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chromosome-5q21 (322) 322
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Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2009, Volume 106, Issue 32, pp. 13481 - 13486
Intestinal cancer is one of the most common human cancers. Aberrant activation of the canonical Wnt signaling cascade, for example, caused by adenomatous... 
β-catenin | Cecal cancer | Ubiquitin ligase | Tumor chemoprevention | ubiquitin ligase | beta-catenin | LOCALIZATION | MULTIDISCIPLINARY SCIENCES | DIOXIN RECEPTOR | IDENTIFICATION | COLON-CANCER | BETA-CATENIN PHOSPHORYLATION | CELL-DENSITY | tumor chemoprevention | cecal cancer | COLORECTAL-CANCER | GENETIC MODEL | CHROMOSOME-5Q21 | INDOLE-3-CARBINOL
Journal Article
Nature Genetics, ISSN 1061-4036, 10/2011, Volume 43, Issue 10, pp. 964 - 970
Journal Article
Veterinary Pathology, ISSN 0300-9858, 9/2018, Volume 55, Issue 5, pp. 654 - 662
Biopsy samples of colorectal polyps were collected and examined from 67 Miniature Dachshund dogs (including 35 cases with an additional biopsy).... 
beta-catenin | dogs | immunohistochemistry | inflammatory polyp | familial adenomatous polyposis | colorectal tumor | FOCAL SQUAMOUS METAPLASIA | PATHOLOGY | IDENTIFICATION | TUMORS | APC | GENES | CHROMOSOME-5Q21 | VETERINARY SCIENCES | MORULA FORMATION | EXPRESSION | TUMORIGENESIS
Journal Article
MOLECULAR CANCER RESEARCH, ISSN 1541-7786, 12/2007, Volume 5, Issue 12, pp. 1296 - 1303
The c-myc oncogene plays an important role in tumorigenesis and is frequently deregulated in many human cancers, including gastrointestinal cancers. In humans,... 
CELLS | ACTIVATION | APC | GENE | ONCOLOGY | THROMBOSPONDIN-1 | TUMOR | CHROMOSOME-5Q21 | BETA-CATENIN | IDENTIFICATION | CANCER | CELL BIOLOGY
Journal Article
SCIENCE, ISSN 0036-8075, 05/1993, Volume 260, Issue 5112, pp. 1317 - 1320
A gene discovered by positional cloning has been identified as the von Hippel-Lindau (VHL) disease tumor suppressor gene. A restriction fragment encompassing... 
POINT MUTATIONS | FAP | MULTIDISCIPLINARY SCIENCES | CHROMOSOME-5Q21 | CANCER | RENAL-CELL CARCINOMA | REGION
Journal Article
Diseases of the Colon & Rectum, ISSN 0012-3706, 04/2015, Volume 58, Issue 4, pp. 444 - 448
Journal Article
Science, ISSN 0036-8075, 5/1996, Volume 272, Issue 5264, pp. 1023 - 1026
The adenomatous polyposis coli gene (APC) is mutated in most colon cancers. The APC protein binds to the cellular adhesion molecule β-catenin, which is a... 
Phosphorylation | Immunoprecipitation | HEK293 cells | Drosophila | Cell lines | Colorectal cancer | Antibodies | Immunoblotting | Reports | Kidney cells | Epitopes | CYTOPLASMIC DOMAIN | ANTIBODIES | PROTEIN | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | CHROMOSOME-5Q21 | E-CADHERIN | MUTATIONS | IDENTIFICATION | ASSOCIATION | GENE-PRODUCT
Journal Article
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/1998, Volume 95, Issue 6, pp. 3020 - 3023
Axin antagonizes the developmental effects of Wnt in vertebrates. We show here that Axin simultaneously binds two components of the Wnt pathway, β -catenin and... 
T lymphocytes | Transfection | HEK293 cells | Complementary DNA | Cell lines | Reporter genes | Antibodies | Cellular immunity | Genetic mutation | Cells | FAP | MULTIDISCIPLINARY SCIENCES | XENOPUS EMBRYOS | CHROMOSOME-5Q21 | GENE-PRODUCT | ARMADILLO | MAMMARY ONCOGENE INT-1 | Protein kinases | Genetic transcription | Research | Biological Sciences
Journal Article
NATURE GENETICS, ISSN 1061-4036, 12/1998, Volume 20, Issue 4, pp. 385 - 388
Most inherited mutant alleles of the adenomatosis polyposis coli gene (APC) cause the appearance of large numbers of colon polyps(1-4), the familial polyposis... 
GENE | FAP | COLORECTAL-CANCER | GENETICS & HEREDITY | CHROMOSOME-5Q21 | FAMILIAL ADENOMATOUS POLYPOSIS | IDENTIFICATION | TUMORS | LOCUS | REGION
Journal Article
Journal Article