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PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e60581
Most conditions detected by expanded newborn screening result from deficiency of one of the enzymes that degrade acyl-coenzyme A (CoA) esters in mitochondria.... 
RAT-LIVER | 3-HYDROXY-3-METHYLGLUTARYL-COA LYASE | INHIBITION | METABOLISM | COENZYME-A PROFILES | PYRUVATE-CARBOXYLASE | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | DEFICIENT MICE | LYASE HL | SPECTROMETRY | Hyperammonemia - metabolism | Humans | Hypoglycemia - mortality | Acetyl Coenzyme A - genetics | Acyl Coenzyme A - genetics | Hepatocytes - metabolism | Mitochondria - ultrastructure | Genes, Lethal | Mitochondria - genetics | Pyruvic Acid - metabolism | Hyperammonemia - mortality | Gene Order | Hypoglycemia - genetics | Gene Targeting | Hyperammonemia - genetics | Leucine - metabolism | Carbon Dioxide - metabolism | Liver - metabolism | Acyl Coenzyme A - deficiency | Metabolome | Mitochondria - metabolism | Gene Knockout Techniques | Hypoglycemia - metabolism | Acetyl Coenzyme A - metabolism | Mice, Knockout | Peroxisomes | Phenotype | Animals | Gluconeogenesis - genetics | Metabolic Networks and Pathways | Models, Biological | Lethargy | Mice | Enzymes | Esters | Metabolites | Glutamate | Analysis | Organic acids | Glutamic acid | Inborn errors of metabolism | Ketogenesis | Laboratories | Liver | Pyruvic acid | Leucine | Defects | Degradation | Proteins | Mitochondria | Rodents | Coenzyme A | Chemical synthesis | Gluconeogenesis | Urine | Medical research | Incubation | Hyperammonemia | Hypoglycemia | Metabolism | Fatty acids | Studies | Urea | Hepatocytes | Carboxylation | Scientific imaging | Mass spectrometry | Acetyl Coenzyme A | Life Sciences | Hépatology and Gastroenterology | Carbon Dioxide | Human health and pathology | Pyruvic Acid | Acyl Coenzyme A
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