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Nature Structural & Molecular Biology, ISSN 1545-9993, 09/2010, Volume 17, Issue 99, pp. 1124 - 1135
Journal Article
Journal Article
Journal Article
Nature Structural and Molecular Biology, ISSN 1545-9993, 03/2013, Volume 20, Issue 3, pp. 317 - 325
The pathogenic sequelae of BRCA1 mutation in human and mouse cells are mitigated by concomitant deletion of 538P1, which binds histone H4 dimethylated at Lys20... 
POLY(ADP-RIBOSE) POLYMERASE | METHYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | DOUBLE-STRAND BREAKS | HISTONE ACETYLTRANSFERASE ACTIVITY | BRCA1 | CELL BIOLOGY | REPAIR PROTEINS | BIOPHYSICS | SITES | CLASS-SWITCH RECOMBINATION | CELL-CYCLE | Chromatin - metabolism | Humans | Histone Acetyltransferases - genetics | Molecular Sequence Data | Homologous Recombination | Intracellular Signaling Peptides and Proteins - metabolism | DNA Breaks, Double-Stranded | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | BRCA1 Protein - metabolism | Histone Acetyltransferases - metabolism | Acetylation | Lysine Acetyltransferase 5 | DNA Helicases - genetics | Intracellular Signaling Peptides and Proteins - genetics | Amino Acid Sequence | ATPases Associated with Diverse Cellular Activities | Chromosomal Proteins, Non-Histone - metabolism | Magnetic Resonance Spectroscopy | Cells, Cultured | Histone Deacetylases - metabolism | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | BRCA1 Protein - genetics | Carrier Proteins - genetics | DNA Helicases - metabolism | Carrier Proteins - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Protein Conformation | Histones - metabolism | Tumor Suppressor p53-Binding Protein 1 | Chromatin - genetics | Care and treatment | Chromatin | BRCA mutations | Physiological aspects | Breast cancer | Genetic aspects | Research | Structure | Health aspects | Risk factors | Mutation | Molecular biology | DNA repair | DNA damage | Index Medicus | 53BP1 | Homologous recombination | PARP inhibitors | TIP60
Journal Article
Nature Cell Biology, ISSN 1465-7392, 08/2018, Volume 20, Issue 8, pp. 954 - 965
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To... 
PATHWAY CHOICE | STRAND BREAK REPAIR | RESECTION | DAMAGE-RESPONSE | 53BP1 | CLASS-SWITCH RECOMBINATION | FANCONI-ANEMIA | DIFFERENTIAL EXPRESSION ANALYSIS | POLYMERASE-ZETA | TELOMERES | CELL BIOLOGY | Osteosarcoma - drug therapy | Mad2 Proteins - metabolism | Humans | Multiprotein Complexes | Ovarian Neoplasms - pathology | Bone Neoplasms - pathology | DNA Breaks, Double-Stranded | Bone Neoplasms - metabolism | Breast Neoplasms - metabolism | Dose-Response Relationship, Drug | Ovarian Neoplasms - genetics | Telomere-Binding Proteins - genetics | DNA End-Joining Repair | HEK293 Cells | Female | Bone Neoplasms - genetics | Ovarian Neoplasms - metabolism | Bone Neoplasms - drug therapy | BRCA1 Protein - deficiency | Telomere-Binding Proteins - metabolism | Ovarian Neoplasms - drug therapy | Osteosarcoma - metabolism | Tumor Suppressor p53-Binding Protein 1 - metabolism | Recombinational DNA Repair | Tumor Suppressor p53-Binding Protein 1 - genetics | Cisplatin - pharmacology | Breast Neoplasms - drug therapy | Proteins - genetics | Xenograft Model Antitumor Assays | BRCA1 Protein - genetics | Poly(ADP-ribose) Polymerase Inhibitors - pharmacology | Drug Resistance, Neoplasm - genetics | Animals | Breast Neoplasms - genetics | Proteins - metabolism | Breast Neoplasms - pathology | Mad2 Proteins - genetics | Cell Line, Tumor | Mice | Osteosarcoma - genetics | Osteosarcoma - pathology | Care and treatment | DNA | Cancer cells | Breast cancer | Genetic aspects | Research | Gene expression | Single-stranded DNA | DNA damage | Homologous recombination | Poly(ADP-ribose) | Homology | Genomes | Inactivation | ADP | Proteins | Ribose | Null cells | Deoxyribonucleic acid--DNA | BRCA2 protein | CRISPR | Deactivation | BRCA1 protein | Poly(ADP-ribose) polymerase | Oligosaccharides | Double-strand break repair | Screens | Cisplatin | Polymerase | Inhibitors | Breast | Prostate | Viability | Tumors | Cancer | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2017, Volume 67, Issue 3, pp. 361 - 373.e4
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2012, Volume 46, Issue 2, pp. 125 - 135
Journal Article
Journal Article