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complicated intraabdominal infections (241) 241
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minocycline - analogs & derivatives (67) 67
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perforated appendicitis (62) 62
tigecycline (62) 62
bacterial infections - drug therapy (60) 60
efficacy (59) 59
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anti-bacterial agents - administration & dosage (49) 49
pharmacokinetics (49) 49
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ventilator-associated pneumonia (48) 48
aged, 80 and over (47) 47
child, preschool (47) 47
critically-ill patients (47) 47
safety (47) 47
peritonitis (43) 43
pseudomonas-aeruginosa (43) 43
urinary-tract-infections (42) 42
young adult (42) 42
minocycline - therapeutic use (41) 41
abdomen (39) 39
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klebsiella-pneumoniae (39) 39
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medicine, general & internal (31) 31
minocycline - pharmacology (31) 31
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abridged index medicus (30) 30
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drug resistance, multiple, bacterial (30) 30
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Journal of Surgical Research, ISSN 0022-4804, 12/2019, Volume 244, pp. 436 - 443
There is a wide variety of disease severity in patients with complicated intraabdominal infection (cIAI). The prognostic role of intraabdominal view (IAV) was... 
Secondary peritonitis | Organ dysfunctions | Sepsis | Cytokines | Intraabdominal view | Complicated intraabdominal infection | Index Medicus
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 05/2015, Volume 60, Issue 10, pp. 1462 - 1471
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 06/2016, Volume 62, Issue 11, pp. 1380 - 1389
Journal Article
The Pediatric Infectious Disease Journal, ISSN 0891-3668, 08/2018, Volume 37, Issue 8, pp. e207 - e213
Journal Article
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, ISSN 1058-4838, 04/2018, Volume 66, Issue 9, pp. 1470 - 1474
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 11/2018, Volume 62, Issue 11
Eravacycline is a novel, fully synthetic fluorocycline antibiotic with in vitro activity against aerobic and anaerobic Gram-positive and Gram-negative... 
Eravacycline, pharmacokinetics | FLUOROCYCLINE | EFFICACY | eravacycline | HEALTHY-SUBJECTS | MICROBIOLOGY | PHARMACODYNAMICS | CARBAPENEM-RESISTANT ENTEROBACTERIACEAE | ACINETOBACTER-BAUMANNII | TIGECYCLINE | COMPLICATED INTRAABDOMINAL INFECTIONS | pharmacokinetics | PHARMACOLOGY & PHARMACY | IN-VITRO ACTIVITY | PATHOGENS
Journal Article
Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, ISSN 0035-9351, 03/2019, Volume 98, Issue 4, pp. 145 - 151
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 09/2016, Volume 63, Issue 6, pp. 754 - 762
Background. The global emergence of carbapenem-resistant Enterobacteriaceae highlights the urgent need to reduce carbapenem dependence. The phase 3 RECAPTURE... 
acute pyelonephritis | ceftazidime-avibactam | complicated urinary tract infection | INFECTIOUS DISEASES | INITIAL ANTIBIOTIC-THERAPY | ANTIMICROBIAL THERAPY | MICROBIOLOGY | IMMUNOLOGY | INTRAABDOMINAL INFECTION | CARBAPENEM-RESISTANT ENTEROBACTERIACEAE | TREATMENT OPTIONS | BACTERICIDAL ACTIVITY | PSEUDOMONAS-AERUGINOSA | LACTAMASE-PRODUCING ENTEROBACTERIACEAE | SPECTRUM BETA-LACTAMASES | KLEBSIELLA-PNEUMONIAE | Doripenem | Azabicyclo Compounds - administration & dosage | Carbapenems - administration & dosage | Humans | Middle Aged | Male | Pyelonephritis - complications | Urinary Tract Infections - complications | Urinary Tract Infections - drug therapy | Carbapenems - adverse effects | Anti-Bacterial Agents - therapeutic use | Carbapenems - therapeutic use | Ceftazidime - administration & dosage | Adult | Azabicyclo Compounds - therapeutic use | Female | Aged | Anti-Bacterial Agents - adverse effects | Ceftazidime - adverse effects | Pyelonephritis - drug therapy | Anti-Bacterial Agents - administration & dosage | Ceftazidime - therapeutic use | Drug Combinations | Azabicyclo Compounds - adverse effects | Care and treatment | Usage | Pyelonephritis | Clinical trials | Urinary tract infections | Influence | Dosage and administration | Ceftazidime | Antibiotics | Drug resistance | Drug therapy | CRE bacteria | Urinary tract diseases | Index Medicus | and Commentaries
Journal Article
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 09/2018, Volume 62, Issue 9
Eravacycline (7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline or TP-434) is a novel, fully synthetic broad-spectrum fluorocycline with potent... 
Eravacycline | Rabbits | Tissue distribution | Pharmacokinetics | FLUOROCYCLINE | EFFICACY | eravacycline | rabbits | MICROBIOLOGY | tissue distribution | COMPLICATED INTRAABDOMINAL INFECTIONS | IN-VIVO | TP-434 | pharmacokinetics | RESISTANCE | PHARMACOLOGY & PHARMACY | ANTIBACTERIAL AGENT
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 2014, Volume 69, Issue 7, pp. 1945 - 1953
We report the largest clinical experience using tigecycline-containing regimens for salvage treatment of patients with Mycobacterium abscessus and... 
