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1. Full Text HIV-1 remission following CCR5 Delta 32/Delta 32 haematopoietic stem-cell transplantation
by Gupta, RK and Abdul-Jawad, S and Mccoy, LE and Mok, HP and Peppa, D and Salgado, M and Martinez-Picado, J and Nijhuis, M and Wensing, AMJ and Lee, H and Grant, P and Nastouli, E and Lambert, J and Pace, M and Salasc, F and Monit, C and Innes, AJ and Muir, L and Waters, L and Frater, J and Lever, AML and Edwards, SG and Gabriel, IH and Olavarria, E
NATURE, ISSN 0028-0836, 04/2019, Volume 568, Issue 7751, pp. 244 - 244
A cure for HIV-1 remains unattainable as only one case has been reported, a decade ago(1,2). The individual-who is known as the 'Berlin patient'-underwent two... 
CORECEPTOR | TROPISM | MULTIDISCIPLINARY SCIENCES | CCR5 | PREDICTION
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2. Full Text Delineating CD4 dependency of HIV-1: Adaptation to infect low level CD4 expressing target cells widens cellular tropism but severely impacts on envelope functionality
by Beauparlant, David and Rusert, Peter and Magnus, Carsten and Kadelka, Claus and Weber, Jacqueline and Uhr, Therese and Zagordi, Osvaldo and Oberle, Corinna and Duenas-Decamp, Maria J and Clapham, Paul R and Metzner, Karin J and Günthard, Huldrych F and Trkola, Alexandra
PLoS Pathogens, ISSN 1553-7366, 03/2017, Volume 13, Issue 3, p. e1006255
A hallmark of HIV-1 infection is the continuously declining number of the virus' predominant target cells, activated CD4(+) T cells. With diminishing CD4(+) T... 
R5 ENVELOPES | LYMPHOID-TISSUES | MICROBIOLOGY | ANTIRETROVIRAL THERAPY | ENHANCES MACROPHAGE TROPISM | IN-VITRO | VIROLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | CORECEPTOR USAGE | ANTI-CD4 MONOCLONAL-ANTIBODY | BIOLOGICAL-PROPERTIES | T-CELLS | PARASITOLOGY | HIV-1 - pathogenicity | Macrophages - virology | Cell Separation | HIV Infections - virology | Humans | Adaptation, Physiological - physiology | HIV Envelope Protein gp120 - metabolism | Leukocytes, Mononuclear - virology | Virus Internalization | CD4 Antigens - metabolism | Viral Tropism - physiology | Tropisms | Genetic aspects | Glycoproteins | Research | Gene expression | T cells | HIV infection | Tropism | Cell culture | Biological evolution | Central nervous system | Antibodies | Viruses | Nervous system | Lymphocytes T | Infections | Macrophages | Epidemiology | Envelopes | Receptors | Immunology | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Infectivity | Human immunodeficiency virus--HIV | Evolution | Drug therapy | Adaptation | CCR5 protein | Immunoglobulins | Shielding | Low level | Virology | CD4 antigen | Medicine | Hospitals | Infectious diseases | Neutralizing | Immune privilege | Mutation | In vitro methods and tests | Fitness | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
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3. Full Text AMD3100 Is a CXCR7 Ligand with Allosteric Agonist Properties
by Irina Kalatskaya and Yamina A. Berchiche and Stéphanie Gravel and Brian J. Limberg and Jan S. Rosenbaum and Nikolaus Heveker
Molecular Pharmacology, ISSN 0026-895X, 05/2009, Volume 75, Issue 5, pp. 1240 - 1247
The bicyclam AMD3100 is known as a small synthetic inhibitor of the CXCL12-binding chemokine receptor CXCR4. Here, we show that AMD3100 also binds to the... 
