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21. Full Text Potential of DNA methylation in rectal cancer as diagnostic and prognostic biomarkers
by Exner, Ruth and Pulverer, Walter and Diem, Martina and Spaller, Lisa and Woltering, Laura and Schreiber, Martin and Wolf, Brigitte and Sonntagbauer, Markus and Schröder, Fabian and Stift, Judith and Wrba, Fritz and Bergmann, Michael and Weinhäusel, Andreas and Egger, Gerda
British Journal of Cancer, ISSN 0007-0920, 09/2015, Volume 113, Issue 7, pp. 1035 - 1045
Background: Aberrant DNA methylation is more prominent in proximal compared with distal colorectal cancers. Although a number of methylation markers were... 
DNA methylation; CpG methylator phenotype; CIMP; rectal cancer; epigenetic biomarker | CPG ISLAND METHYLATION | MICROSATELLITE INSTABILITY | rectal cancer | PHENOTYPE | epigenetic biomarker | RADIATION | CpG methylator phenotype | COLON-CANCER | KRAS MUTATIONS | GENE | ONCOLOGY | CIMP | COLORECTAL-CANCER | DNA methylation | EXPRESSION | CARCINOMA | Prognosis | Oligonucleotide Array Sequence Analysis - methods | Humans | Middle Aged | Male | Cyclin-Dependent Kinase Inhibitor p16 | DNA Methylation | Rectal Neoplasms - genetics | Survival Analysis | Aged, 80 and over | CpG Islands | Adult | Female | Aged | Biomarkers, Tumor - genetics | DNA, Neoplasm - analysis | Rectal Neoplasms - pathology | Neoplasm Proteins - genetics | Molecular Diagnostics
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22. Full Text The serrated pathway to colorectal carcinoma: current concepts and challenges
by Bettington, Mark and Walker, Neal and Clouston, Andrew and Brown, Ian and Leggett, Barbara and Whitehall, Vicki
Histopathology, ISSN 0309-0167, 02/2013, Volume 62, Issue 3, pp. 367 - 386
Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway, named for the pattern of crypts in the precursor polyps. Molecular... 
histopathology | serrated neoplasia pathway | large intestine | colorectal neoplasms | colonic polyps | Histopathology | Colorectal neoplasms | Serrated neoplasia pathway | Colonic polyps | Large intestine | HYPERPLASTIC POLYPS | EARLY NEOPLASTIC PROGRESSION | PATHOLOGY | MICROSATELLITE-INSTABILITY | CELLULAR SENESCENCE | CELL BIOLOGY | ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | BRAF MUTATION | LOW CIMP-LOW | FIBROBLASTIC POLYP | PATHOLOGICAL FEATURES | Colonic Polyps - genetics | Colonic Polyps - pathology | Colorectal Neoplasms - genetics | Humans | Precancerous Conditions - metabolism | Precancerous Conditions - pathology | Colonic Polyps - metabolism | Colorectal Neoplasms - pathology | Precancerous Conditions - genetics | Colorectal Neoplasms - metabolism | Carcinoma | Gene mutations | Colorectal cancer | Development and progression | Methylation | Histochemistry | Cancer
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23. Full Text Role of the Serrated Pathway in Colorectal Cancer Pathogenesis
by Leggett, Barbara and Whitehall, Vicki
Gastroenterology, ISSN 0016-5085, 2010, Volume 138, Issue 6, pp. 2088 - 2100
The “serrated neoplastic pathway” describes the progression of serrated polyps, including sessile serrated adenomas and traditional serrated adenomas, to... 