Atypical mycobacterial infections | Non-tuberculous mycobacteria | Cystic fibrosis | Pulmonary | ANTIMICROBIAL SUSCEPTIBILITY | INFECTIOUS DISEASES | EFFICACY | NONTUBERCULOUS MYCOBACTERIA | SAFETY | pulmonary | MICROBIOLOGY | PHASE-3 | RAPIDLY GROWING MYCOBACTERIA | atypical mycobacterial infections | FORTUITUM | SKIN-STRUCTURE INFECTIONS | cystic fibrosis | COMPLICATED INTRAABDOMINAL INFECTIONS | non-tuberculous mycobacteria | PHARMACOLOGY & PHARMACY | VANCOMYCIN-AZTREONAM | Salvage Therapy - adverse effects | Antitubercular Agents - adverse effects | Nausea - chemically induced | Humans | Middle Aged | Minocycline - analogs & derivatives | Male | Nausea - epidemiology | Drug-Related Side Effects and Adverse Reactions - pathology | Young Adult | Minocycline - adverse effects | Minocycline - therapeutic use | Mycobacterium Infections, Nontuberculous - microbiology | Aged, 80 and over | Adult | Female | Child | Antitubercular Agents - therapeutic use | Treatment Outcome | Drug-Related Side Effects and Adverse Reactions - epidemiology | Nontuberculous Mycobacteria - isolation & purification | Drug Therapy, Combination - methods | Adolescent | Aged | Mycobacterium Infections, Nontuberculous - drug therapy | Salvage Therapy - methods | Bacterial infections | Pulmonary fibrosis | Medical treatment | Index Medicus | Original Research
Journal Article
International Journal of Antimicrobial Agents, ISSN 0924-8579, 2017, Volume 49, Issue 5, pp. 579 - 588
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 07/2013, Volume 68, Issue 2, pp. ii45 - ii55
Antimicrobial drug resistance is a growing problem in Europe and, even with differences in epidemiology, it is of great concern. The treatment of complicated... 
Complicated skin and soft-tissue infections | Complicated intra-abdominal infections | Non-interventional studies | Broad-spectrum antibacterial therapy | Polymicrobial infections | INFECTIOUS DISEASES | non-interventional studies | complicated skin and soft-tissue infections | ESCHERICHIA-COLI | MICROBIOLOGY | broad-spectrum antibacterial therapy | IN-VITRO SUSCEPTIBILITY | polymicrobial infections | complicated intra-abdominal infections | SEVERELY ILL PATIENTS | METALLO-BETA-LACTAMASE | SKIN-STRUCTURE INFECTIONS | INTENSIVE-CARE-UNIT | COMPLICATED INTRAABDOMINAL INFECTIONS | PHARMACOLOGY & PHARMACY | STAPHYLOCOCCUS-AUREUS | BLOOD-STREAM INFECTIONS | KLEBSIELLA-PNEUMONIAE | Skin Diseases, Bacterial - microbiology | Gram-Positive Bacteria - drug effects | Minocycline - pharmacology | Humans | Middle Aged | Minocycline - analogs & derivatives | Drug Resistance, Bacterial | Male | Skin Diseases, Bacterial - drug therapy | Gram-Negative Bacteria - isolation & purification | Anti-Bacterial Agents - therapeutic use | Skin Diseases, Bacterial - epidemiology | Minocycline - therapeutic use | Aged, 80 and over | Adult | Female | Soft Tissue Infections - drug therapy | Bacterial Infections - microbiology | Bacterial Infections - drug therapy | Intraabdominal Infections - microbiology | Europe | Treatment Outcome | Soft Tissue Infections - epidemiology | Intraabdominal Infections - epidemiology | Gram-Negative Bacteria - drug effects | Drug Therapy, Combination - methods | Soft Tissue Infections - microbiology | Bacterial Infections - epidemiology | Gram-Positive Bacteria - isolation & purification | Aged | Anti-Bacterial Agents - pharmacology | Intraabdominal Infections - drug therapy | Pathogens | Effectiveness | Antibiotics | Antimicrobial agents | Drug resistance | Drug therapy | Epidemiology | Index Medicus
Journal Article
International Journal of Antimicrobial Agents, ISSN 0924-8579, 05/2018, Volume 51, Issue 5, pp. 727 - 732
After the pharmacokinetic (PK) profile of eravacycline, a novel fluorocycline, was defined, understanding its pharmacodynamic (PD) profile became essential.... 
Eravacycline | Pharmacodynamics | Humanised dose | Tetracycline | INFECTIOUS DISEASES | SAFETY | MICROBIOLOGY | PHARMACOKINETICS | COMPLICATED INTRAABDOMINAL INFECTIONS | ERTAPENEM | MEN | PHARMACOLOGY & PHARMACY | MICE | Antibacterial agents | Analysis | Bacterial infections | Index Medicus
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 2018, Volume 73, Issue 8, pp. 2021 - 2029
Background: Ceftazidime/avibactam is approved for complicated intra-abdominal and urinary tract infections (UTIs) based on results from randomized controlled... 
MEROPENEM | INFECTIOUS DISEASES | COMPLICATED INTRAABDOMINAL INFECTIONS | DOUBLE-BLIND | LACTAMASE-PRODUCING ENTEROBACTERIACEAE | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | PLUS METRONIDAZOLE | HOSPITALIZED ADULTS | PHASE-3 | AVIBACTAM
Journal Article