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Human Molecular Genetics, ISSN 0964-6906, 02/2011, Volume 20, Issue 4, pp. 731 - 751
Mammalian circadian rhythms are synchronized to the external time by daily resetting of the suprachiasmatic nucleus (SCN) in response to light. As the master... 
RESPONSE ELEMENT | POLY(A) BINDING-PROTEIN | MESSENGER-RNA | RETT-SYNDROME | SUPRACHIASMATIC NUCLEUS | BIOCHEMISTRY & MOLECULAR BIOLOGY | SLEEP PHASE SYNDROME | GENETICS & HEREDITY | GENE-EXPRESSION | POLY(A)-BINDING PROTEIN | HISTONE ACETYLTRANSFERASE | ACTIVE GENES | NIH 3T3 Cells | Humans | Methyl-CpG-Binding Protein 2 - metabolism | Chromatin Assembly and Disassembly - genetics | MicroRNAs - metabolism | E1A-Associated p300 Protein - metabolism | Chromatin Assembly and Disassembly - drug effects | Retinoblastoma-Binding Protein 2 - metabolism | Immediate-Early Proteins - metabolism | Period Circadian Proteins - genetics | Light | HEK293 Cells | Suprachiasmatic Nucleus - metabolism | DNA-Binding Proteins | Tumor Suppressor Proteins - metabolism | Signal Transduction | Mice, Inbred C57BL | Circadian Rhythm - genetics | Computational Biology | Gene Expression Regulation | Mice, Transgenic | RNA Stability | Animals | Period Circadian Proteins - metabolism | Mice | MicroRNAs - genetics | Jumonji Domain-Containing Histone Demethylases | Index Medicus | Suprachiasmatic nucleus | Calcium | Transcription | CLOCK protein | BTG2 protein | Period 1 protein | Methyl-CpG binding protein | Entrainment | miRNA | Period 2 protein | Circadian rhythms | Obesity | Translation | mRNA turnover | Cyclic AMP | Light effects | Oscillators | Promoters | Chromatin remodeling | Neurological diseases | Period protein | Sleep | MeCP2 protein | Workers | Pacemakers | Cardiovascular diseases | Cancer
Journal Article
Science, ISSN 0036-8075, 7/2012, Volume 337, Issue 6091, pp. 189 - 194
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 04/2016, Volume 18, Issue 4, pp. 355 - 365
Aim: To determine the impact of a functional human islet clock on insulin secretion and gene transcription. Methods: Efficient circadian clock disruption was... 
human pancreatic islet | circadian bioluminescence | insulin secretion | RNA | circadian clock | sequencing | Circadian clock | RNA sequencing | Circadian bioluminescence | Human pancreatic islet | Insulin secretion | PERIPHERAL CLOCKS | SYSTEM | TRANSCRIPTOME | BEHAVIOR | BETA-CELLS | METABOLISM | CHANNEL | GENES | ENDOCRINOLOGY & METABOLISM | OSCILLATIONS | EXPRESSION | Islets of Langerhans - drug effects | Sodium-Potassium-Exchanging ATPase - genetics | Cation Transport Proteins - antagonists & inhibitors | Sodium-Potassium-Exchanging ATPase - chemistry | Zinc Transporter 8 | Humans | CLOCK Proteins - genetics | Gene Expression Profiling | Potassium Channels, Inwardly Rectifying - chemistry | Qa-SNARE Proteins - chemistry | CLOCK Proteins - metabolism | Insulin-Secreting Cells - metabolism | Vesicle-Associated Membrane Protein 3 - chemistry | GTP-Binding Protein alpha Subunits, Gq-G11 - chemistry | RNA Interference | Cation Transport Proteins - metabolism | Islets of Langerhans - metabolism | Islets of Langerhans - cytology | Qa-SNARE Proteins - genetics | Cation Transport Proteins - genetics | Potassium Channels, Inwardly Rectifying - antagonists & inhibitors | Insulin-Secreting Cells - cytology | GTP-Binding Protein alpha Subunits, Gq-G11 - metabolism | Insulin Secretion | Vesicle-Associated Membrane Protein 3 - antagonists & inhibitors | Vesicle-Associated Membrane Protein 3 - genetics | GTP-Binding Protein alpha Subunits, Gq-G11 - genetics | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Circadian Clocks - drug effects | Colforsin - pharmacology | Vesicle-Associated Membrane Protein 3 - metabolism | CLOCK Proteins - antagonists & inhibitors | Cells, Cultured | GTP-Binding Protein alpha Subunits, Gq-G11 - antagonists & inhibitors | Potassium Channels, Inwardly Rectifying - genetics | Gene Expression Regulation - drug effects | Hyperglycemia - metabolism | Sodium-Potassium-Exchanging ATPase - metabolism | Insulin - metabolism | Insulin-Secreting Cells - drug effects | Qa-SNARE Proteins - metabolism | Genes, Reporter - drug effects | Qa-SNARE Proteins - antagonists & inhibitors | RNA, Small Interfering | Cation Transport Proteins - chemistry | Potassium Channels, Inwardly Rectifying - metabolism | Pancreatic beta cells | Analysis | Glucose | Insulin | Dextrose | Circadian rhythm | Pancreas | Rodents | Circadian rhythms | Transcription | Secretion | Islet cells | siRNA | Islets of Langerhans | Gene expression | Index Medicus
Journal Article
European Neuropsychopharmacology, ISSN 0924-977X, 2016, Volume 26, Issue 8, pp. 1310 - 1319
Abstract Bipolar disorder (BD) is characterized by depression, mania, and circadian rhythm abnormalities. Lithium, a treatment for BD stabilizes mood and... 
