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Biochemical Journal, ISSN 0264-6021, 12/2004, Volume 384, Issue 2, pp. 201 - 232
The death morphology commonly known as apoptosis results from a post-translational pathway driven largely by specific limited proteolysis. In the last decade... 
Zymogen | Caspase | Inhibitor | Protease | Inhibitor of apoptosis protein (IAP) | Apoptosis | INDUCED-PROXIMITY MODEL | VIRAL SERPIN CRMA | X-LINKED INHIBITOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | inhibitor of apoptosis protein (IAP) | apoptosis | zymogen | caspase | INTERLEUKIN-1-BETA CONVERTING-ENZYME | protease | PROGRAMMED CELL-DEATH | TOLL-LIKE RECEPTOR-2 | inhibitor | ANTI-APOPTOTIC ACTIVITY | CYTOCHROME-C RELEASE | DEATH-EFFECTOR DOMAIN | SIGNALING COMPLEX DISC | Caspases - physiology | Enzyme Precursors - chemistry | Humans | Models, Molecular | Molecular Sequence Data | Substrate Specificity | Amino Acid Sequence - physiology | Structure-Activity Relationship | Caspase Inhibitors | Enzyme Precursors - metabolism | Animals | Caspases - metabolism | Protein Conformation | Molecular Structure | Caspases - chemistry | Enzyme Activation - physiology | CAD, caspase-activated DNase | FLICE, FADD-like ICE | TNF, tumour necrosis factor | CARD, LRR and NACHT-containing protein | Rip, receptor-interacting protein | DRONC, Drosophila Nedd2-like caspase | CARD-containing ICE-associated kinase | Ipaf | ICAD, inhibitor of CAD | CED, cell death-defective | DFF, DNA fragmentation factor | CARD, caspase-recruitment domain | APAF-1, apoptotic protease activating factor-1 | CLARP, caspase-like apoptosis-regulatory protein | DIABLO, direct IAP-binding protein with low pI | CLAN, ICE-protease-activating factor | RAIDD, caspase-2 and RipK1 domain-containing adaptor with death domain | ICE, interleukin-1β-converting enzyme | NALP1, NACHT, LRR and Pyrin domain containing 1 | ALPS, autoimmune lymphoproliferative syndrome | LRR, leucine-rich repeat | PYD- and CARD-containing molecule | NOD, nucleotide-binding and oligomerization domain-containing protein | NACHT, NTPase-domain named after NAIP, CIITA, HET-E and TP1 | S1, S2, …Sn and S1′, S2′, …Sm′ refer to the cognate pockets on the protease that accept these side chains | PYCARD, apoptosis-associated speck-like protein containing a CARD | PARP, poly(ADP-ribose) polymerase | P1, P2, …Pn and P1′, P2′, …Pm′ designate the side chains in substrates and inhibitors in the N- and C-terminal direction respectively from the P1–P1′ scissile peptide bond | TFPI, tissue factor pathway inhibitor | TLR, Toll-like receptor | serpin, serine protease inhibitor | RING, really interesting new gene | XIAP | DED, death effector domain | Review | PIDD, p53-induced protein with a death domain | TRAIL, TNF-related apoptosis-inducing ligand | IAP, inhibitor of apoptosis protein | NBD, nucleotide-binding domain | ASC | TRAF, TNF receptor-associated factor | BIRC4, X-linked IAP | DD, death domain | Smac, second mitochondrial activator of caspases | DIAP1, Drosophila inhibitor of apoptosis 1 | BIR, baculoviral IAP repeat | IBM, IAP binding motif | TRADD, TNFRSF1A-associated via death domain | CRADD | DISC, death-inducing signalling complex | FADD, Fas (TNFRSF6)-associated via death domain | FLIP, FLICE inhibitory protein | NF-κB, nuclear factor-κB | CARP, caspase-associated RING protein | CrmA, cytokine response modifier A | CARDIAK, Rip-like interacting CLARP kinase | RICK | Rip-associated protein with a death domain | baculoviral IAP repeat-containing 4
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 1, pp. 213 - 219
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from... 
