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British Journal of Clinical Pharmacology, ISSN 0306-5251, 01/2018, Volume 84, Issue 1, pp. 112 - 121
Aims This phase 1, open‐label, crossover study sought to evaluate drug–drug interactions between tivantinib and cytochrome P450 (CYP) substrates and tivantinib... 
pharmacokinetics | cancer | P‐glycoprotein | cytochrome P450 | tivantinib | drug interaction | P-glycoprotein | ADVANCED HEPATOCELLULAR-CARCINOMA | TARGETING MET | CYTOTOXIC ACTIVITY | COOPERSTOWN 5+1 COCKTAIL | CELL LUNG-CANCER | TYROSINE KINASE INHIBITORS | METABOLISM | DOUBLE-BLIND | PHARMACOLOGY & PHARMACY | MET INHIBITION | PHASE-I | Neoplasms - metabolism | Quinolines - blood | Chromatography, High Pressure Liquid - methods | Humans | Middle Aged | Omeprazole - blood | Cytochrome P-450 Enzyme System - metabolism | Male | Antineoplastic Agents - therapeutic use | Quinolines - pharmacology | Warfarin - pharmacology | Drug Interactions | Neoplasms - blood | Pyrrolidinones - pharmacology | Aged, 80 and over | Caffeine - pharmacology | Adult | Female | Omeprazole - pharmacology | Antineoplastic Agents - pharmacology | Tandem Mass Spectrometry - methods | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Caffeine - blood | Pyrrolidinones - therapeutic use | Pyrrolidinones - blood | ATP Binding Cassette Transporter, Subfamily B - metabolism | Neoplasms - drug therapy | Cross-Over Studies | Drug Therapy, Combination - methods | Midazolam - blood | Warfarin - blood | Antineoplastic Agents - blood | Aged | Quinolines - therapeutic use | Midazolam - pharmacology | Medical research | Care and treatment | Warfarin | Digoxin | Drug interactions | Cytochrome P-450 | Omeprazole | Complications and side effects | Analysis | Medicine, Experimental | Dosage and administration | Tumors | Caffeine
Journal Article
Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, 09/2016, Volume 119, Issue 3, pp. 284 - 290
Cytochrome P450 (CYP) activity can be assessed using a ‘cocktail’ phenotyping approach. Recently, we have developed a cocktail (Geneva cocktail) which combines... 
2D6 | PARAXANTHINE | BUPROPION | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | FLURBIPROFEN | METABOLIZING-ENZYMES | COOPERSTOWN 5+1 COCKTAIL | ORAL-CONTRACEPTIVES | P-GLYCOPROTEIN | Caffeine - administration & dosage | Humans | Midazolam - administration & dosage | Male | Genotyping Techniques | Cytochrome P-450 CYP2B6 - metabolism | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Dose-Response Relationship, Drug | Young Adult | Drug Interactions | Cytochrome P-450 CYP3A - genetics | Dried Blood Spot Testing - methods | Cytochrome P-450 CYP1A2 - genetics | Flurbiprofen - administration & dosage | Adult | Female | Dextromethorphan - pharmacokinetics | Cytochrome P-450 CYP2C9 - metabolism | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Cytochrome P-450 CYP2D6 - genetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 CYP2B6 - genetics | Omeprazole - administration & dosage | Cytochrome P-450 CYP2C19 - genetics | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Midazolam - pharmacokinetics | Cytochrome P-450 CYP1A2 - metabolism | Bupropion - administration & dosage | Cytochrome P-450 CYP2C9 - genetics | Cross-Over Studies | Phenotype | Cytochrome P-450 CYP3A - metabolism | Adolescent | Cytochrome P-450 CYP2D6 - metabolism | Cytochrome P-450 Enzyme System - genetics | Cytochrome P-450 CYP2C19 - metabolism | Dextromethorphan - administration & dosage | Medical examination | Drug interactions | Analysis | Methods | Blood | Cytochrome P-450 | Confidence intervals | Cytochrome | Prescription drugs | Drug dosages | Index Medicus
Journal Article
Journal Article
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2014, Volume 18, Issue 10, pp. 1439 - 1447
BACKGROUND AND AIM: Probe drugs have been widely used to assess the activities of various CYP450 (cytochromes P450) isoenzymes in many fields of drug... 
Nephrotic syndrome | Rat | Pharmacokinetics | CYP450 | Probe drug | METABOLITES | HUMAN PLASMA | BIOANALYTICAL METHODS | PROTEIN-BINDING | TANDEM MASS-SPECTROMETRY | KAROLINSKA COCKTAIL | COOPERSTOWN 5+1 COCKTAIL | CYTOCHROME-P450 ENZYMES | PITTSBURGH COCKTAIL | PHARMACOLOGY & PHARMACY
Journal Article
Journal Article
Journal Article
Journal of Chromatography B, ISSN 1570-0232, 2010, Volume 878, Issue 15, pp. 1169 - 1177
Journal Article
Latin American Journal of Pharmacy, ISSN 0326-2383, 2014, Volume 33, Issue 6, pp. 914 - 919
Dimethoate (DM) as a kind of high-effective organophosphorus pesticides (OPPs) is widely used in agricultural production; however, its residues in... 
Rat | Dimethoate | Pharmacokinetics | CYP450 | Liver | OXIDATIVE STRESS | VITAMIN-E | TANDEM MASS-SPECTROMETRY | KAROLINSKA COCKTAIL | COOPERSTOWN 5+1 COCKTAIL | ANTIOXIDANT STATUS | PHARMACOLOGY & PHARMACY | ORGANOPHOSPHORUS PESTICIDE | EXPOSURE | BLOOD
Journal Article
Latin American Journal of Pharmacy, ISSN 0326-2383, 2013, Volume 32, Issue 10, pp. 1452 - 1456
The effect of China Bayberry (Myrica rubra) on cytochrome p450 isozymes CYP1A2, CYP2C9, CYP2D6, CYP3A4, CYP2C19, CYP2B6 by cocktail method has been studied.... 
CYP450 | Rat pharmacokinetics | China bayberry | METABOLITES | HUMAN PLASMA | BIOANALYTICAL METHODS | VALIDATION | TANDEM MASS-SPECTROMETRY | KAROLINSKA COCKTAIL | COOPERSTOWN 5+1 COCKTAIL | FRUIT | PITTSBURGH COCKTAIL | PHARMACOLOGY & PHARMACY | MYRICA-RUBRA-SIEB
Journal Article
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