Internal Medicine | Psychiatry | Circadian rhythms | Bipolar disorder | Lithium | Phosphatase | Kinase | PSYCHIATRY | MAP KINASE | PER2 GENE | NEUROSCIENCES | CLINICAL NEUROLOGY | SLEEP PATTERNS | PHASE-SHIFTS | GENE-EXPRESSION | SUPRACHIASMATIC-NUCLEI | PHARMACOLOGY & PHARMACY | CLOCK | BRAIN | GENOME-WIDE ASSOCIATION | ERK | Bipolar Disorder - metabolism | NIH 3T3 Cells | Dual Specificity Phosphatase 6 - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | ets-Domain Protein Elk-1 - genetics | Period Circadian Proteins - agonists | Mitogen-Activated Protein Kinase 1 - chemistry | Lithium - therapeutic use | Period Circadian Proteins - genetics | Protein Processing, Post-Translational - drug effects | RNA Interference | ets-Domain Protein Elk-1 - metabolism | Early Growth Response Protein 1 - genetics | Phosphorylation - drug effects | Mitogen-Activated Protein Kinase 3 - chemistry | Antimanic Agents - therapeutic use | Antimanic Agents - pharmacology | Lithium - pharmacology | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Cells, Cultured | ets-Domain Protein Elk-1 - antagonists & inhibitors | Bipolar Disorder - drug therapy | Cyclic AMP Response Element-Binding Protein - genetics | Dual Specificity Phosphatase 6 - metabolism | Animals | MAP Kinase Signaling System - drug effects | Period Circadian Proteins - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Cyclic AMP Response Element-Binding Protein - antagonists & inhibitors | Cyclic AMP Response Element-Binding Protein - metabolism | Bipolar Disorder - pathology | Dual Specificity Phosphatase 6 - antagonists & inhibitors | Early Growth Response Protein 1 - antagonists & inhibitors | Genes, Reporter - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Circadian Rhythm - drug effects | Early Growth Response Protein 1 - metabolism | Mitogen-Activated Protein Kinase 1 - metabolism | Analysis | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 503, Issue 7476, pp. 414 - 417
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 08/2017, Volume 292, Issue 34, pp. 14165 - 14175
Circadian clock and Smad2/3/4-mediated Nodal signaling regulate multiple physiological and pathological processes. However, it remains unknown whether Clock... 
VERTEBRATE DEVELOPMENT | TGF-BETA | SMAD3 | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | INDUCTION | nodal | mesoderm | MOUSE EMBRYO | CIRCADIAN CLOCK | GASTRULATION | LOOP-HELIX PROTEINS | hematopoiesis | SMAD transcription factor | zebrafish | clock gene | transcription promoter | CELL | Embryo, Nonmammalian - cytology | Humans | Embryo, Nonmammalian - metabolism | Mesoderm - drug effects | Nodal Protein - metabolism | Smad3 Protein - metabolism | Mesoderm - cytology | Embryo, Nonmammalian - drug effects | Recombinant Fusion Proteins - metabolism | Hematopoiesis - drug effects | DNA-Binding Proteins - metabolism | Smad3 Protein - genetics | In Situ Hybridization | Mesoderm - abnormalities | Nodal Protein - genetics | Nodal Protein - agonists | Gene Expression Regulation, Developmental | HEK293 Cells | Zebrafish Proteins - agonists | Recombinant Proteins - metabolism | DNA-Binding Proteins - antagonists & inhibitors | Microinjections | Zebrafish Proteins - metabolism | Zebrafish Proteins - antagonists & inhibitors | Recombinant Proteins - chemistry | Zebrafish | Recombinant Fusion Proteins - chemistry | DNA-Binding Proteins - genetics | Smad3 Protein - antagonists & inhibitors | Response Elements - drug effects | Smad3 Protein - agonists | Embryo, Nonmammalian - abnormalities | Animals | Signal Transduction - drug effects | Morpholinos - pharmacology | Luminescent Proteins - genetics | Mesoderm - metabolism | Mutation | Zebrafish Proteins - genetics | Embryonic Development - drug effects | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Index Medicus | Developmental Biology
Journal Article
Molecular Cell, ISSN 1097-2765, 11/2016, Volume 64, Issue 4, pp. 774 - 789
For many years, a connection between circadian clocks and cancer has been postulated. Here we describe an unexpected function for the circadian repressor CRY2... 