Receptors, CXCR - chemistry | Receptors, CXCR4 - antagonists & inhibitors | Allosteric Regulation | Humans | Cells, Cultured | Heterocyclic Compounds - pharmacology | Luminescence | Arrestins - metabolism | Chemokine CXCL12 - metabolism | Chemokine CXCL12 - pharmacology | beta-Arrestins | Dimerization | Receptors, CXCR - agonists | MOLECULAR-MECHANISM | BICYCLAM AMD3100 | ACTIVATION | IMMUNODEFICIENCY-VIRUS CORECEPTOR | CHEMOKINE RECEPTOR | RESONANCE ENERGY-TRANSFER | PHARMACOLOGY & PHARMACY | HIV-1 CORECEPTOR | ANTAGONISTS | MODULATION | REVEALS
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4. Full Text A novel cd8-cis-regulatory element preferentially directs expression in CD44 hi CD62L + CD8 + T cells and in CD8αα + dendritic cells
by Sakaguchi, Shinya and Hombauer, Matthias and Hassan, Hammad and Tanaka, Hirokazu and Yasmin, Nighat and Naoe, Yoshinori and Bilic, Ivan and Moser, Mirjam A and Hainberger, Daniela and Mayer, Herbert and Seiser, Christian and Bergthaler, Andreas and Taniuchi, Ichiro and Ellmeier, Wilfried
Journal of Leukocyte Biology, ISSN 0741-5400, 04/2015, Volume 97, Issue 4, pp. 635 - 644
Transgenics | Enhancer | CD8 coreceptor | Gene expression
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5. Full Text Disparate impact on CD4 T cell count by two distinct HIV-1 phylogenetic clusters from the same Glade
by Song, HS and Ou, WD and Feng, Y and Zhang, JL and Li, F and Hu, J and Peng, H and Xing, H and Ma, LY and Tan, QX and Li, DL and Wang, LJ and Wu, BL and Shao, YM
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 01/2019, Volume 116, Issue 1, pp. 239 - 244
HIV-1 evolved into various genetic subtypes and circulating recombinant forms (CRFs) in the global epidemic. The same subtype or CRF is usually considered to... 
Coreceptor tropism | E INFECTION | MULTIDISCIPLINARY SCIENCES | CXCR4 | HIV-1 pathogenesis | HUMAN-IMMUNODEFICIENCY-VIRUS | PROGNOSTIC VALUE | CORECEPTOR USE | CRF01_AE | SYNCYTIUM-INDUCING PHENOTYPE | EXPERIENCED PATIENTS | TYPE-1 | CCR5 | CD4 count | BIOLOGICAL PHENOTYPE | DISEASE PROGRESSION
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6. Full Text Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist RevealsMechanisms of Chemokine Recognition and Molecular Mimicry by HIV
by Zheng, Y and Han, GW and Abagyan, R and Wu, BL and Stevens, RC and Cherezov, V and Kufareva, I and Handel, TM
IMMUNITY, ISSN 1074-7613, 06/2017, Volume 46, Issue 6, pp. 1005 - 1005
CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120.... 
AMINO-TERMINAL DOMAIN | CORECEPTOR | PEPTIDES | RANTES | CRYSTAL-STRUCTURE | CXCR4 | HIGH-AFFINITY BINDING | N-TERMINUS | GP120 | IMMUNOLOGY | MEMBRANE-PROTEINS
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7. Full Text Canine tissue-associated CD4(+)CD8 alpha(+) double-positive T cells are an activated T cell subpopulation with heterogeneous functional potential
by Rabiger, FV and Bismarck, D and Protschka, M and Kohler, G and Moore, PF and Buttner, M and von Buttlar, H and Alber, G and Eschke, M
PLOS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3, p. e0213597
Canine CD4(+)CD8 alpha(+) double-positive (dp) T cells of peripheral blood are a unique effector memory T cell subpopulation characterized by an increased... 
ANTIBODIES | CORECEPTOR | MULTIDISCIPLINARY SCIENCES | PURIFICATION | CD4(+) | PERIPHERAL-BLOOD | FLOW-CYTOMETRIC ANALYSIS | EXPRESSION | FOXP3 | INTRAEPITHELIAL LYMPHOCYTES | CD8-ALPHA-ALPHA
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8. Full Text Deep third variable sequencing for HIV type 1 tropism in treatment-naive patients: A reanalysis of the MERIT trial of maraviroc
by Swenson, Luke C and Mo, Theresa and Dong, Winnie W. Y and Zhong, Xiaoyin and Woods, Conan K and Thielen, Alexander and Jensen, Mark A and Knapp, David J. H. F and Chapman, Douglass and Portsmouth, Simon and Lewis, Marilyn and James, Ian and Heera, Jayvant and Valdez, Hernan and Harrigan, P. Richard
Clinical Infectious Diseases, ISSN 1058-4838, 10/2011, Volume 53, Issue 7, pp. 732 - 742
Background. Deep sequencing is a highly sensitive technique that can detect and quantify the proportion of non-R5 human immunodeficiency virus (HIV) variants,... 
POPULATION | INFECTIOUS DISEASES | ENTRY | ASSAY | THERAPY | ENHANCED SENSITIVITY | MICROBIOLOGY | INFECTION | IMMUNOLOGY | CCR5 | CORECEPTOR TROPISM
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9. Full Text Population-based V3 genotypic tropism assay: A retrospective analysis using screening samples from the A4001029 and MOTIVATE studies
by McGovern, Rachel A and Thielen, Alexander and Mo, Theresa and Dong, Winnie and Woods, Conan K and Chapman, Douglass and Lewis, Marilyn and James, Ian and Heera, Jayvant and Valdez, Hernan and Harrigan, P. Richard
AIDS, ISSN 0269-9370, 10/2010, Volume 24, Issue 16, pp. 2517 - 2525
Background: The MOTIVATE-1 and 2 studies compared maraviroc (MVC) along with optimized background therapy (OBT) vs. placebo along with OBT in... 
