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1. Full Text Potassium-competitive acid blockers: Advanced therapeutic option for acid-related diseases
by Inatomi, Nobuhiro and Matsukawa, Jun and Sakurai, Yuuichi and Otake, Kazuyoshi
Pharmacology & therapeutics (Oxford), ISSN 0163-7258, 12/2016, Volume 168, pp. 12 - 22
Peptic ulcer | Gastric acid secretion | Potassium-competitive acid blocker | receptor | Acid-related diseases | Proton pump inhibitor | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Potassium - metabolism | Proton Pump Inhibitors - adverse effects | Proton Pump Inhibitors - pharmacology | Histamine H2 Antagonists - pharmacology | Gastroesophageal Reflux - physiopathology | Humans | Helicobacter Infections - complications | Gastric Acid - secretion | Gastrointestinal Agents - pharmacology | Animals | Helicobacter Infections - drug therapy | Drug Design | Peptic Ulcer - physiopathology | Gastrointestinal Agents - adverse effects | Helicobacter pylori - isolation & purification | Gastroesophageal Reflux - drug therapy | Peptic Ulcer - drug therapy | Gastroesophageal reflux | Care and treatment | Health aspects | Antacids | Index Medicus
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2. Full Text Characteristics of the Novel Potassium-Competitive Acid Blocker Vonoprazan Fumarate (TAK-438)
by Otake, Kazuyoshi and Sakurai, Yuuichi and Nishida, Haruyuki and Fukui, Hideo and Tagawa, Yoshihiko and Yamasaki, Hitomi and Karashima, Masatoshi and Otsuka, Keiichi and Inatomi, Nobuhiro
Advances in therapy, ISSN 0741-238X, 7/2016, Volume 33, Issue 7, pp. 1140 - 1157
Potassium-competitive acid blockers | Vonoprazan | Acid-related diseases | TAK-438 | Rheumatology | Helicobacter pylori eradication | PPI | Internal Medicine | Oncology | Reflux esophagitis | Proton pump inhibitor | Medicine & Public Health | Gastroenterology | Cardiology | Pharmacology/Toxicology | Endocrinology | Lansoprazole | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Gastrointestinal Agents - pharmacology | Pyrroles - pharmacology | Pyrroles - pharmacokinetics | Sulfonamides - therapeutic use | Gastrointestinal Diseases - drug therapy | Humans | Gastrointestinal Agents - therapeutic use | Gastrointestinal Agents - pharmacokinetics | Pyrroles - therapeutic use | Sulfonamides - pharmacology | Sulfonamides - pharmacokinetics | Hydrogen-Ion Concentration | Gastroesophageal reflux | Physiological aspects | Peptic ulcer | Antacids | Genetic polymorphisms | Cytochrome P-450 | Health technology assessment
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3. Full Text DL-threo-β-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters
by Shimamoto, Keiko and LeBrun, Bruno and Yasuda-Kamatani, Yoshimi and Sakaitani, Masahiro and Shigeri, Yasushi and Yumoto, Noboru and Nakajima, Terumi
Molecular pharmacology, ISSN 0026-895X, 1998, Volume 53, Issue 2, pp. 195 - 201
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Binding, Competitive | Receptors, Neurotransmitter - antagonists & inhibitors | Humans | Xenopus laevis | Amino Acid Transport System X-AG | Structure-Activity Relationship | Oocytes | Excitatory Amino Acid Transporter 2 | Animals | Transfection | Cloning, Molecular | Excitatory Amino Acids - metabolism | Aspartic Acid - analogs & derivatives | Aspartic Acid - chemistry | Excitatory Amino Acid Antagonists - chemistry | COS Cells | Aspartic Acid - pharmacology | ATP-Binding Cassette Transporters - antagonists & inhibitors | Index Medicus
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4. Full Text A physiologically-based pharmacokinetic model adequately predicted the human pharmacokinetic profiles of YH4808, a novel K+-competitive acid blocker
by Lee, Hyun A and Lee, Kyeong-Ryoon and Jang, Seong Bok and Chung, Soo Yong and Yu, Kyung-Sang and Lee, Howard
European journal of pharmaceutical sciences, ISSN 0928-0987, 03/2019, Volume 130, pp. 1 - 10
