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Cancer Research, ISSN 0008-5472, 02/2011, Volume 71, Issue 3, pp. 884 - 894
COP1 is a p53-targeting E3 ubiquitin ligase that is downregulated by DNA damage through mechanisms that remain obscure. Here we report that COP1 is not... 
COP1 | 14-3-3σ | ubiquitination | p53
Journal Article
Experimental Cell Research, ISSN 0014-4827, 09/2019, Volume 382, Issue 1, p. 111428
Fatty acid-induced lipotoxicity plays an important role in the pathogenesis of diabetes mellitus. Our previous studies have documented that lipotoxicity... 
TRB3 | Insulin resistance | COP1 | Lipotoxicity | SIRT1 | OXIDATIVE STRESS | ACTIVATION | TRIBBLES HOMOLOG | FATTY-ACID-METABOLISM | SENSITIVITY | CELL BIOLOGY | MODULATES GLUCONEOGENESIS | GLUCOSE-HOMEOSTASIS | C/EBP-ALPHA | ONCOLOGY | UBIQUITIN LIGASE COP1 | INFLAMMATION
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 02/2011, Volume 71, Issue 3, pp. 884 - 894
Constitutive photomorphogenic 1 (COP1) is a p53-targeting E3 ubiquitin ligase that is downregulated by DNA damage through mechanisms that remain obscure. Here,... 
INHIBITION | ARABIDOPSIS COP1 | ONCOLOGY | UBIQUITIN LIGASE COP1 | DNA-DAMAGE | C-JUN | IDENTIFICATION | PROTEINS | PROGRESSION | NEGATIVE REGULATOR | P53
Journal Article
The EMBO Journal, ISSN 0261-4189, 02/2019, Volume 38, Issue 4, p. n/a
Journal Article
Journal Article
Cell Cycle, ISSN 1538-4101, 07/2015, Volume 14, Issue 14, pp. 2265 - 2273
The COP9 signalosome subunit 6 (CSN6), which is involved in ubiquitin-mediated protein degradation, is overexpressed in many types of cancer. CSN6 is critical... 
COP9 signalosome | COP1 | p27 | ubiquitination | CSN6 | Ubiquitination | P27
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 03/2017, Volume 114, Issue 13, pp. 3539 - 3544
Journal Article
Current Biology, ISSN 0960-9822, 06/2019, Volume 29, Issue 12, pp. 1954 - 1962.e4
In plants, cryptochromes are photoreceptors that negatively regulate the ubiquitin ligase CRL4 . In mammals, cryptochromes are core components of the circadian... 
c-Jun | glucocorticoid receptor | CRL4 | transrepression | cryptochromes | glucagon | Cul4 | circadian clock | Cop1 | Det1
Journal Article
by Jin, HH and Zhu, ZQ
TRENDS IN PLANT SCIENCE, ISSN 1360-1385, 07/2019, Volume 24, Issue 7, pp. 569 - 571
It is well known that E3 ubiquitin ligase COP1 is a negative regulator of plant photomorphogenesis. However, COP1 acts as a positive regulator under UV-B... 
PERCEPTION | PHOTOMORPHOGENESIS | PLANT SCIENCES | Ligases | Proteolysis | Analysis | U.V. radiation
Journal Article
Trends in Plant Science, ISSN 1360-1385, 10/2013, Volume 18, Issue 10, pp. 575 - 583
Journal Article
Nature Communications, ISSN 2041-1723, 2017, Volume 8, Issue 1, p. 15234
Plant cryptochromes undergo blue light-dependent phosphorylation to regulate their activity and abundance, but the protein kinases that phosphorylate plant... 
COP1 ACTIVITY | 1 INTERACTS | PROTEIN | QUANTIFICATION | MULTIDISCIPLINARY SCIENCES | IN-VIVO | CRY2 | DEGRADATION | FLORAL INITIATION | PHOTOACTIVATION | SPA1
Journal Article
Annual Review of Plant Biology, ISSN 1543-5008, 04/2013, Volume 64, Issue 1, pp. 403 - 427
The dynamic light environment of vegetation canopies is perceived by phytochromes, cryptochromes, phototropins, and UV RESISTANCE LOCUS 8 (UVR8). These... 
Shade avoidance | Auxin | PHYTOCHROME INTERACTING FACTOR (PIF) | Cryptochrome | Phytochrome | phytochrome | ARABIDOPSIS-THALIANA | NATURAL-ENVIRONMENT | auxin | BLUE-LIGHT RECEPTORS | PHYTOCHROME INTERACTING FACTOR-3 | HYPOCOTYL GROWTH | PLANT SCIENCES | CIRCADIAN CLOCK | shade avoidance | COP1 E3 LIGASE |