CLAN | Caspase 1 | Nod2 | Nod1 | Nuclear factor κB (NF-κB) | Interleukin-1β | nuclear factor kappa B (NF-kappa B) | APOPTOSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | caspase 1 | BACTERIAL PEPTIDOGLYCAN | SELF-ASSOCIATION | PROCASPASE-9 | interleukin-1 beta | CARD PROTEIN | SYNDROME | OLIGOMERIZATION | NF-KAPPA-B | Neuronal Apoptosis-Inhibitory Protein | Peptidoglycan - metabolism | Protein Kinases - metabolism | Kidney - embryology | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Monocytes - metabolism | NF-kappa B - metabolism | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Protein Isoforms - metabolism | Cloning, Molecular | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins | Nod2 Signaling Adaptor Protein | Immunity, Innate | Macromolecular Substances | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | CARD Signaling Adaptor Proteins | Nod1 Signaling Adaptor Protein | Interleukin-1 - secretion | Nucleoside-Phosphate Kinase - metabolism | NB-ARC domain, nucleotide-binding domain shared by Apaf-1, certain R gene products and CED-4 | NACHT, NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein) | TLR, Toll-like receptor | CARDIAK, CARD-containing interleukin-1β-converting-enzyme-associated kinase | Apaf-1, apoptotic protease-activating factor 1 | RICK, RIP-like interacting CLARP kinase | CLAN, CARD, LRR and NACHT domain-containing protein | interleukin-1β | ECL®, enhanced chemiluminescence | NAC, nucleotide-binding domain and CARD-containing protein | CARD, caspase-recruitment domain | NALP, NACHT, LRR and PYRIN protein 1 | PAN, PAAD- and NACHT-containing protein | NF-κB, nuclear factor κB | ORF, open reading frame | RIP2, receptor-interacting protein | LRR, leucine-rich repeat | IKK, inhibitory κB kinase | PAAD, pyrin, AIM (absent-in-melanoma), ASC (apoptosis-associated speck-like protein containing a CARD) and death-domain-like | PGN, peptidoglycan | LPS, lipopolysaccharide | RACE, rapid amplification of cDNA ends | nuclear factor κB (NF-κB) | PAMP, pathogen-associated molecular pattern | HEK-293T, human embryonic kidney
Journal Article
FEBS Open Bio, ISSN 2211-5463, 2014, Volume 4, Issue 1, pp. 128 - 140
Nasopharyngeal carcinoma (NPC) is a prevalent malignancy in Southeast Asia among the Chinese population. Aberrant regulation of transcripts has been implicated... 
Nasopharyngeal carcinoma | RNA sequencing | Nasopharyngeal cell lines/xenograft (NP460, HK1, C666, X666) | Transcriptome analysis | TP53 | class II, major histocompatibility complex, transactivator | GADD45 | LMP1 | CIITA | BCL2-asscoiated X protein | single nucleotide polymorphism | interleukin 18 | PTEN | insertion and deletion | INDEL | gene ontology | UTR | glutathione S-transferase pi 1 | PI3K | guanine nucleotide binding protein (G protein), Gamma 11 | IL18 | AIP | untranslated region | phosphatase and tensin homolog | DKK1 | MMP19 | NGS | MET | phosphoinositide 3-kinase | NPC | fibulin 2 | GSTP1 | LTBP2 | RNASeq | FBLN2 | aryl hydrocarbon receptor interacting protein | EGFR | SNP | Dickkopf-Like protein 1 | EBV | miRNA | Epstein–Barr virus | early growth response 1 | EGR1 | next-generation sequencing | epidermal growth factor receptor | TNFRSF9 | MDM2 oncogene, E3 ubiquitin protein ligase | Epstein–Barr virus latent membrane protein 1 | GNG11 | ECM | matrix metallopeptidase 19 | growth arrest and DNA-damage-inducible | latent transforming growth factor beta binding protein 2 | tumour necrosis factor receptor superfamily, member 9 | met proto-oncogene | MDM2 | microRNA | BAX | extracellular matrix | STEM-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR GENE | RECEPTOR | CELL-LINES | CANCER | PATHWAY | MUTATION | GLUTATHIONE-S-TRANSFERASE | EXPRESSION | EPSTEIN-BARR-VIRUS | Wnt protein | Transcription | Epithelial cells | p53 Protein | AKT protein | Infections | Malignancy | Regulatory sequences | Kinases | Cell surface | Proteins | Genotype & phenotype | Cell growth | Cell cycle | Xenografts | Extracellular matrix | Growth factors | Deoxyribonucleic acid--DNA | Epidermal growth factor receptors | ErbB protein | MiRNA | Cell differentiation | Gene expression | 1-Phosphatidylinositol 3-kinase | Studies | Biopsy | MicroRNAs | Cell lines | Cancer
Journal Article
PLOS ONE, ISSN 1932-6203, 02/2016, Volume 11, Issue 2, pp. e0148753 - e0148753
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2018, Volume 200, Issue 7, pp. 2372 - 2390
Transplant recipients developing donor-specific HLA class II (HLA-II) Abs are at higher risk for Ab-mediated rejection (AMR) and transplant vasculopathy. To... 
