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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 08/2010, Volume 132, Issue 33, pp. 11443 - 11445
G protein-coupled receptors (GPCRs) represent a large fraction of current pharmaceutical targets, and of the GPCRs, the beta(2) adrenergic receptor (beta(2)AR)... 
CONFORMATIONAL-CHANGES | PROTEIN-COUPLED RECEPTOR | LIGAND | CHEMISTRY, MULTIDISCIPLINARY | BETA-ADRENERGIC RECEPTOR | PREDICTION
Journal Article
NATURE, ISSN 0028-0836, 11/2007, Volume 450, Issue 7168, pp. 383 - U4
Structural analysis of G-protein-coupled receptors (GPCRs) for hormones and neurotransmitters has been hindered by their low natural abundance, inherent... 
CRYSTALLIZATION | AGONIST ACTIVATION | DOMAIN | CONFORMATIONAL-CHANGES | LIGAND-BINDING | BOVINE RHODOPSIN | MULTIDISCIPLINARY SCIENCES | INTERMEDIATE | CRYSTALLOGRAPHY | BACTERIORHODOPSIN | BETA-ADRENERGIC RECEPTOR
Journal Article
SCIENCE, ISSN 0036-8075, 04/2011, Volume 332, Issue 6027, pp. 322 - 327
Activation of G protein-coupled receptors upon agonist binding is a critical step in the signaling cascade for this family of cell surface proteins. We report... 
SUBTYPE-SELECTIVITY | COMPLEX | CONFORMATIONAL-CHANGES | ANTAGONIST | CRYSTAL-STRUCTURE | LIGAND RECOGNITION | MULTIDISCIPLINARY SCIENCES | BINDING-SITE | ALLOSTERIC MODULATION | RESIDUES | PROTEIN-COUPLED-RECEPTOR | Adenosine | Research | Properties | Protein binding
Journal Article
SCIENCE, ISSN 0036-8075, 03/2012, Volume 335, Issue 6072, pp. 1106 - 1110
Extracellular ligand binding to G protein-coupled receptors (GPCRs) modulates G protein and beta-arrestin signaling by changing the conformational states of... 
PARTIAL AGONISTS | BETA-2-ADRENERGIC RECEPTOR | BETA ADRENERGIC-RECEPTOR | CONFORMATIONAL-CHANGES | LIGAND-BINDING | PROTEIN-COUPLED RECEPTOR | TRANSMEMBRANE RECEPTORS | CRYSTAL-STRUCTURE | NMR-SPECTROSCOPY | MULTIDISCIPLINARY SCIENCES | A(2A) ADENOSINE RECEPTOR
Journal Article
Biochemistry, ISSN 0006-2960, 12/2018, Volume 57, Issue 51, pp. 6919 - 6922
Aggregation of transthyretin (TTR) causes TTR amyloidoses. The native TTR tetramer (a dimer of dimers) is stabilized by packing of phenylalanine 87 (F87) into... 
BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCED CONFORMATIONAL-CHANGES
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 12/2018, Volume 122, Issue 49, pp. 11554 - 11560
Low-affinity protein complexes and their transient states are difficult to measure in single-molecule experiments because of their low population at low... 
DYNAMICS | CHEMISTRY, PHYSICAL | HSP90 | CONFORMATIONAL-CHANGES | SPECTROSCOPY | DILUTION
Journal Article
Biochimica et biophysica acta. Proteins and proteomics, ISSN 1570-9639, 07/2019
Fungi cellulases are used to degrade cellulose-containing biomass for bioethanol production. Industrial cellulases such as Cel7A from Trichoderma reesei... 
Journal Article
Chemical Communications, ISSN 1359-7345, 2017, Volume 53, Issue 84, pp. 11560 - 11563
G-quadruplexes (G4) represent attractive supramolecular scaffolds. In this communication, we show that the lipid modification of a G4 prone oligonucleotide... 
CONFORMATIONAL-CHANGES | AMPHIPHILES | CHEMISTRY, MULTIDISCIPLINARY | DNA | STABILITY | NUCLEIC-ACIDS
Journal Article
NATURE, ISSN 0028-0836, 02/2016, Volume 530, Issue 7590, pp. 298 - 298
U4/U6.U5 tri-snRNP represents a substantial part of the spliceosome before activation. A cryo-electron microscopy structure of Saccharomyces cerevisiae... 
GROUP-II INTRON | SPLICEOSOME ACTIVATION | ELECTRON CRYOMICROSCOPY | CONFORMATIONAL-CHANGES | ACTIVE-SITE | U5 SNRNP | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | SACCHAROMYCES-CEREVISIAE | SPLICING FACTOR | PRE-MESSENGER-RNA
Journal Article
SCIENCE, ISSN 0036-8075, 11/2007, Volume 318, Issue 5854, pp. 1266 - 1273
The beta(2)-adrenergic receptor (beta(2)AR) is a well-studied prototype for heterotrimeric guanine nucleotide-binding protein ( G protein)-coupled receptors... 
