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Chemical Communications, ISSN 1359-7345, 07/2014, Volume 50, Issue 52, pp. 6853 - 6855
A highly stereoselective one-pot procedure involving an enantio-selective Michael addition promoted by low loading of an amino-squaramide catalyst followed by... 
DOMINO REACTIONS | CASCADE REACTIONS | SQUARAMIDE | TRICYCLIC CARBON FRAMEWORKS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | 6 CONTIGUOUS STEREOCENTERS | MICHAEL ADDITION | TOOL | Stereoisomerism | Spiro Compounds - chemical synthesis | Models, Molecular | Crystallography, X-Ray | Molecular Structure | Catalysis | Cyclohexanes - chemical synthesis
Journal Article
by Zhang, CL and Han, YF and Ye, S
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 07/2019, Volume 55, Issue 55, pp. 7966 - 7969
The N-heterocyclic carbene-catalyzed beta-addition of enals to 3-alkylenyloxindoles was developed. All of the beta-aryl, beta-alkenyl and beta-alkyl enals... 
ASYMMETRIC-SYNTHESIS | ORGANOCATALYTIC MICHAEL ADDITION | ISATYLIDENE-3-ACETALDEHYDES APPLICATION | CONSTRUCTION | 1,6-MICHAEL ADDITION | 4 CONTIGUOUS STEREOCENTERS | BEARING | 3-METHYL-4-NITRO-5-ALKENYL-ISOXAZOLES | CHEMISTRY, MULTIDISCIPLINARY | GAMMA-BUTYROLACTONES | ACCESS
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 01/2012, Volume 51, Issue 5, pp. 1248 - 1251
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 02/2009, Volume 50, Issue 6, pp. 704 - 707
Organocatalytic domino oxa-Michael-Michael-Michael-aldol condensation of 2-((E)-2-nitrovinyl)phenol and 2 equiv of α,β-unsaturated aldehydes (e.g.,... 
MACHAERIUM-MULTIFLORUM | CATALYSIS | ASYMMETRIC-SYNTHESIS | TANDEM | TRICYCLIC CARBON FRAMEWORKS | ALPHA,BETA-UNSATURATED ALDEHYDES | ADDITION-REACTIONS | CONSTRUCTION | MULTISUBSTITUTED CYCLOPENTANES | CHEMISTRY, ORGANIC | CONTIGUOUS STEREOCENTERS
Journal Article
Organic Letters, ISSN 1523-7060, 11/2017, Volume 19, Issue 22, pp. 6112 - 6115
An organocatalyzed enantioselective Michael–Michael–Michael–aldol cascade reaction for the construction of cyclopentane fused spirooxindoles was achieved. The... 
DOMINO REACTION | SPIROOXINDOLE DERIVATIVES | CITRINADIN-A | NATURAL-PRODUCTS | ALPHA,BETA-UNSATURATED ALDEHYDES | DRUG DISCOVERY | CONSTRUCTION | AZOMETHINE YLIDES | CHEMISTRY, ORGANIC | 4 CONTIGUOUS STEREOCENTERS | MARINE-DERIVED FUNGUS
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 05/2012, Volume 354, Issue 8, pp. 1401 - 1406
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 05/2018, Volume 59, Issue 18, pp. 1776 - 1778
A stereoselective tandem conjugate addition reaction with a chiral amine-derived nucleophile is reported in which the enolate intermediate is quenched with... 
Asymmetric synthesis | Electrophilic bromination | Conjugate addition | ASYMMETRIC-SYNTHESIS | ACID | ESTERS | CONSTRUCTION | CHEMISTRY, ORGANIC | DERIVATIVES | CONTIGUOUS CHIRAL CENTERS | ADDITION-CYCLIZATION | MICHAEL ADDITION
Journal Article
Journal of Organic Chemistry, ISSN 0022-3263, 05/2015, Volume 80, Issue 9, pp. 4627 - 4637
A novel asymmetric synthetic approach for the construction of enantioenriched functionalized dihydroquinones incorporating adjacent quaternary and tertiary... 
3 CONTIGUOUS STEREOCENTERS | TETRAHYDROTHIOPHENES | PHTHALIDES | ALDOL TANDEM REACTION | CARBON | METHODOLOGIES | CONSTRUCTION | CHEMISTRY, ORGANIC | BOND FORMATION | HENRY REACTION | CYCLIZATION | Benzofurans - chemistry | Naphthoquinones - chemistry | Molecular Structure | Stereoisomerism | Naphthoquinones - chemical synthesis | Allyl Compounds - chemistry
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 10/2016, Volume 358, Issue 20, pp. 3153 - 3153
The front cover image, provided by Xu and co‐workers, illustrates the diarylprolinol silyl ether‐catalyzed domino reaction between α,β‐unsaturated aldehydes,... 
organocatalysis | seven contiguous stereocenters | asymmetric catalysis | oxabicyclo[2.2.2]octanes | domino reaction
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 06/2013, Volume 15, Issue 12, pp. 3042 - 3045
An effective reflexive-Michael (r-M) reaction has been disclosed to access drug-like six-membered spirooxindoles in good yields and excellent... 
MULTIPLE STEREOCENTERS | ORGANOCATALYST | DIELS-ALDER REACTION | CONSTRUCTION | CHEMISTRY, ORGANIC | CARBONYL-COMPOUNDS | CONTIGUOUS STEREOCENTERS | SPIROCYCLIC OXINDOLES | CONCISE SYNTHESIS | DERIVATIVES | HIGHLY EFFICIENT
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 11/2016, Volume 81, Issue 21, pp. 10558 - 10568
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 01/2017, Volume 82, Issue 1, pp. 397 - 406
An efficient organocatalytic cascade reaction has been developed involving a Michael–hemiaminalization relay for the asymmetric synthesis of spiropiperidinone... 
CONTIGUOUS STEREOGENIC CENTERS | PRIMARY AMINE | NONADJACENT STEREOCENTERS | 1,3-DICARBONYL COMPOUNDS | CARBON QUATERNARY STEREOCENTERS | CHEMISTRY, ORGANIC | ENAMINE CATALYSIS | ALPHA-ALLYLATION | DUAL CATALYSIS | BETA-KETOCARBONYLS | MICHAEL ADDITION
Journal Article
RSC Advances, ISSN 2046-2069, 10/2016, Volume 6, Issue 98, pp. 96154 - 96175
Organocatalytic domino/cascade reactions provide a convenient method for the construction of highly functionalized cyclic molecular structures bearing multiple... 
SULFA-MICHAEL/MICHAEL ADDITION | ASYMMETRIC-SYNTHESIS | QUATERNARY STEREOCENTER | ENANTIOSELECTIVE SYNTHESIS | CONSTRUCTION | EFFICIENT SYNTHESIS | CONTIGUOUS STEREOCENTERS | DERIVATIVES | CHEMISTRY, MULTIDISCIPLINARY | DYNAMIC KINETIC RESOLUTION | ACCESS
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 06/2018, Volume 54, Issue 50, pp. 6607 - 6621
Chiral spirooxindoles are privileged heterocyclic motifs, which are widely found in natural alkaloids and pharmaceuticals. Moreover, the construction of chiral... 
Journal Article