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Journal of biological rhythms, ISSN 0748-7304, 1986
Journal
Chronobiology international, ISSN 0742-0528, 1984
Journal
Journal Article
PLoS computational biology, ISSN 1553-7358, 2011, Volume 7, Issue 9, p. e1002143
Circadian timing largely modifies efficacy and toxicity of many anticancer drugs. Recent findings suggest that optimal circadian delivery patterns depend on... 
SN-38 | TRANSPORT | CPT-11 | RHYTHMS | CAMPTOTHECIN | COLORECTAL-CANCER | LIVER | BIOCHEMICAL RESEARCH METHODS | MATHEMATICAL & COMPUTATIONAL BIOLOGY | GENE-EXPRESSION | TOPOISOMERASE-I | ACTIVE METABOLITE | Caco-2 Cells | Camptothecin - pharmacokinetics | DNA Topoisomerases, Type I - metabolism | Drug Administration Schedule | Humans | RNA, Messenger - genetics | Circadian Rhythm Signaling Peptides and Proteins - genetics | Computational Biology | Drug Chronotherapy | Circadian Rhythm - physiology | Circadian Rhythm Signaling Peptides and Proteins - biosynthesis | Gene Expression Profiling | RNA, Messenger - biosynthesis | Antineoplastic Agents, Phytogenic - administration & dosage | Circadian Rhythm Signaling Peptides and Proteins - metabolism | Models, Biological | Camptothecin - administration & dosage | Gene Expression Regulation, Neoplastic - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Antineoplastic Agents, Phytogenic - pharmacokinetics | Camptothecin - pharmacology | Camptothecin - analogs & derivatives | Circadian rhythms | Usage | Colorectal cancer | Physiological aspects | Genetic aspects | Mathematical models | Research | Drug therapy | Circadian Rhythm Signaling Peptides and Proteins | Camptothecin | Antineoplastic Agents, Phytogenic | Biochemistry, Molecular Biology | Gene Expression Regulation, Neoplastic | DNA Topoisomerases, Type I | Circadian Rhythm | Life Sciences | RNA, Messenger | Enzymes | Cell culture | Parameter estimation | Cytotoxicity | Circadian rhythm | Gene expression | Cancer therapies | Patients | DNA repair | Optimization | Algorithms | Deoxyribonucleic acid | DNA | Cell cycle | Software
Journal Article