ALLOGRAFT DYSFUNCTION | ACTIVATION | IFN-GAMMA | RIBOSOMAL-PROTEIN | SMOOTH-MUSCLE-CELLS | FOCAL ADHESION KINASE | GRAFT FAILURE | TNF-ALPHA | IMMUNOLOGY | MTOR | MOLECULES | Cell Line | RNA, Small Interfering - genetics | Phosphorylation | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Humans | Cell Proliferation - physiology | Phosphatidylinositol 3-Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Extracellular Signal-Regulated MAP Kinases - genetics | Cell Movement - physiology | Focal Adhesion Protein-Tyrosine Kinases - genetics | Phosphatidylinositol 3-Kinases - genetics | Signal Transduction - immunology | Histocompatibility Antigens Class II - immunology | Rapamycin-Insensitive Companion of mTOR Protein - genetics | RNA Interference | Endothelial Cells - cytology | HEK293 Cells | src-Family Kinases - metabolism | Graft Rejection - immunology | Mechanistic Target of Rapamycin Complex 2 - genetics | Proto-Oncogene Proteins c-akt - metabolism | src-Family Kinases - genetics | TOR protein | Cell proliferation | AKT protein | Activation | Kinases | Cell growth | Vascular diseases | Cascades | Pretreatment | Extracellular signal-regulated kinase | Pharmacology | Rapamycin | siRNA | Tumor necrosis factor-α | Src protein | Ribonucleic acid--RNA | Adhesion | CIITA protein | Endothelial cells | 1-Phosphatidylinositol 3-kinase | Graft rejection | Rejection | Ribosomal protein S6 kinase | Signaling | Inhibitors | γ-Interferon | Histocompatibility antigen HLA | Focal adhesion kinase | Cell migration
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2010, Volume 107, Issue 31, pp. 13794 - 13799
Journal Article
IMMUNOLOGY, ISSN 0019-2805, 09/2009, Volume 128, Issue 1, pp. e652 - e660
P>Members of the protein kinase C (PKC) family are activated by interferon-gamma (IFN-gamma) and modulate IFN-gamma-induced cellular responses by regulating... 
DEPENDENT PHOSPHORYLATION | STAT1 | IFN-GAMMA | CIITA GENE-EXPRESSION | IMMUNOLOGY | SERINE PHOSPHORYLATION | CLASS-II EXPRESSION | macrophages | nuclear translocation | SIGNALING PATHWAY | MONOCYTE ADHESION | LEISHMANIA-DONOVANI PROMASTIGOTES | PKC-EPSILON | interferon-gamma | protein kinase C | phosphatidylinositol 3-kinase | Phosphorylation | Protein Kinase C-alpha - metabolism | Trans-Activators - drug effects | STAT1 Transcription Factor - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Nucleus - enzymology | STAT1 Transcription Factor - metabolism | Janus Kinase 2 - metabolism | Female | Nuclear Proteins - drug effects | p38 Mitogen-Activated Protein Kinases - metabolism | Chromones - pharmacology | Janus Kinase 2 - antagonists & inhibitors | Macrophages - immunology | Cell Line | Protein Kinase C-alpha - antagonists & inhibitors | Signal Transduction | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Nuclear Proteins - metabolism | Imidazoles - pharmacology | Tyrphostins - pharmacology | Macrophages - enzymology | Animals | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Macrophages - drug effects | Trans-Activators - metabolism | Mice | Mice, Inbred BALB C | Pyridines - pharmacology | Enzyme Activation | Interferon-gamma - pharmacology | Enzyme Inhibitors | Macrophages | Phosphatidylinositol 3-Kinases | Janus Kinase 2 | Life Sciences | Protein Kinase C-alpha | p38 Mitogen-Activated Protein Kinases | Pyridines | Interferon-gamma | Trans-Activators | Morpholines | Nuclear Proteins | Human health and pathology | Imidazoles | Infectious diseases | STAT1 Transcription Factor | Tyrphostins | Cell Nucleus | Chromones | interferon-γ | Original
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 03/2017, Volume 101, Issue 3, pp. 759 - 773
Molecular mechanisms employed by B. abortus to inhibit MHC‐II surface expression, in order to evade host immunity and establish a chronic infection. Brucella... 
