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Biochemical journal, ISSN 1470-8728, 2014, Volume 458, Issue 3, pp. 559 - 573
WNK-regulated SPAK/OSR1 act as direct phosphorylators and major regulators of the KCC isoforms, which explains how activation of the WNK signalling pathway can... 
Signal transduction | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | γ-aminobutyric acid (GABA) | Cl | Blood pressure/hypertension | 2Cl | co-transporter 2 (KCC2) | Ion homoeostasis | co-transporter 3 (KCC3) | SALT TRANSPORT | CELL-VOLUME | signal transduction | CATION-CHLORIDE COTRANSPORTERS | ION-TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | blood pressure/hypertension | ion homoeostasis | HYPOKALEMIC ALKALOSIS | K+-Cl- co-transporter 3 (KCC3) | Na+-K+-2Cl(-) co-transporter 1 (NKCC1) | K+-Cl- co-transporter 2 (KCC2) | protein kinase | BLOOD-PRESSURE | PROTEIN-KINASES | BARTTERS-SYNDROME | Na+-Cl- co-transporter (NCC) | ALANINE-RICH KINASE | MOLECULAR PHYSIOLOGY | gamma-aminobutyric acid (GABA) | Potassium - metabolism | Amino Acid Sequence | Cell Line | Phosphorylation | Signal Transduction | Humans | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - metabolism | Symporters - metabolism | Transcription Factors - metabolism | Protein Isoforms - metabolism | Chlorides - metabolism | Symporters - antagonists & inhibitors | Phosphopeptides - metabolism | Protein Isoforms - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | N[K]CC, Na+–K+ ion co-transporter | HEK, human embryonic kidney | TTBS, Tris-buffered saline containing Tween 20 | HRP, horseradish peroxidase | ES, embryonic stem | Na+–Cl− co-transporter (NCC) | CCT, conserved C-terminal | NCC, Na+–Cl− co-transporter | Na+–K+–2Cl− co-transporter 1 (NKCC1) | OSR1, oxidative stress-responsive kinase 1 | CCC, cation–Cl− co-transporter | K+–Cl− co-transporter 3 (KCC3) | KCC, K+–Cl− co-transporter | blood pressure | ERK1, extracellular-signal-regulated kinase 1 | SLC12, solute carrier family 12 | LDS, lithium dodecyl sulfate | NKCC, Na+–K+–2Cl− co-transporter | SPAK, SPS1-related proline | NTD, N-terminal cytoplasmic domain | WNK, WNK lysine-deficient protein kinase | CTD, C-terminal cytoplasmic domain | hypertension | XIC, extracted ion chromatogram | K+–Cl− co-transporter 2 (KCC2) | alanine-rich kinase
Journal Article
Journal Article
International Journal of Hydrogen Energy, ISSN 0360-3199, 05/2016, Volume 41, Issue 19, pp. 7802 - 7813
This study deals with a comparative assessment of various chlorine family cycles, namely copper–chlorine (CuCl), magnesium–chlorine (MgCl), iron–chlorine... 
V–Cl | Thermochemical | Hydrogen | Fe–Cl | Mg–Cl | Cu–Cl | Mg-Cl | Cu-Cl | Fe-Cl | V-Cl | ELECTROCHEMISTRY | ENERGY | ENERGY & FUELS | CHEMISTRY, PHYSICAL | DRIVEN | PRODUCTION STEP | EXERGY ANALYSES | Air pollution | Comparative analysis | Air quality management | Greenhouse gases | Mechanical engineering | Hydrogen-based energy | Chlorine | Sustainability | Exergy | Assessments | Energy management | Hydrogen production
Journal Article
Biochemical journal, ISSN 1470-8728, 2013, Volume 451, Issue 1, pp. 111 - 122
The WNK (with no lysine kinase)–SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an... 