Tropism | CCR5 antagonist | Coreceptor | Genotyping | Maraviroc | INFECTIOUS DISEASES | maraviroc | MOLECULE | genotyping | tropism | coreceptor | IMMUNOLOGY | TRIAL | VIROLOGY | TREATMENT-EXPERIENCED PATIENTS | CCR5 INHIBITOR | CORECEPTOR USAGE | HIV-1 INFECTION | HIV Envelope Protein gp120 - genetics | Triazoles - administration & dosage | HIV Infections - genetics | HIV Infections - virology | Humans | Genotype | Male | CD4 Lymphocyte Count | Clinical Trials as Topic | Cyclohexanes - administration & dosage | HIV-1 - genetics | Receptors, HIV - genetics | Sequence Analysis, DNA | Viral Load | HIV-1 - physiology | RNA, Viral - genetics | Adult | Female | HIV Envelope Protein gp120 - physiology | Viral Tropism - genetics | Viral Tropism - physiology
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10. Full Text Improving CLL V gamma 9V delta 2-T-cell fitness for cellular therapy by ex vivo activation and ibrutinib
by de Weerdt, I and Hofland, T and Lameris, R and Endstra, S and Jongejan, A and Moerland, PD and de Bruin, RCG and Remmerswaal, EBM and ten Berge, IJM and Liu, N and van der Stelt, M and Faber, LM and Levin, MD and Eldering, E and Tonino, SH and de Gruijl, TD and van der Vliet, HJ and Kater, AP
BLOOD, ISSN 0006-4971, 11/2018, Volume 132, Issue 21, pp. 2260 - 2272
The efficacy of autologous (ab) T-cell-based treatment strategies in chronic lymphocytic leukemia (CLL) has been modest. The V gamma 9V delta 2-T cell subset... 
INTERLEUKIN-2 | ZOLEDRONATE | CORECEPTOR | RECOGNIZE | IMMUNOTHERAPY | REMISSIONS | CHRONIC LYMPHOCYTIC-LEUKEMIA | DELTA-T-CELLS | INHIBITOR | HEMATOLOGY | PHASE-I
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11. Full Text Shared and distinct phenotypes and functions of human cD161++ Vα7.2+ T cell subsets
by Kurioka, Ayako and Jahun, Aminu S and Hannaway, Rachel F and Walker, Lucy J and Fergusson, Joannah R and Sverremark-Ekström, Eva and Corbett, Alexandra J and Ussher, James E and Willberg, Christian B and Klenerman, Paul
Frontiers in Immunology, ISSN 1664-3224, 08/2017, Volume 8, p. 1031
Human mucosal-associated invariant T (MAIT) cells are an important T cell subset that are enriched in tissues and possess potent effector functions. Typically... 
Mucosal-associated invariant T cells, Innate-like T cells, MHC class I-related protein 1-tetramer, MHC class I-related protein 1, Subsets, Transcription factors, CD8 coreceptor | mucosal-associated invariant T cells | innate-like T cells | transcription factors | MHC class I-related protein 1-tetramer | MHC class I-related protein 1 | subsets
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12. Full Text Selective use of primate CD4 receptors by HIV-1
by Warren, CJ and Meyerson, NR and Dirasantha, O and Feldman, ER and Wilkerson, GK and Sawyer, SL
PLOS BIOLOGY, ISSN 1544-9173, 06/2019, Volume 17, Issue 6, p. e3000304
Individuals chronically infected with HIV-1 harbor complex viral populations within their bloodstreams. Recently, it has come to light that when these people... 
HAPLOTYPE RECONSTRUCTION | MACROPHAGE-TROPIC HIV-1 | TRANSMISSION | POSITIVE SELECTION | VARIANTS | ENVELOPE GLYCOPROTEINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | TYPE-1 | ENTRY PHENOTYPES | MONONUCLEAR PHAGOCYTES | Biological properties | Visualization | Animal models | Viruses | Infections | Lymphocytes T | Vaccines | Blood | Proteins | T-cell receptor | Receptors | Human immunodeficiency virus--HIV | Virions | Primates | Species | Binding | Medical research | Phenotypes | Developmental biology | Monkeys & apes | CD4 antigen | Disease transmission | Herpes viruses | Affinity | Laboratory animals | HIV | Human immunodeficiency virus
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13. Full Text Glycosylphosphatidylinositol-anchored proteins as chaperones and co-receptors for FERONIA receptor kinase signaling in Arabidopsis
by Li, Chao and Yeh, Fang-Ling and Cheung, Alice Y and Duan, Qiaohong and Kita, Daniel and Liu, Ming-Che and Maman, Jacob and Luu, Emily J and Wu, Brendan W and Gates, Laura and Jalal, Methun and Kwong, Amy and Carpenter, Hunter and Wu, Hen-Ming
eLife, ISSN 2050-084X, 06/2015, Volume 4, Issue JUNE, pp. 1 - 21
The Arabidopsis receptor kinase FERONIA (FER) is a multifunctional regulator for plant growth and reproduction. Here we report that the female... 