bacteria | monocytes/macrophages | host immunity | immune‐evasion strategies | Bacteria | Monocytes/macrophages | Host immunity | Immuneevasion strategies | MYCOBACTERIUM-TUBERCULOSIS | monocytes | COMPLEX | TYROSINE PHOSPHORYLATION | immune-evasion strategies | ANTIGEN PRESENTATION | IMMUNOLOGY | CELL BIOLOGY | macrophages | INTERFERON-GAMMA | GENE | CYTOKINE SIGNALING SOCS | TRANSACTIVATOR CIITA | HEMATOLOGY | EXPRESSION | Phosphorylation | Brucella abortus - physiology | Humans | Antigens, Bacterial - immunology | Brucellosis - immunology | Interferon-gamma - metabolism | STAT1 Transcription Factor - metabolism | Lipoproteins - metabolism | Trans-Activators - genetics | Brucellosis - pathology | Histocompatibility Antigens Class II - metabolism | Transcription, Genetic | Nuclear Proteins - genetics | Interleukin-6 - metabolism | Brucellosis - microbiology | Cell Line | Monocytes - microbiology | Bacterial Outer Membrane Proteins - immunology | Down-Regulation | Nuclear Proteins - metabolism | Suppressor of Cytokine Signaling 1 Protein - metabolism | Cathepsins - metabolism | Models, Biological | Intracellular Space - metabolism | Nuclear Proteins - antagonists & inhibitors | Trans-Activators - metabolism | HLA-DR Antigens - immunology | Trans-Activators - antagonists & inhibitors | Lipoproteins - immunology | Suppressor of Cytokine Signaling 3 Protein - metabolism | Interferon Regulatory Factor-1 - metabolism | Regulators | Elk | Chronic infection | Infections | Lymphocytes T | Interferon regulatory factor 1 | Invariant chain | Macrophages | Immunity | Interleukin 6 | Proteins | Animal vaccines | Lymphocytes | Inhibition | Stat1 protein | Chemical synthesis | Chromosomes | Pathogens | Antigen presentation | Secretion | Outer membrane proteins | CIITA protein | CD4 antigen | Membrane proteins | Signaling | Monocytes | Lipoproteins | Molecular modelling | Major histocompatibility complex | γ-Interferon | Interferon | Genetic recombination
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2018, Volume 13, Issue 9, p. e0204168
Background Antigen presentation on monocyte surface to T-cells by Major Histocompatibility Complex, Class II (MHC-II) molecules is fundamental for pathogen... 
CELLS | CIITA | HLA-DR | MULTIDISCIPLINARY SCIENCES | GENE-EXPRESSION | SEPTIC SHOCK | DR EXPRESSION | MULTIPLE ORGAN FAILURE | CTCF | CD14 | CHROMATIN ARCHITECTURE | Humans | CCCTC-Binding Factor - genetics | Receptors, IgG - deficiency | Male | Monocytes - immunology | Genetic Loci | Case-Control Studies | Receptors, IgG - genetics | Sepsis - pathology | Antigen Presentation | GPI-Linked Proteins - deficiency | Base Sequence | Chromatin - immunology | Monocytes - pathology | Trans-Activators - genetics | Adult | Female | Transcription, Genetic | CCCTC-Binding Factor - immunology | T-Lymphocytes - pathology | Nuclear Proteins - genetics | Trans-Activators - immunology | Chromatin - chemistry | Sepsis - immunology | GPI-Linked Proteins - immunology | Signal Transduction | Gene Expression Regulation | Lipopolysaccharide Receptors - immunology | Receptors, IgG - immunology | DNA, Intergenic - genetics | Nuclear Proteins - immunology | Sepsis - genetics | Histocompatibility Antigens Class II - immunology | Regulatory Elements, Transcriptional | Lipopolysaccharide Receptors - genetics | Protein Binding | T-Lymphocytes - immunology | Histocompatibility Antigens Class II - genetics | Immunocompromised Host | DNA, Intergenic - immunology | GPI-Linked Proteins - genetics | Flow cytometry | Chromatin | Intensive care | Immunoprecipitation | Genes | Critical care | Lymphocytes T | Genomes | Regulatory sequences | Gender | CD14 antigen | Blood | Gene sequencing | Proteins | Immunology | DNA-binding protein | Deoxyribonucleic acid--DNA | Enzyme-linked immunosorbent assay | Antigen presentation | Cytokines | Inflammation | Gene expression | Ribonucleic acid--RNA | Patients | Loci | CIITA protein | Immunosuppression | CD16 antigen | Monocytes | Hospitals | Major histocompatibility complex | Epigenetics | Sepsis | Histocompatibility antigen HLA | Anesthesiology | Histocompatibility | Binding sites | RNA | Deoxyribonucleic acid | Ribonucleic acid | DNA
Journal Article