Gastroenterology and Hepatology | Colorectal Cancer | Hyperplastic Polyposis | Serrated Polyp | SPORADIC COLON-CANCER | DNA METHYLATION | MICROSATELLITE INSTABILITY | BRAF V600E MUTATION | PROMOTER POLYMORPHISM | ISLAND METHYLATOR PHENOTYPE | KRAS MUTATIONS | LOW CIMP-LOW | GASTROENTEROLOGY & HEPATOLOGY | ABERRANT CRYPT FOCI | Predictive Value of Tests | Microsatellite Instability | Prognosis | Adenoma - genetics | Colonic Polyps - pathology | Colorectal Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Adenoma - therapy | Colonic Polyps - genetics | Cell Transformation, Neoplastic - genetics | Colonoscopy | Precancerous Conditions - pathology | Genetic Predisposition to Disease | Precancerous Conditions - therapy | Risk Assessment | Risk Factors | Colorectal Neoplasms - prevention & control | Precancerous Conditions - genetics | Animals | Biopsy | Adenoma - pathology | Mutation | Cell Transformation, Neoplastic - pathology | Colonic Polyps - therapy | Colorectal Neoplasms - pathology | Development and progression | Protein kinases | Colorectal cancer | Protein binding
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24. Full Text LOC283731 promoter hypermethylation prognosticates survival after radiochemotherapy in IDH1 wild‐type glioblastoma patients
by Mock, Andreas and Geisenberger, Christoph and Orlik, Christian and Warta, Rolf and Schwager, Christian and Jungk, Christine and Dutruel, Céline and Geiselhart, Lea and Weichenhan, Dieter and Zucknick, Manuela and Nied, Ann‐Katrin and Friauf, Sara and Exner, Janina and Capper, David and Hartmann, Christian and Lahrmann, Bernd and Grabe, Niels and Debus, Jürgen and von Deimling, Andreas and Popanda, Odilia and Plass, Christoph and Unterberg, Andreas and Abdollahi, Amir and Schmezer, Peter and Herold‐Mende, Christel
International Journal of Cancer, ISSN 0020-7136, 07/2016, Volume 139, Issue 2, pp. 424 - 432
MGMT promoter methylation status is currently the only established molecular prognosticator in IDH wild‐type glioblastoma multiforme (GBM). Therefore, we aimed... 
brain tumor | G‐CIMP | biomarker | methylation | G-CIMP | GLIOMAS | LONG-TERM SURVIVAL | KINASE | DOWN-REGULATION | CPG METHYLATION | MULTIFORME | ADJUVANT TEMOZOLOMIDE | ONCOLOGY | CONCOMITANT | RADIOTHERAPY | MUTATIONS | Promoter Regions, Genetic | Genome-Wide Association Study | Reproducibility of Results | Prognosis | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Kaplan-Meier Estimate | Brain Neoplasms - genetics | Isocitrate Dehydrogenase - genetics | Male | Chemoradiotherapy | Glioblastoma - therapy | Young Adult | DNA Methylation | Glioblastoma - genetics | Brain Neoplasms - therapy | Aged, 80 and over | CpG Islands | Adult | Female | Aged | Brain Neoplasms - mortality | Glioblastoma - mortality | Epigenetic inheritance | Methylation | Glioblastoma multiforme | Patient outcomes | Radiology | Biomarkers | Chemotherapy | Brain cancer | Mortality | Immunoprecipitation | Profiling | DNA probes | Genes | Glioblastoma | Independent study | Patients | Survival | Surgery | DNA methylation | Epigenetics | DNA fingerprinting | Probes | Deoxyribonucleic acid--DNA | CpG islands
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25. Full Text Clustering of cancer cell lines using a promoter- Targeted liquid hybridization capture-based bisulfite sequencing approach
by Gao, Fei and Wang, Junwen and Ji, Guanyu and Liu, Siyang and Yao, Yu and Wang, Tong and Wu, Honglong and Xia, Yudong and Gong, Desheng and Jiang, Hui and Yang, Huanming and Zhang, Xiuqing
Technology in Cancer Research and Treatment, ISSN 1533-0346, 01/2015, Volume 14, Issue 4, pp. 383 - 394
Promoter | DNA methylation | Cancer classification | CIMP | Targeted bisulfite sequencing
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26. Full Text Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis
by Juo, Y. Y and Johnston, F. M and Zhang, D. Y and Juo, H. H and Wang, H and Pappou, E. P and Yu, T and Easwaran, H and Baylin, S and van Engeland, M and Ahuja, N
Annals of Oncology, ISSN 0923-7534, 12/2014, Volume 25, Issue 12, pp. 2314 - 2327
Background: Divergent findings regarding the prognostic value of CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) patients exist in current... 
adjuvant chemotherapy | colorectal cancer | tumor marker | prognosis | CIMP | epigenetics | Tumor marker | Epigenetics | Adjuvant chemotherapy | Prognosis | Colorectal cancer | HYPERMETHYLATION | SURVIVAL BENEFIT | MICROSATELLITE INSTABILITY | CLASSIFICATION | STAGE-II | COLON-CANCER | 5-FLUOROURACIL | ONCOLOGY | BRAF MUTATION | ASSOCIATION | DNA Methylation | Phenotype | Colorectal Neoplasms - genetics | Humans | CpG Islands | Colorectal Neoplasms - pathology | Reviews
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27. Full Text Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer
by Carethers, John M and Jung, Barbara H
Gastroenterology, ISSN 0016-5085, 2015, Volume 149, Issue 5, pp. 1177 - 1190.e3
Sporadic colorectal cancer (CRC) is a somatic genetic disease in which pathogenesis is influenced by the local colonic environment and the patient’s genetic... 