BETA ADRENERGIC-RECEPTOR | LIGAND-BINDING SPECIFICITY | CONSTITUTIVE ACTIVATION | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED-RECEPTORS | CONSERVED ASPARTIC-ACID | RESONANCE ENERGY-TRANSFER | BETA-2-ADRENERGIC RECEPTORS | IDENTIFICATION | AGONISTS | INDUCED CONFORMATIONAL-CHANGES
Journal Article
NATURE REVIEWS DRUG DISCOVERY, ISSN 1474-1776, 03/2013, Volume 12, Issue 3, pp. 205 - 216
Agonists of seven-transmembrane receptors, also known as G protein-coupled receptors (GPCRs), do not uniformly activate all cellular signalling pathways linked... 
BETA ADRENERGIC-RECEPTOR | CONFORMATIONAL-CHANGES | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | HEART-FAILURE | IN-VIVO | PROTEIN-COUPLED RECEPTORS | FUNCTIONAL SELECTIVITY | PHARMACOLOGY & PHARMACY | ALLOSTERIC MODULATION | MU-OPIOID RECEPTOR | ACTIVE STATE | PHARMACOLOGICAL AGONISM
Journal Article
Chemical Society Reviews, ISSN 0306-0012, 7/2010, Volume 39, Issue 8, pp. 2751 - 2767
Recently, expanded porphyrins have come to the forefront in the research field of aromaticity, and been recognized as the most appropriate molecular system to... 
ANTIAROMATICITY | METALATION | CONFORMATIONAL-CHANGES | MOBIUS AROMATICITY | 2-PHOTON ABSORPTION | NONLINEAR-OPTICAL PROPERTIES | HUCKEL | ABSORPTION CROSS-SECTION | HEXAPHYRINS | CHEMISTRY, MULTIDISCIPLINARY | MOLECULES
Journal Article
Accounts of Chemical Research, ISSN 0001-4842, 03/2012, Volume 45, Issue 3, pp. 404 - 413
Journal Article
Chemical Communications, ISSN 1359-7345, 1/2011, Volume 47, Issue 4, pp. 1124 - 115
Dynamic covalent functionality has been acknowledged as a powerful tool for the construction of organised architectures, the reversible nature... 
COVALENT ORGANIC FRAMEWORKS | APPENDED BIPYRIDINIUM SALTS | CHIRAL DERIVATIZATION PROTOCOLS | AIR-WATER-INTERFACE | B-N BOND | X-RAY CRYSTALLOGRAPHY | AFFINITY-CHROMATOGRAPHY | CHEMISTRY, MULTIDISCIPLINARY | FLUORESCENT SACCHARIDE SENSORS | INDUCED CONFORMATIONAL-CHANGES | HYDROGEN STORAGE MATERIALS
Journal Article
Journal of Molecular Liquids, ISSN 0167-7322, 02/2019, Volume 275, pp. 304 - 311
To elucidate the binding interaction and adsorption isotherms and kinetics of molybdenum disulfides quantum dots (MoS QDs) with bovine hemoglobin (BHB) in... 
MoS | quantum dots | Adsorption | Hemoglobin | Binding mechanism | Conformational changes
Journal Article
Nature Communications, ISSN 2041-1723, 11/2016, Volume 7, Issue 1, pp. 13416 - 13416
G Protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors and drug targets. GPCR signalling and desensitization is critically... 
7-TRANSMEMBRANE RECEPTORS | ACTIVATION | RHODOPSIN INTERACTIONS | CONFORMATIONAL-CHANGES | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED RECEPTORS | ARRESTIN/CLATHRIN INTERACTION | BINDING | BETA-ADRENERGIC RECEPTOR | VISUAL ARRESTIN | Index Medicus
Journal Article
NATURE CHEMISTRY, ISSN 1755-4330, 03/2015, Volume 7, Issue 3, pp. 215 - 220
A new intersection between reaction chemistry and electronic circuitry is emerging from the ultraminiaturization of electronic devices. Over decades chemists... 
CONDUCTANCE | CONJUGATION | TRANSPORT | DISTANCE | CONFORMATIONAL-CHANGES | CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | TETRASILANE | ELECTRONICS | DEPENDENCE
Journal Article
Journal of Physical Chemistry B, ISSN 1520-6106, 03/2019, Volume 123, Issue 11, pp. 2567 - 2575
The immobilization of proteins on inorganic supports is attracting increasing interest since the realization of active surfaces finds application in... 
OXIDATION | CONFORMATIONAL-CHANGES | CIRCULAR-DICHROISM | PROTEIN ADSORPTION | STABILITY | SIZE | CHEMISTRY, PHYSICAL | HORSERADISH-PEROXIDASE | EFFICIENCY | RESIDUES | PROBES
Journal Article
NATURE CHEMICAL BIOLOGY, ISSN 1552-4450, 07/2012, Volume 8, Issue 7, pp. 622 - 630
Functional selectivity of G protein-coupled receptor (GPCR) ligands toward different downstream signals has recently emerged as a general hallmark of this... 
PATHWAYS | ACTIVATION | CONFORMATIONAL-CHANGES | BETA-ARRESTIN-2 | ADENYLYL-CYCLASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | INCREASES | PROTEIN-COUPLED RECEPTORS | FUNCTIONAL SELECTIVITY | BETA-ARRESTIN | SIGNALING COMPLEXES
Journal Article