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ck-1827452 (13) 13
cardiac myosin activator (9) 9
heart failure (8) 8
index medicus (7) 7
omecamtiv mecarbil (7) 7
urea - analogs & derivatives (7) 7
urea - pharmacology (7) 7
animals (6) 6
humans (6) 6
cardiac & cardiovascular systems (5) 5
levosimendan (5) 5
milrinone (5) 5
urea - therapeutic use (5) 5
cardiac myosins - drug effects (4) 4
cardiotonic agents - therapeutic use (4) 4
heart failure, systolic - drug therapy (4) 4
myocardial contraction - drug effects (4) 4
pharmacology & pharmacy (4) 4
trial (4) 4
1st (3) 3
analysis (3) 3
cardiac contractility (3) 3
cardiac myosins - metabolism (3) 3
disease models, animal (3) 3
heart failure, systolic - physiopathology (3) 3
inotrope (3) 3
inotropic agents (3) 3
myosin (3) 3
systolic ejection time (3) 3
calcium sensitizer (2) 2
cardiac function (2) 2
cardiomyopathy (2) 2
cardiotonic agents - pharmacology (2) 2
cardiovascular (2) 2
clinical trials, phase i as topic (2) 2
clinical trials, phase ii as topic (2) 2
conscious dogs (2) 2
digoxin (2) 2
dogs (2) 2
female (2) 2
heart failure - drug therapy (2) 2
male (2) 2
management (2) 2
muscle proteins (2) 2
myocytes (2) 2
randomized controlled trials as topic (2) 2
stroke volume - drug effects (2) 2
systolic heart-failure (2) 2
ventricular function, left - drug effects (2) 2
activateur de la myosine cardiaque (1) 1
acute heart failure (1) 1
adult (1) 1
aged (1) 1
agents (1) 1
agents inotropes (1) 1
amg-423 (1) 1
analysis of variance (1) 1
anesthesia (1) 1
anesthesia & perioperative care (1) 1
arrhythmia (1) 1
article (1) 1
association (1) 1
bioavailability (1) 1
ca2+ sensitizers (1) 1
calcium (1) 1
calcium transient (1) 1
cardiac myosin activators (1) 1
cardiac myosins - physiology (1) 1
cardiac patients (1) 1
cardiac-myosin (1) 1
cardiology and cardiovascular medicine (1) 1
cardiomyocytes (1) 1
cardiotonic agents - adverse effects (1) 1
cardiovascular agents - pharmacology (1) 1
cardiovascular agents - therapeutic use (1) 1
cardiovascular diseases - drug therapy (1) 1
care and treatment (1) 1
cell biology (1) 1
chronic heart-failure (1) 1
ck-452 (1) 1
ck1122534 (1) 1
ck‐1827452 (1) 1
clevedipine (1) 1
clinical trials (1) 1
concentration-dependent manner (1) 1
consciousness (1) 1
contractility (1) 1
contractilité cardiaque (1) 1
cross-over studies (1) 1
delayed afterdepolarizations (1) 1
diagnosis (1) 1
diastole - drug effects (1) 1
dobutamine (1) 1
dobutamine - pharmacology (1) 1
dosage and administration (1) 1
double-blind (1) 1
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Circulation Research, ISSN 0009-7330, 06/2011, Volume 109, Issue 1, pp. 5 - 7
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 04/2016, Volume 94, Issue 10, pp. 1033 - 1039
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2016, Volume 94, Issue 10, pp. 1033 - 1039
Heart failure became a leading cause of mortality in the past few decades with a progressively increasing prevalence. Its current therapy is restricted largely... 
contractilité cardiaque | inotropic agents | cardiac myosin activator | heart failure | sensibilisateur de calcium | agents inotropes | omecamtiv mecarbil | CK-1827452 | insuffisance cardiaque | activateur de la myosine cardiaque | cardiac contractility | calcium sensitizer
Journal Article
Journal Article
Cardiovascular and Hematological Disorders - Drug Targets, ISSN 1871-529X, 2009, Volume 9, Issue 3, pp. 193 - 205
Acute heart failure (AHF) represents a major public health problem due to its high prevalence, high rates of mortality and readmissions and significant... 
CK-1827452 | Inotropic drugs | Levosimendan | Istaroxime | Acute heart failure
Journal Article
Chinese Journal of New Drugs, ISSN 1003-3734, 08/2013, Volume 22, Issue 16, pp. 1916 - 1920
Journal Article
Drugs of the Future, ISSN 0377-8282, 2009, Volume 34, Issue 12, pp. 950 - 961
Positive inotropic agents are used in the treatment of heart failure. Intravenous inotropes (dopamine, dobutamine, milrinone) improve the hemodynamic and... 
VENTRICULAR EJECTION FRACTION | DIAGNOSIS | MANAGEMENT | CK-452 | INCREASES SYSTOLIC FUNCTION | GUIDELINES | LEVOSIMENDAN | CONCENTRATION-DEPENDENT MANNER | AMG-423 | CK-1827452 | DIGOXIN | PHARMACOLOGY & PHARMACY | EPIDEMIOLOGY
Journal Article
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