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CNS drugs, ISSN 1172-7047, 1994
Source: National Library of New Zealand Te Puna Matauranga o Aotearoa, licensed by the Department of Internal Affairs for re-use under the Creative Commons... 
Periodicals | Neuropsychopharmacology | VLMedicine
Journal
Nature, ISSN 0028-0836, 04/2015, Volume 520, Issue 7547, pp. 368 - 372
Drug resistance invariably limits the clinical efficacy of targeted therapy with kinase inhibitors against cancer(1,2). Here we show that targeted therapy with... 
CNS CELL-TYPES | MELANOMA | METASTASIS | MICROENVIRONMENT | TRANSLATIONAL PROFILING APPROACH | MULTIDISCIPLINARY SCIENCES | RAF INHIBITOR RESISTANCE | ACQUIRED-RESISTANCE | KINASE INHIBITORS | DRUG-RESISTANCE | CANCER CHEMORESISTANCE | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Clone Cells - drug effects | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Proto-Oncogene Proteins c-fos - deficiency | Adenocarcinoma - metabolism | Neoplasm Metastasis - drug therapy | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Female | Proto-Oncogene Proteins c-akt - metabolism | Melanoma - metabolism | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Melanoma - pathology | Down-Regulation - drug effects | Enzyme Activation - drug effects | Adenocarcinoma - drug therapy | Disease Progression | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Cell Movement - drug effects | Lung Neoplasms - secretion | Melanoma - secretion | Animals | Clone Cells - pathology | Metabolome - drug effects | Signal Transduction - drug effects | Neoplasm Metastasis - pathology | Protein Kinase Inhibitors - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Adenocarcinoma - secretion | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Drug Resistance, Neoplasm - drug effects | Antimitotic agents | Pharmaceutical research | Care and treatment | Oncology, Experimental | Dosage and administration | Research | Drug therapy | Drug resistance | Antineoplastic agents | Tumors | Cancer | Melanoma | Mutation | Metastasis | Kinases | Cancer therapies | Index Medicus
Journal Article
CNS drug reviews, ISSN 1080-563X, 1995
Journal
CNS neuroscience & therapeutics, ISSN 1755-5930, 2008
Journal
ACS Chemical Neuroscience, ISSN 1948-7193, 01/2018, Volume 9, Issue 1, pp. 29 - 39
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 01/2012, Volume 3, Issue 1, pp. 50 - 68
Journal Article
BMJ, ISSN 0959-8138, 8/2011, Volume 343, Issue 7819, pp. 354 - 354
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 3/2003, Volume 20, Issue 3, pp. 409 - 416
Journal Article
ACS Chemical Neuroscience, ISSN 1948-7193, 06/2010, Volume 1, Issue 6, pp. 435 - 449
The interplay among commonly used physicochemical properties in drug design was examined and utilized to create a prospective design tool focused on the... 
CNS drugs | Multiparameter optimization (MPO) | CNS MPO | High-throughput screening | Most basic pK | Polarity | Topological polar surface area | Hydrogen bond donor | Central nervous system (CNS) | Lipophilicity | Molecular weight | CNS candidates | desirability score | hydrogen bond donor | Madin-Darby canine kidney | central nervous system (CNS) | DISCOVERY | drug-drug interactions | dofetilide binding | most basic pK(a) | multivariant optimization | Harrington optimization | polarity | BIOCHEMISTRY & MOLECULAR BIOLOGY | high-throughput screening | molecular weight | PROLONGATION | NEUROSCIENCES | PREDICTION | P-glycoprotein | passive permeability | lipophilicity | cellular toxicity | human liver microsome stability | topological polar surface area | Unbound intrinsic clearance | transformed human liver epithelial cells | BINDING | Cell Line | Cell Survival - drug effects | Molecular Weight | Humans | Microsomes, Liver - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Central Nervous System - pathology | Cytochrome P-450 Enzyme System - metabolism | Structure-Activity Relationship | Drug Discovery | Central Nervous System Agents - pharmacokinetics | Algorithms | Animals | Hydrogen Bonding | Central Nervous System Agents - pharmacology | Dogs | Drug Design | Endpoint Determination | Central Nervous System - drug effects | Neurons - drug effects | Central Nervous System Agents - toxicity | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2011, Volume 6, Issue 12, pp. e27865 - e27865
Currently, the major drug discovery paradigm for neurodegenerative diseases is based upon high affinity ligands for single disease-specific targets. For... 
CNS DISORDERS | LEARNING-DEFICITS | HIPPOCAMPAL-LESIONS | TRANSGENIC MOUSE | MEMORY DEFICITS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | STRESS-RESPONSE | AMYLOID-BETA-PROTEIN | LONG-TERM POTENTIATION | MICE LACKING | Immunohistochemistry | Memory - drug effects | Solubility - drug effects | Inflammation - pathology | Curcumin - analogs & derivatives | Curcumin - chemistry | Humans | Oxidants - metabolism | Structure-Activity Relationship | Hippocampus - drug effects | Alzheimer Disease - pathology | Nerve Growth Factors - pharmacology | Pyrazoles - chemistry | Neuroprotective Agents - pharmacology | Synapses - metabolism | Long-Term Potentiation - drug effects | Amyloid beta-Peptides - metabolism | Behavior, Animal - drug effects | Brain-Derived Neurotrophic Factor - metabolism | Phosphorylation - drug effects | Disease Models, Animal | Pyrazoles - pharmacology | Synapses - drug effects | Alzheimer Disease - physiopathology | Neuroprotective Agents - chemistry | Heat-Shock Proteins - metabolism | Curcumin - pharmacology | Alzheimer Disease - drug therapy | Rats | Hippocampus - pathology | Cognition - drug effects | Up-Regulation - drug effects | Hippocampus - metabolism | Animals | Alzheimer Disease - metabolism | Mice | Oxidative Stress - drug effects | Physiological aspects | Advertising executives | Genetic engineering | Drug discovery | Drug therapy | Alzheimer's disease | Cell culture | Oxidative stress | Neurosciences | Animal models | Laboratories | Memory | Cognitive ability | Neurobiology | Risk factors | Proteins | Transgenic animals | Rodents | Aging | Trends | Age | Pharmaceutical sciences | Neurodegenerative diseases | Research & development--R&D | Metabolism | Neurological diseases | Brain research | Cognition & reasoning | β-Amyloid | Alzheimers disease | Index Medicus | Research & development | R&D
Journal Article
JOURNAL OF CLINICAL MEDICINE, ISSN 2077-0383, 11/2018, Volume 7, Issue 11, p. 384
Journal Article
Peptides, ISSN 0196-9781, 03/2017, Volume 89, pp. 82 - 89
Journal Article