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Blood, ISSN 0006-4971, 03/2019, Volume 133, Issue 11, pp. 1167 - 1168
In this issue of Blood, Beauchamp et al1 reveal that the kinase CDK9, typically associated with transcriptional elongation, 2 directly modulates translation... 
CLINICAL-TRIAL | HEMATOLOGY
Journal Article
The Oncologist, ISSN 1083-7159, 07/2019, Volume 24, Issue 7, pp. 887 - e416
经验获取 对于既往接受多次治疗的转移性三阴性乳腺癌患者,单剂 Selinexor 的活性有限。 Selinexor 60mg口服,每周两次,总体耐受良好,副作用与先前临床试验结果一致。 未来针对 Selinexor 对于这类患者的研究应侧重于联合用药和以生物标志物为驱动的策略,确定最有可能从中受益的患者。 摘要... 
Clinical Trial Results
Journal Article
The Oncologist, ISSN 1083-7159, 07/2019, Volume 24, Issue 7, pp. 883 - e407
经验获取 体力状态良好或无肝脏转移的转移性结直肠癌患者可受益于阿帕替尼。 循环肿瘤 DNA 丰度可能是肿瘤负荷连续监测的预测因子。 摘要 背景。 阿帕替尼是一种口服血管内皮生长因子 (VEGF) 受体‐ 2... 
Clinical Trial Results
Journal Article
The Oncologist, ISSN 1083-7159, 07/2019, Volume 24, Issue 7, pp. 885 - e413
临床试验结果 经验获取 APPEARANCE试验的结果表明,与安慰剂相比,阿达帕林并不能预防痤疮样皮疹,当添加到局部保湿剂和口服米诺环素中时,反而可能会产生有害影响。因此,不推荐使用阿达帕林预防由抗表皮生长因子受体疗法诱发的痤疮样皮疹。... 
Clinical Trial Results
Journal Article
The Oncologist, ISSN 1083-7159, 07/2019, Volume 24, Issue 7, pp. 889 - e421
经验总结 在本研究中,唑来膦酸辅助治疗未能降低骨巨细胞瘤 (GCTB) 的复发率。由于样本量小,无法确定疗效。 即使是Denosumab 治疗时代,仍存在 GCTB 复发问题,因此,探讨唑来膦酸辅助治疗 GCTB 的有效性随机研究仍然需要。 摘要 背景。 双膦酸盐被认为可以抑制骨巨细胞瘤 (GCTB)... 
Clinical Trial Results
Journal Article
The Oncologist, ISSN 1083-7159, 07/2019, Volume 24, Issue 7, pp. 891 - e431
经验总结 纳武单抗治疗剂量每 2 周 (Q2W) 3 mg/kg、240 mg Q2W、360 mg Q3W 的用药方式在中国人群中耐受性良好,没有发现新的安全信号。 对比 3 mg/kg Q2W 纳武单抗用药方式在中国与全球人群中的强化药代动力学特征,结果显示,纳武单抗治疗没有种族差异。... 
Clinical Trial Results
Journal Article
ANESTHESIOLOGY, ISSN 0003-3022, 11/2018, Volume 129, Issue 5, pp. 1048 - 1049
Journal Article
The Oncologist, ISSN 1083-7159, 07/2018, Volume 23, Issue 7, pp. 762 - e79
经验总结 • 使用随机交叉设计并以连续变量(如听力阈值和急性肾损伤生物标志物变化)作为短期终点,确定有机阳离子转运蛋白2抑制剂泮托拉唑并未减轻与顺铂相关的肾毒性或耳毒性。 •... 
ONCOLOGY | Clinical Trial Results
Journal Article
03/2013
Objective: Clonidine is an α2-agonist which is used as a sedative premedication in children. There are conflicting results in the published literature about... 
Appendectomy | Vomiting | Clinical trial | Clonidine
Web Resource
JAMA Dermatology, ISSN 2168-6068, 07/2018, Volume 154, Issue 7, pp. 850 - 851
Journal Article
Journal Article
JACC: Heart Failure, ISSN 2213-1779, 10/2014, Volume 2, Issue 5, pp. 458 - 465
The GUIDE-IT (Guiding Evidence Based Therapy Using Biomarker Intensified Treatment in Heart Failure) study is designed to determine the safety, efficacy, and... 
Heart failure | Biomarkers | Clinical trial
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 02/2009, Volume 106, Issue 8, pp. 2729 - 2734
Journal Article
British Journal of Ophthalmology, ISSN 0007-1161, 2019, p. bjophthalmol-2018-313313
To compare the effectiveness of intravitreal ziv-aflibercept (IVZ) to intravitreal bevacizumab (IVB) administered preoperatively to patients undergoing pars... 
clinical trial | treatment surgery | retina
Journal Article
Journal of Dermatological Treatment, ISSN 0954-6634, 11/2018, Volume 29, Issue 8, pp. 823 - 824
Journal Article
International Journal of Neuropsychopharmacology, ISSN 1461-1457, 03/2013, Volume 16, Issue 2, pp. 313 - 321
Journal Article
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