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Natural Product Reports, ISSN 0265-0568, 2009, Volume 26, Issue 7, pp. 916 - 935
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 06/2005, Volume 48, Issue 12, pp. 4087 - 4099
A series of cis- and trans-stilbenes related to combretastatin A-4 (1a), with a variety of substituents at the X-position of the aryl B-ring, were synthesized... 
ANTITUMOR AGENTS | IN-VITRO | CHEMISTRY, MEDICINAL | BASIC SIDE-CHAIN | DNA TOPOISOMERASE-II | ANTIMITOTIC NATURAL-PRODUCTS | COMBRETASTATIN A-4 | BIOLOGICAL EVALUATION | TUBULIN POLYMERIZATION | COMBRETUM-CAFFRUM | CELL-GROWTH
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2007, Volume 48, Issue 39, pp. 7007 - 7010
Combretastatins A-4 and AVE-8062A have been synthesized by coupling 3,4,5-trimethoxyphenylacetylene with the corresponding iodomethoxyphenol and... 
COLCHICINE | CROSS-COUPLING REACTION | NATURAL-PRODUCTS | ARYL HALIDES | ANTINEOPLASTIC AGENTS | CHEMISTRY, ORGANIC | COMBRETUM-CAFFRUM | TUBULIN
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 2008, Volume 49, Issue 7, pp. 1107 - 1110
An efficient stereoselective synthesis of -stilbenes has been developed from diarylalkynes via a new hydrosilylation–protodesilylation process. The scope and... 
Combretastatin A-4 | Hydrosilylation | ( Z)-Stilbenes | Platinum | Desilylation | (Z)-Stilbenes | ANALOGS | ANTICANCER AGENTS | ANTINEOPLASTIC AGENTS | CHEMISTRY, ORGANIC | COMBRETUM-CAFFRUM | ALKYNES | REGIOCONTROL | platinum | combretastatin A-4 | desilylation | hydrosilylation | STEREOSELECTIVE-SYNTHESIS | OXIDE CATALYZED HYDROSILYLATION | TUBULIN | DERIVATIVES
Journal Article
Journal Article
Cancer Letters, ISSN 0304-3835, 09/2017, Volume 403, pp. 289 - 295
The search for small molecule inhibitors has gained prominence with the recognition of their inherent advantage for cancer therapy. Combretastatin is a... 
Cell proliferation | Suppression of EMT | Suppression of tumour progression | Combretastatins | Cell motility and invasion | Angiogenesis inhibitor | HEPATOCELLULAR-CARCINOMA CELLS | TOPOISOMERASE-II | MITOTIC CATASTROPHE | ANTINEOPLASTIC AGENTS | COMBRETUM-CAFFRUM | INHIBITS HIF-1-ALPHA | LUNG-CANCER CELLS | COLCHICINE-BINDING-SITE | VASCULAR DISRUPTING ACTIVITY | ONCOLOGY | SIGNALING PATHWAY | Bibenzyls - therapeutic use | Neoplasm Invasiveness | Humans | Neovascularization, Pathologic | Epithelial-Mesenchymal Transition - drug effects | Neoplasms - blood supply | Disease Progression | Neoplasms - drug therapy | Cell Movement - drug effects | Animals | Signal Transduction - drug effects | Tumor Burden - drug effects | Angiogenesis Inhibitors - therapeutic use | Cell Proliferation - drug effects | Neoplasms - pathology | Antimitotic agents | Development and progression | Antineoplastic agents | Tubulins | Cancer | Encapsulation | Drugs | Drug delivery systems | Mesenchyme | AKT protein | Drug delivery | Metastasis | Kinases | Cancer therapies | Metastases | Anticancer properties | Nanoparticles | Angiogenesis | Signal transduction | Biological effects | Allosteric properties | Tubulin | Actin | Cell cycle | Protein-tyrosine kinase receptors | Inhibition | Growth factors | Protein-tyrosine kinase | Tyrosine | Polymerization | Breast cancer | Permeability | Derivatives | Signalling systems | Inhibitors | Nanospheres | Microtubules | Cytoskeleton | Ligands | Binding sites | Tumors | Apoptosis
Journal Article
Journal Article
Natural Product Reports, ISSN 0265-0568, 12/2003, Volume 20, Issue 6, pp. 558 - 564
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 12/2015, Volume 23, Issue 24, pp. 7497 - 7520
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 08/2012, Volume 53, Issue 31, pp. 3947 - 3950
Journal Article
Synlett, ISSN 0936-5214, 05/2012, Volume 2012, Issue 8, pp. 1205 - 1208
Abstract A series of novel combretastatin A-4 analogues was synthesized in 36–64% yields by Negishi cross-coupling reaction under mild conditions. The prepared... 
letter | cross-coupling | magnesium-zinc exchange | organometallic reagents | cytotoxicity | antitumor agents | ANTICANCER AGENTS | NATURAL-PRODUCTS | VASCULAR-DISRUPTING AGENTS | ANTINEOPLASTIC AGENTS | ANTIMITOTIC AGENT | CHEMISTRY, ORGANIC | COMBRETUM-CAFFRUM | RAMBERG-BACKLUND REACTION | 4-ARYLCOUMARIN ANALOGS | TUBULIN | BINDING
Journal Article