protein 2 - metabolism | Biomarkers | Horses | Cell Culture Techniques | Cell Hypoxia - genetics | Chondrocytes - metabolism | Tissue Engineering | Medical research | Cell culture | Therapy | Collagen (type I) | Bone morphogenetic protein 2 | RNA-mediated interference | Interference | Clinical trials | Implantation | Data processing | Ribonucleic acid--RNA | Cartilage | Biomedical materials | Collagen | Chondrocytes | Autologous chondrocyte implantation | Extracellular matrix | Biocompatibility | Osteoarthritis | Three dimensional models | Cartilage diseases | Life Sciences
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2012, Volume 336, Issue 6082, pp. 717 - 721
Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular cartilage and eventually leads to disability. Molecules that... 
Cartilage | Molecules | REPORTS | Chondrocytes | Collagens | Stem cells | Lead | Arthritis | Chondrogenesis | Osteoarthritis | Vehicles | PATHOGENESIS | GENE | ARTICULAR-CARTILAGE | MULTIDISCIPLINARY SCIENCES | FILAMIN | OSTEOARTHRITIS | BONE | TRANSCRIPTION FACTOR | EXPRESSION | CHONDROGENESIS | CHONDROCYTE DIFFERENTIATION | Anilides - therapeutic use | Chondrocytes - cytology | Phthalic Acids - chemistry | Humans | Anilides - chemistry | Structure-Activity Relationship | Osteoarthritis - drug therapy | Osteoarthritis - physiopathology | Chondrocytes - drug effects | Mesenchymal Stromal Cells - cytology | Cell Nucleus - metabolism | Chondrocytes - physiology | Cattle | Microfilament Proteins - metabolism | Osteoarthritis - pathology | Phthalic Acids - pharmacology | Contractile Proteins - metabolism | Chondrocytes - metabolism | Mesenchymal Stromal Cells - physiology | Core Binding Factor beta Subunit - metabolism | Disease Models, Animal | Mesenchymal Stromal Cells - drug effects | Phthalic Acids - therapeutic use | Core Binding Factor Alpha 2 Subunit - metabolism | Cartilage, Articular - cytology | Filamins | Phthalic Acids - administration & dosage | Regeneration | Animals | High-Throughput Screening Assays | Anilides - administration & dosage | Small Molecule Libraries | Anilides - pharmacology | Mice | Care and treatment | Physiological aspects | Transplantation | Methods | Molecular biology | Biomedical materials | Effectiveness | Breakdown | Biocompatibility | Articular | Adults
Journal Article
Annals of biomedical engineering, ISSN 1573-9686, 2016, Volume 44, Issue 5, pp. 1325 - 1354
Journal Article
Scientific reports, ISSN 2045-2322, 2017, Volume 7, Issue 1, pp. 658 - 10
Journal Article
Central-European journal of immunology, ISSN 1426-3912, 2018, Volume 43, Issue 2, pp. 209 - 219
Journal Article
Development (Cambridge), ISSN 1477-9129, 2017, Volume 144, Issue 2, pp. 221 - 234
Fractures heal predominantly through the process of endochondral ossification. The classic model of endochondral ossification holds that chondrocytes mature to... 
Pluripotency programs | Fracture repair | Endochondral ossification | Chondrocyte transformation | OSTEOBLAST DIFFERENTIATION | MARROW | DEVELOPMENTAL BIOLOGY | SIGNALING CENTER | MESENCHYMAL STEM-CELLS | CHONDROCYTE DIFFERENTIATION | CRE ACTIVITY | OCT4 EXPRESSION | IN-VIVO | HYPERTROPHIC CHONDROCYTES | SOX9 | Human Umbilical Vein Endothelial Cells | Bony Callus - growth & development | Chondrocytes - cytology | Osteogenesis - physiology | Humans | Male | Cell Transdifferentiation - genetics | Chondrocytes - physiology | Cartilage - cytology | Fracture Healing - physiology | Cartilage - physiology | Osteoblasts - cytology | Bone and Bones - cytology | Bone and Bones - physiology | Neovascularization, Physiologic - genetics | Mice, Inbred C57BL | Osteoblasts - physiology | Pluripotent Stem Cells - physiology | Cells, Cultured | Up-Regulation - genetics | Mice, Knockout | Chondrogenesis - physiology | Neovascularization, Physiologic - physiology | Animals | Mice | Fracture Healing - genetics | Bony Callus - metabolism | Callus | Transformation | Therapeutic applications | Oct-4 protein | Cell division | Bone healing | Osteoblasts | Endothelial cells | Ossification | Cartilage | Growth plate | Regeneration | Fractures | Molecular modelling | Rodents | Chondrocytes | Bone (endochondral) | Pluripotency | Hypertrophy | Apoptosis | Stem Cells and Regeneration
Journal Article
Journal Article
Acta biomaterialia, ISSN 1742-7061, 2017, Volume 52, pp. 130 - 144
Journal Article
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 02/2014, Volume 18, Issue 2, pp. 283 - 292
Berberine, a plant alkaloid used in Chinese medicine, has broad cell‐protective functions in a variety of cell lines. Chondrocyte apoptosis contributes to the... 
cartilage degeneration | Akt | berberine | IL‐1β‐stimulated chondrocytes | rat OA model | Berberine | Cartilage degeneration | Rat OA model | IL-1β-stimulated chondrocytes | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | ACTIVATION | CRUCIATE LIGAMENT TRANSECTION | CANCER CELLS | PHOSPHORYLATION | PREVENTION | DEATH | CELL BIOLOGY | IL-1-stimulated chondrocytes | ARTICULAR-CARTILAGE | PATHWAY | EXPRESSION | Interleukin-1beta - pharmacology | Antigens, Nuclear - metabolism | Male | Osteoarthritis - drug therapy | Proto-Oncogene Proteins c-akt - genetics | Collagen Type II - metabolism | Chondrocytes - drug effects | Cartilage, Articular - metabolism | Protective Agents - pharmacology | Osteoarthritis - pathology | Proto-Oncogene Proteins c-akt - metabolism | Chondrocytes - metabolism | Interleukin-1beta - antagonists & inhibitors | Animals, Newborn | Cell Survival - drug effects | Chondrocytes - pathology | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Cells, Cultured | Gene Expression Regulation | Osteoarthritis - metabolism | Rats | Ribosomal Protein S6 Kinases, 70-kDa - genetics | Aggrecans - metabolism | Aggrecans - genetics | Rats, Sprague-Dawley | Collagen Type II - genetics | Osteoarthritis - genetics | Berberine - pharmacology | Cartilage, Articular - pathology | Animals | Antigens, Nuclear - genetics | Cell Proliferation - drug effects | Cartilage, Articular - drug effects | Immunohistochemistry | Phosphorylation | Pathogenesis | Interleukin | AKT protein | Cell viability | Arthritis | Kinases | Experiments | Western blotting | Proteins | Cartilage | Signal transduction | Biomedical materials | Surgery | Proliferating cell nuclear antigen | Degeneration | Medicinal plants | Antigens | Level (quantity) | Cell survival | Proteoglycans | Cytokines | Plant protection | Pharmacology | Cartilage (articular) | Chemical compounds | Herbal medicine | Protein synthesis | Cell lines | Chondrocytes | Aggrecan | Laboratory animals | Osteoarthritis | Apoptosis | Cartilage diseases | Original
Journal Article