Gastroenterology and Hepatology | Genomic Instability | Microsatellite Instability | Chromosomal Instability | CIMP | MISMATCH-REPAIR DEFICIENCY | BONE MORPHOGENETIC PROTEIN | CPG ISLAND | SUSCEPTIBILITY LOCI | RANDOMIZED-TRIAL | MICROSATELLITE-INSTABILITY | STAGE-II | ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | GASTROENTEROLOGY & HEPATOLOGY | GENOME-WIDE ASSOCIATION | DNA Methylation | Genetic Predisposition to Disease | Prognosis | Colorectal Neoplasms - genetics | Humans | MicroRNAs | Gene Expression Regulation, Neoplastic | CpG Islands | Genetic Markers | Mutation | Genome-Wide Association Study - methods | Epigenetic inheritance | Genomics | Colorectal cancer | Genetic research | Genetic aspects | Tumor proteins | Biological markers | Cancer | microsatellite instability | genomic instability | chromosomal instability
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28. Full Text Serrated colorectal cancer: Molecular classification, prognosis, and response to chemotherapy
by Oscar Murcia Miriam Juárez Eva Hernández-Illán Cecilia Egoavil Mar Giner-Calabuig María Rodríguez-Soler Rodrigo Jover
世界胃肠病学杂志：英文版, ISSN 1007-9327, 2016, Volume 22, Issue 13, pp. 3516 - 3530
Molecular advances support the existence of an alternative pathway of colorectal carcinogenesis that is based on the hypermethylation of specific DNA regions... 
Colorectal | pathway;Chemotherapy;CIMP | phenotype;Serrated | cancer;Methylator | Serrated pathway | Chemotherapy | CIMP | Colorectal cancer | Methylator phenotype | ADJUVANT CHEMOTHERAPY | BRAF MUTATION STATUS | 1ST-LINE TREATMENT | HYPERPLASTIC POLYPS | III COLON-CANCER | DNA METHYLATION | MISMATCH REPAIR | MICROSATELLITE-INSTABILITY | ISLAND METHYLATOR PHENOTYPE | CETUXIMAB PLUS IRINOTECAN | GASTROENTEROLOGY & HEPATOLOGY | Predictive Value of Tests | Genetic Predisposition to Disease | Microsatellite Instability | Proto-Oncogene Proteins p21(ras) - genetics | Colorectal Neoplasms - genetics | Humans | Treatment Outcome | Antineoplastic Agents - therapeutic use | Colorectal Neoplasms - classification | DNA Methylation | Molecular Diagnostic Techniques | Phenotype | Proto-Oncogene Proteins B-raf - genetics | Colorectal Neoplasms - drug therapy | CpG Islands | Biomarkers, Tumor - genetics | Mutation | Colorectal Neoplasms - pathology | Neoplasm Staging | Index Medicus | Review
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29. Full Text Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
by Yamauchi, Mai and Morikawa, Teppei and Kuchiba, Aya and Imamura, Yu and Qian, Zhi Rong and Nishihara, Reiko and Liao, Xiaoyun and Waldron, Levi and Hoshida, Yujin and Huttenhower, Curtis and Chan, Andrew T and Giovannucci, Edward and Fuchs, Charles and Ogino, Shuji
Gut, ISSN 0017-5749, 06/2012, Volume 61, Issue 6, pp. 847 - 854
ObjectiveColorectal cancer is typically classified into proximal colon, distal colon and rectal cancer. Tumour genetic and epigenetic features differ by tumour... 