RAC/ROP GTPASES | MALE-GAMETE DELIVERY | NADPH OXIDASE | CELL ELONGATION | PEPTIDE-HORMONE | POLLEN-TUBE RECEPTION | BIOLOGY | FLUORESCENCE COMPLEMENTATION BIFC | ENDOPLASMIC-RETICULUM | GPI-ANCHORS | ABSCISIC-ACID | Phosphotransferases - metabolism | Arabidopsis - physiology | Arabidopsis Proteins - genetics | Immunoprecipitation | Molecular Chaperones - metabolism | Reactive Oxygen Species - metabolism | Membrane Glycoproteins - metabolism | Electrophoresis, Polyacrylamide Gel | Immunoblotting | DNA Primers | Reverse Transcriptase Polymerase Chain Reaction | GPI-Linked Proteins - metabolism | Membrane Glycoproteins - genetics | Arabidopsis Proteins - metabolism | Peptide Hormones - metabolism | Two-Hybrid System Techniques | Glycosylphosphatidylinositols - metabolism | rho GTP-Binding Proteins - metabolism | Signal Transduction - physiology | Microscopy, Fluorescence | GPI-Linked Proteins - genetics | Transcription factors | Sperm | Biology | Hormones | Chaperones | Gene expression | Kinases | Cell surface | Seedlings | Proteins | Cell growth | Microscopy | Glycosylphosphatidylinositol | Endoplasmic reticulum | Deoxyribonucleic acid--DNA | Guanosinetriphosphatase
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14. Full Text Engineering HIV-resistant human CD4+ T cells with CXCR4-specific zinc-finger nucleases
by Wilen, Craig B and Wang, Jianbin and Tilton, John C and Miller, Jeffrey C and Kim, Kenneth A and Rebar, Edward J and Sherrill-Mix, Scott A and Patro, Sean C and Secreto, Anthony J and Jordan, Andrea P. O and Lee, Gary and Kahn, Joshua and Aye, Pyone P and Bunnell, Bruce A and Lackner, Andrew A and Hoxie, James A and Danet-Desnoyers, Gwenn A and Bushman, Frederic D and Riley, James L and Gregory, Philip D and June, Carl H and Holmes, Michael C and Doms, Robert W
PLoS Pathogens, ISSN 1553-7366, 04/2011, Volume 7, Issue 4, p. e1002020
HIV-1 entry requires the cell surface expression of CD4 and either the CCR5 or CXCR4 coreceptors on host cells. Individuals homozygous for the ccr5 Delta 32... 
CD4(+) T-CELLS | CXCR4 | MICROBIOLOGY | EXTRACELLULAR LOOP | IN-VITRO | VIROLOGY | BASE-LINE RESISTANCE | CHEMOKINE RECEPTOR | CORECEPTOR USAGE | GENE-TRANSFER | TYPE-1 | PARASITOLOGY | CCR5 CORECEPTOR | Cell Proliferation | Humans | Receptors, CCR5 - genetics | Transplantation, Autologous | Transplantation, Heterologous | Macaca mulatta | Receptors, CCR5 - immunology | Virus Internalization | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Deoxyribonucleases - immunology | Receptors, CCR5 - metabolism | Deoxyribonucleases - biosynthesis | Receptors, CXCR4 - genetics | Disease Models, Animal | HIV-1 - metabolism | HIV Infections - genetics | CD4-Positive T-Lymphocytes - metabolism | HIV-1 - genetics | Receptors, CXCR4 - metabolism | Deoxyribonucleases - genetics | HIV-1 - immunology | Animals | Genetic Engineering | CD4-Positive T-Lymphocytes - transplantation | Receptors, CXCR4 - immunology | HIV Infections - therapy | Mice | HIV Infections - metabolism | Nucleases | Physiological aspects | Research | HIV (Viruses) | T cells | Health aspects | Chemokine receptors | Proteins | Studies | Cell growth | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Infections | Genomes | Mutation | Deoxyribonucleic acid--DNA | AIDS | HIV | Acquired immune deficiency syndrome | Deoxyribonucleic acid | DNA | Human immunodeficiency virus
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