X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (154) 154
comt inhibitor (139) 139
comt inhibitors (139) 139
levodopa (136) 136
parkinson's disease (128) 128
pharmacology & pharmacy (127) 127
tolcapone (117) 117
entacapone (116) 116
male (114) 114
catechol o-methyltransferase inhibitors (112) 112
parkinsons-disease (104) 104
clinical neurology (98) 98
catechol-o-methyltransferase (97) 97
parkinson disease - drug therapy (97) 97
animals (81) 81
pharmacokinetics (79) 79
female (75) 75
l-dopa (72) 72
index medicus (69) 69
rats (64) 64
neurosciences (63) 63
antiparkinson agents - therapeutic use (60) 60
double-blind (60) 60
metabolism (60) 60
nitriles (59) 59
middle aged (55) 55
motor fluctuations (54) 54
levodopa - therapeutic use (49) 49
aged (45) 45
enzyme inhibitors - pharmacology (45) 45
catechol o-methyltransferase - metabolism (44) 44
nitrophenols (43) 43
catechols - pharmacology (39) 39
selective comt inhibitors (38) 38
antiparkinson agents - adverse effects (37) 37
dose-response relationship, drug (34) 34
levodopa - pharmacokinetics (34) 34
adult (33) 33
benzophenones - pharmacology (33) 33
antiparkinson agents - pharmacokinetics (32) 32
catechols - therapeutic use (32) 32
brain (30) 30
rats, wistar (30) 30
dopamine agonists (29) 29
double-blind method (29) 29
drug therapy, combination (29) 29
levodopa - adverse effects (29) 29
enzyme inhibitors - therapeutic use (28) 28
dopamine (27) 27
antiparkinson agents - administration & dosage (26) 26
antiparkinson agents - pharmacology (25) 25
parkinson disease - physiopathology (24) 24
dopa (23) 23
dopamine - metabolism (23) 23
drug interactions (23) 23
rat (23) 23
levodopa - administration & dosage (22) 22
therapy (22) 22
carbidopa (20) 20
healthy-volunteers (20) 20
pharmacodynamics (20) 20
benzophenones - therapeutic use (19) 19
catechols - administration & dosage (19) 19
improves motor function (19) 19
psychiatry (19) 19
catechols - adverse effects (18) 18
catechols - pharmacokinetics (18) 18
levodopa - pharmacology (18) 18
opicapone (18) 18
toxicology (18) 18
analysis (17) 17
area under curve (17) 17
efficacy (17) 17
kinetics (17) 17
parkinson’s disease (17) 17
pharmacology (17) 17
safety (17) 17
adjuncts (16) 16
chemistry, medicinal (16) 16
comt (16) 16
corpus striatum - drug effects (16) 16
cross-over studies (16) 16
methylation (16) 16
parkinsons disease (16) 16
treatment outcome (16) 16
chromatography, high pressure liquid (15) 15
disease (15) 15
fluctuations (15) 15
levodopa - blood (15) 15
levodopa - metabolism (15) 15
placebo-controlled trial (15) 15
time factors (15) 15
biological availability (14) 14
catechol o-methyltransferase - genetics (14) 14
catechol-o-methyltransferase inhibitors (14) 14
drug combinations (14) 14
drug therapy (14) 14
enzyme inhibitors - administration & dosage (14) 14
enzyme inhibitors - pharmacokinetics (14) 14
healthy-subjects (14) 14
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (314) 314
German (15) 15
Spanish (5) 5
Chinese (2) 2
Italian (2) 2
Japanese (2) 2
Czech (1) 1
French (1) 1
Portuguese (1) 1
Russian (1) 1
Slovenian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Expert Opinion on Pharmacotherapy, ISSN 1465-6566, 03/2017, Volume 18, Issue 4, pp. 445 - 453
Journal Article
CLINICAL PHARMACOKINETICS, ISSN 0312-5963, 02/2013, Volume 52, Issue 2, pp. 139 - 151
Background and Objectives Opicapone is a novel catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to evaluate the tolerability,... 
MOTOR FLUCTUATIONS | TRANSPORT | 3-O-METHYLDOPA | COMT INHIBITOR | L-DOPA | NEBICAPONE | PHARMACOLOGY & PHARMACY | TOLCAPONE | BRAIN | PARKINSONS-DISEASE | LEVODOPA | Physiological aspects | Enzyme inhibitors | Research | Analysis
Journal Article
Chinese Journal of Organic Chemistry, ISSN 0253-2786, 04/2015, Volume 35, Issue 4, pp. 843 - 850
Journal Article
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY, ISSN 1388-6150, 10/2018, Volume 134, Issue 1, pp. 711 - 720
Entacapone, a selective and reversible inhibitor of catechol-O-methyltransferase, is used in the treatment of Parkinson's disease in combination with... 
Compatibility study | LC DETERMINATION | CHEMISTRY, ANALYTICAL | MANAGEMENT | EFFICACY | COMT INHIBITOR | Kinetic study | CONTROLLED-RELEASE | CHEMISTRY, PHYSICAL | Excipient | THERMODYNAMICS | PHARMACOKINETICS | FTIR | KINETICS | Entacapone | Thermal analysis | TOLCAPONE | Catechin | Enzyme inhibitors | Patient compliance | Analysis | Transferases | Antiparkinsonian agents
Journal Article
Neurology, ISSN 0028-3878, 11/1998, Volume 51, Issue 5, pp. 1309 - 1314
Objective: To study the effect and safety of entacapone as an adjunct to levodopa treatment in patients with PD with wearing-off motor fluctuations.... 
CATECHOL-O-METHYLTRANSFERASE | MULTICENTER | PHARMACOKINETICS | METABOLISM | COMT INHIBITOR | DISEASE | DOUBLE-BLIND | PLACEBO-CONTROLLED TRIAL | TOLCAPONE | CLINICAL NEUROLOGY | WEARING-OFF PHENOMENON
Journal Article
Journal Article
Neurology, ISSN 0028-3878, 1997, Volume 49, Issue 4, pp. 1066 - 1071
We studied the new catechol-O-methyltransferase inhibitor tolcapone, 100 and 200 mg, three times daily (tid) in a randomized, double-blind, parallel-group... 
PHARMACOKINETICS | COMT INHIBITOR | FLUCTUATIONS | DISEASE | MECHANISMS | PHARMACODYNAMICS | CLINICAL NEUROLOGY | INHIBITOR TOLCAPONE | LEVODOPA
Journal Article
Journal Article
Dementia and Neurocognitive Disorders, ISSN 1738-1495, 12/2012, Volume 11, Issue 4, pp. 136 - 140
Elevated homocysteine (hcy) levels are associated with dementia, which is a frequent non-motor symptom of Parkinson's disease (PD). High levels of hcy in PD... 
dementia | COMT-inhibitor | Homocysteine | Parkinson\'s disease
Journal Article
Journal Article
Journal Article
International Review of Neurobiology, ISSN 0074-7742, 2010, Volume 95, Issue C, pp. 207 - 225
Journal Article
Clinical Pharmacology in Drug Development, ISSN 2160-763X, 05/2016, Volume 5, Issue 3, pp. 232 - 240
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.