ISLAND METHYLATOR PHENOTYPE | DNA METHYLATION | LINE-1 HYPOMETHYLATION | GENE | BRAF MUTATION | MICROSATELLITE INSTABILITY | CIMP | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | COLONIC-MUCOSA | P-GLYCOPROTEIN | ras Proteins - genetics | Colonic Neoplasms - genetics | Microsatellite Instability | Proto-Oncogene Proteins p21(ras) | Cecal Neoplasms - pathology | Colorectal Neoplasms - genetics | Humans | Long Interspersed Nucleotide Elements - genetics | Male | Colonic Neoplasms - metabolism | Sigmoid Neoplasms - genetics | Rectal Neoplasms - genetics | Female | Rectal Neoplasms - pathology | Colorectal Neoplasms - metabolism | Cecal Neoplasms - genetics | Mutation Rate | Proto-Oncogene Proteins - genetics | DNA Methylation - genetics | Mutation - genetics | Phosphatidylinositol 3-Kinases - genetics | Class I Phosphatidylinositol 3-Kinases | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | CpG Islands - genetics | Aged | Rectal Neoplasms - metabolism | DNA, Neoplasm - genetics | Colorectal Neoplasms - pathology | Sigmoid Neoplasms - pathology | Development and progression | Genetic aspects | Colon (Anatomy) | Research | Gene mutations | Colorectal cancer | Medical personnel | Studies | Hypotheses | Hospitals | Biopsy | Rodents | Epigenetics | Mutation | Data bases | Tumors | Index Medicus | Abridged Index Medicus
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30. Full Text Aberrant glycosylation in colorectal cancer with genomic and epigenomic alterations
by Okayama, Hirokazu and Noda, Masaru and Kono, Koji
Oncotarget, ISSN 1949-2553, 11/2018, Volume 9, Issue 86, pp. 35609 - 35610
CpG island methylator phenotype (CIMP) | Tn-Antigen | Glycosylation | DNA mismatch repair deficiency (dMMR) | Colorectal cancer
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31. Full Text PIK3CA Mutation Is Associated With Poor Prognosis Among Patients With Curatively Resected Colon Cancer
by Shuji Ogino and Katsuhiko Nosho and Gregory J. Kirkner and Kaori Shima and Natsumi Irahara and Shoko Kure and Andrew T. Chan and Jeffrey A. Engelman and Peter Kraft and Lewis C. Cantley and Edward L. Giovannucci and Charles S. Fuchs
Journal of Clinical Oncology, ISSN 0732-183X, 03/2009, Volume 27, Issue 9, pp. 1477 - 1484
Purpose PIK3CA mutation and subsequent activation of the AKT pathway play an important role in colorectal carcinogenesis. However, little is known about the... 
ISLAND METHYLATOR PHENOTYPE | KRAS MUTATIONS | SURVIVAL | CETUXIMAB | POPULATION | GENE | ONCOLOGY | COLORECTAL-CANCER | MICROSATELLITE INSTABILITY | CIMP | EXPRESSION | Colonic Neoplasms - genetics | Prognosis | Humans | Male | Phosphatidylinositol 3-Kinases - genetics | Colonic Neoplasms - surgery | Class I Phosphatidylinositol 3-Kinases | Proto-Oncogene Proteins B-raf - genetics | Colonic Neoplasms - pathology | Female | Aged | Biomarkers, Tumor - genetics | Colonic Neoplasms - enzymology | Mutation | Genes, ras | Neoplasm Staging | Index Medicus | To15 | Original Reports | To8 | To11 | To2 | Gic7
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32. Full Text High SMAD4 levels appear in microsatellite instability and hypermethylated colon cancers, and indicate a better prognosis
by Isaksson‐Mettävainio, Martin and Palmqvist, Richard and Dahlin, Anna M and Van Guelpen, Bethany and Rutegård, Jörgen and Öberg, Åke and Henriksson, Maria L
International Journal of Cancer, ISSN 0020-7136, 08/2012, Volume 131, Issue 4, pp. 779 - 788
Colorectal cancer (CRC) is one of the most common causes of cancer‐related deaths in western countries. CRC are commonly divided in cancers showing... 
high expression | SMAD4 | MSI | colon cancer | CIMP | TGF-BETA | CIMP-LOW | PHENOTYPE | LIVER METASTASIS | HUMAN COLORECTAL-CANCER | GROWTH-FACTOR-BETA | ONCOLOGY | BRAF MUTATION | PROTEIN EXPRESSION | GENES | IMMUNOHISTOCHEMISTRY | Immunohistochemistry | Colonic Neoplasms - genetics | Microsatellite Instability | Prognosis | Humans | Middle Aged | Male | Smad4 Protein - metabolism | Colonic Neoplasms - metabolism | DNA Methylation | Chromosomes, Human, Pair 18 | Colonic Neoplasms - pathology | Aged, 80 and over | Female | Aged | Medical prognosis | Colorectal cancer | Tumors
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