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European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2014, Volume 78, pp. 340 - 374
Journal Article
1977, Chemistry of heterocyclic compounds., ISBN 0471382124, Volume 31, xii, 1196 p. --
Book
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 93, pp. 539 - 563
Journal Article
Zhongguo Zhongyao Zazhi, ISSN 1001-5302, 02/2019, Volume 44, Issue 4, pp. 712 - 716
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2012, Volume 48, Issue 18, pp. 3319 - 3327
Abstract Background SF1126 is a peptidic pro-drug inhibitor of pan-PI3K/mTORC. A first-in-human study evaluated safety, dose limiting toxicities (DLT), maximum... 
Hematology, Oncology and Palliative Medicine | Pharmacodynamics | PI3K/mTORC pathway | SF1126 | Pharmacokinetics | Refractory solid tumours | B-cell malignancies | ACTIVATION | ANGIOGENESIS | PHOSPHATIDYLINOSITOL 3-KINASE | KINASE | GUIDELINES | CANCER | ONCOLOGY | PI3K PATHWAY | CHRONIC LYMPHOCYTIC-LEUKEMIA | INHIBITOR | ASSOCIATION | Humans | Middle Aged | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Oligopeptides - therapeutic use | Young Adult | Chromones - adverse effects | Aged, 80 and over | Antineoplastic Agents - pharmacokinetics | Chromones - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - enzymology | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Maximum Tolerated Dose | Oligopeptides - administration & dosage | TOR Serine-Threonine Kinases | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Oligopeptides - pharmacology | Proteins - antagonists & inhibitors | Prodrugs - administration & dosage | Multiprotein Complexes | Salvage Therapy | Chromones - administration & dosage | Molecular Targeted Therapy | Oligopeptides - adverse effects | Mechanistic Target of Rapamycin Complex 1 | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Hypokalemia - chemically induced | Adult | Female | Antineoplastic Agents - pharmacology | Chromones - therapeutic use | Hematologic Diseases - chemically induced | Oligopeptides - pharmacokinetics | Neoplasms - enzymology | Chromones - pharmacokinetics | Prodrugs - adverse effects | Prodrugs - pharmacokinetics | Protein Kinase Inhibitors - therapeutic use | Aged | Prodrugs - therapeutic use | Protein Kinase Inhibitors - pharmacology | Infusions, Intravenous | Prodrugs - pharmacology | Gastrointestinal Diseases - chemically induced | Medicine, Experimental | Medical research | Care and treatment | Emergency medical services | Cancer | Index Medicus | PI3K | mTORC pathway
Journal Article
Phytochemistry, ISSN 0031-9422, 02/2019, Volume 158, pp. 46 - 55
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2017, Volume 60, Issue 19, pp. 7941 - 7957
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 633 - 665
Journal Article