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Journal of Pharmaceutical Sciences, ISSN 0022-3549, 08/2017, Volume 106, Issue 8, pp. 2136 - 2143
FXa is a recombinant human FXa variant which is currently being evaluated in the clinic for treating intracerebral hemorrhage. The aim of our studies is to... 
pharmacodynamics | pharmacokinetics | FXaI16L | metabolism | coagulation factor Xa | tissue distribution | interspecies scaling | FXa
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 03/2008, Volume 130, Issue 9, pp. 2817 - 2831
Journal Article
Postepy biochemii, ISSN 0032-5422, 01/2017, Volume 63, Issue 3, pp. 198 - 204
Journal Article
Frontiers in Bioscience, ISSN 1093-9946, 01/2009, Volume 14, Issue 6, pp. 2051 - 2088
Journal Article
Journal Article
British Journal of Clinical Pharmacology, ISSN 0306-5251, 11/2013, Volume 76, Issue 5, pp. 776 - 786
Journal Article
THROMBOSIS AND HAEMOSTASIS, ISSN 0340-6245, 09/2018, Volume 118, Issue 9, pp. 1535 - 1544
Increasing number of patients are treated with direct oral anticoagulants (DOAC). An antidote for dabigatran inhibiting thrombin (idarucizumab) is available... 
ANDEXANET ALPHA | ACTIVATION | COAGULATION-FACTOR-XA | oral anticoagulant | HUMAN ALPHA-MACROGLOBULIN | ALPHA-MACROGLOBULIN COMPLEXES | rivaroxaban | apixaban | REVERSAL | 3-DIMENSIONAL STRUCTURE | DABIGATRAN | antidote | PERIPHERAL VASCULAR DISEASE | ALPHA-2-MACROGLOBULIN | HEMATOLOGY
Journal Article
Drugs, ISSN 0012-6667, 7/2018, Volume 78, Issue 10, pp. 1049 - 1055
Journal Article
Thrombosis and Haemostasis, ISSN 0340-6245, 2015, Volume 113, Issue 5, pp. 1038 - 1048
Summary The Endothelial Protein C receptor (EPCR) is essential for the anticoagulant and cytoprotective functions of the Protein C (PC) system. Selected... 
Blood Cells, Inflammation and Infection | Endothelial protein C receptor | Malaria | Endothelial cells | PfEMP1 | endothelial cells | ACTIVATION | FALCIPARUM-MALARIA | RECEPTOR | MECHANISMS | AFRICAN CHILDREN | endothelial protein C receptor | IN-VIVO | ENDOTHELIAL-CELLS | PERIPHERAL VASCULAR DISEASE | COAGULATION-FACTOR XA | HEMATOLOGY | BINDING | CEREBRAL MALARIA
Journal Article
Pharmacological Reviews, ISSN 0031-6997, 10/2016, Volume 68, Issue 4, pp. 1110 - 1142
Journal Article
JAMA - Journal of the American Medical Association, ISSN 0098-7484, 07/2018, Volume 320, Issue 4, pp. 399 - 400
The article discusses how Andexxa is being looked upon as a suitable antidote for apixaban as well as rivaroxaban. Some of the positive and negative aspects... 
ANDEXANET ALPHA | MEDICINE, GENERAL & INTERNAL | REVERSAL | Dose-response relationship (Biochemistry) | Rivaroxaban | Dosage and administration | Analysis | Apixaban | Prescription drugs | Anticoagulants | Regulatory agencies | Inhibitors | Coagulation | Thrombin | Coagulation factor Xa | Recombinant
Journal Article
SCIENTIFIC REPORTS, ISSN 2045-2322, 03/2019, Volume 9, Issue 1, pp. 3909 - 9
Atherosclerosis is a progressive inflammatory vascular disorder, complicated by plaque rupture and subsequently atherothrombosis. In vitro studies indicate... 
PROTEASE-ACTIVATED RECEPTORS | DABIGATRAN ETEXILATE | INFLAMMATION | STABILITY | MULTIDISCIPLINARY SCIENCES | THROMBIN INHIBITION | PROGRESSION | LESIONS | Immunohistochemistry | Thrombin | Smooth muscle | Macrophages | Apolipoproteins | Clotting | Apolipoprotein E | Arteriosclerosis | Collagen | Aortic arch | Atherosclerosis | Aorta | Coagulation factor Xa | Plaques
Journal Article