Physiologically-based pharmacokinetics | Potassium-competitive acid blocker | Pharmacodynamics | pH-dependent solubility | Pharmacokinetics | Intragastric pH | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Index Medicus
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5. Full Text Efficacy of Vonoprazan, a Novel Potassium-Competitive Acid Blocker, in Patients with Proton Pump Inhibitor-Refractory Acid Reflux
by Akiyama, Junichi and Hosaka, Hiroko and Kuribayashi, Shiko and Moriyasu, Shiori and Hisada, Yuya and Okubo, Hidetaka and Watanabe, Kazuhiro and Imbe, Koh and Nagata, Naoyoshi and Kojima, Yasushi and Yokoi, Chizu and Uemura, Naomi and Shimoyama, Yasuyuki and Kawamura, Osamu and Yamada, Masanobu and Kusano, Motoyasu
Digestion, ISSN 0012-2823, 03/2020, Volume 101, Issue 2, pp. 174 - 183
Research Article | Acid suppression | Potassium-competitive acid blocker | Impedance-pH monitoring | Gastroesophageal reflux disease | Proton pump inhibitor | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Index Medicus
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6. Full Text Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2′-piperidin)-1-ones as potassium-competitive acid blockers
by Imaeda, Toshihiro and Ono, Koji and Nakai, Kazuo and Hori, Yasunobu and Matsukawa, Jun and Takagi, Terufumi and Fujioka, Yasushi and Tarui, Naoki and Kondo, Mitsuyo and Imanishi, Akio and Inatomi, Nobuhiro and Kajino, Masahiro and Itoh, Fumio and Nishida, Haruyuki
Bioorganic & medicinal chemistry, ISSN 0968-0896, 07/2017, Volume 25, Issue 14, pp. 3719 - 3735
Potassium-competitive acid blockers | H+,K+-ATPase | Docking analysis | 3,4-Dihydro-1H-spiro[naphthalene-2,2′-piperidin]-1-one derivatives | S-Enantiomer | Histamine - toxicity | Potassium - metabolism | Area Under Curve | Half-Life | Structure-Activity Relationship | Gastric Mucosa - metabolism | Gastric Acid - secretion | H(+)-K(+)-Exchanging ATPase - chemistry | Spiro Compounds - chemical synthesis | Gastric Mucosa - drug effects | Inhibitory Concentration 50 | Piperidines - pharmacokinetics | Proton Pump Inhibitors - chemical synthesis | Drug Evaluation, Preclinical | Binding Sites | Spiro Compounds - chemistry | Naphthalenes - chemistry | Piperidines - chemistry | H(+)-K(+)-Exchanging ATPase - metabolism | Rats | Piperidines - chemical synthesis | Spiro Compounds - pharmacokinetics | Potassium - chemistry | Administration, Intravenous | Animals | Proton Pump Inhibitors - chemistry | Proton Pump Inhibitors - pharmacokinetics | Gastric Mucosa - secretion | ROC Curve | Molecular Docking Simulation | Gastric Acid - metabolism | Antacids | Resveratrol | Gastroesophageal reflux | Dimethylformamide | Chemical tests and reagents | Lithium compounds | Cytokinins | Histamine | Proton pump inhibitors | Metallocenes | Derivatives (Financial instruments) | High performance liquid chromatography | Adenosine triphosphatase | Index Medicus
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7. Full Text Safety of first-line triple therapy with a potassium-competitive acid blocker for Helicobacter pylori eradication in children
by Kusano, Chika and Kusano, Chika and Gotoda, Takuji and Gotoda, Takuji and Suzuki, Sho and Suzuki, Sho and Ikehara, Hisatomo and Ikehara, Hisatomo and Moriyama, Mitsuhiko and Moriyama, Mitsuhiko
Journal of gastroenterology, ISSN 0944-1174, 6/2018, Volume 53, Issue 6, pp. 718 - 724
Potassium-competitive acid blocker | Medicine & Public Health | Helicobacter pylori | Colorectal Surgery | Hepatology | Gastroenterology | Abdominal Surgery | Children | Surgical Oncology | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Prevention | Urea | Antihistamines | Enzymes | Helicobacter infections | High schools | Junior high school students | Antibacterial agents | Antacids | Cancer | Confidence intervals | Urine | Clarithromycin | Vomiting | Hypersensitivity | Amoxicillin | Potassium | Stomach cancer | Gastric cancer | Enzyme-linked immunosorbent assay | Index Medicus
