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Nature Chemical Biology, ISSN 1552-4450, 10/2016, Volume 12, Issue 10, pp. 773 - 775
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2011, Volume 286, Issue 41, pp. 35562 - 35570
Journal Article
Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, ISSN 0037-9980, 2018, Volume 76, Issue 5, pp. 490 - 493
Journal Article
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, ISSN 0037-9980, 05/2018, Volume 76, Issue 5, pp. 490 - 493
Colibactin, a secondary metabolite produced by a commensal Escherichia coli harboring pks island, exhibits a genotoxicity to mammalian cells and progresses to... 
colorectal cancer | secondary metabolites | carcinogenesis | PRECOLIBACTIN | DNA | biosynthesis | CHEMISTRY, ORGANIC | commensal bacteria | PRODRUG ACTIVATION MECHANISM | colibactin
Journal Article
NATURE CHEMISTRY, ISSN 1755-4330, 10/2019, Volume 11, Issue 10, pp. 890 - 898
The clb gene cluster encodes the biosynthesis of metabolites known as precolibactins and colibactins. The clb pathway is found in gut commensal Escherichia... 
METABOLOMICS | MECHANISM | COLIBACTIN BIOSYNTHESIS | DIAZOTRANSFER | CANCER | CHEMISTRY, MULTIDISCIPLINARY | ALPHA-AZIDO KETONES | Purification | Peptidase | Colorectal carcinoma | Genotoxicity | Adenine | Crosslinking | Biosynthesis | High-performance liquid chromatography | Intermediates | Metabolites | E coli | Biomimetics | Cleavage | Deoxyribonucleic acid--DNA
Journal Article
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 12/2017, Volume 139, Issue 49, pp. 17719 - 17722
Certain commensal Escherichia coli contain the clb biosynthetic gene cluster that codes for small molecule prodrugs known as precolibactins. Precolibactins are... 
GENOTOXIN COLIBACTIN | METABOLOMICS | MECHANISM | PATHWAY | BIOSYNTHESIS | COLI | PRECOLIBACTIN | SUPERFAMILY | MICROBIOTA | CANCER | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Current Topics in Medicinal Chemistry, ISSN 1568-0266, 06/2016, Volume 16, Issue 15, pp. 1705 - 1716
Journal Article
Critical Reviews in Microbiology, ISSN 1040-841X, 09/2018, Volume 44, Issue 5, pp. 619 - 632
To the multiple factors that may eventually result in colorectal cancer (CRC), strains of E. coli have now been added, in particular strains producing... 
cyclomodulins | Escherichia coli | colibactin | Colorectal cancer | MICROBIOLOGY | E. COLI | PKS ISLAND | BACTERIAL GENOTOXIN | INFLAMMATORY-BOWEL-DISEASE | GENE-CLUSTER | PHYLOGENETIC DISTRIBUTION | COLIBACTIN BIOSYNTHESIS | CELL-CYCLE | HUMAN GUT | HEALTHY-VOLUNTEERS
Journal Article
Molecular Microbiology, ISSN 0950-382X, 03/2016, Volume 99, Issue 5, pp. 897 - 908
The genomic pks island codes for the biosynthetic machinery that produces colibactin, a peptide-polyketide metabolite. Colibactin is a genotoxin that... 
GENOTOXIN COLIBACTIN | ANTIBIOTICS | BACTERIA | MECHANISM | COLON-TUMOR GROWTH | BIOSYNTHESIS | PERSISTENCE | BIOCHEMISTRY & MOLECULAR BIOLOGY | BREAKS | POLYKETIDE | MICROBIOLOGY | CROSS-LINKS | Proteins | E coli | Toxicity | DNA repair | Genomics | Bacteriology
Journal Article
Synlett, ISSN 0936-5214, 09/2018, Volume 29, Issue 14, pp. 1823 - 1835
Abstract Emergence is the phenomenon by which novel properties arise from the combination of simpler fragments that lack those properties at their given levels... 
account | colibactins | functional group reactivity | natural products | emergence | lomaiviticin | DIAZO GROUP | ANTITUMOR ANTIBIOTICS | DNA CLEAVAGE | ENANTIOSELECTIVE SYNTHESIS | CHEMISTRY, ORGANIC | DOUBLE-STRAND BREAKS | SCALABLE SYNTHESIS | KINAMYCIN-F | COLIBACTIN BIOSYNTHESIS | COLORECTAL-CANCER | BIOLOGICAL-ACTIVITY
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 04/2016, Volume 138, Issue 16, pp. 5426 - 5432
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2015, Volume 54, Issue 36, pp. 10408 - 10411
Gut reaction: There is increasing evidence that the impact on human health and disease of the microbes living in and on us has been underestimated. Several of... 
colorectal cancer | prodrug activation | microbiome | colibactin | dysbiosis | NONRIBOSOMAL PEPTIDES | METABOLITES | LINKS | CHEMISTRY, MULTIDISCIPLINARY | SYMBIONTS | PATHWAY | BIOSYNTHESIS | DNA | DISEASE | HEALTH | PRODRUG ACTIVATION MECHANISM | Microbiota | Intestines - microbiology | Peptides - pharmacology | Polyketides - pharmacology | Colorectal cancer | Bacteria | Biosynthesis | Genotoxicity | Race | Human | Microorganisms | Pathways | Health
Journal Article
Frontiers in Microbiology, ISSN 1664-302X, 08/2017, Volume 8, p. 1494
Increased incidences of antimicrobial resistance and the emergence of pan-resistant 'superbugs' have provoked an extreme sense of urgency amongst researchers... 
PKS | NRPS | Bioactive compounds | Symbiont | Antibiotic resistance | ANTIBIOTICS | NATURAL-PRODUCTS | symbiont | MICROBIOLOGY | POLYKETIDE SYNTHASES | DISCOVERY | MARINE SPONGE | ACTINOMYCETE | antibiotic resistance | COLIBACTIN BIOSYNTHESIS | bioactive compounds | SP-NOV | DIVERSITY | EXPRESSION
Journal Article