Ubiquitin | Cullin-RING E3 ligase (CRL) | SPS1-related proline/alanine-rich kinase/oxidative stress-responsive kinase 1 (SPAK/OSR1) | co-transporter (NCC) | co-transporter 2 (NKCC2) | BTB domain | Cl | 2Cl | Kelch-like domain (KLHL domain) | SPAK | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Na+/K+/2Cl(-) co-transporter 2 (NKCC2) | ubiquitin | BLOOD-PRESSURE | DOMINANT RETINITIS-PIGMENTOSA | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | ADAPTER | BTB-KELCH PROTEINS | RING UBIQUITIN LIGASES | KINASES | Minor Histocompatibility Antigens | Pseudohypoaldosteronism - genetics | Humans | Protein-Serine-Threonine Kinases - genetics | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Cullin Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Pseudohypoaldosteronism - enzymology | Ubiquitination | Carrier Proteins - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | HEK293 Cells | Cullin Proteins - metabolism | HeLa Cells | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Substitution | HEK, human embryonic kidney | 2Cl− co-transporter | RT, reverse transcription | TTBS, Tris-buffered saline containing Tween 20 | DTT, dithiothreitol | rTEV, recombinant tobacco etch virus | HRP, horseradish peroxidase | LC, liquid chromatography | UBE2D3, ubiquitin-conjugating enzyme E2 D3 | qRT-PCR, real time quantitative reverse transcription PCR | TAL, thick ascending limb | OSR1, oxidative stress-responsive kinase 1 | GST, glutathione transferase | RBX1, RING-box 1, E3 ubiquitin protein ligase | 2Cl− co-transporter 2 (NKCC2) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | UBE1, ubiquitin-like modifier-activating enzyme 1 | Cullin–RING E3 ligase (CRL) | GFP, green fluorescent protein | Cl− co-transporter | NKCC, Na+ | DCT, distal convoluted tubule | KEAP1, Kelch-like ECH-associated protein 1 | CRL, Cullin–RING E3 ligase | SPAK, SPS1-related proline | Accelerated Publication | Cl− co-transporter (NCC) | siRNA, small interfering RNA | NRF2, NF-E2-related factor 2 | oxidative stress-responsive kinase 1 (SPAK | WNK, with no lysine kinase | RPL13A, ribosomal protein L13a | KLHL3, Kelch-like 3 | CUL3, Cullin-3 | Na+ | SPS1-related proline | NCC, Na+ | alanine-rich kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 325 - 337
Mutations in the WNK with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has... 
Signal transduction | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | Cl | 2Cl | Coiled-coil domain | Osmotic stress | KINASE-ACTIVITY | SPAK | coiled-coil domain | HOMEOSTASIS | Na+/K+/2Cl(-) co-transporter 1 (NKCC1) | signal transduction | PHOSPHORYLATION | PROTEIN-KINASE | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein kinase | BLOOD-PRESSURE | osmotic stress | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | MUTATIONS | HYPERTENSION | Protein Structure, Tertiary | Amino Acid Sequence | Phosphorylation | Minor Histocompatibility Antigens | Humans | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Transcription Factors - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | Protein Isoforms | HEK293 Cells | Embryonic Stem Cells | Mutation | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CCD, coiled-coil domain | PI3K, phosphoinositide 3-kinase | WNK, with no lysine (K) kinase | 2Cl− co-transporter | DTT, dithiothreitol | ERK, extracellular-signal-regulated kinase | ES, embryonic stem | DMEM, Dulbecco's modified Eagle's medium | CCT, conserved C-terminal | GST, glutathione transferase | HEK-293, human embryonic kidney 293 | 2Cl− co-transporter 1 (NKCC1) | Cl− co-transporter | NKCC, Na+ | SPAK, SPS1-related proline | Cl− co-transporter (NCC) | OSR, oxidative stress-responsive kinase | LRRK2, leucine-repeat-rich kinase 2 | CATCHtide, cation chloride co-transporter peptide substrate | Na+ | NCC, Na+ | MAPK, mitogen-activated protein kinase | alanine-rich kinase
Journal Article