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8. Full Text Radiographic Localization Study of a Novel Potassium-Competitive Acid Blocker, Vonoprazan, in the Rat Gastric Mucosa
by Matsukawa, Jun and Kogame, Akifumi and Tagawa, Yoshihiko and Inatomi, Nobuhiro
Digestive diseases and sciences, ISSN 0163-2116, 7/2016, Volume 61, Issue 7, pp. 1888 - 1894
Biochemistry, general | Potassium-competitive acid blocker | Vonoprazan | Medicine & Public Health | Rat | Hepatology | Gastric mucosa | Gastroesophageal reflux disease | TAK-438 | Gastroenterology | Oncology | Transplant Surgery | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Autoradiography | Animals | Proton Pump Inhibitors - pharmacokinetics | Pyrroles - pharmacokinetics | Rats | Male | Tritium | Gastric Mucosa - metabolism | Sulfonamides - pharmacokinetics | Gastroesophageal reflux | Antacids | Index Medicus | Abridged Index Medicus
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9. Full Text Factors Associated with Potassium-Competitive Acid Blocker Non-Response in Patients with Proton Pump Inhibitor-Refractory Gastroesophageal Reflux Disease
by Okuyama, Masatsugu and Nakahara, Kenichi and Iwakura, Narika and Hasegawa, Tomoki and Oyama, Maizumi and Inoue, Ayumi and Ishizu, Hirotaka and Satoh, Hiroshi and Fujiwara, Yasuhiro
Digestion, ISSN 0012-2823, 07/2017, Volume 95, Issue 4, pp. 281 - 287
Potassium-competitive acid blocker | Vonoprazan | Drug therapy | Proton pump inhibitor-refractory gastroesophageal reflux disease | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Humans | Middle Aged | Male | Proton Pump Inhibitors - therapeutic use | Gastroesophageal Reflux - complications | Sulfonamides - therapeutic use | Treatment Failure | Aged, 80 and over | Sleep Wake Disorders - prevention & control | Female | Aged | Gastroesophageal Reflux - drug therapy | Pyrroles - therapeutic use | Sleep Wake Disorders - etiology | Index Medicus
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10. Full Text Potent potassium-competitive acid blockers: A new era for the treatment of acid-related diseases
by Oshima, Tadayuki and Miwa, Hiroto
Journal of neurogastroenterology and motility, ISSN 2093-0879, 2018, Volume 24, Issue 3, pp. 334 - 344
Esophagitis | exchanging ATPase | Potassium-competitive acid blocker | Anti-inflammatory agents,non-steroidal | K | Helicobacter pylori | Gastroenterology & Hepatology | Clinical Neurology | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | non-steroidal | Review | H+, K+-exchanging ATPase | Anti-inflammatory agents
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11. Full Text Pathogenesis of Potassium-Competitive Acid Blocker-Resistant Non-Erosive Reflux Disease
by Kawami, Noriyuki and Hoshino, Shintaro and Hoshikawa, Yoshimasa and Takenouchi, Nana and Umezawa, Mariko and Hanada, Yuriko and Kaise, Mitsuru and Iwakiri, Katsuhiko
Digestion, ISSN 0012-2823, 10/2018, Volume 98, Issue 3, pp. 194 - 200
Non-erosive reflux disease | Vonoprazan | Impedance-pH monitoring | Helicobacter pylori | Potassium-competitive acid blocker-resistant | Gastroenterology & Hepatology | Life Sciences & Biomedicine | Science & Technology | Proton Pump Inhibitors - pharmacology | Gastroesophageal Reflux - diagnosis | Esophageal pH Monitoring | Gastroesophageal Reflux - pathology | Humans | Middle Aged | Heartburn - diagnosis | Male | Treatment Outcome | Proton Pump Inhibitors - therapeutic use | Gastroesophageal Reflux - complications | Heartburn - etiology | Gastric Acidity Determination | Female | Gastric Acid - metabolism | Gastroesophageal Reflux - drug therapy | Potassium | Drug Resistance | Heartburn - pathology | Index Medicus
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