MYC | circadian rhythm | CRY2 | cryptochrome | FBXL3 | circadian clock | ubiquitin | CIRCADIAN CLOCK | CRYPTOCHROME | PROTEIN | UBIQUITIN LIGASE | TUMOR SUPPRESSION | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | GENE-EXPRESSION | CANCER-RISK | FACTOR PERIOD 2 | CELL BIOLOGY | Humans | Gene Expression Regulation, Neoplastic | Cryptochromes - genetics | Circadian Clocks - genetics | Lymphoma - mortality | Lymphoma - metabolism | S-Phase Kinase-Associated Proteins - chemistry | Cell Transformation, Neoplastic - genetics | Proteolysis | HEK293 Cells | Cullin Proteins - metabolism | Fibroblasts | Carrier Proteins - chemistry | Lymphoma - pathology | Protein Stability | Cryptochromes - metabolism | Protein Structure, Secondary | Signal Transduction | F-Box Proteins - metabolism | F-Box Proteins - chemistry | Circadian Rhythm - genetics | Lymphoma - genetics | Models, Molecular | S-Phase Kinase-Associated Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Mice, Knockout | Cullin Proteins - chemistry | Cullin Proteins - genetics | Carrier Proteins - genetics | Animals | Carrier Proteins - metabolism | Survival Analysis | S-Phase Kinase-Associated Proteins - genetics | Cryptochromes - chemistry | Mice | Proto-Oncogene Proteins c-myc - genetics | Cell Transformation, Neoplastic - pathology | Proto-Oncogene Proteins c-myc - chemistry | F-Box Proteins - genetics | Ubiquitin | Physiological aspects | Drug discovery | Research institutes | Ligases | Index Medicus | Basic Medicine | Medical and Health Sciences | Medicin och hälsovetenskap | Cell and Molecular Biology | Medicinska och farmaceutiska grundvetenskaper | Cell- och molekylärbiologi
Journal Article
Science, ISSN 0036-8075, 7/2001, Volume 293, Issue 5529, pp. 506 - 509
Neuronal PAS domain protein 2 (NPAS2) is a transcription factor expressed primarily in the mammalian forebrain. NPAS2 is highly related in primary amino acid... 
Somatosensory cortex | Messenger RNA | HEK293 cells | Neurons | Genes | DNA | Cell lines | Forebrain | Reports | Mice | In situ hybridization | DOUBLE-TIME | ORTHOLOG | PROTEIN | MECHANISM | MULTIDISCIPLINARY SCIENCES | LIGHT | LOOP | GENE-EXPRESSION | SUPRACHIASMATIC CIRCADIAN CLOCK | HYPOXIA | RHYTHMICITY | Darkness | Transcription Factors - chemistry | Ecdysterone - pharmacology | Oligonucleotide Array Sequence Analysis | Humans | Molecular Sequence Data | Trans-Activators - chemistry | Nerve Tissue Proteins - chemistry | In Situ Hybridization | Transfection | Light | Cloning, Molecular | Prosencephalon - metabolism | Tumor Cells, Cultured | Nuclear Proteins - genetics | Dimerization | Basic Helix-Loop-Helix Transcription Factors | ARNTL Transcription Factors | Amino Acid Sequence | Cell Line | Drosophila Proteins | Flavoproteins - metabolism | Flavoproteins - genetics | Gene Expression Regulation | Receptors, G-Protein-Coupled | Nuclear Proteins - metabolism | Circadian Rhythm - physiology | Transcription Factors - genetics | Mice, Inbred Strains | Ecdysterone - analogs & derivatives | Nerve Tissue Proteins - genetics | Period Circadian Proteins | Nerve Tissue Proteins - metabolism | Transcription Factors - metabolism | Blotting, Northern | Animals | CLOCK Proteins | Biological Clocks - physiology | Cryptochromes | Trans-Activators - metabolism | Eye Proteins | Cell Cycle Proteins | Photoreceptor Cells, Invertebrate | Circadian rhythms | Mammals | Research | Proteins | Brain | Neurology | Circadian rhythm | Neuronal PAS domain protein 2 | Per1 protein | NPAS2 protein | Per2 protein | Cry1 protein | BMAL1 protein | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 11/2002, Volume 420, Issue 6912, pp. 178 - 182
Journal Article
Journal Article