X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (9188) 9188
Publication (760) 760
Book Chapter (33) 33
Book Review (21) 21
Conference Proceeding (17) 17
Dissertation (8) 8
Magazine Article (8) 8
Book / eBook (7) 7
Reference (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
chromones - pharmacology (5807) 5807
morpholines - pharmacology (4321) 4321
animals (4062) 4062
humans (3829) 3829
index medicus (2931) 2931
enzyme inhibitors - pharmacology (2349) 2349
phosphatidylinositol 3-kinases - antagonists & inhibitors (2340) 2340
phosphatidylinositol 3-kinases - metabolism (2171) 2171
male (1671) 1671
mice (1595) 1595
rats (1544) 1544
biochemistry & molecular biology (1459) 1459
phosphorylation (1296) 1296
signal transduction - drug effects (1235) 1235
proto-oncogene proteins c-akt - metabolism (1226) 1226
female (1147) 1147
signal transduction (1127) 1127
cells, cultured (1116) 1116
cell line, tumor (1096) 1096
apoptosis (1058) 1058
activation (1009) 1009
cell biology (998) 998
chromones - chemistry (969) 969
chromones (960) 960
androstadienes - pharmacology (927) 927
pharmacology & pharmacy (882) 882
apoptosis - drug effects (830) 830
cell line (814) 814
chemistry, organic (775) 775
expression (772) 772
dose-response relationship, drug (737) 737
chemistry, medicinal (704) 704
oncology (702) 702
akt (683) 683
flavonoids - pharmacology (679) 679
phosphatidylinositol 3-kinase (678) 678
phosphorylation - drug effects (628) 628
chromone (618) 618
proto-oncogene proteins c-akt (572) 572
blotting, western (569) 569
chromones - therapeutic use (568) 568
time factors (552) 552
cell proliferation - drug effects (544) 544
molecular structure (543) 543
derivatives (520) 520
cell survival - drug effects (502) 502
chemistry, multidisciplinary (495) 495
rats, sprague-dawley (491) 491
signal transduction - physiology (485) 485
proto-oncogene proteins - metabolism (472) 472
cancer (469) 469
cells (467) 467
enzyme activation (460) 460
inhibition (456) 456
analysis (448) 448
in-vitro (420) 420
transfection (414) 414
proto-oncogene proteins c-akt - antagonists & inhibitors (403) 403
protein kinase inhibitors - pharmacology (399) 399
chromones - chemical synthesis (388) 388
neurosciences (387) 387
pathway (384) 384
wortmannin (383) 383
in vitro techniques (382) 382
phosphoinositide 3-kinase (377) 377
antineoplastic agents - pharmacology (375) 375
phosphatidylinositol 3-kinases - physiology (371) 371
proteins (367) 367
article (354) 354
adult (352) 352
research (350) 350
tumor cells, cultured (346) 346
chemistry (345) 345
immunology (342) 342
structure-activity relationship (336) 336
protein-serine-threonine kinases (335) 335
enzyme activation - drug effects (332) 332
plant sciences (320) 320
growth (317) 317
protein-serine-threonine kinases - metabolism (317) 317
kinases (314) 314
asthma - drug therapy (313) 313
physiology (309) 309
chromones - administration & dosage (306) 306
guinea pigs (303) 303
proliferation (303) 303
chromones - isolation & purification (302) 302
nitriles - pharmacology (300) 300
pi3k (295) 295
mitogen-activated protein kinases - metabolism (293) 293
pyridines - pharmacology (287) 287
research article (285) 285
flavonoids (284) 284
middle aged (280) 280
butadienes - pharmacology (279) 279
sirolimus - pharmacology (279) 279
rna, messenger - metabolism (276) 276
gene-expression (274) 274
inhibitors (272) 272
kinase (268) 268
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (8749) 8749
Chinese (167) 167
Japanese (86) 86
German (68) 68
French (59) 59
Italian (43) 43
Russian (21) 21
Polish (8) 8
Hebrew (6) 6
Korean (6) 6
Dutch (5) 5
Hungarian (4) 4
Spanish (4) 4
Czech (2) 2
Danish (2) 2
Finnish (2) 2
Romanian (2) 2
Ukrainian (2) 2
Norwegian (1) 1
Portuguese (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


European Journal of Medicinal Chemistry, ISSN 0223-5234, 05/2014, Volume 78, pp. 340 - 374
Journal Article
European Journal of Cancer, ISSN 0959-8049, 2012, Volume 48, Issue 18, pp. 3319 - 3327
Abstract Background SF1126 is a peptidic pro-drug inhibitor of pan-PI3K/mTORC. A first-in-human study evaluated safety, dose limiting toxicities (DLT), maximum... 
