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chrebp (221) 221
index medicus (193) 193
animals (165) 165
glucose (115) 115
humans (108) 108
mice (96) 96
liver (90) 90
element-binding protein (81) 81
male (81) 81
metabolism (78) 78
biochemistry & molecular biology (75) 75
glucose - metabolism (61) 61
basic helix-loop-helix leucine zipper transcription factors - metabolism (60) 60
liver - metabolism (59) 59
gene expression (54) 54
lipogenesis (54) 54
insulin-resistance (53) 53
transcription factors - metabolism (53) 53
protein binding (51) 51
cell biology (50) 50
endocrinology & metabolism (50) 50
gene-expression (50) 50
insulin (48) 48
nuclear proteins - metabolism (48) 48
transcription factor (48) 48
rats (46) 46
basic helix-loop-helix leucine zipper transcription factors - genetics (44) 44
mice, inbred c57bl (42) 42
expression (41) 41
dextrose (40) 40
hepatic steatosis (40) 40
fatty acids (39) 39
obesity (39) 39
transcription factors - genetics (39) 39
nuclear proteins - genetics (37) 37
transcription (37) 37
insulin resistance (36) 36
gene expression regulation (34) 34
glucose - pharmacology (32) 32
glucose metabolism (32) 32
physiological aspects (31) 31
adipose-tissue (30) 30
cell line (29) 29
female (29) 29
pyruvate-kinase gene (29) 29
article (28) 28
biophysics (28) 28
phosphorylation (28) 28
proteins (28) 28
activation (26) 26
genes (25) 25
hepatocytes - metabolism (25) 25
nutrition & dietetics (25) 25
cells, cultured (24) 24
diabetes (24) 24
fructose (24) 24
lipid metabolism (24) 24
lipids (24) 24
transcription factors (24) 24
triglycerides (24) 24
enzymes (23) 23
fatty liver (23) 23
biology (22) 22
carbohydrates (22) 22
lipid-metabolism (22) 22
promoter regions, genetic (22) 22
research (21) 21
synthesis (21) 21
carbohydrate response element (20) 20
srebp-1c (19) 19
center-dot-mlx (18) 18
fgf21 (18) 18
mice, knockout (18) 18
research article (18) 18
rodents (18) 18
steatosis (18) 18
fatty liver-disease (17) 17
fatty-acid synthase (17) 17
gene expression regulation - drug effects (17) 17
lipogenesis - genetics (17) 17
liver - drug effects (17) 17
medicine, research & experimental (17) 17
mlx (17) 17
ob/ob mice (17) 17
rats, sprague-dawley (17) 17
rna, messenger - metabolism (17) 17
de-novo lipogenesis (16) 16
genetic aspects (16) 16
glucose-metabolism (16) 16
lipogenic enzyme genes (16) 16
liver diseases (16) 16
messenger-rna (16) 16
ppar-alpha (16) 16
sterol regulatory element binding protein 1 - metabolism (16) 16
binding protein chrebp (15) 15
fatty-acid synthesis (15) 15
genetic transcription (15) 15
glycolysis (15) 15
metabolic syndrome (15) 15
nafld (15) 15
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11/2009
ChREBP has emerged as one of the key controllers of hepatic lipogenesis. While the function of ChREBP has been extensively investigated, mechanisms underlying... 
ChREBP | Oct-1 | Liver | 0719 | Insulin
Dissertation
International journal of molecular sciences, ISSN 1422-0067, 09/2019, Volume 20, Issue 18, p. 4424
Hyperglycemia is the major characteristic of diabetes mellitus, and a chronically high glucose (HG) level causes β-cell glucolipotoxicity, which is... 
TXNIP | ChREBP | p90RSK | INS-1 | FMK
Journal Article
Annual Review of Nutrition, ISSN 0199-9885, 2004, Volume 24, Issue 1, pp. 345 - 376
Journal Article
JOURNAL OF HEPATOLOGY, ISSN 0168-8278, 07/2013, Volume 59, Issue 1, pp. 178 - 179
Nonalcoholic fatty liver disease (NAFLD) is associated with all features of the metabolic syndrome. Although deposition of excess triglycerides within liver... 
NAFLD | ChREBP | NASH | GASTROENTEROLOGY & HEPATOLOGY
Journal Article
Diabetes, ISSN 0012-1797, 08/2006, Volume 55, Issue 8, pp. 2159 - 2170
Liver-Specific Inhibition of ChREBP Improves Hepatic Steatosis and Insulin Resistance in ob/ob Mice Renaud Dentin 1 , Fadila Benhamed 1 , Isabelle Hainault 2 ,... 
