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Journal of Clinical Investigation, ISSN 0021-9738, 12/2007, Volume 117, Issue 12, pp. 3846 - 3856
Persistently activated or tyrosine-phosphorylated STAT3 (pSTAT3) is found in 50% of lung adenocarcinomas. pSTAT3 is found in primary adenocarcinomas and cell... 
RECEPTOR GENE-MUTATIONS | BREAST-CANCER | MEDICINE, RESEARCH & EXPERIMENTAL | SIGNALING PATHWAYS | CONSTITUTIVE ACTIVATION | EPIDERMAL-GROWTH-FACTOR | PROSTATE-CANCER CELLS | SQUAMOUS-CELL CARCINOMA | TYROSINE KINASES | NF-KAPPA-B | MAMMARY EPITHELIAL-CELLS | Janus Kinases | Neoplasm Transplantation | Receptor, Epidermal Growth Factor - genetics | Transcription, Genetic - drug effects | Adenocarcinoma - pathology | Interleukin-6 - antagonists & inhibitors | Cytokine Receptor gp130 - genetics | Humans | Lung Neoplasms - metabolism | Lung Neoplasms - pathology | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | Female | Adenocarcinoma - genetics | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Gene Expression Regulation, Neoplastic - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Lung Neoplasms - genetics | Cytokine Receptor gp130 - metabolism | Interleukin-6 - genetics | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Lung Neoplasms - therapy | Signal Transduction - genetics | Animals | Adenocarcinoma - therapy | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Interleukin-6 - biosynthesis | Mice | Mutation | Transcription, Genetic - genetics | Research | Gene mutations | Lung cancer | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
International Immunopharmacology, ISSN 1567-5769, 2008, Volume 8, Issue 7, pp. 974 - 981
The objective of this study was to assess the effect of ursolic acid, a triterpene on inducing apoptosis in B16F-10 melanoma cells. Treatment of B16F-10 cells... 
Pro-inflammatory cytokines | NF-κB | Ursolic acid | Apoptosis | B16F-10 | PROTEIN FAMILY | DEATH RECEPTORS | SIGNALING PATHWAYS | CONSTITUTIVE ACTIVATION | TRANSCRIPTION | apoptosis | IMMUNOLOGY | CANCER | pro-inflammatory | ursolic acid | NF-kappa B | IMMUNE-SYSTEM | GROWTH | PHARMACOLOGY & PHARMACY | cytokines | CYTOCHROME-C RELEASE | PROGRESSION
Journal Article
Molecular Cell, ISSN 1097-2765, 10/2009, Volume 36, Issue 2, pp. 326 - 339
Journal Article
Journal Article
Expert Opinion on Therapeutic Targets, ISSN 1472-8222, 01/2010, Volume 14, Issue 1, pp. 45 - 55
Importance of the field: Nuclear factor kappa B (NF-κB) is activated by a variety of cancer-promoting agents. The reciprocal activation between NF-κB and... 
NF-κB | chemoresistance | carcinogenesis | proliferation | therapy | apoptosis | cancer | prevention | Prevention | Therapy | Chemoresistance | Proliferation | Carcinogenesis | Apoptosis | Cancer | SIGNALING PATHWAYS | CONSTITUTIVE ACTIVATION | DNA-DAMAGE | DEATH DOMAIN KINASE | CELL-DEATH | LUNG-CANCER | JNK ACTIVATION | TUMOR-NECROSIS-FACTOR | NF-kappa B | ALPHA-DEPENDENT APOPTOSIS | PHARMACOLOGY & PHARMACY | INDUCED CYTOTOXICITY
Journal Article
Environmental Science and Pollution Research, ISSN 0944-1344, 6/2018, Volume 25, Issue 17, pp. 16411 - 16419
PCB 136 is an environmentally relevant chiral PCB congener, which has been found in vivo to be present in form of rotational isomers (atropisomers). Its... 
Environmental Health | Ecotoxicology | Chiral | Pregnane X receptor | Estrogen receptors | Constitutive androstane receptor | Environment, general | Atropisomer | Androgen receptor | Environment | Waste Water Technology / Water Pollution Control / Water Management / Aquatic Pollution | Polychlorinated biphenyl | Environmental Chemistry | Atmospheric Protection/Air Quality Control/Air Pollution | CHIRAL POLYCHLORINATED-BIPHENYLS | REPORTER GENE ASSAY | FEMALE MICE | PXR | INDUCTION | DRUG-METABOLIZING-ENZYMES | DISPOSITION | ENVIRONMENTAL SCIENCES | CAR | EXPRESSION | HYDROXYLATED METABOLITES | Animals | Polychlorinated Biphenyls - chemistry | Receptors, Steroid - metabolism | Stereoisomerism | Biotransformation | Humans | Receptors, Cytoplasmic and Nuclear - chemistry | Receptors, Cytoplasmic and Nuclear - metabolism | Receptors, Steroid - chemistry | Androgens | Estrogen | Polychlorinated biphenyls | Physiological aspects | Exhibitions | Enantiomers | Gene expression | Stereoisomers | Endocrine disruptors | Estrogens | Congeners | Activation | Isomers | Human tissues | PCB compounds | Receptors | Neurotoxicity | Hexachlorobiphenyl | Xenoestrogens | Animal tissues | Metabolism | Nuclear receptors | Rotation | PCB | Polychlorinated biphenyls--PCB | Stereospecificity | Catabolism | Index Medicus | androgen receptor | chiral | constitutive androstane receptor | pregnane X receptor | polychlorinated biphenyl | estrogen receptors | atropisomer
Journal Article
Cancer Research, ISSN 0008-5472, 11/2005, Volume 65, Issue 21, pp. 9891 - 9898
The chemokine stromal-derived factor-lot (SDF-1 alpha/CXCL-12) and its receptor, CXCR4, play a crucial role in adhesion and transendothelium migration (TEM) of... 
CARCINOMA-CELLS | HUMAN PROSTATE-CANCER | HEMATOPOIETIC PROGENITOR CELLS | ONCOLOGY | CHEMOKINE RECEPTOR CXCR4 | CONSTITUTIVE ACTIVATION | BONE-MARROW | ALPHA | FACTOR-I | TRANSCRIPTION FACTOR | TRANSDUCTION PATHWAYS
Journal Article
Oncogene, ISSN 0950-9232, 11/2012, Volume 31, Issue 45, pp. 4798 - 4802
Journal Article
Toxicological Sciences, ISSN 1096-6080, 01/2019, Volume 167, Issue 1, pp. 172 - 189
Abstract Exposure to environmentally relevant chemicals that activate the xenobiotic receptors aryl hydrocarbon receptor (AhR), constitutive androstane... 
PPAR-ALPHA | Cyp2b | CYTOCHROMES P450 | transcript profiling | MOUSE-LIVER | INDUCTION | PXR | aryl hydrocarbon receptor | MESSENGER-RNA | Nrf2 | constitutive androstane receptor | ARYL-HYDROCARBON RECEPTOR | CAR | MICROSOMES | Keap1 | GENE-EXPRESSION | liver cancer | TOXICOLOGY | peroxisome proliferator-activated receptor | oxidative stress
Journal Article
Cancer Research, ISSN 0008-5472, 09/2007, Volume 67, Issue 17, pp. 8051 - 8057
Journal Article