Hematology, Oncology and Palliative Medicine | Pharmacodynamics | PI3K/mTORC pathway | SF1126 | Pharmacokinetics | Refractory solid tumours | B-cell malignancies | ACTIVATION | ANGIOGENESIS | PHOSPHATIDYLINOSITOL 3-KINASE | KINASE | GUIDELINES | CANCER | ONCOLOGY | PI3K PATHWAY | CHRONIC LYMPHOCYTIC-LEUKEMIA | INHIBITOR | ASSOCIATION | Humans | Middle Aged | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Oligopeptides - therapeutic use | Young Adult | Chromones - adverse effects | Aged, 80 and over | Antineoplastic Agents - pharmacokinetics | Chromones - pharmacology | Protein Kinase Inhibitors - pharmacokinetics | Lymphoma, Large B-Cell, Diffuse - drug therapy | Lymphoma, Large B-Cell, Diffuse - enzymology | Neoplasms - drug therapy | Protein Kinase Inhibitors - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Maximum Tolerated Dose | Oligopeptides - administration & dosage | TOR Serine-Threonine Kinases | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Oligopeptides - pharmacology | Proteins - antagonists & inhibitors | Prodrugs - administration & dosage | Multiprotein Complexes | Salvage Therapy | Chromones - administration & dosage | Molecular Targeted Therapy | Oligopeptides - adverse effects | Mechanistic Target of Rapamycin Complex 1 | Dose-Response Relationship, Drug | Antineoplastic Agents - adverse effects | Hypokalemia - chemically induced | Adult | Female | Antineoplastic Agents - pharmacology | Chromones - therapeutic use | Hematologic Diseases - chemically induced | Oligopeptides - pharmacokinetics | Neoplasms - enzymology | Chromones - pharmacokinetics | Prodrugs - adverse effects | Prodrugs - pharmacokinetics | Protein Kinase Inhibitors - therapeutic use | Aged | Prodrugs - therapeutic use | Protein Kinase Inhibitors - pharmacology | Infusions, Intravenous | Prodrugs - pharmacology | Gastrointestinal Diseases - chemically induced | Medicine, Experimental | Medical research | Care and treatment | Emergency medical services | Cancer | Index Medicus | PI3K | mTORC pathway
Journal Article
1977, Chemistry of heterocyclic compounds., ISBN 0471382124, Volume 31, xii, 1196 p. --
Book
European Journal of Medicinal Chemistry, ISSN 0223-5234, 03/2015, Volume 93, pp. 539 - 563
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2017, Volume 60, Issue 19, pp. 7941 - 7957
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 01/2015, Volume 90, pp. 633 - 665
Journal Article
Current Medicinal Chemistry, ISSN 0929-8673, 09/2011, Volume 18, Issue 25, pp. 3825 - 3852
The chemistry of chromones is very well known. This system is widely used in organic chemistry as an intermediate compound for the synthesis of numerous... 
Mast cell stabilizers | Benzopyran-4-ones | Occurrence | Biological activity | Chromones | STELLERA-CHAMAEJASME L | CHEMISTRY, MEDICINAL | biological activity | mast cell stabilizers | BIOCHEMISTRY & MOLECULAR BIOLOGY | benzopyran-4-ones | DNA-BINDING PROPERTIES | occurrence | CONCENTRATING HORMONE-RECEPTOR-1 ANTAGONISTS | ANTI-HIV AGENTS | BENZOYL HYDRAZONE | ALDOSE REDUCTASE INHIBITORS | CHEMICAL-CONSTITUENTS | ANTIBACTERIAL ACTIVITY | LN(III) COMPLEXES | PHARMACOLOGY & PHARMACY | POTENTIAL ANTIINFLAMMATORY AGENTS | Plant Extracts - chemistry | Anti-Infective Agents - isolation & purification | Antioxidants - chemistry | Plant Extracts - pharmacology | Anti-Infective Agents - pharmacology | Humans | Anti-Infective Agents - chemistry | Enzyme Inhibitors - chemistry | Anti-Inflammatory Agents - therapeutic use | Anti-Inflammatory Agents - isolation & purification | Plants - chemistry | Antineoplastic Agents, Phytogenic - therapeutic use | Chromones - pharmacology | Chromones - therapeutic use | Anti-Inflammatory Agents - pharmacology | Enzyme Inhibitors - pharmacology | Anti-Infective Agents - therapeutic use | Antineoplastic Agents, Phytogenic - chemistry | Plant Extracts - isolation & purification | Antioxidants - pharmacology | Enzyme Inhibitors - therapeutic use | Enzyme Inhibitors - isolation & purification | Neoplasms - drug therapy | Chromones - chemistry | Antioxidants - therapeutic use | Animals | Anti-Inflammatory Agents - chemistry | Antioxidants - isolation & purification | Chromones - isolation & purification | Antineoplastic Agents, Phytogenic - pharmacology | Plant Extracts - therapeutic use | Antineoplastic Agents, Phytogenic - isolation & purification
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 6/2012, Volume 29, Issue 6, pp. 1485 - 1494
The aim of the present study is to evaluate the formulation effect on the oral absorption of poorly water-soluble drugs using a dissolution/permeation system... 
Biomedical Engineering | Biochemistry, general | Biomedicine |