X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (433) 433
binding, competitive (341) 341
humans (244) 244
rats (224) 224
male (202) 202
index medicus (187) 187
pharmacology & pharmacy (166) 166
kinetics (109) 109
competitive acid blocker (108) 108
biochemistry & molecular biology (106) 106
dose-response relationship, drug (92) 92
binding, competitive - drug effects (90) 90
female (90) 90
mice (90) 90
neurosciences (89) 89
in vitro techniques (88) 88
proton pump inhibitors (86) 86
gastroenterology & hepatology (80) 80
vonoprazan (74) 74
binding sites (71) 71
calcium channel blockers - pharmacology (70) 70
molecular sequence data (66) 66
amino acid sequence (65) 65
radioligand assay (62) 62
rats, sprague-dawley (62) 62
structure-activity relationship (61) 61
potassium-competitive acid blocker (54) 54
binding (53) 53
brain - metabolism (52) 52
helicobacter pylori (52) 52
ligands (49) 49
research (47) 47
cells, cultured (45) 45
calcium - metabolism (43) 43
calcium channel blockers - metabolism (43) 43
article (41) 41
patch-clamp techniques (41) 41
proton pump inhibitors - therapeutic use (41) 41
analysis (38) 38
excitatory amino acid antagonists - pharmacology (37) 37
physiology (37) 37
protein binding (37) 37
rat-brain (37) 37
receptors (37) 37
middle aged (36) 36
proton pump inhibitor (35) 35
receptors, n-methyl-d-aspartate - antagonists & inhibitors (35) 35
molecular structure (34) 34
proteins (34) 34
chemistry, medicinal (32) 32
gastroesophageal reflux (32) 32
gastroesophageal-reflux disease (32) 32
guinea pigs (32) 32
lansoprazole (32) 32
membrane potentials - drug effects (32) 32
pharmacology (32) 32
rats, wistar (32) 32
tritium (32) 32
cell membrane - metabolism (31) 31
esomeprazole (31) 31
neurons - drug effects (31) 31
receptor (31) 31
brain (30) 30
cell line (30) 30
inhibition (30) 30
drug interactions (29) 29
adult (28) 28
gastroesophageal reflux disease (28) 28
helicobacter infections - drug therapy (28) 28
mutation (28) 28
pyrroles - therapeutic use (28) 28
treatment outcome (28) 28
triple therapy (28) 28
aged (27) 27
multidisciplinary sciences (27) 27
peptides - pharmacology (27) 27
physiological aspects (27) 27
sulfonamides - therapeutic use (27) 27
brain - drug effects (26) 26
cricetinae (26) 26
enzyme inhibitors - pharmacology (26) 26
expression (26) 26
glutamate (26) 26
stereoisomerism (26) 26
therapy (26) 26
transfection (26) 26
calcium (25) 25
cerebral cortex - metabolism (25) 25
erosive esophagitis (25) 25
models, molecular (25) 25
research article (25) 25
antacids (24) 24
clarithromycin (24) 24
esophagitis (24) 24
infection (24) 24
omeprazole (24) 24
pharmacokinetics (24) 24
potassium (24) 24
3-pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-phenyl (23) 23
binding, competitive - physiology (23) 23
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (726) 726
Japanese (4) 4
Russian (3) 3
German (1) 1
Korean (1) 1
Polish (1) 1
Spanish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal Article
Journal of Gastroenterology, ISSN 0944-1174, 6/2018, Volume 53, Issue 6, pp. 718 - 724
Journal Article
Digestion, ISSN 0012-2823, 2019, pp. 1 - 10
We evaluated the efficacy of vonoprazan (VPZ), a novel potassium-competitive acid blocker, in patients with proton pump inhibitor (PPI)-refractory... 
Acid suppression | Potassium-competitive acid blocker | Impedance-pH monitoring | Gastroesophageal reflux disease | Proton pump inhibitor
Journal Article
European Journal of Pharmaceutical Sciences, ISSN 0928-0987, 03/2019, Volume 130, pp. 1 - 10
A physiologically-based pharmacokinetic (PBPK) model was developed for YH4808, a novel potassium-competitive acid blocker, using the SimCYP® Simulator based on... 
Physiologically-based pharmacokinetics | Potassium-competitive acid blocker | Pharmacodynamics | pH-dependent solubility | Pharmacokinetics | Intragastric pH | PERMEABILITY | TISSUE DISTRIBUTION | STRATEGY | PHARMACOLOGY & PHARMACY | SIMULATION | INHIBITION ASSAYS | Index Medicus
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 13, pp. 3298 - 3314
Journal Article
Advances in Therapy, ISSN 0741-238X, 7/2016, Volume 33, Issue 7, pp. 1140 - 1157
Journal Article
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 14, pp. 3719 - 3735
With the aim to discover a gastric antisecretory agent more potent than the existing proton pump inhibitors, novel 3,4-dihydro-1... 
Potassium-competitive acid blockers | H+,K+-ATPase | Docking analysis | 3,4-Dihydro-1H-spiro[naphthalene-2,2′-piperidin]-1-one derivatives | S-Enantiomer | CHEMISTRY, MEDICINAL | GASTROESOPHAGEAL-REFLUX DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | 3,4-Dihydro-1H-spirotnaphthalene-2,2 '-piperidin]-1-one derivatives | Histamine - toxicity | Potassium - metabolism | Area Under Curve | Half-Life | Structure-Activity Relationship | Gastric Mucosa - metabolism | Gastric Acid - secretion | H(+)-K(+)-Exchanging ATPase - chemistry | Spiro Compounds - chemical synthesis | Gastric Mucosa - drug effects | Inhibitory Concentration 50 | Piperidines - pharmacokinetics | Proton Pump Inhibitors - chemical synthesis | Drug Evaluation, Preclinical | Binding Sites | Spiro Compounds - chemistry | Naphthalenes - chemistry | Piperidines - chemistry | H(+)-K(+)-Exchanging ATPase - metabolism | Rats | Piperidines - chemical synthesis | Spiro Compounds - pharmacokinetics | Potassium - chemistry | Administration, Intravenous | Animals | Proton Pump Inhibitors - chemistry | Proton Pump Inhibitors - pharmacokinetics | Gastric Mucosa - secretion | ROC Curve | Molecular Docking Simulation | Gastric Acid - metabolism | Antacids | Resveratrol | Gastroesophageal reflux | Dimethylformamide | Chemical tests and reagents | Lithium compounds | Cytokinins | Histamine | Proton pump inhibitors | Metallocenes | Derivatives (Financial instruments) | High performance liquid chromatography | Adenosine triphosphatase
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 13, pp. 3447 - 3460
Journal Article
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, ISSN 0037-9980, 03/2019, Volume 77, Issue 3, pp. 254 - 261
The major target in the pharmacological treatment for acid related diseases is the gastric proton pump enzyme H+,K+-ATPase which is responsible for acid... 
H+,K+-ATPase | potassium-competitive acid blocker (P-CAB) | TAK-438 | ligand-lipophilicity efficiency (LLE) | CHEMISTRY, ORGANIC | acid-related diseases | Vonoprazan Fumarate (Takecab (R)) | high through-put screening (HTS)
Journal Article
Journal Article
Digestion, ISSN 0012-2823, 08/2017, Volume 96, Issue 1, pp. 52 - 59
Journal Article