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clc-5 (118) 118
humans (66) 66
chloride channels - genetics (53) 53
index medicus (52) 52
animals (48) 48
chloride channel (48) 48
urology & nephrology (48) 48
male (46) 46
endocytosis (40) 40
dent's disease (36) 36
dents-disease (34) 34
kidney (32) 32
chloride channels - metabolism (31) 31
mutation (31) 31
physiology (31) 31
renal chloride channel (26) 26
molecular-weight proteinuria (25) 25
mutations (25) 25
hypercalciuria (24) 24
impairs endocytosis (24) 24
biochemistry & molecular biology (22) 22
child (22) 22
clcn5 (22) 22
dent disease (22) 22
nephrolithiasis (22) 22
mice (21) 21
megalin (20) 20
phenotype (20) 20
proteinuria - genetics (20) 20
expression (19) 19
kidney tubules, proximal - metabolism (19) 19
nephrocalcinosis (19) 19
proteinuria (19) 19
receptor-mediated endocytosis (19) 19
proximal tubule (18) 18
cell line (17) 17
child, preschool (17) 17
model (15) 15
cell biology (14) 14
adolescent (13) 13
clcn5 gene (13) 13
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genetics & heredity (13) 13
adult (12) 12
cells (12) 12
cells, cultured (12) 12
dent disease - genetics (12) 12
gene (12) 12
mice, knockout (12) 12
rats (12) 12
endocytosis - physiology (11) 11
hypercalciuric nephrolithiasis (11) 11
kidney - metabolism (11) 11
low density lipoprotein receptor-related protein-2 - metabolism (11) 11
molecular sequence data (11) 11
molecular-basis (11) 11
mouse model (11) 11
trafficking (11) 11
kidney diseases - genetics (10) 10
pedigree (10) 10
protein (10) 10
proteins (10) 10
acidification (9) 9
clcn5 mutations (9) 9
cubilin (9) 9
dent’s disease (9) 9
disease (9) 9
endosomal acidification (9) 9
genetic diseases, x-linked - genetics (9) 9
genetic-heterogeneity (9) 9
hydrogen-ion concentration (9) 9
hypercalciuria - genetics (9) 9
japanese children (9) 9
mutation - genetics (9) 9
research (9) 9
transport (9) 9
albumin (8) 8
chloride channels (8) 8
dent disease - physiopathology (8) 8
disease models, animal (8) 8
gene expression (8) 8
genetic aspects (8) 8
identification (8) 8
mouse (8) 8
phosphoric monoester hydrolases - genetics (8) 8
renal-failure (8) 8
urogenital system (8) 8
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid - pharmacology (7) 7
amino acid sequence (7) 7
base sequence (7) 7
biophysics (7) 7
chloride channels - physiology (7) 7
dna mutational analysis (7) 7
endosomes (7) 7
kidney calculi - genetics (7) 7
kidney diseases (7) 7
kidney diseases - metabolism (7) 7
kidney tubules, proximal - cytology (7) 7
kidney tubules, proximal - physiopathology (7) 7
life sciences (7) 7
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06/2012
Mutations in the chloride-proton antiporter, ClC-5, cause Dent’s disease, a kidney disease defined by excessive loss of proteins in the urine. ClC-5 resides on... 
ClC-5 | Dent's Disease | 0379
Dissertation
Kidney International, ISSN 0085-2538, 04/2017, Volume 91, Issue 4, pp. 776 - 778
Studies in mice have suggested bone marrow transplantation as a strategy to correct the endocytic dysfunction of the proximal tubules in renal Fanconi... 
IMPAIRS ENDOCYTOSIS | UROLOGY & NEPHROLOGY | CLC-5 | CHLORIDE CHANNEL | MODEL
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2006, Volume 398, Issue 2, pp. 289 - 294
Journal Article
Neuron, ISSN 0896-6273, 2001, Volume 29, Issue 1, pp. 185 - 196
Several plasma membrane chloride channels are well characterized, but much less is known about the molecular identity and function of intracellular Cl... 
LOCALIZATION | CLC-5 | TRANSPORTER | RAT | GENE | FUNCTIONAL EXPRESSION | DISEASE | CELL-SURFACE | MICE | NEUROSCIENCES | INTEGRAL MEMBRANE-PROTEIN
Journal Article
Pflügers Archiv - European Journal of Physiology, ISSN 0031-6768, 7/2016, Volume 468, Issue 7, pp. 1183 - 1196
Dent’s disease is characterized by defective endocytosis in renal proximal tubules (PTs) and caused by mutations in the 2Cl−/H+ exchanger, CLC-5. However, the... 
CLC-5 | Endosomal acidification | Gating glutamate | Endocytosis | Biomedicine | V-ATPase | Human Physiology | Dent’s disease
Journal Article
Frontiers in physiology, ISSN 1664-042X, 2018, Volume 9, p. 1490
Dent disease 1 (DD1) is a renal salt-wasting tubulopathy associated with mutations in the Cl /H antiporter ClC-5. The disease typically manifests with... 
Journal Article
DNA and Cell Biology, ISSN 1044-5498, 12/2017, Volume 36, Issue 12, pp. 1151 - 1158
Journal Article
Clinical Kidney Journal, ISSN 2048-8505, 2018, Volume 11, Issue 4, pp. 459 - 461
Dent's disease is characterized by manifestations of proximal tubule dysfunction including hypercalciuria, kidney stones, proteinuria, rickets and... 
Calcification | Chronic renal failure | Nephrolithiasis | Gene polymorphism | Proteinuria | CLC-5 | chronic renal failure | proteinuria | nephrolithiasis | MOLECULAR-WEIGHT PROTEINURIA | UROLOGY & NEPHROLOGY | gene polymorphism | calcification | KIDNEY
Journal Article
Frontiers in Physiology, ISSN 1664-042X, 10/2018, Volume 9
Dent disease 1 (DD1) is a renal salt-wasting tubulopathy associated with mutations in the Cl-/H+ antiporter ClC-5. The disease typically manifests with... 
Bartter syndrome | CLC transport | ClC-5 | Dent disease | Barttin | Kidney | Golgi bypass | Phenotype | Care and treatment | Research | Dent's disease | Risk factors | kidney | barttin
Journal Article
Membranes, ISSN 2077-0375, 07/2014, Volume 4, Issue 3, pp. 333 - 335
Receptor-mediated endocytosis in renal proximal tubule epithelial cells (PTECs) is important for the reabsorption and metabolization of proteins and other... 
CLC-5 | Clathrin | Endocytosis | Exosome | Cubilin | Trafficking | ARH | NHE3 | Megalin | ClC-5 | clathrin | megalin | endocytosis | exosome | trafficking | cubilin
Journal Article
Journal Article
Human molecular genetics, ISSN 0964-6906, 06/2019, Volume 28, Issue 12, pp. 1931 - 1946
Journal Article