ACC, acetyl-CoA carboxylase | Ad-GFP, GFP adenovirus | Ad-shChREBP, recombinant adenovirus expressing short hairpin RNA against ChREBP | ERK, extracellular signal-related kinase | ChREBP, carbohydrate responsive element-binding protein | DIABETES-MELLITUS | FATTY-ACID OXIDATION | DE-NOVO LIPOGENESIS | MALONYL-COA | DISEASE | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | CARBOHYDRATE | ELEMENT-BINDING PROTEIN | NONALCOHOLIC STEATOHEPATITIS | DEFICIENT MICE | RNA, Small Interfering - genetics | Nuclear Proteins - analysis | Insulin - physiology | RNA, Messenger - analysis | Male | Lipids - biosynthesis | Obesity - genetics | Adipose Tissue - metabolism | Transfection | Insulin Resistance - physiology | Muscle, Skeletal - chemistry | Fatty Acids, Nonesterified - blood | Nuclear Proteins - genetics | Glycogen - analysis | Dietary Carbohydrates - administration & dosage | Fatty Liver - genetics | Glucose Tolerance Test | Blood Glucose - analysis | Signal Transduction | Obesity - complications | Liver - metabolism | Fatty Liver - prevention & control | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | Down-Regulation - genetics | Liver - chemistry | Animals | Nuclear Proteins - antagonists & inhibitors | Triglycerides - blood | Glucose - metabolism | Mice, Obese | Mice | Lipids - analysis | Leptin - deficiency | Fatty Liver - etiology | Prevention | Insulin resistance | Care and treatment | Research | Diabetes | Health aspects
Journal Article
BMB Reports, ISSN 1976-6696, 2018, Volume 51, Issue 9, pp. 429 - 436
Fructose in the form of sucrose and high fructose corn syrup is absorbed by the intestinal transporter and mainly metabolized in the small intestine. However,... 
Fructose metabolism | ChREBP | Small intestine | Irritable bowel syndrome | Fructose intolerance
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2015, Volume 93, Issue 12, pp. 1029 - 1041
Considering the current obesity epidemic in the United States (>100 million adults are overweight or obese), the prevalence of hypertriglyceridemia is likely... 
ChREBP | AMPK | SREBP1 | PPARα | FGF21
Journal Article
The International Journal of Biochemistry & Cell Biology, ISSN 1357-2725, 12/2019, Volume 117, p. 105618
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2012, Volume 443, Issue 1, pp. 111 - 123
Journal Article
Journal Article
Nutrients, ISSN 2072-6643, 09/2017, Volume 9, Issue 9, pp. 1 - 20
Journal Article
Molecular Metabolism, ISSN 2212-8778, 2014, Volume 4, Issue 1, pp. 51 - 57
Abstract Objective Fibroblast growth factor 21 (FGF21) is a hormone with pleiotropic metabolic activities which, in rodents, is robustly regulated by fasting... 
Endocrinology & Metabolism | ChREBP | Metabolic syndrome | Fructose | FGF21 | PPAR-ALPHA | LIPID-METABOLISM | ACID | TRANSCRIPTION | OBESITY | INSULIN-RESISTANCE | LIVER | ENDOCRINOLOGY & METABOLISM | GROWTH-FACTOR 21 | ADIPOSE-TISSUE
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 01/2016, Volume 30, Issue 1, pp. 230 - 240
Estrogen and estrogen receptor (ER)-alpha suppress visceral fat development through actions in several organs via unclear mechanisms that we sought to... 
Preadipocytes | ChREBP | BMSCs | Adipocyte hypertrophy | Kinase activation | kinase activation | PRENATAL EXPOSURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | preadipocytes | ALPHA | BODY-FAT DISTRIBUTION | OBESOGEN TRIBUTYLTIN | adipocyte hypertrophy | BETA | CELL BIOLOGY | GLUCOSE-METABOLISM | INSULIN-RESISTANCE | BIOLOGY | REPLACEMENT THERAPY | HEPATIC STEATOSIS | ADIPOSE-TISSUE
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 09/2019, Volume 141, pp. 182 - 191
Recently repeated heat stress and dehydration have been reported to cause oxidative stress and kidney damage that is enhanced by rehydrating with fructose... 
Fructokinase | NFAT5 | ChREBP | Polyol pathway | Vasopressin | ACTIVATION | KEAP1-NRF2 | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-ACETYLCYSTEINE | GLUTATHIONE | DEHYDRATION | DISEASE | ENDOCRINOLOGY & METABOLISM | SECRETION | EPIDEMIC
Journal Article